EKS-MOD-00291
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00291
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR502.62.2E-151643900258
StatusUnreviewed
Ensembl ProteinENSMODP00000019665
UniProt AccessionF6ZSZ9;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4
Gene Synonyms/Alias ERBB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000015755ENSMODP00000019665ENSMODT00000020019
OrganismMonodelphis domestica
Functional Description
Protein Length1233
Protein Sequence
(FASTA)
LLQSIREVTG YVLVALNQFR YLPLENLRII RGTKLYEDRY ALAIFLNYRK DGNFGLQELG 60
LKNLTEILNG GVYVDQNKFL CYADTIHWQD IVRNPWPSNF TLVSTNGSSG CGRCHKSCTG 120
RCWGPTEHHC QSLTKTVCAE QCDGRCYGPY VSDCCHRECA GGCSGPKDTD CFACMNFNDS 180
GACVTQCPQT FVYNPTTFQL EHNFNAKYTY GAFCVKKCPH NFVVDSSSCV RACPSSKMEV 240
EENGIKMCKP CTDICPKACD GIGTGTLMSA QTVDSSNIDK FINCTKINGN LIFLVTGIHG 300
DPYNAIEAMD PEKLNIFRTV REITGFLNIQ SWPPNMTDFS VFSNLVTIGG RVLYSGLSLL 360
ILKQQGITSL QFQSLKEISA GNIYITDNTN LCYYHTVNWT TLFSTLNQRI VIRDNRKAEN 420
CTAEGMVCNL LCSSDGCWGP GPDQCLSCKR FSRGRTCIES CNLYDGEFRE FENGSICVEC 480
DPQCEKMEDG ILTCHGPGPD NCTKCSHFKD GPNCVEKCPD GLQGANSFIF KYADQDHECH 540
PCHPNCTQGC SGPSSHDCIY YPWTGHSTLP QHARTPLIAA GVIGGLFILV IVGLTFAVYV 600
RRKSIKKKRA LRRFLETELV EPLTPSGTAP NQAQLRILKE TELKRVKVLG SGAFGTVYKG 660
IWVPEGETVK IPVAIKILNE TTGPKANVEF MDEALIMASM DHPHLVRLLG VCLSPTIQLV 720
TQLMPHGCLL DYVHEHKDNI GSQLLLNWCV QIAKGMMYLE ERRLVHRDLA ARNVLVKSPN 780
HVKITDFGLA RLLEGDEKEY NADGGKMPIK WMALECIHYR KFTHQSDVWS YGVTIWELMT 840
FGGKPYDGIP TREIPDLLEK GERLPQPPIC TIDVYMVMVK CWMIDADSRP KFKELAAEFS 900
RMARDPQRYL VIQGDDRMKL PSPNDSKFFQ NLLDEEDLED MMDAEEYLVP QAFNIPPPIY 960
TSRARIDSNR SEFGHSPPPA YTPMSGNQFV YRDGGFATEQ GVSLPYRATS CIIPEAPVVQ 1020
GATAEIFDDT CCNGTLRKQV APLVQEDSST QRYSADPTVF VAERSPRGEM DEDGYMTPMR 1080
DKPKQDYLNP VEENPFVSRR KNGDLQALDN PEYHNASNGP PKAEDEYVNE PLYLNTFANT 1140
LGNAEYLKNN GLPGPEKAKK AFDNPDYWNH SLPPRSTLQH PDYLQEYSTK YFYKQNGRIR 1200
PIVAENPEYL SEFSLKPGTV LPPPPYRHRN TVV 1233
Nucleotide Sequence
(FASTA)
TTATTGCAGT CTATTCGAGA GGTCACTGGG TATGTCTTAG TGGCTCTTAA TCAGTTTCGT 60
TACCTGCCTC TGGAGAATTT GCGTATCATA CGTGGGACAA AACTTTATGA AGACCGATAT 120
GCACTGGCAA TATTTTTAAA CTACAGAAAA GATGGGAATT TTGGACTCCA AGAACTTGGT 180
CTGAAGAACT TAACTGAAAT CTTAAATGGA GGAGTATACG TTGACCAGAA TAAATTCCTG 240
TGTTATGCAG ACACCATTCA TTGGCAAGAT ATTGTTCGCA ATCCATGGCC TTCTAATTTT 300
ACACTGGTTT CAACCAATGG TAGTTCAGGA TGTGGGAGGT GCCACAAGTC TTGCACTGGC 360
AGATGTTGGG GACCCACAGA GCATCACTGC CAGAGCCTGA CCAAGACAGT CTGTGCTGAA 420
CAATGTGATG GCAGGTGCTA TGGCCCGTAT GTAAGTGACT GCTGCCACCG AGAATGTGCT 480
GGAGGATGCT CAGGACCCAA AGATACAGAC TGCTTTGCCT GCATGAATTT CAATGACAGT 540
GGGGCATGTG TCACCCAGTG CCCCCAAACA TTTGTCTACA ATCCAACCAC TTTTCAACTA 600
GAGCACAATT TCAATGCAAA GTATACCTAT GGAGCCTTCT GTGTCAAGAA ATGCCCACAT 660
AACTTTGTGG TAGATTCCAG TTCTTGTGTG CGGGCTTGTC CTAGCTCCAA AATGGAGGTT 720
