EKS-MOD-00120
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00120
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Met480.11.8E-14410761336261
StatusUnreviewed
Ensembl ProteinENSMODP00000019742
UniProt AccessionF7FDY1;
Protein Name
Protein Synonyms/Alias
Gene NameMET
Gene Synonyms/Alias MET;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000015822ENSMODP00000019742ENSMODT00000020096
OrganismMonodelphis domestica
Functional Description
Protein Length1379
Protein Sequence
(FASTA)
MKPTAMLVPG FLIFLLALVQ NCKGECKEAL VKSEMDVNRK YPLPNFIAET EIQNIILHNN 60
HIFLGAVNKI YVLNEDLHNV SEYKTGPVLE HPDCAPCQDC SHKANLSGSI WKDNVNKALL 120
VDTYYDDQLI SCGSVNRGTC QRHVFQPNNT ADIQSNVYCI YSPQMDEESL QCPDCVVSTL 180
GTKVLLSEKE RFINFFVGNT INSSDPDNSL HSISVRRLKE TQDGFKFLTD QSYIDVLPEF 240
QDSYPIKYIH AFESSDFIYF LTVQRETLES QTYHTRIIRF CSVDSGLHSY MEMPLECILT 300
EKRRKRSTRE EVFNILQAAY VSKPGAHLAK QIGVGPNDDI IFGVFAQSKP DSSEPTKRSA 360
VCAFPIKFVN DFFNKIVNKN NVKCLQHFYG NNHKHCFNRT FLRNSSGCEA RDDEYRTEFT 420
TGLQRIDLFT GQFKQVLLTS ISTFIKGNLT IANLGTSDGR FMQVVVSRGQ STPHVNFQLD 480
SHPVSPEVIV QHPLNTDGFT LVITGKKITK IPLNGLGCDH FKSCSQCLSA PSFVQCTWCH 540
NQCVKSEECV TELGNQDICL PTIYEILPTS APLEGGTTLT VCGWDFGLRK NNKFDFRKTK 600
VLIGNESCIL NTSESTTNKL KCTVGPAKNL HFNVSISVSN GREATQFNTF SYVDPIITNI 660
SPSYGPKAGG TLLTLTGKYL NSGNSRCISI GGKSCILKSV SHSSLECYTP PQTIPNEYPI 720
KMKIDLANRE AYSFTYKEDP VVHEIHPTKS FLSGGSTITG FGKNLNSASV PKMVINVPQV 780
ERNFTVACKQ RSNSEIICCS TPSLQQLNLQ PPLETKALFI FDGIHSTYFD LIYVHNPVFK 840
PFEKPVMISM GNENVLEIKG NDIDPEAVKG EVLKVGNKSC ENIRLHSEAV LCTVPNDLLK 900
LNSELNIEWK QAISSTVLGK VIVQPDQNFT GLIVGVVLIS LLLLLLLGLF LWLKKRKQIK 960
DLGSDLVRYD ARVHTPHLDR LVSARSVSPT TEMVSNESVD YRATFPEDQF PNSSQNGSCR 1020
QAHYPLTDLS PILTSGDSDL SSPLLQNHVH IDISALNPEL VQAVQHVVIG PNSLIVHFNE 1080
IIGRGHFGCV YHGTLLDNDD KKIHCAVKSL NRITDIGEVS QFLTEGIIMK DFSHPNVLSL 1140
LGICLRSEGS PLVVLPYMKH GDLRNFIRNE THNPTVKDLI GFGLQVAKGM KYLASKKFVH 1200
RDLAARNCML DEKFTVKVAD FGLARDMYDK EYYSVHNKTG AKLPVKWMAL ESLQTQKFTT 1260
KSDVWSFGVL LWELMTRGAP PYPDVNTFDI TVYLLQGRRL LQPEYCPDPL YEVMLKCWHP 1320
KAEMRPSFSE LVSKISVIFS TFIGEHYVHV NATYVNVKCV APYPSLLSSQ DNIDREVDT 1379
Nucleotide Sequence
(FASTA)
ATGAAGCCCA CTGCTATGCT TGTGCCTGGG TTTCTGATCT TCCTGCTTGC CTTGGTGCAG 60
AATTGCAAAG GAGAATGTAA AGAAGCCCTC GTCAAGTCTG AGATGGACGT TAATAGGAAG 120
TATCCACTTC CCAACTTTAT TGCAGAAACT GAGATCCAAA ACATTATTTT ACACAATAAC 180
CACATCTTCC TGGGTGCAGT CAACAAGATT TATGTCTTAA ATGAAGATCT CCATAATGTT 240
TCTGAGTACA AGACAGGACC TGTGCTAGAA CACCCGGACT GTGCTCCATG TCAAGACTGT 300
AGTCACAAAG CTAACTTATC TGGTAGCATT TGGAAGGATA ATGTCAACAA AGCCTTGCTC 360
GTTGATACTT ACTATGACGA TCAGCTTATT AGTTGTGGTA GTGTTAATCG AGGGACCTGC 420
