EKS-MOD-00295

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00295

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	531.3	4.7E-160	702	971	270

Status

Unreviewed

Ensembl Protein

ENSMODP00000019385

UniProt Accession

F6VHJ5;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

ALK

Gene Synonyms/Alias

ALK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000015531	ENSMODP00000019385	ENSMODT00000019733

Organism

Monodelphis domestica

Functional Description

Protein Length

1204

Protein Sequence
(FASTA)

MSLCVSALPG MPPISKMALK SSFTCWNGTA IHLGQACNFQ RDCSEGEDEG ELCKALPAGF 60

YCDFEDGDCG WIQGMTMPQT PQWQVGILTD APFPNHQGYT MLFNTSKASP AETVVLTSNM 120

FPAPMKNSPC ELQMLWLIHG SLEGNVSLML MENKTGKEQS QTIWYFANRE GLGIWQRMVL 180

PLPDVSDRFW LQIVTWWEEG SGAIIAFDNI SLSLDCYLTI NGEEKISKDE APNSSNLFDI 240

NSYKKPLQDP RSKKTSHGEI LNFDPTVQWL FTTCGASGPQ GPTQTQCNNA YRNSNLSVVV 300

GSEGVLKGVQ IWRVPATDTY SISGYGAAGG KGGKNTMMRS HGVSVLGVFD LEKDDFLYIL 360

VGQQGEDACP STSEIIQKVC IGENNVIEEE IRANQSVNEW AGGGGGGGGA TYIFKMKNGI 420

PVPLIIAAGG GGRAYGAKTD TFHPERLENN SSVLGLNGNS GAAGGGGGWN DNTSLLWSGK 480

SLLEGATGGH SCPQAMKKWG WETRGGFGGG GGGCSSGGGG GGYIGGNAAV NNDPEVDGED 540

GVSFISPLGI LYTPALKVME GHGEVNIKLY LNCSHCEVDE CHIDPESHKV ICFCEHGTVL 600

AEDGVSCIVS PPSEPHLPLS LILSVVTSAL VAALVLAFSG IMIVYRRKHQ ELQAMQMELQ 660

SPEYKLSKLR TSTIMTDYNP NYCFAGKTTS ISDLKEVPRK NISLIRGLGH GAFGEVYEGQ 720

VSGIPSDPSP LQVAVKTLPE VCSEQDELDF LMEALIISKF NHQNIVRCIG VSLQALPRFI 780

LLELMAGGDL KSFLRETRPR PNQPSSLAML DLLHVARDIA CGCQYLEENH FIHRDIAARN 840

CLLTCSGPGR VAKIGDFGMA RDIYRASYYR KGGCAMLPVK WMPPEAFMEG IFTSKTDTWS 900

FGVLLWEIFS LGYMPYPSKS NQEVLEFVTN GGRMDPPKNC PGPVYRIMTQ CWQHLPEDRP 960

NFATVLERIE YCTQDPDVIN TALPIEYGPV TEEEEKVPMR PEDPDRIPPL LVSPQQEKKE 1020

AACAPSAPPP LATTSSGKPL KKALALEPPV RITRGAPVEG GHINMAYSQS NPPSELHKGR 1080

GSRNKPTSLW NPTYGSWFTE KSAPKNSPRA EPEQPERGKA GPEGHCTPGP PGRLPGSSLL 1140

LEPSSLTSSM TEVPLFRLRH FPCGNVHYGY QQQGLPLEAG ATPAAAGYGD SALRNPSGGS 1200

QAGP 1204

Nucleotide Sequence
(FASTA)

