EKS-MOD-00279
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00279
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR394.82.3E-118241534294
StatusUnreviewed
Ensembl ProteinENSMODP00000018937
UniProt AccessionF7CFN3;
Protein Name
Protein Synonyms/Alias
Gene NameTGFBR2
Gene Synonyms/Alias TGFBR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000015155ENSMODP00000018937ENSMODT00000019279
OrganismMonodelphis domestica
Functional Description
Protein Length564
Protein Sequence
(FASTA)
MSRALLWSPG LLLLFLWTRN ASTIPPHVQK IVDGVPVTEE NGAIKSSLLC KFCDIQPSNC 60
TNDRSCPSYC GITSICEKAH EICVAVWRKN DKNITIETLC HDPSLEVHGF PLEDSNSDKC 120
IMREKKVPGE TFFMCSCRKE ECNDILFFSE DVLDNFDLMA IIFKVTVISL LPPLGIAIAV 180
IIIFYCYRVH RRRKLSTAWE TSKPGKPDYS EGCAMMLDDD RSDISSTCAN NLNHNTELLP 240
IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKEI FSDINLKHEN 300
ILQFLTAEER KMDLGKQYWL ITAFHARGNL QEYLTRHVIS WEDLWKLGSS LARGIAHLHS 360
DHTPCGRPKT AIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 420
YMAPEVLESR MNLENMESFK QTDVYSMALV LWEMTSRCNE IGEVKEYEPP FGSKVREHPC 480
VESMKDNVLR DRGRPEIPNT WLSHRGIQMV CETLAECWDH DPEARLTAQC VAERFDQLGD 540
LDRLSGRSCS EEKIPEDCSL SPTK 564
Nucleotide Sequence
(FASTA)
ATGAGTCGGG CTCTCCTGTG GAGCCCGGGG CTACTGCTCC TCTTCCTGTG GACGCGCAAT 60
GCCAGCACCA TCCCTCCCCA CGTCCAGAAG ATCGTTGATG GAGTTCCAGT CACGGAGGAA 120
AATGGTGCCA TCAAGTCTTC ACTCCTTTGC AAGTTTTGTG ATATCCAACC CTCCAACTGC 180
ACCAATGATA GGAGCTGCCC AAGTTACTGT GGCATCACAT CAATCTGTGA AAAGGCACAC 240
GAAATCTGCG TAGCTGTGTG GAGGAAGAAT GATAAAAATA TTACCATAGA AACACTCTGT 300
CATGATCCTA GCCTTGAGGT CCATGGTTTT CCCCTGGAGG ATTCTAATTC TGATAAATGC 360
ATAATGCGGG AAAAAAAGGT CCCTGGTGAG ACCTTCTTCA TGTGTTCCTG TAGGAAGGAG 420
GAATGCAATG ACATCTTGTT CTTCTCAGAA GATGTCCTTG ACAATTTCGA CCTCATGGCC 480
ATCATCTTCA AAGTGACTGT CATCAGCCTC CTTCCCCCAC TGGGCATCGC CATTGCCGTG 540
ATCATCATCT TCTACTGTTA CCGAGTCCAC CGCCGGAGAA AGCTGAGCAC CGCCTGGGAG 600
ACGAGCAAGC CAGGGAAGCC AGACTACAGC GAGGGCTGTG CCATGATGTT GGATGACGAC 660
CGCTCGGACA TCAGCTCCAC GTGCGCCAAC AACCTCAACC ACAACACCGA GCTCCTGCCC 720
ATCGAGCTGG ACACGCTGGT GGGGAAGGGT CGCTTCGCTG AGGTCTACAA GGCCAAGCTG 780
AAACAGAACA CGTCCGAGCA GTTCGAGACG GTGGCCGTCA AGATCTTCCC CTACGAGGAA 840
TACGCCTCCT GGAAGACGGA GAAGGAAATC TTCTCCGACA TCAACCTGAA ACACGAGAAC 900
ATCCTCCAGT TCTTGACGGC GGAGGAGCGG AAGATGGACC TGGGGAAGCA GTACTGGCTC 960
ATCACCGCCT TCCACGCCAG GGGCAACCTG CAAGAGTATC TCACTCGGCA TGTCATCAGC 1020
TGGGAAGACC TGTGGAAGCT GGGCAGCTCC CTGGCCCGGG GCATTGCCCA TCTCCATAGC 1080
GACCACACGC CCTGTGGGAG ACCCAAAACG GCCATCGTGC ACCGAGACCT GAAGAGCTCC 1140
AACATCCTGG TGAAGAACGA CCTGACCTGC TGCCTCTGTG ACTTCGGGCT CTCCCTGAGG 1200
TTGGACCCGA CCCTCTCTGT GGATGACTTG GCTAACAGCG GGCAGGTTGG GACAGCAAGA 1260
TATATGGCTC CCGAAGTTTT GGAATCCAGA ATGAACTTGG AGAATATGGA GTCTTTCAAG 1320
CAAACAGATG TATATTCCAT GGCCCTTGTT CTCTGGGAAA TGACATCTCG CTGCAATGAG 1380
ATAGGAGAGG TCAAGGAATA TGAGCCGCCA TTTGGTTCCA AGGTGAGAGA GCACCCCTGC 1440
GTTGAAAGCA TGAAGGACAA CGTGCTGAGA GACCGAGGAC GGCCCGAGAT CCCAAACACT 1500
TGGCTCAGTC ACCGAGGTAT CCAGATGGTC TGTGAGACTC TGGCTGAATG CTGGGACCAC 1560
GATCCAGAGG CCCGACTGAC CGCTCAGTGC GTGGCCGAGC GTTTCGACCA ACTGGGGGAC 1620
CTGGACCGGC TGTCGGGGAG AAGCTGTTCG GAGGAAAAGA TCCCTGAGGA CTGTTCTCTG 1680