GAAGAAAATG GAATTAAAAT GTGTAAACCT TGTACCGACA TTTGTCCAAA AGCATGTGAT 780
GGCATTGGCA CAGGAACTCT GATGTCTGCT CAGACTGTGG ATTCCAGCAA CATTGACAAG 840
TTCATAAATT GTACCAAGAT CAATGGGAAT TTGATCTTCC TTGTCACTGG TATTCATGGG 900
GATCCTTACA ATGCAATTGA GGCCATGGAT CCTGAGAAAC TGAACATCTT CCGGACAGTC 960
AGAGAGATAA CAGGTTTCTT GAACATACAG TCTTGGCCCC CAAACATGAC AGATTTCAGT 1020
GTCTTTTCTA ACCTGGTCAC CATTGGTGGA AGAGTACTGT ATAGTGGCCT CTCATTGCTT 1080
ATCCTTAAGC AACAAGGCAT CACCTCTTTG CAATTCCAGT CCTTGAAGGA AATCAGTGCA 1140
GGAAACATCT ATATAACTGA CAACACCAAC CTATGTTATT ATCATACAGT TAATTGGACT 1200
ACCCTCTTCA GTACCCTCAA CCAAAGAATA GTGATTCGTG ACAACAGGAA GGCAGAAAAC 1260
TGTACTGCAG AAGGAATGGT GTGTAATCTT CTGTGTTCAA GCGATGGCTG CTGGGGGCCA 1320
GGCCCAGACC AATGCTTATC ATGTAAACGT TTCAGCAGGG GACGGACTTG CATTGAGTCC 1380
TGTAATCTCT ACGATGGTGA ATTTCGGGAG TTTGAGAATG GATCCATCTG TGTAGAATGT 1440
GACCCCCAAT GTGAGAAGAT GGAAGATGGC ATCTTGACAT GCCATGGACC GGGACCAGAC 1500
AACTGCACTA AGTGCTCTCA TTTTAAGGAT GGCCCAAATT GTGTGGAAAA ATGCCCTGAT 1560
GGTTTACAGG GGGCCAATAG CTTTATATTT AAATATGCTG ACCAGGACCA TGAGTGCCAC 1620
CCCTGTCACC CAAACTGTAC CCAAGGGTGT AGCGGTCCCT CTAGTCATGA CTGCATTTAC 1680
TACCCATGGA CGGGCCATTC CACTTTACCA CAACATGCTA GAACTCCCCT GATTGCTGCA 1740
GGAGTTATTG GTGGACTCTT CATCCTGGTG ATTGTGGGCC TGACATTTGC TGTGTATGTT 1800
CGACGCAAGA GCATCAAAAA GAAGAGAGCA TTGAGAAGGT TTCTAGAGAC AGAGTTGGTA 1860
GAACCCTTAA CCCCAAGTGG CACAGCACCT AACCAGGCCC AACTGCGAAT CCTAAAAGAG 1920
ACGGAGCTCA AAAGAGTGAA GGTGCTTGGA TCTGGAGCAT TTGGAACTGT GTATAAGGGA 1980
ATTTGGGTAC CTGAAGGAGA GACAGTAAAG ATACCTGTGG CCATAAAGAT TCTCAATGAG 2040
ACAACTGGTC CGAAAGCAAA TGTTGAGTTC ATGGATGAAG CTTTGATCAT GGCAAGTATG 2100
GATCATCCAC ACTTGGTACG ATTATTGGGT GTCTGTCTGA GCCCAACCAT TCAGCTCGTT 2160
ACTCAACTAA TGCCTCATGG CTGCCTGTTG GATTATGTTC ACGAACATAA GGATAACATT 2220
GGCTCCCAAC TCCTCTTAAA CTGGTGTGTC CAGATAGCAA AGGGAATGAT GTACCTGGAA 2280
GAAAGACGCC TTGTCCATAG AGATCTGGCA GCTCGTAATG TCTTGGTAAA GTCACCAAAC 2340
CATGTGAAGA TCACTGACTT TGGTTTAGCC AGACTCTTAG AAGGAGATGA AAAGGAATAT 2400
AATGCTGATG GAGGGAAGAT GCCAATTAAA TGGATGGCCC TGGAGTGCAT CCACTATAGG 2460
AAATTCACCC ATCAGAGTGA TGTTTGGAGC TATGGGGTCA CAATTTGGGA ACTAATGACC 2520
TTTGGAGGAA AACCCTATGA TGGAATTCCA ACAAGAGAAA TTCCAGATTT ATTAGAGAAA 2580
GGGGAACGCC TGCCCCAGCC TCCTATCTGC ACCATCGATG TTTATATGGT TATGGTCAAA 2640
TGTTGGATGA TTGATGCTGA CAGCAGACCT AAATTCAAAG AACTGGCTGC TGAATTTTCT 2700
AGAATGGCCC GTGACCCTCA ACGATACCTA GTCATTCAGG GTGATGATCG TATGAAGCTT 2760
CCTAGTCCAA ATGACAGCAA GTTCTTTCAG AATCTCCTGG ATGAGGAGGA CTTGGAAGAT 2820
ATGATGGATG CTGAGGAATA CTTAGTTCCT CAAGCCTTCA ACATTCCACC ACCTATCTAT 2880
ACTTCCAGAG CAAGAATTGA CTCTAATAGG AGTGAATTTG GACACAGCCC TCCTCCTGCC 2940
TACACTCCCA TGTCAGGAAA CCAATTTGTG TATAGAGACG GGGGCTTTGC CACAGAACAA 3000
GGAGTATCTC TGCCATACAG GGCTACCAGC TGCATAATCC CTGAAGCACC TGTTGTACAA 3060
GGGGCCACAG CAGAGATTTT TGACGACACG TGTTGTAATG GCACTCTGCG CAAACAAGTG 3120