ATGTCCTTGT GTGTTTCTGC CCTCCCAGGG ATGCCGCCTA TCTCCAAAAT GGCCCTGAAG 60

AGCTCCTTCA CCTGCTGGAA TGGAACAGCC ATCCACCTGG GACAAGCTTG CAACTTCCAA 120

AGAGACTGTT CAGAGGGTGA AGACGAGGGA GAGTTGTGCA AAGCACTTCC AGCTGGATTT 180

TATTGTGACT TTGAGGATGG AGACTGTGGC TGGATTCAGG GCATGACCAT GCCTCAAACT 240

CCCCAGTGGC AGGTTGGGAT CTTGACGGAT GCCCCATTTC CAAATCACCA AGGTTACACT 300

ATGCTATTTA ACACTAGCAA GGCTAGCCCA GCAGAAACTG TGGTCCTGAC CAGCAACATG 360

TTTCCTGCAC CAATGAAGAA CTCTCCTTGT GAGCTCCAAA TGTTGTGGCT CATCCATGGA 420

TCCTTGGAAG GAAATGTCTC CCTGATGCTT ATGGAGAATA AAACTGGGAA GGAGCAAAGC 480

CAGACCATCT GGTACTTTGC CAACAGAGAA GGTTTGGGCA TTTGGCAACG GATGGTCTTA 540

CCTCTTCCCG ATGTGTCAGA CAGATTCTGG CTACAGATTG TCACATGGTG GGAAGAAGGC 600

TCGGGAGCCA TCATTGCTTT TGACAACATT TCCCTCAGCC TGGACTGCTA CCTAACAATT 660

AATGGGGAAG AGAAAATATC AAAGGATGAA GCTCCCAATT CAAGCAACCT CTTTGATATA 720

AATAGCTATA AGAAGCCACT ACAGGATCCA AGATCCAAGA AGACTTCACA TGGAGAGATC 780

CTCAACTTTG ATCCCACAGT TCAATGGCTG TTCACCACAT GCGGGGCCAG CGGGCCCCAA 840

GGACCCACGC AGACCCAGTG CAACAACGCC TACAGGAATT CCAACCTAAG CGTGGTAGTG 900

GGCAGCGAAG GAGTCCTGAA GGGAGTGCAG ATCTGGAGAG TACCAGCCAC CGACACATAC 960

AGCATCTCAG GCTATGGAGC AGCTGGAGGT AAAGGAGGGA AGAACACAAT GATGAGGTCC 1020

CATGGCGTAT CTGTTTTGGG AGTCTTCGAT CTGGAGAAGG ATGACTTCCT ATACATCTTG 1080

GTAGGACAGC AAGGGGAAGA TGCTTGTCCC AGTACCAGTG AAATTATCCA GAAAGTCTGC 1140

ATTGGAGAGA ACAATGTGAT AGAGGAAGAA ATCCGAGCCA ACCAGAGTGT GAATGAGTGG 1200

GCTGGAGGTG GAGGAGGTGG GGGTGGAGCG ACCTACATTT TTAAGATGAA GAATGGAATA 1260

CCAGTACCTC TAATCATTGC AGCTGGAGGT GGTGGAAGAG CCTATGGGGC CAAAACAGAT 1320

ACATTCCATC CAGAAAGACT GGAAAATAAC TCCTCTGTTC TAGGTCTAAA TGGCAATTCT 1380

GGAGCCGCAG GTGGTGGAGG TGGCTGGAAT GATAACACTT CCTTGCTCTG GTCTGGAAAA 1440

TCTTTGCTGG AAGGAGCTAC AGGAGGACAT TCCTGCCCCC AGGCCATGAA GAAGTGGGGG 1500

TGGGAGACAA GAGGGGGTTT CGGAGGGGGT GGAGGGGGGT GCTCCTCAGG TGGAGGAGGC 1560

GGAGGATACA TAGGGGGTAA CGCAGCTGTG AACAATGACC CCGAAGTAGA TGGGGAGGAT 1620

GGGGTCTCCT TCATCAGTCC ATTGGGCATC CTGTATACCC CGGCTCTCAA AGTGATGGAG 1680

GGCCATGGGG AAGTGAACAT CAAGCTTTAC CTGAACTGCA GCCACTGTGA GGTGGATGAA 1740

TGCCACATTG ACCCAGAGAG TCACAAAGTT ATCTGCTTCT GTGAGCATGG CACAGTGCTG 1800

GCCGAAGACG GGGTCTCCTG CATAGTGTCA CCCCCCTCTG AGCCTCACCT GCCTCTCTCC 1860

CTGATATTGT CTGTTGTGAC CTCTGCTTTG GTGGCTGCCC TGGTCCTGGC ATTCTCAGGA 1920

ATCATGATTG TGTACCGCAG GAAGCATCAA GAGCTCCAAG CAATGCAAAT GGAACTGCAG 1980

AGCCCCGAGT ACAAACTCAG CAAGCTAAGA ACTTCCACAA TCATGACAGA CTACAACCCC 2040

AACTACTGTT TTGCTGGAAA AACTACATCT ATCAGTGACC TGAAAGAGGT ACCTCGGAAA 2100

AACATCTCCC TCATTCGGGG TCTGGGCCAT GGTGCCTTTG GGGAAGTGTA TGAAGGACAA 2160

GTGTCTGGAA TCCCCAGTGA CCCTAGTCCT CTACAGGTGG CTGTTAAGAC ACTTCCAGAG 2220

GTGTGTTCAG AACAGGACGA GTTGGATTTC CTCATGGAAG CATTGATCAT CAGCAAATTC 2280

AATCACCAGA ACATTGTTCG CTGTATTGGG GTGAGCCTGC AGGCCTTACC CCGATTTATC 2340