CAGCGGCATG TGTTTCAACC TAATAATACT GCTGACATAC AGTCAAATGT TTATTGTATA 480
TACTCCCCAC AGATGGATGA GGAGTCCCTC CAATGTCCTG ACTGTGTGGT AAGCACTTTA 540
GGTACTAAAG TTCTGCTGTC AGAAAAAGAA CGATTTATAA ACTTCTTTGT GGGCAATACC 600
ATTAACTCTT CTGATCCCGA CAATTCTTTA CATTCAATAT CTGTCAGGAG GTTAAAGGAA 660
ACACAAGACG GTTTTAAATT TTTGACAGAC CAGTCCTATA TTGATGTTCT ACCAGAATTC 720
CAAGATTCTT ACCCCATTAA ATACATACAT GCCTTTGAAA GCAGTGACTT CATTTACTTT 780
TTAACAGTCC AAAGAGAAAC TCTGGAATCT CAGACTTATC ACACAAGAAT AATCAGGTTC 840
TGTTCAGTTG ACTCTGGATT GCATTCATAT ATGGAAATGC CTCTTGAATG TATTCTTACC 900
GAAAAGAGAA GAAAAAGGTC AACAAGGGAA GAAGTATTTA ACATTCTACA AGCAGCATAT 960
GTAAGTAAAC CTGGTGCACA TCTGGCTAAG CAAATAGGTG TTGGGCCCAA TGATGACATT 1020
ATCTTTGGAG TTTTTGCACA AAGTAAACCA GACTCTTCAG AACCAACCAA GAGATCAGCC 1080
GTCTGTGCAT TTCCAATCAA GTTTGTCAAC GATTTCTTTA ACAAAATTGT GAACAAGAAT 1140
AACGTGAAAT GTCTTCAGCA TTTTTATGGG AACAATCACA AGCACTGTTT TAATAGGACA 1200
TTCTTAAGAA ACTCATCAGG TTGTGAAGCA AGAGATGATG AATATCGAAC AGAATTTACT 1260
ACAGGCTTGC AGCGTATTGA CTTATTCACA GGACAATTCA AGCAAGTCCT TTTAACATCG 1320
ATATCCACCT TTATCAAAGG AAACCTAACT ATTGCAAACC TTGGAACCTC AGATGGCCGA 1380
TTTATGCAGG TTGTGGTTTC TCGAGGACAA TCAACCCCTC ATGTGAATTT TCAACTGGAT 1440
TCCCATCCTG TTTCTCCAGA AGTGATTGTT CAACATCCTC TAAATACAGA TGGCTTCACA 1500
TTGGTTATCA CTGGGAAGAA GATAACCAAG ATCCCACTGA ATGGCCTAGG CTGTGATCAT 1560
TTCAAATCCT GCAGTCAGTG CCTCTCAGCC CCTTCTTTTG TGCAGTGCAC TTGGTGCCAT 1620
AATCAATGTG TGAAATCTGA GGAATGTGTC ACCGAGCTAG GGAATCAGGA TATTTGTCTG 1680
CCTACCATTT ATGAGATTCT CCCAACTAGT GCACCCCTGG AGGGTGGTAC AACTTTGACG 1740
GTGTGTGGCT GGGATTTTGG ATTAAGAAAA AATAATAAAT TTGATTTTAG AAAAACCAAA 1800
GTTCTCATTG GAAATGAGAG CTGCATATTG AATACAAGTG AGAGCACTAC CAATAAGTTG 1860
AAATGTACTG TTGGTCCTGC TAAGAATCTG CATTTCAATG TATCCATCTC TGTTTCAAAT 1920
GGTCGAGAAG CAACACAATT TAATACATTC TCTTATGTGG ATCCTATAAT AACAAATATT 1980
TCTCCAAGCT ATGGTCCCAA GGCTGGTGGC ACATTACTTA CCTTAACTGG GAAATATCTA 2040
AACAGTGGAA ATTCTAGATG TATTTCAATT GGTGGAAAAT CGTGTATTTT AAAAAGTGTG 2100
TCTCATAGCA GTCTAGAATG CTACACTCCT CCTCAAACCA TTCCAAATGA GTACCCTATT 2160
AAAATGAAAA TTGACTTAGC CAATCGAGAA GCCTACAGTT TTACATACAA AGAGGACCCC 2220
GTTGTTCATG AAATCCATCC AACCAAATCT TTTCTTAGTG GTGGAAGCAC AATAACAGGT 2280
TTTGGGAAAA ACCTAAATTC TGCTAGTGTT CCCAAGATGG TAATAAATGT TCCTCAAGTA 2340
GAAAGAAACT TCACAGTGGC ATGTAAACAG CGCTCTAATT CAGAGATAAT ATGTTGTTCA 2400
ACTCCTTCCT TACAACAGCT AAATCTGCAA CCCCCCTTGG AAACAAAAGC TCTTTTCATA 2460
TTTGATGGTA TCCATTCCAC TTACTTTGAT CTCATTTATG TCCATAATCC TGTATTTAAG 2520
CCTTTTGAAA AGCCAGTGAT GATCTCAATG GGCAATGAAA ATGTACTGGA AATTAAGGGA 2580
AATGATATTG ACCCTGAGGC AGTAAAAGGT GAAGTGTTAA AAGTGGGAAA TAAGAGCTGT 2640