GCACCTCTTG TCCAGGAAGA CAGCAGCACC CAAAGGTATA GTGCTGACCC GACAGTATTT 3180
GTAGCTGAGC GGAGCCCAAG AGGTGAAATG GATGAAGATG GCTACATGAC TCCAATGCGT 3240
GACAAACCCA AACAAGATTA CCTGAACCCT GTTGAAGAGA ATCCTTTCGT TTCTCGGCGA 3300
AAGAACGGTG ATCTTCAAGC CCTGGATAAC CCTGAATATC ATAACGCCTC CAACGGGCCA 3360
CCAAAGGCAG AGGATGAGTA CGTGAACGAG CCTCTGTACC TCAATACCTT TGCCAACACC 3420
TTGGGAAACG CGGAGTACCT GAAGAATAAC GGACTGCCTG GGCCAGAGAA AGCCAAGAAA 3480
GCTTTTGACA ACCCTGACTA CTGGAACCAC AGCCTTCCTC CTCGGAGCAC CCTTCAACAC 3540
CCAGACTACC TGCAGGAATA CAGCACAAAA TATTTTTACA AACAGAATGG ACGGATCCGG 3600
CCTATTGTGG CAGAGAACCC CGAATACCTC TCTGAGTTCT CCCTGAAGCC AGGCACTGTG 3660
CTGCCTCCCC CACCCTACAG ACACCGAAAC ACAGTGGTG 3699
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh
Q: 643   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  702
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 703   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  762
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+
Q: 763   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  822
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw
Q: 823   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  882
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkfkela+efs
Q: 883   MIDADSRPKFKELAAEFS  900
         ****************96
Domain Sequence
(FASTA)
LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-ANC-00288
EKS-BOT-00300
EKS-CAE-00255
EKS-CAJ-00303
EKS-CAF-00303
EKS-CAP-00332
EKS-CIS-00072
EKS-DRM-00152
EKS-EQC-00288
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-LOA-00307
EKS-MAM-00300
EKS-MEG-00242
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-ORN-00387
EKS-ORA-00263
EKS-ORC-00279
EKS-ORL-00356
EKS-OTG-00306
EKS-PAT-00282
EKS-PES-00266
EKS-PEM-00164
EKS-POA-00290
EKS-RAN-00313
EKS-SUS-00266
EKS-TAG-00313
EKS-TAR-00389
EKS-TEN-00384
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00381
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0016021; C:integral to membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0044212; F:transcription regulatory region DNA binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0061026; P:cardiac muscle tissue regeneration
GO:0045165; P:cell fate commitment
GO:0021551; P:central nervous system morphogenesis
GO:0009880; P:embryonic pattern specification
GO:0007507; P:heart development
GO:0007595; P:lactation
GO:0060749; P:mammary gland alveolus development
GO:0060644; P:mammary gland epithelial cell differentiation
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0001755; P:neural crest cell migration
GO:0021889; P:olfactory bulb interneuron differentiation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366; P:positive regulation of STAT protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0030334; P:regulation of cell migration
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013