AGCCCCACCA AATAA 1695
Domain Profile
S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54
         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ekei++ ++l+hen
Q: 241   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKEIFSDINLKHEN  300
         678899***************99999999*******************************
S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114
         ilqf++a+++++d+ ++++l+t++h +g+L++yL+r+++++e+l +l +sla+G+ahLH+
Q: 301   ILQFLTAEERKMDLGKQYWLITAFHARGNLQEYLTRHVISWEDLWKLGSSLARGIAHLHS  360
         ************************************************************
S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174
         + ++ +g+ K ai+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt 
Q: 361   D-HTPCGRPKTAIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  419
         *.8999******************************************************
S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234
         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc+e  +ev+ey++pf ++v+++
Q: 420   RYMAPEVLESRMNLENMESFKQTDVYSMALVLWEMTSRCNE-IGEVKEYEPPFGSKVREH  478
         *****************************************.999***************
S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290
         P++e+mk+ v++++ rP+ip++w ++  +++++++l ecWd+dpeaRlta++v++r
Q: 479   PCVESMKDNVLRDRGRPEIPNTWLSHRGIQMVCETLAECWDHDPEARLTAQCVAER  534
         *****************************************************987
Domain Sequence
(FASTA)
IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKEI FSDINLKHEN 60
ILQFLTAEER KMDLGKQYWL ITAFHARGNL QEYLTRHVIS WEDLWKLGSS LARGIAHLHS 120
DHTPCGRPKT AIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180
YMAPEVLESR MNLENMESFK QTDVYSMALV LWEMTSRCNE IGEVKEYEPP FGSKVREHPC 240
VESMKDNVLR DRGRPEIPNT WLSHRGIQMV CETLAECWDH DPEARLTAQC VAER 294
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00266
EKS-ANC-00272
EKS-BOT-00284
EKS-CAJ-00290
EKS-CAF-00290
EKS-CAP-00319
EKS-CII-00167
EKS-CIS-00048
EKS-DAR-00626
EKS-EQC-00276
EKS-ERE-00022
EKS-FEC-00270
EKS-GAM-00178
EKS-GAG-00237
EKS-GAA-00350
EKS-GOG-00283
EKS-HOS-00290
EKS-ICT-00268
EKS-LAC-00295
EKS-LOA-00294
EKS-MAM-00286
EKS-MEG-00224
EKS-MUM-00315
EKS-MUP-00279
EKS-MYL-00286
EKS-NOL-00262
EKS-OCP-00027
EKS-ORN-00367
EKS-ORA-00245
EKS-ORC-00266
EKS-ORL-00343
EKS-OTG-00289
EKS-PAT-00268
EKS-PES-00253
EKS-PEM-00154
EKS-POA-00275
EKS-RAN-00300
EKS-SAH-00266
EKS-SUS-00252
EKS-TAG-00296
EKS-TAR-00368
EKS-TAS-00020
EKS-TEN-00365
EKS-TUT-00042
EKS-XET-00356
EKS-XIM-00361
Gene Ontology
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004702; F:receptor signaling protein serine/threonine kinase activity
GO:0005026; F:transforming growth factor beta receptor activity, type II
GO:0023014; P:signal transduction by phosphorylation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
InterPros
IPR000333; Activin_II/TGFBeta-II_recpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR017194; Transform_growth_fac-b_typ-2.
IPR015013; Transforming_GF_b_rcpt_2_ecto.
Pfam
PF08917; ecTbetaR2; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00653; ACTIVIN2R.
Created Date20-Feb-2013