EKS-MOD-00337

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00337

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	239.5	5.1E-71	250	501	252

Status

Unreviewed

Ensembl Protein

ENSMODP00000028915

UniProt Accession

F7CM70;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK2

Gene Synonyms/Alias

EIF2AK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000015286	ENSMODP00000028915	ENSMODT00000030492

Organism

Monodelphis domestica

Functional Description

Protein Length

521

Protein Sequence
(FASTA)

MASSLQPGLH SSKLNEYCQK NLLTFNYKEI AVKGPPHNLE FTIKVIIGDT EFPEGKGKSK 60

KEAKNEAARL ALDKLEKKVS HFNFFFVSEA EQSAIPNYII LLNHYTQKKK LAVASDTDQV 120

FEPSGITRYS HRFKIGEKFY DFGWGSNKQE AKQSAAKIAY EQLIAKNSQD MNSFMSPQPS 180

QPSRISEIKT SPTTNYISLL NQYVQKNRLT LNFLKNNEKR IGWPRAALAN PGLSLKRKSC 240

LALRFIKDFS DIEELKNGGY GQVFKARHRI DKKFYAIKRV KFNNEKVLRE VKALANLDHE 300

NIVKYNTCWD GNDVCYTEDG GYASSSETKC LFISMELCER GTLNDWINER RSIGSDKILS 360

LKLFQQITAG VEYIHSENLI HRDIKPSNIF LVDEIKIKIG DFGLATSLKN GADQTKNIGT 420

MRYISPEQNC FQPYGKEVDI FALGLILFEL LYICPTFQEI LTVNNESISK YAVWSEKLTQ 480

LLKQLLSEKP AKRLKASKIL EILKAWEKEE SNGENMYSHT Y 521

Nucleotide Sequence
(FASTA)

