EKS-MOD-00050

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00050

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	405.5	1.3E-121	519	780	262

Status

Unreviewed

Ensembl Protein

ENSMODP00000019181

UniProt Accession

F6WHP0;

Protein Name

Protein Synonyms/Alias

Gene Name

KSR2

Gene Synonyms/Alias

KSR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000015362	ENSMODP00000019181	ENSMODT00000019527

Organism

Monodelphis domestica

Functional Description

Protein Length

802

Protein Sequence
(FASTA)

MANYVPVFVC LNPGGSLSKQ DWTIQWPTPE AGKENNPACP AESTPWIRTH LSQSPKVQSK 60

CIQHYCPPGP TLGPVYTHVD RLTVEGYPGL CPPLESGHRS LPPSPRQRHA VRTPPRTPNI 120

VTTVTPPGTP PMRRKNKLKP PGTPPPSSRK LIHLIPGFTA LHRSKSHEFQ LGHRVDESHT 180

PKVKKRNKPL NLKIHNSVGS CENIPSQRSP LLSERSLRSF FVGYPPFLPS TPPVHPEANF 240

STNTLSVPRW SPQIPRRDLG NSIKHRFSTK YWMSQTCTVC GKGMLFGLKC KNCKLKCHNK 300

CTKEAPPCHL LIIHRGDPAR LVRTESVPCD INNPLRKPPR YSDLHISQTL PKTNKINKDH 360

IPVPYQPDSS SNPSSTTSST PSSPAPPLPP SATPPSPLHP SPQCTRQQKN FNLPASHYYK 420

YKQQFIFPDV VPVPETPNRA PQVILHPVNS NPILEGNPLL QIEVEPTSEN EEGNNEAEES 480

EDDFEEMNLS LLSARNFPRK ASQTSIFLQE WDIPFEQLEM GELIGKGRFG KVYHGRWHGE 540

VAIRLIDIER DNEDQLKAFK REVMAYRQTR HENVVLFMGA CMSPPHLAII TSLCKGRTLY 600

SVVRDAKIVL DVNKTRQIAQ EIVKGMGYLH AKGILHKDLK SKNVFYDNGK VVITDFGLFS 660

ISGVLQAGRR ENKLRIQNGW LCHLAPEIIR QLSPDTEEDK LPFSKHSDVF ALGTIWYELH 720

AREWPYKTQP AEAIIWQMGR GMKPNLSQIG LGKEISDILL FCWAFEQEER PTFTKLMEML 780

EKLPKRNRRL SHPGHFWKSA EL 802

Nucleotide Sequence
(FASTA)

