EKS-MOD-00214
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00214
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/NKF2547.01.8E-164156504349
StatusUnreviewed
Ensembl ProteinENSMODP00000019920
UniProt AccessionF7FR77;
Protein Name
Protein Synonyms/Alias
Gene NamePINK1
Gene Synonyms/Alias PINK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000015961ENSMODP00000019920ENSMODT00000020276
OrganismMonodelphis domestica
Functional Description
Protein Length573
Protein Sequence
(FASTA)
MALRQALGRG LQLGRALLLR FSAKPGAPGG LGRAERPGPG WGLGARGAAA RGTVPGSGQG 60
LGLPSRYHFF RESVAGLAAR LQRQLVLRAR GAGAPCGRAV FLAFGLGLGL IEEKQAEGQR 120
AVSACRDIQE IFTQKNKLIP DPLASRRWQG FRLEEYLIGQ SIGKGCSAAV YEAMMPTLPH 180
KQERPKDGLT PQAESKQNAQ HMATAFPLAI KMMWNISAGS SSEAIFSTMS QELVPASRMA 240
LSGEYGSGIF RRQERGSKQL TPHPNIIRVL RAFTSSVPLL PGALVDYPDV LPPKLYPSGL 300
GHGRTLFLVM KNYPWTLRQY LQVRPPSPRL AAMMILQLLE GVDHLVQQGI AHRDLKSDNI 360
LVEFDSAGCP WLVITDFGCC LADESIGLQL PFTSWYVDRG GNSCLMAPEV STAFPGPGVV 420
IDYSKADAWA VGAIAYEIFG LPNPFYGQGG TQLESRSYQE AQLPALPETV PLDVRQLVKA 480
LLQRDASKRP SARVAANVLH LSLWGERVLA LKSLKADKMI GWLLHQSAAT LLTNRLIEGN 540
SIETKMKMCF LASLEYEALC QAAFLLCSWR VTP 573
Nucleotide Sequence
(FASTA)
ATGGCTCTGC GGCAGGCGCT GGGTCGGGGC CTACAGCTCG GCCGGGCGCT GCTGCTGCGC 60
TTCTCTGCCA AGCCAGGCGC GCCTGGGGGC CTAGGGCGGG CGGAGAGGCC GGGGCCGGGC 120
TGGGGGCTCG GGGCCCGAGG GGCAGCGGCG CGGGGAACTG TACCGGGGTC AGGGCAGGGT 180
CTAGGCCTTC CCAGTCGCTA CCACTTTTTT CGGGAGTCGG TGGCTGGGCT GGCAGCCCGC 240
CTGCAGCGTC AGCTGGTGCT TCGGGCCCGG GGCGCCGGGG CCCCTTGCGG CCGCGCAGTC 300
TTCCTGGCTT TCGGCCTGGG CCTGGGGCTC ATCGAGGAGA AGCAGGCGGA GGGTCAGCGG 360
GCGGTCTCGG CCTGCCGGGA CATCCAGGAG ATTTTTACCC AGAAAAACAA GCTTATTCCT 420
GACCCTTTGG CAAGTAGGCG TTGGCAGGGC TTCCGACTGG AGGAATACCT CATTGGACAG 480
TCCATTGGCA AAGGATGCAG TGCTGCAGTA TATGAAGCCA TGATGCCCAC ATTGCCCCAC 540
AAGCAGGAAC GCCCCAAGGA TGGACTTACC CCACAGGCAG AAAGCAAGCA GAATGCTCAG 600
CACATGGCCA CAGCCTTTCC TTTAGCTATC AAGATGATGT GGAACATCTC AGCAGGTTCC 660
TCCAGTGAAG CCATCTTCAG CACCATGAGC CAGGAGCTGG TCCCAGCCAG TCGCATGGCC 720
CTGTCTGGGG AGTACGGGTC TGGCATTTTC AGGAGACAAG AGAGAGGTTC TAAGCAGCTG 780
ACCCCACACC CTAACATTAT CCGGGTACTT CGGGCCTTCA CCTCATCTGT GCCCCTACTA 840
CCTGGGGCTC TGGTCGACTA TCCTGACGTC CTTCCTCCAA AGCTGTACCC CTCAGGTCTG 900
GGCCATGGAC GAACACTGTT CCTTGTTATG AAGAACTACC CCTGGACCCT GCGCCAATAC 960
CTGCAGGTGC GCCCTCCAAG CCCCCGCCTT GCCGCCATGA TGATCTTGCA GTTATTGGAA 1020
GGGGTGGATC ACCTGGTTCA GCAGGGCATC GCACACAGGG ACTTAAAGTC AGACAACATC 1080
CTAGTGGAGT TTGACTCAGC TGGCTGCCCT TGGCTGGTAA TAACAGATTT CGGTTGCTGC 1140
CTGGCTGATG AGAGCATTGG CCTACAATTG CCTTTCACCA GCTGGTACGT GGACCGGGGA 1200
GGAAATAGCT GCTTGATGGC TCCTGAGGTT TCCACAGCCT TCCCTGGTCC TGGAGTAGTG 1260
ATCGACTACA GCAAAGCTGA CGCCTGGGCA GTAGGAGCAA TTGCCTATGA GATCTTTGGA 1320
CTCCCCAATC CCTTCTATGG TCAAGGTGGG ACCCAACTGG AAAGCCGAAG TTACCAGGAG 1380
GCTCAGCTTC CTGCACTGCC AGAGACTGTG CCCTTAGACG TAAGGCAGCT GGTAAAGGCC 1440
CTGCTCCAGC GAGATGCCAG CAAGAGACCC TCTGCCCGGG TAGCAGCAAA TGTACTTCAC 1500
TTAAGCCTTT GGGGTGAAAG GGTTTTAGCC CTGAAGAGTT TGAAAGCAGA CAAGATGATT 1560
GGCTGGCTCC TTCACCAGTC AGCTGCCACT CTGCTGACTA ATCGGTTAAT AGAGGGGAAC 1620
AGCATAGAAA CCAAAATGAA AATGTGCTTC TTGGCTAGCC TGGAGTATGA AGCTCTCTGT 1680
CAGGCTGCAT TCTTGCTCTG TTCCTGGAGG GTAACCCCAT GA 1722
Domain Profile
S: 1     yligealgkgcnaavyeatlatldqelekakhlgllgkevtvvlaeidqesavaakkfpl  60