GAGAATATCC GCTTGCACTC TGAAGCAGTC TTATGTACAG TCCCCAATGA CCTGCTGAAA 2700
CTGAACAGTG AGCTAAATAT AGAGTGGAAG CAAGCAATTT CTTCAACTGT CCTTGGAAAA 2760
GTGATAGTAC AACCAGACCA GAATTTCACA GGACTCATTG TTGGAGTCGT CTTGATATCA 2820
TTATTGCTCT TGTTACTACT AGGGCTTTTC CTGTGGCTGA AAAAGAGGAA GCAGATTAAA 2880
GATCTGGGCA GTGATTTAGT TCGCTATGAT GCAAGAGTAC ACACTCCTCA CTTGGATAGG 2940
CTTGTAAGCG CCCGAAGTGT AAGCCCTACC ACGGAAATGG TTTCCAATGA ATCTGTAGAC 3000
TACAGAGCAA CATTTCCAGA AGATCAGTTT CCAAATTCTT CCCAGAATGG ATCCTGCAGA 3060
CAAGCTCATT ATCCTCTGAC AGATTTGTCC CCCATCCTAA CCAGTGGAGA CTCAGATCTC 3120
TCCAGTCCGC TGCTTCAGAA TCACGTCCAC ATTGATATCA GCGCTTTAAA TCCTGAGCTG 3180
GTCCAAGCAG TTCAGCATGT GGTAATTGGG CCAAACAGCC TGATTGTACA TTTCAATGAA 3240
ATCATAGGAA GAGGGCATTT TGGGTGTGTA TATCATGGGA CTTTATTGGA TAATGATGAC 3300
AAGAAGATTC ATTGTGCTGT GAAATCCTTG AATAGAATTA CTGACATAGG TGAGGTTTCC 3360
CAGTTTCTGA CTGAAGGGAT CATCATGAAA GATTTTAGTC ACCCAAATGT CCTCTCACTT 3420
TTGGGAATCT GCCTTCGTAG TGAAGGGTCT CCATTGGTGG TTCTACCATA TATGAAACAC 3480
GGAGATCTTC GAAACTTCAT AAGAAATGAG ACTCATAATC CAACAGTGAA GGACCTCATT 3540
GGTTTTGGCC TTCAAGTAGC AAAAGGCATG AAATACCTTG CAAGCAAAAA GTTCGTACAC 3600
AGAGACTTGG CTGCAAGAAA TTGTATGCTG GATGAAAAAT TTACTGTCAA GGTTGCTGAT 3660
TTTGGGCTTG CCAGAGATAT GTATGATAAA GAATATTATA GTGTACACAA TAAAACAGGA 3720
GCAAAACTGC CAGTGAAATG GATGGCTTTA GAAAGTCTAC AAACTCAGAA GTTTACTACA 3780
AAGTCAGATG TGTGGTCGTT TGGAGTGCTT CTCTGGGAAT TAATGACCAG AGGAGCACCT 3840
CCTTATCCTG ATGTGAATAC CTTTGATATA ACAGTTTACT TATTGCAAGG TCGAAGGCTC 3900
TTGCAGCCTG AATACTGCCC AGATCCACTG TATGAAGTCA TGCTAAAGTG CTGGCACCCC 3960
AAAGCTGAAA TGCGTCCCTC CTTCTCTGAA TTGGTGTCAA AGATATCAGT CATATTCTCT 4020
ACATTCATTG GAGAGCATTA TGTTCACGTG AATGCAACCT ACGTCAATGT GAAGTGTGTC 4080
GCTCCCTACC CTTCCCTTTT GTCATCCCAA GACAACATCG ACAGGGAGGT GGACACCTGA 4140
Domain Profile
S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60
         v+++e+iG+GhfG+vy+g+l+d+++kki++avksl+ritdi++v++fl+eg++mk+++hp
Q: 1076  VHFNEIIGRGHFGCVYHGTLLDNDDKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP  1135
         799*********************************************************
S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120
         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas
Q: 1136  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1195
         ************************************************************
S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180
         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt
Q: 1196  KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1255
         ************************************************************
S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240