ATGGCTAACT ACGTGCCTGT GTTTGTCTGT TTAAACCCAG GAGGCAGCCT TTCCAAGCAG 60

GACTGGACCA TCCAGTGGCC AACCCCAGAG GCTGGGAAGG AGAACAATCC AGCTTGCCCA 120

GCTGAGTCTA CTCCGTGGAT CCGTACCCAC CTTTCCCAGA GCCCCAAAGT CCAGTCCAAG 180

TGTATTCAGC ACTACTGTCC CCCTGGCCCC ACTCTTGGCC CTGTGTACAC CCATGTGGAC 240

AGACTGACCG TGGAAGGCTA CCCAGGCCTC TGCCCCCCAC TGGAGTCTGG GCACCGGTCC 300

CTGCCACCCT CTCCCCGGCA GCGGCATGCG GTCCGTACAC CACCCCGCAC GCCGAACATT 360

GTCACCACGG TGACCCCACC TGGTACACCT CCCATGAGGC GGAAGAACAA GCTGAAGCCC 420

CCGGGGACCC CACCCCCTTC CTCCCGTAAA CTAATCCACC TCATCCCTGG CTTCACTGCT 480

CTGCACCGGA GCAAGTCCCA CGAATTTCAG TTGGGGCATC GGGTGGACGA GAGCCACACT 540

CCAAAGGTCA AGAAAAGGAA CAAGCCCCTG AATTTAAAGA TTCATAATAG TGTGGGCAGC 600

TGTGAGAACA TCCCATCGCA GCGCTCTCCC CTCCTCTCTG AGCGATCTCT GCGGTCCTTC 660

TTCGTGGGCT ACCCACCCTT CCTTCCTTCC ACTCCTCCAG TCCATCCTGA AGCCAATTTC 720

TCCACCAACA CACTGTCAGT GCCTCGATGG TCTCCTCAGA TTCCTCGAAG AGATCTGGGC 780

AACTCAATAA AACACAGATT TTCCACCAAG TACTGGATGT CTCAGACTTG CACTGTCTGT 840

GGGAAAGGAA TGTTGTTTGG ACTGAAATGT AAAAACTGCA AGTTAAAATG TCATAACAAA 900

TGCACCAAAG AAGCTCCCCC ATGCCACTTA CTGATCATAC ATCGTGGAGA TCCAGCAAGG 960

TTAGTCCGGA CAGAGTCTGT GCCCTGTGAC ATCAACAACC CCCTGAGGAA GCCTCCCCGG 1020

TATTCTGACC TGCACATCAG TCAGACGCTC CCTAAAACCA ACAAGATCAA CAAGGACCAC 1080

ATTCCAGTAC CTTACCAGCC TGACTCCAGC AGCAACCCCT CCTCCACAAC ATCCTCTACG 1140

CCCTCCTCAC CAGCCCCGCC GCTCCCGCCC AGTGCCACCC CTCCTTCCCC GCTACACCCC 1200

TCCCCACAGT GCACCAGACA ACAGAAGAAT TTCAACCTGC CAGCTTCCCA TTACTACAAA 1260

TACAAACAGC AGTTCATTTT CCCAGATGTG GTCCCAGTGC CTGAGACACC TAATCGAGCA 1320

CCCCAAGTCA TTCTCCATCC AGTGAACTCA AATCCAATCC TGGAAGGAAA CCCATTACTT 1380

CAAATTGAAG TGGAGCCAAC GTCAGAGAAT GAGGAGGGGA ACAATGAAGC TGAGGAATCA 1440

GAAGATGACT TTGAGGAGAT GAACCTCTCG CTCCTCTCTG CCCGCAATTT CCCTCGAAAA 1500

GCCAGCCAGA CCAGCATCTT CCTCCAGGAG TGGGACATCC CCTTTGAGCA GCTGGAGATG 1560

GGCGAACTCA TCGGCAAGGG CCGATTTGGG AAGGTGTATC ATGGCCGCTG GCATGGCGAA 1620

GTGGCCATAA GGCTTATTGA TATCGAGAGG GACAATGAGG ACCAGCTGAA GGCCTTCAAG 1680

CGGGAGGTCA TGGCCTACCG TCAGACACGG CATGAGAACG TGGTGCTCTT CATGGGGGCC 1740

TGCATGAGCC CACCCCACTT GGCGATCATC ACCAGTCTGT GTAAAGGACG GACTCTATAC 1800

TCAGTGGTGA GAGATGCCAA AATTGTCTTG GATGTCAACA AAACAAGGCA GATTGCCCAA 1860

GAGATTGTGA AGGGCATGGG GTATCTCCAT GCCAAAGGAA TCCTACATAA AGACCTCAAG 1920

TCCAAAAATG TCTTCTATGA CAATGGCAAA GTGGTGATCA CAGACTTCGG GCTCTTCAGC 1980

ATATCAGGAG TGCTGCAGGC GGGCAGGAGG GAGAACAAAC TACGCATCCA AAATGGTTGG 2040

CTGTGCCACC TTGCTCCAGA AATCATCCGT CAGCTCTCTC CTGACACAGA GGAGGACAAG 2100

CTCCCCTTTT CTAAGCACTC AGATGTGTTT GCACTTGGCA CAATCTGGTA TGAACTCCAT 2160

GCCAGGGAAT GGCCTTACAA GACTCAACCG GCAGAGGCAA TAATATGGCA GATGGGAAGA 2220

GGAATGAAAC CAAACCTCAG CCAGATTGGA CTAGGAAAAG AGATCTCGGA CATTCTTCTT 2280

TTCTGCTGGG CTTTTGAGCA GGAAGAGAGA CCGACCTTCA CCAAGCTCAT GGAAATGCTG 2340

GAGAAACTGC CGAAGCGAAA CCGCCGCCTT TCTCACCCTG GACATTTCTG GAAGTCAGCA 2400

GAGCTTTGA 2409

Domain Profile

S: 2     elaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLFm  61

         e++e iG+GrfG+vy+g+whG+va++l+++e+++e+ql+aFk+ev+ay++tRhen+vLFm

Q: 519   EMGELIGKGRFGKVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFM  578

         68899*******************************************************

S: 62    G.yvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120

         G ++s+p+lai+tslckg++Ly+++++++  ld++k+++ia++i++gm+YLhak+ilhkD

Q: 579   GaCMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKD  638

         ************************************************************

S: 121   lksknilleeglkvvitDFgllsvkrllsg.rrekqleipkgwilylapeviralsidle  179

         lkskn+++++g kvvitDFgl+s++ +l++ rre++l+i++gw+++lape+ir+ls+d+e

Q: 639   LKSKNVFYDNG-KVVITDFGLFSISGVLQAgRRENKLRIQNGWLCHLAPEIIRQLSPDTE  697

         ***********.***************9977*****************************

S: 180   qdelpfskesDvyafGivlyellarelpykeesadqilfavgrGlkpdlskvksklpkel  239

         +d+lpfsk+sDv+a+G+++yel+are+pyk+++a++i++++grG+kp+ls++   l+ke+

Q: 698   EDKLPFSKHSDVFALGTIWYELHAREWPYKTQPAEAIIWQMGRGMKPNLSQI--GLGKEI  755

         ****************************************************..******

S: 240   kellleClkfekeeRPlftqilkkl  264

         +++ll C++fe+eeRP+ft+++++l

Q: 756   SDILLFCWAFEQEERPTFTKLMEML  780

         **********************985

Domain Sequence
(FASTA)

EMGELIGKGR FGKVYHGRWH GEVAIRLIDI ERDNEDQLKA FKREVMAYRQ TRHENVVLFM 60

GACMSPPHLA IITSLCKGRT LYSVVRDAKI VLDVNKTRQI AQEIVKGMGY LHAKGILHKD 120

LKSKNVFYDN GKVVITDFGL FSISGVLQAG RRENKLRIQN GWLCHLAPEI IRQLSPDTEE 180

DKLPFSKHSD VFALGTIWYE LHAREWPYKT QPAEAIIWQM GRGMKPNLSQ IGLGKEISDI 240

LLFCWAFEQE ERPTFTKLME ML 262

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00109

; C1; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013