EKS-MOD-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	339.8	1.3E-101	847	1118	272

Status

Unreviewed

Ensembl Protein

ENSMODP00000019196

UniProt Accession

F6WH53;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

JAK2

Gene Synonyms/Alias

JAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000015373	ENSMODP00000019196	ENSMODT00000019543

Organism

Monodelphis domestica

Functional Description

Protein Length

1130

Protein Sequence
(FASTA)

MACLTMTEME GSATSSTHQN GDIPGNEDTL KQTEPVLQVY LYHSLGKTEG DYLRFPIGEY 60

IAEEICIAAC KACGITPVYH NMFALMSEAE RIWYPPNHVF HVDEATRYNV LYRIRFYFPH 120

WYCNGSNRTY RYGISRGTET PLLDDFVMSY LFAQWREDFV HGWIKVPVTH ETQEECLGMA 180

VLDIMRIAKE NDQTPLAVYN STSYKTFLPK CVRAKIQDYH ILTRKRIRYR FRRFIQQFSQ 240

CKATARNLKL KYLINLETLQ SAFYSEQFEV KEPGRGPSGE EIFATIIITG NGGIQWSRGK 300

HKDSETLTEQ DLQMYCDFPD IIDVSIKQAN QEGSNENRVV TIHKQDGKNL EIEFHSLREA 360

LSFVSLIDGY YRLIADAHHY LCKEVAPPTV LENIQSNCHG PISMDFATSK LKKAGNQTGL 420

YVLRRSPKDF NTYFLTFAIE RESTTDYKHC LITKNENGEF NLSGTKKNFT NLKDLLNCYQ 480

METVRSDSII FQFTKCCPPK PKDKSNLLVF RSNGISDVPT SPTLQRHNNV NQMVFHKIRN 540

EDLIFNESLG QGTFTKIFKG VRREIGDYGQ LHETEVLLKV LDKAHRNYSE SFFEAASMMS 600

QLSYKHLVLN YGVCVCGEEN ILVQEFVKFG SLDTYLKKNK NSINILWKLE VAKQLAWAMH 660

FLEEKSLTHG NVCTKNILLI REEDRKTGNP PFIKLSDPGI SITVLPKDIL QERIPWVPPE 720

CIENAKNLSL AADKWSFGTT LWEICSGGDK PLSALDSQRK LQFYEDRHQL PAPKWTELAN 780

LINNCMDYEP DFRPSFRAII RDLNSLFTPD YELLTENDML PNMRNGALGF SYAFEDRDPT 840

QFEERHLKFL QQLGKGNFGS VEMCRYDPLQ DNTGEVVAVK KLQHSTEEHL RDFEREIEIL 900

KSLQHDNIVK YKGVCYSAGR RNLRLIMEYL PYGSLRDYLQ KHKERLDHKK LLQYTSQICK 960

GMEYLGTKRY IHRDLATRNI LVENENRVKI GDFGLTKVLP QDKEYYKVKE PGESPIFWYA 1020

PESLTESKFS VASDVWSFGV VLYELFTYIE KSKSPPAEFM RMIGNDKQGQ MIVFHLIELL 1080

KNNGRLPRPD GCPDEIYSIM TECWNNNVSL RPAFRDLALR VDQIRDDMGG 1130

Nucleotide Sequence
(FASTA)