         ylig+++gkgc+aavyea ++tl+++ e+ k+ gl+        ae +q+ +  a +fpl
Q: 156   YLIGQSIGKGCSAAVYEAMMPTLPHKQERPKD-GLT------PQAESKQNAQHMATAFPL  208
         99**********************99998775.443......334556666677889***
S: 61    aiklmfnieadssseallksmsqelvpasrvaldgeygav........pkllakhPnivr  112
         aik+m+ni+a+sssea++++msqelvpasr+al+geyg+          k+l++hPni+r
Q: 209   AIKMMWNISAGSSSEAIFSTMSQELVPASRMALSGEYGSGifrrqergSKQLTPHPNIIR  268
         *************************************99778****9999**********
S: 113   vlrafidsvkllPdalldyPdalparlypeglgegktlylvmkrydqtlreylesqdrst  172
         vlraf++sv+llP+al+dyPd+lp++lyp+glg+g+tl+lvmk+y+ tlr+yl+++ +s+
Q: 269   VLRAFTSSVPLLPGALVDYPDVLPPKLYPSGLGHGRTLFLVMKNYPWTLRQYLQVRPPSP  328
         ************************************************************
S: 173   rlaalllaqlleavdhlvkhgvahrdlksdnilveldddeiPvlviadfGCcladkvdgl  232
         rlaa++++qlle+vdhlv++g+ahrdlksdnilve+d+ ++P+lvi+dfGCclad+++gl
Q: 329   RLAAMMILQLLEGVDHLVQQGIAHRDLKSDNILVEFDSAGCPWLVITDFGCCLADESIGL  388
         ************************************************************
S: 233   rlpyessevdkGGnaalmaPeistavpGpsavinyekadtWavGalayeifglsnPfyge  292
         +lp++s++vd+GGn++lmaPe+sta pGp +vi+y+kad+WavGa+ayeifgl nPfyg+
Q: 389   QLPFTSWYVDRGGNSCLMAPEVSTAFPGPGVVIDYSKADAWAVGAIAYEIFGLPNPFYGQ  448
         ************************************************************
S: 293   gkaslesasyqeaqlPalpesvppelrqlvydllkreaskrvsadiaanvlqlslf  348
         g ++les+syqeaqlPalpe+vp ++rqlv +ll+r+askr+sa++aanvl+lsl+
Q: 449   GGTQLESRSYQEAQLPALPETVPLDVRQLVKALLQRDASKRPSARVAANVLHLSLW  504
         *******************************************************9
Domain Sequence
(FASTA)
YLIGQSIGKG CSAAVYEAMM PTLPHKQERP KDGLTPQAES KQNAQHMATA FPLAIKMMWN 60
ISAGSSSEAI FSTMSQELVP ASRMALSGEY GSGIFRRQER GSKQLTPHPN IIRVLRAFTS 120
SVPLLPGALV DYPDVLPPKL YPSGLGHGRT LFLVMKNYPW TLRQYLQVRP PSPRLAAMMI 180
LQLLEGVDHL VQQGIAHRDL KSDNILVEFD SAGCPWLVIT DFGCCLADES IGLQLPFTSW 240
YVDRGGNSCL MAPEVSTAFP GPGVVIDYSK ADAWAVGAIA YEIFGLPNPF YGQGGTQLES 300
RSYQEAQLPA LPETVPLDVR QLVKALLQRD ASKRPSARVA ANVLHLSLW 349
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00200
EKS-BOT-00215
EKS-CAE-00184
EKS-CAJ-00221
EKS-CAF-00221
EKS-CAP-00240
EKS-CHH-00045
EKS-CIS-00247
EKS-DAR-00520
EKS-DIO-00111
EKS-DRM-00108
EKS-ECT-00082
EKS-EQC-00209
EKS-FEC-00202
EKS-GAM-00122
EKS-GAG-00181
EKS-GAA-00264
EKS-GOG-00211
EKS-HOS-00221
EKS-ICT-00205
EKS-LAC-00227
EKS-LOA-00212
EKS-MAM-00217
EKS-MUM-00218
EKS-MUP-00216
EKS-MYL-00218
EKS-NOL-00201
EKS-OCP-00140
EKS-ORN-00275
EKS-ORA-00189
EKS-ORC-00196
EKS-ORL-00255
EKS-OTG-00221
EKS-PAT-00204
EKS-PES-00192
EKS-POA-00209
EKS-RAN-00210
EKS-SAH-00204
EKS-SOA-00066
EKS-SUS-00188
EKS-TAG-00234
EKS-TAR-00275
EKS-TEN-00271
EKS-TUB-00057
EKS-XIM-00267
Gene Ontology
GO:0005829; C:cytosol
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0010857; F:calcium-dependent protein kinase activity
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0000422; P:mitochondrion degradation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0033603; P:positive regulation of dopamine secretion
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic
GO:0043254; P:regulation of protein complex assembly
GO:0031396; P:regulation of protein ubiquitination
GO:0006950; P:response to stress
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013