CTCCTAGAGT TGATGGCTGG AGGAGACCTC AAATCCTTTC TTCGGGAGAC TCGCCCTCGC 2400

CCAAACCAGC CCTCCTCCCT GGCTATGTTG GACCTGCTGC ATGTGGCCCG TGACATTGCC 2460

TGTGGCTGTC AGTATCTGGA AGAAAACCAC TTCATCCACC GGGATATTGC TGCTAGGAAC 2520

TGTCTCTTGA CCTGCTCTGG ACCAGGCAGG GTGGCCAAGA TTGGAGACTT TGGAATGGCT 2580

CGGGACATCT ACAGAGCGAG CTACTACAGG AAAGGAGGAT GTGCCATGCT TCCAGTTAAG 2640

TGGATGCCCC CAGAGGCCTT CATGGAGGGA ATATTTACAT CCAAAACAGA CACGTGGTCC 2700

TTTGGAGTGC TTCTGTGGGA GATATTCTCC CTTGGATACA TGCCATACCC AAGCAAAAGC 2760

AATCAGGAGG TTCTGGAGTT TGTCACCAAT GGAGGACGGA TGGATCCACC CAAAAATTGC 2820

CCCGGGCCTG TGTACCGGAT AATGACGCAG TGCTGGCAGC ATCTGCCCGA GGACCGGCCC 2880

AACTTTGCCA CCGTCTTAGA GAGGATCGAA TACTGCACCC AGGATCCAGA CGTGATTAAT 2940

ACAGCTTTGC CCATTGAATA TGGTCCAGTG ACGGAGGAGG AAGAGAAGGT GCCCATGAGG 3000

CCAGAAGACC CTGACCGGAT ACCTCCTCTT TTAGTCTCTC CCCAACAAGA GAAAAAGGAG 3060

GCTGCGTGTG CCCCATCAGC TCCCCCACCA CTGGCCACCA CCTCCTCCGG GAAGCCCCTG 3120

AAGAAGGCTT TAGCTCTTGA GCCCCCGGTC CGCATCACCA GAGGGGCGCC TGTGGAAGGA 3180

GGGCACATCA ACATGGCTTA CTCTCAGTCC AACCCACCAT CGGAGCTGCA CAAAGGGCGC 3240

GGATCTAGGA ACAAGCCAAC CAGCCTCTGG AACCCCACGT ATGGCTCCTG GTTCACAGAG 3300

AAATCTGCCC CCAAGAACAG TCCCCGGGCA GAGCCGGAGC AGCCGGAGCG GGGGAAAGCG 3360

GGGCCGGAGG GACATTGTAC CCCAGGGCCA CCAGGCAGGC TGCCGGGGTC CTCCCTGCTC 3420

TTGGAACCAT CTTCCCTGAC TTCCAGCATG ACGGAAGTGC CTCTGTTTAG GCTCCGCCAC 3480

TTCCCTTGTG GGAACGTCCA CTACGGCTAT CAGCAGCAGG GCCTCCCTTT GGAGGCTGGC 3540

GCCACCCCAG CTGCCGCTGG CTACGGGGAC TCTGCTCTTA GAAACCCGAG TGGTGGGAGC 3600

CAGGCTGGTC CCTGA 3615

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i l+r+lG+GafGevyeg+vsg+p+d+s+l+vavktlpe++seqdeldfl+ealiiskfn

Q: 702   ISLIRGLGHGAFGEVYEGQVSGIPSDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFN  761

         679*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+q+sslam dll+va+d+a+

Q: 762   HQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPSSLAMLDLLHVARDIAC  821

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+ll+++Gp+rvaki+dfGmardiyra+yyrkgg+a+lpvkw

Q: 822   GCQYLEENHFIHRDIAARNCLLTCSGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKW  881

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk++p

Q: 882   MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTNGGRMDPPKNCP  941

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h pedrp+f+++ler+++

Q: 942   GPVYRIMTQCWQHLPEDRPNFATVLERIEY  971

         ***************************986

Domain Sequence
(FASTA)

ISLIRGLGHG AFGEVYEGQV SGIPSDPSPL QVAVKTLPEV CSEQDELDFL MEALIISKFN 60

HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFLRETRPRP NQPSSLAMLD LLHVARDIAC 120

GCQYLEENHF IHRDIAARNC LLTCSGPGRV AKIGDFGMAR DIYRASYYRK GGCAMLPVKW 180

MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSKSN QEVLEFVTNG GRMDPPKNCP 240

GPVYRIMTQC WQHLPEDRPN FATVLERIEY 270

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013