ATGGCTTGCC TCACCATGAC AGAAATGGAG GGATCTGCCA CATCTTCTAC CCACCAAAAT 60

GGAGATATTC CTGGAAATGA GGATACTTTG AAGCAGACAG AGCCAGTTCT TCAGGTCTAT 120

CTTTACCACT CTCTTGGAAA GACTGAGGGA GATTATCTGC GGTTTCCAAT TGGGGAATAT 180

ATTGCTGAGG AAATTTGTAT TGCTGCTTGT AAAGCTTGTG GCATCACGCC TGTATATCAT 240

AATATGTTTG CTTTAATGAG TGAAGCTGAG AGGATCTGGT ATCCTCCCAA TCATGTCTTC 300

CATGTAGATG AGGCAACCAG GTACAATGTA CTCTACCGAA TAAGGTTTTA TTTTCCTCAT 360

TGGTATTGTA ATGGAAGTAA TAGAACCTAT CGGTATGGAA TATCTCGAGG TACAGAGACC 420

CCTCTTCTTG ATGATTTTGT CATGTCTTAC CTTTTTGCTC AGTGGCGGGA GGATTTTGTG 480

CATGGATGGA TCAAAGTGCC TGTGACTCAT GAAACACAGG AAGAATGTCT TGGGATGGCT 540

GTTCTAGATA TTATGAGAAT AGCTAAAGAA AATGATCAGA CCCCACTGGC TGTCTATAAC 600

TCTACCAGCT ACAAGACCTT TTTACCAAAA TGTGTTCGAG CAAAGATCCA AGATTATCAT 660

ATTTTGACTC GAAAGCGAAT AAGGTACAGA TTCCGCAGAT TTATTCAACA GTTCAGCCAA 720

TGCAAAGCTA CTGCCAGAAA CTTGAAACTT AAATATCTTA TAAATCTGGA AACTCTTCAG 780

TCTGCCTTCT ACTCAGAACA ATTTGAAGTA AAAGAACCTG GCAGAGGTCC TTCAGGTGAG 840

GAGATTTTTG CAACCATTAT AATAACTGGA AACGGTGGAA TTCAGTGGTC ACGAGGGAAA 900

CATAAAGACA GTGAGACTCT GACAGAACAG GACTTACAGA TGTACTGTGA CTTTCCTGAT 960

ATTATTGATG TCAGCATTAA ACAAGCAAAT CAAGAAGGTT CAAATGAGAA TAGAGTGGTG 1020

ACTATTCATA AACAAGATGG CAAGAATTTG GAAATTGAAT TTCACTCATT GAGAGAAGCT 1080

CTGTCTTTTG TATCATTAAT TGATGGATAC TATAGATTAA TAGCAGATGC ACACCATTAC 1140

CTCTGTAAAG AAGTAGCACC CCCAACAGTC CTTGAAAATA TCCAAAGCAA CTGTCATGGC 1200

CCAATTTCGA TGGATTTTGC CACAAGTAAA CTGAAGAAAG CAGGTAATCA GACTGGCCTC 1260

TATGTCCTTC GACGTAGCCC TAAGGACTTT AATACATACT TCCTCACTTT TGCTATTGAG 1320

CGAGAAAGTA CCACTGATTA TAAGCACTGT TTGATTACAA AAAATGAGAA TGGGGAATTC 1380

AACCTTAGTG GGACTAAGAA GAACTTCACT AATCTTAAGG ATCTTTTGAA TTGCTACCAA 1440

ATGGAAACTG TCCGCTCAGA TAGCATTATT TTCCAGTTTA CCAAGTGCTG CCCTCCAAAG 1500

CCCAAAGATA AATCGAATCT TCTAGTCTTC AGGAGTAATG GTATTTCTGA TGTCCCCACA 1560

TCACCAACAT TGCAGAGACA CAATAATGTG AACCAAATGG TATTTCATAA AATCAGAAAT 1620

GAAGATTTAA TATTTAATGA AAGTCTTGGG CAAGGCACTT TTACCAAGAT TTTTAAAGGT 1680

GTAAGAAGAG AAATAGGAGA CTATGGCCAG CTCCATGAAA CAGAAGTCCT TTTAAAAGTT 1740

TTGGATAAAG CACATAGAAA TTATTCAGAG TCTTTTTTTG AAGCAGCAAG CATGATGAGC 1800

CAGCTTTCTT ACAAGCATCT GGTTTTAAAT TATGGGGTCT GTGTCTGTGG AGAAGAGAAT 1860

ATTCTTGTTC AAGAATTTGT GAAATTTGGA TCATTAGACA CATACCTGAA AAAGAACAAA 1920

AATTCTATAA ATATATTATG GAAGCTTGAA GTAGCCAAAC AATTGGCATG GGCCATGCAT 1980

TTTCTTGAAG AAAAAAGCCT CACTCATGGT AATGTGTGTA CTAAGAACAT TTTACTGATC 2040

AGAGAAGAGG ACAGAAAGAC AGGCAACCCT CCTTTCATCA AACTCAGTGA TCCTGGCATT 2100

AGTATTACAG TACTGCCAAA AGACATTCTT CAGGAGAGAA TACCATGGGT TCCACCTGAA 2160

TGTATTGAAA ATGCTAAAAA CCTAAGTTTG GCAGCAGATA AATGGAGTTT TGGTACCACT 2220

TTGTGGGAAA TCTGCAGTGG AGGAGACAAA CCTCTGAGTG CATTAGATTC TCAAAGAAAA 2280

CTGCAGTTCT ATGAAGATAG ACATCAGCTC CCCGCACCAA AGTGGACAGA ACTGGCAAAT 2340

CTTATCAATA ACTGTATGGA TTATGAGCCA GATTTCAGGC CTTCTTTCCG GGCCATCATA 2400

CGAGACCTTA ACAGTTTATT CACTCCAGAT TATGAACTAC TAACAGAAAA TGACATGTTG 2460

CCAAATATGA GAAATGGTGC CCTAGGATTT TCTTATGCTT TTGAAGATAG AGATCCCACA 2520

CAATTTGAAG AGAGACACCT CAAATTCCTA CAGCAACTTG GCAAGGGTAA TTTTGGGAGT 2580

GTGGAAATGT GCCGATATGA CCCCCTGCAA GACAACACTG GTGAAGTGGT GGCTGTGAAA 2640

AAGTTACAAC ACAGTACTGA GGAACACCTG AGAGACTTTG AAAGAGAAAT TGAAATTCTT 2700

AAATCTTTGC AACATGACAA CATTGTCAAA TACAAAGGAG TATGCTACAG TGCTGGCCGT 2760