ATGGCTAGCA GTCTTCAACC AGGTCTCCAC TCTTCAAAAC TAAATGAGTA TTGCCAGAAG 60

AATCTCTTGA CGTTTAATTA TAAAGAAATT GCAGTGAAAG GACCCCCTCA TAATTTGGAG 120

TTTACCATCA AGGTTATAAT AGGAGACACA GAATTTCCAG AAGGTAAAGG CAAATCAAAA 180

AAAGAAGCAA AAAATGAGGC TGCCAGGCTA GCTCTTGACA AGCTAGAAAA AAAGGTGAGC 240

CATTTCAATT TTTTTTTTGT ATCAGAAGCA GAACAATCAG CCATTCCAAA TTATATAATT 300

CTTCTTAATC ACTACACACA AAAGAAAAAA CTAGCTGTAG CCTCTGACAC AGACCAAGTA 360

TTTGAACCTT CTGGTATTAC ACGCTATTCT CATAGATTTA AGATTGGAGA GAAATTCTAT 420

GACTTTGGAT GGGGATCTAA TAAACAAGAG GCAAAACAAT CTGCAGCCAA GATTGCATAT 480

GAGCAATTAA TAGCCAAAAA TTCACAGGAT ATGAACTCTT TTATGTCACC TCAGCCTTCT 540

CAACCCTCAA GAATTTCAGA AATCAAAACA TCACCCACTA CGAATTATAT TAGTCTTCTG 600

AACCAGTACG TACAAAAGAA TAGACTCACT CTGAATTTCC TTAAAAATAA TGAGAAAAGG 660

ATAGGCTGGC CCAGGGCAGC CCTGGCCAAC CCAGGCCTAA GCCTTAAGAG AAAATCATGT 720

CTTGCTTTAA GGTTTATCAA AGATTTTAGT GACATAGAAG AGCTTAAAAA TGGTGGATAT 780

GGCCAAGTTT TTAAAGCAAG ACATAGAATA GACAAGAAGT TTTATGCCAT CAAACGTGTG 840

AAGTTCAATA ATGAGAAAGT ATTGCGTGAA GTGAAAGCAC TGGCCAACCT TGATCATGAA 900

AATATTGTTA AATATAATAC TTGTTGGGAT GGTAATGATG TTTGTTATAC TGAAGATGGA 960

GGATATGCTT CAAGCTCAGA GACTAAGTGC CTCTTTATTT CAATGGAACT CTGTGAAAGG 1020

GGGACATTAA ATGACTGGAT TAATGAGAGA AGAAGTATTG GGTCTGATAA AATTTTGTCT 1080

TTGAAGTTAT TTCAACAAAT AACAGCAGGA GTGGAATATA TACATTCAGA AAATTTAATT 1140

CACAGAGATA TTAAACCATC TAATATATTT TTAGTAGATG AAATCAAAAT AAAGATTGGT 1200

GACTTTGGAC TTGCAACCTC ATTAAAAAAT GGAGCGGATC AAACAAAAAA TATAGGAACA 1260

ATGCGGTATA TTAGCCCAGA ACAAAATTGT TTCCAACCAT ATGGGAAGGA AGTCGATATC 1320

TTTGCATTGG GATTAATTCT TTTTGAACTT CTTTATATAT GTCCCACTTT TCAGGAAATA 1380

TTGACGGTAA ATAATGAAAG TATTTCAAAG TATGCTGTAT GGAGTGAGAA ATTAACACAA 1440

CTTCTAAAGC AACTACTTTC AGAAAAGCCT GCAAAAAGAC TCAAAGCATC TAAAATCCTG 1500

GAGATACTGA AAGCATGGGA GAAAGAAGAG AGCAATGGAG AGAATATGTA TTCACATACA 1560

TATTAG 1566

Domain Profile

S: 2     eeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpnivr  61

          +i+ l +Gg+g+V+ka++++dkk yaikr+k n+     ekv+revkaLa+l+h+niv+

Q: 250   SDIEELKNGGYGQVFKARHRIDKKFYAIKRVKFNN-----EKVLREVKALANLDHENIVK  304

         56777889**************************9.....78******************

S: 62    YfaawleekeesltdsseveaeaeleesesseesdtkllyiqmelceketLkdwiderkl  121

         Y+++w  ++                e     ++s+tk+l+i melce+ tL+dwi+er++

Q: 305   YNTCWDGNDVCYT------------EDGGYASSSETKCLFISMELCERGTLNDWINERRS  352

         ******9998555............445566788999*********************87

S: 122   lesrselvmrlfkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLatalaeal  181

         + s + l ++lf+q+  g+ey+Hs+ liHrd+kpsniFl ++ ++KigDFgLat+l++

Q: 353   IGSDKILSLKLFQQITAGVEYIHSENLIHRDIKPSNIFLVDEIKIKIGDFGLATSLKNGA  412

         777776667**********************************************87775

S: 182   kedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLlypfsteme  241

                       +t+++gt +y+sPeq   + Y+k+vDif+LGlilfeLly + t +e

Q: 413   D-------------QTKNIGTMRYISPEQNCFQPYGKEVDIFALGLILFELLYICPTFQE  459

         5.............59*****************************************999

S: 242   rvetltelrd..gkipedfddkvpkekkllqkllsrdpkeRpsasellk  288

           ++++e  +        +++   k  +ll++lls++p++R++as++l+

Q: 460   ILTVNNESISkyAV----WSE---KLTQLLKQLLSEKPAKRLKASKILE  501

         99888765541333....333...55669*****************997

Domain Sequence
(FASTA)

SDIEELKNGG YGQVFKARHR IDKKFYAIKR VKFNNEKVLR EVKALANLDH ENIVKYNTCW 60

DGNDVCYTED GGYASSSETK CLFISMELCE RGTLNDWINE RRSIGSDKIL SLKLFQQITA 120

GVEYIHSENL IHRDIKPSNI FLVDEIKIKI GDFGLATSLK NGADQTKNIG TMRYISPEQN 180

CFQPYGKEVD IFALGLILFE LLYICPTFQE ILTVNNESIS KYAVWSEKLT QLLKQLLSEK 240

PAKRLKASKI LE 252

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0003725	; F:double-stranded RNA binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030968	; P:endoplasmic reticulum unfolded protein response
GO:0033689	; P:negative regulation of osteoblast proliferation
GO:0046777	; P:protein autophosphorylation
GO:0006412	; P:translation
GO:0006926	; P:virus-infected cell apoptotic process

KEGG

InterPros

IPR001159	; Ds-RNA-bd.
IPR014720	; dsRNA-bd-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00035	; dsrm; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00358

; DSRM; 2.

Prosites

PS50137	; DS_RBD; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013