EKS-MOD-00005
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00005
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph515.52.1E-155611870260
StatusUnreviewed
Ensembl ProteinENSMODP00000020127
UniProt AccessionF7EAT1;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB2
Gene Synonyms/Alias EPHB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000016114ENSMODP00000020127ENSMODT00000020484
OrganismMonodelphis domestica
Functional Description
Protein Length975
Protein Sequence
(FASTA)
CLQLLLCALL AETLMDSTTA TAELGWIVHP PSGWEEVSGY NENMNTIRTY QVCNVFESSQ 60
NNWLRTRYIR RRGAQRIHVE MKFSVRDCSS IPNVPGSCKE TFNLYYYEAD FDSATKTFPN 120
WMENPWVKVD TIAADESFSQ VDLGGRVMKI NTEVRSFGPV SRNGFYLAFQ DYGGCMSLIA 180
VRVFYRKCPR VIQNGAVFQE TLSGAESTSL VAARGTCIPN AEEVDVPIKL YCNGDGEWLV 240
PIGRCMCKAG YESVENGTAC RGCPSGPSGH QGDEGCTHCP INSRTTSEGA TNCVCRNGYY 300
RADLDPLEMP CTTIPSAPQA VISSINETSL MLEWTPPRDS GGREDLVYNI ICKSCGSGRG 360
ACTRCGDNVQ FAPRQLGLTE PRIYISDLLA HTQYTFEIQA VNGVTDQSPF SPQFASVNIT 420
TNQAAPSAVS IVHQVSRTVD SMTLSWSQPD QPNGVILDYE LQYYEKDLSE YNATAVKSPT 480
NTVTVQGLKA GTIYVFQVRA RTVAGYGRYS GKMYFQTMTE AEYQTSIQEK LPLIIGSSAA 540
GLVFLIAVVV IAIVCNRRGF ERADSEYTDK LQHYTSGHMT PGMKIYIDPF TYEDPNEAVR 600
EFAKEIDISC VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT EKQRRDFLSE 660
ASIMGQFDHP NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV IQLVGMLRGI 720
AAGMKYLADM NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY TSALGGKIPI 780
RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE QDYRLPPPMD 840
CPNALHQLML DCWQKDRNHR PKFGQIVNTL DKMIRNPNSL KAMAPLSSGI NLPLLDRTVP 900
DYTSFNTVDE WLEAIKMGQY KESFANAGFT SFDVVSQMMM EDILRVGVTL AGHQKKILNS 960
IQVMRAQMNQ IQSVE 975
Nucleotide Sequence
(FASTA)
TGTCTCCAGC TCCTCCTCTG TGCTCTCCTT GCAGAAACGT TGATGGACTC CACCACAGCC 60
ACCGCAGAAC TCGGCTGGAT CGTACATCCT CCATCCGGGT GGGAGGAGGT GAGTGGCTAC 120
AATGAAAACA TGAACACCAT CCGGACCTAT CAGGTGTGCA ACGTCTTTGA GTCTAGTCAG 180
AACAACTGGC TCCGCACCAG GTACATCCGC AGACGAGGAG CTCAGCGCAT CCACGTGGAG 240
ATGAAATTCT CTGTCCGGGA CTGTAGCAGT ATCCCCAACG TCCCTGGCTC CTGCAAGGAG 300
ACCTTCAACC TCTATTACTA TGAAGCCGAC TTTGACTCGG CCACCAAAAC CTTTCCCAAC 360
TGGATGGAGA ACCCATGGGT CAAAGTCGAT ACAATTGCTG CGGACGAAAG CTTTTCCCAA 420
GTGGACCTTG GGGGGCGGGT GATGAAGATT AACACGGAGG TTCGGAGCTT TGGGCCTGTC 480
TCCAGGAATG GCTTCTACCT AGCCTTTCAA GACTATGGCG GCTGTATGTC CCTCATTGCT 540
GTCCGGGTGT TCTACCGCAA GTGTCCCCGT GTAATCCAGA ATGGGGCTGT CTTCCAGGAG 600
ACGCTGTCTG GGGCTGAGAG CACATCTCTG GTGGCTGCCC GGGGCACCTG CATCCCAAAT 660
GCTGAAGAAG TAGATGTGCC CATTAAGCTC TACTGCAATG GGGATGGAGA ATGGCTGGTG 720
CCCATTGGGA GATGCATGTG CAAGGCTGGC TACGAATCCG TGGAGAATGG GACTGCCTGC 780
CGAGGCTGCC CATCTGGACC TTCAGGCCAC CAGGGCGATG AAGGATGTAC TCACTGCCCC 840