CGTAATCTGA GATTAATTAT GGAATATTTA CCTTATGGAA GTTTACGTGA TTATCTCCAG 2820

AAACATAAGG AAAGGCTGGA TCATAAGAAA CTTCTGCAGT ACACTTCTCA GATCTGCAAG 2880

GGAATGGAAT ATCTTGGTAC AAAAAGGTAT ATCCATAGAG ATCTGGCCAC AAGAAATATT 2940

TTGGTGGAGA ATGAGAATAG AGTTAAAATT GGAGATTTTG GATTGACAAA AGTCTTGCCA 3000

CAAGACAAAG AATACTACAA AGTGAAAGAA CCTGGTGAAA GCCCCATATT CTGGTATGCT 3060

CCAGAATCTC TCACAGAAAG CAAGTTCTCT GTAGCCTCAG ATGTATGGAG TTTTGGAGTA 3120

GTTCTGTATG AACTTTTCAC ATATATTGAG AAAAGCAAAA GCCCACCAGC GGAATTTATG 3180

CGTATGATTG GCAATGACAA ACAAGGGCAA ATGATTGTAT TCCATCTAAT AGAACTTTTG 3240

AAAAATAATG GAAGATTGCC AAGACCGGAT GGATGTCCTG ATGAGATTTA TTCTATCATG 3300

ACAGAATGTT GGAACAATAA TGTAAGCTTA CGTCCAGCCT TTAGGGACCT TGCACTTCGA 3360

GTGGATCAGA TAAGAGATGA CATGGGTGGA TGA 3393

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+

Q: 847   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  906

         6899********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk+kgvc++ g++  rl+mey+++GsL++yL+k+ke+l++++ll++++q++k+meYL+

Q: 907   NIVKYKGVCYSAGRRnlRLIMEYLPYGSLRDYLQKHKERLDHKKLLQYTSQICKGMEYLG  966

         **********999888********************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         +k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a

Q: 967   TKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  1020

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224

         pe+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++el

Q: 1021  PESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpaefMRMIGNDkqgqmivfHLIEL  1079

         ********.*******************************999999999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262

         l+++ rlp+p+ cp+e++ +mt+c++++ s rp+Fr+++

Q: 1080  LKNNGRLPRPDgCPDEIYSIMTECWNNNVSLRPAFRDLA  1118

         ************************************995

Domain Sequence
(FASTA)

LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60

NIVKYKGVCY SAGRRNLRLI MEYLPYGSLR DYLQKHKERL DHKKLLQYTS QICKGMEYLG 120

TKRYIHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180

SKFSVASDVW SFGVVLYELF TYIEKSKSPP AEFMRMIGND KQGQMIVFHL IELLKNNGRL 240

PRPDGCPDEI YSIMTECWNN NVSLRPAFRD LA 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0020037	; F:heme binding
GO:0035401	; F:histone kinase activity (H3-Y41 specific)
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0006915	; P:apoptotic process
GO:0060396	; P:growth hormone receptor signaling pathway
GO:0035722	; P:interleukin-12-mediated signaling pathway
GO:0061180	; P:mammary gland epithelium development
GO:0030099	; P:myeloid cell differentiation
GO:0008285	; P:negative regulation of cell proliferation
GO:0043392	; P:negative regulation of DNA binding
GO:0010811	; P:positive regulation of cell-substrate adhesion
GO:0050727	; P:regulation of inflammatory response
GO:0046677	; P:response to antibiotic
GO:0007262	; P:STAT protein import into nucleus
GO:0033209	; P:tumor necrosis factor-mediated signaling pathway
GO:0007260	; P:tyrosine phosphorylation of STAT protein

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693	; Tyr_kinase_non-rcpt_Jak2.

Pfam

PF07714	; Pkinase_Tyr; 2.
PF00017	; SH2; 1.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01825	; JANUSKINASE2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013