         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd ly+vm
Q: 1256  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM  1314
         **.*********************************************************
S: 241   lkcwkakpaerpqfsdlvsiis  262
         lkcw++k+++rp+fs+lvs+is
Q: 1315  LKCWHPKAEMRPSFSELVSKIS  1336
         *******************997
Domain Sequence
(FASTA)
VHFNEIIGRG HFGCVYHGTL LDNDDKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60
NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120
KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180
QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDPLYEVML 240
KCWHPKAEMR PSFSELVSKI S 261
KeywordComplete proteome; Disulfide bond; Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00115
EKS-ANC-00111
EKS-BOT-00123
EKS-CAJ-00125
EKS-CAF-00126
EKS-CAP-00120
EKS-CII-00062
EKS-CIS-00142
EKS-DAR-00379
EKS-EQC-00119
EKS-FEC-00114
EKS-GAG-00103
EKS-GAA-00142
EKS-GOG-00122
EKS-HOS-00125
EKS-ICT-00115
EKS-LAC-00128
EKS-LOA-00118
EKS-MAM-00119
EKS-MEG-00093
EKS-MUM-00124
EKS-MUP-00126
EKS-MYL-00133
EKS-NOL-00115
EKS-OCP-00079
EKS-ORN-00150
EKS-ORA-00101
EKS-ORC-00115
EKS-ORL-00139
EKS-OTG-00126
EKS-PAT-00111
EKS-PES-00105
EKS-PEM-00067
EKS-POA-00116
EKS-RAN-00120
EKS-SAH-00115
EKS-SUS-00109
EKS-TAG-00152
EKS-TAR-00154
EKS-TEN-00142
EKS-VIP-00058
EKS-XET-00102
Gene Ontology
GO:0009925; C:basal plasma membrane
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005008; F:hepatocyte growth factor-activated receptor activity
GO:0000187; P:activation of MAPK activity
GO:0030534; P:adult behavior
GO:0007420; P:brain development
GO:0048754; P:branching morphogenesis of a tube
GO:0042593; P:glucose homeostasis
GO:0001889; P:liver development
GO:0014812; P:muscle cell migration
GO:0051450; P:myoblast proliferation
GO:0014902; P:myotube differentiation
GO:0001890; P:placenta development
GO:0010828; P:positive regulation of glucose transport
GO:0046777; P:protein autophosphorylation
GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
KEGG
InterPros
IPR013783; Ig-like_fold.
IPR014756; Ig_E-set.
IPR002909; IPT_TIG_rcpt.
IPR011009; Kinase-like_dom.
IPR003659; Plexin-like.
IPR016201; Plexin-like_fold.
IPR000719; Prot_kinase_cat_dom.
IPR001627; Semaphorin/CD100_Ag.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016244; Tyr_kinase_HGF/MSP_rcpt.
IPR015943; WD40/YVTN_repeat-like_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF01403; Sema; 1.
PF01833; TIG; 3.
SMARTs
SM00429; IPT; 4.
SM00423; PSI; 1.
SM00630; Sema; 1.
SM00219; TyrKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS51004; SEMA; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013