ATCAACAGCC GGACAACTTC AGAAGGAGCT ACTAACTGTG TCTGCCGCAA TGGGTACTAC 900
CGAGCTGACC TAGACCCGCT GGAGATGCCG TGTACCACCA TCCCATCTGC ACCTCAGGCT 960
GTGATCTCCA GCATCAATGA GACCTCCCTC ATGCTAGAGT GGACGCCACC CCGGGACTCA 1020
GGTGGCCGAG AGGATCTGGT TTACAACATC ATCTGCAAAA GCTGTGGCTC GGGTCGGGGC 1080
GCCTGCACCC GCTGTGGGGA CAATGTGCAG TTTGCCCCCC GACAACTGGG TCTAACGGAG 1140
CCCAGGATCT ACATCAGCGA CCTGCTGGCC CACACCCAGT ACACCTTTGA GATCCAGGCA 1200
GTGAATGGAG TCACTGACCA GAGTCCCTTC TCACCCCAGT TTGCTTCTGT CAATATCACC 1260
ACCAATCAGG CAGCCCCATC TGCCGTGTCC ATTGTGCACC AGGTGAGCCG GACGGTGGAC 1320
AGCATGACTT TGTCCTGGTC CCAGCCTGAC CAGCCCAATG GCGTCATCCT CGACTATGAA 1380
TTACAGTACT ACGAAAAGGA CCTGAGTGAG TACAATGCCA CTGCAGTCAA AAGCCCCACC 1440
AACACAGTTA CCGTGCAGGG CCTCAAAGCG GGCACCATCT ATGTCTTCCA GGTGCGGGCA 1500
CGCACCGTTG CGGGCTATGG GCGCTACAGT GGCAAAATGT ATTTCCAGAC GATGACTGAA 1560
GCCGAGTACC AGACAAGCAT CCAGGAGAAG CTGCCTCTCA TCATTGGCTC ATCTGCGGCA 1620
GGGCTGGTCT TCCTCATAGC CGTGGTGGTC ATTGCCATCG TGTGTAACAG ACGGGGGTTT 1680
GAGCGTGCCG ACTCCGAGTA CACCGACAAA CTGCAGCATT ACACCAGTGG CCACATGACT 1740
CCAGGCATGA AAATCTACAT TGACCCCTTC ACCTACGAAG ACCCCAATGA AGCCGTTCGA 1800
GAGTTTGCCA AGGAAATTGA CATCTCCTGT GTCAAAATTG AGCAGGTGAT TGGAGCAGGG 1860
GAATTTGGTG AAGTCTGCAG TGGCCACCTA AAGCTGCCAG GCAAAAGAGA AATCTTTGTG 1920
GCCATCAAGA CCCTCAAGTC AGGCTACACA GAAAAGCAGC GCCGGGACTT CTTGAGCGAG 1980
GCCAGCATCA TGGGCCAGTT TGATCACCCC AATGTCATTC ACCTAGAAGG CGTGGTCACC 2040
AAGAGCACAC CAGTCATGAT CATCACTGAG TTCATGGAGA ATGGTTCTCT GGATTCCTTT 2100
CTCCGGCAAA ATGATGGGCA ATTCACAGTG ATCCAGCTGG TGGGCATGCT TCGGGGCATC 2160
GCTGCGGGCA TGAAGTACCT GGCAGACATG AACTACGTCC ATCGAGACTT GGCCGCCCGG 2220
AATATTCTGG TCAATAGCAA CTTGGTCTGC AAGGTGTCCG ACTTTGGACT CTCCCGCTTC 2280
CTGGAGGATG ATACCTCTGA CCCCACCTAC ACCAGTGCCC TGGGTGGGAA GATCCCCATA 2340
CGCTGGACAG CTCCAGAAGC CATCCAGTAC AGGAAATTCA CATCTGCCAG TGATGTGTGG 2400
AGTTATGGCA TAGTCATGTG GGAAGTGATG TCCTATGGGG AGAGACCGTA CTGGGACATG 2460
ACCAATCAAG ATGTAATCAA TGCTATAGAA CAAGACTATC GGCTGCCCCC TCCCATGGAC 2520
TGCCCCAATG CCCTACACCA GCTCATGCTG GACTGCTGGC AAAAAGACCG GAACCACCGA 2580
CCCAAGTTTG GGCAGATTGT GAACACGCTG GACAAAATGA TTCGAAACCC CAATAGCCTC 2640
AAAGCCATGG CTCCCCTCTC CTCTGGGATC AACCTCCCCT TGTTGGATCG AACAGTCCCT 2700
GACTACACCA GCTTTAACAC AGTGGACGAG TGGCTGGAGG CCATCAAGAT GGGCCAATAC 2760
AAGGAGAGCT TTGCCAATGC TGGCTTCACG TCCTTCGATG TGGTCTCCCA AATGATGATG 2820
GAGGACATTC TTCGTGTCGG TGTCACTCTA GCTGGTCATC AAAAGAAAAT TCTGAACAGT 2880
ATTCAGGTGA TGCGAGCTCA AATGAACCAG ATCCAGTCAG TGGAA 2925
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevcsG+lklpgkrei vaiktlk+g+tekqrrdflseasi+Gqfdhp
Q: 611   VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHP  670
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         n+i+leGvvtks+pvmi+te+meng+ldsflr++dgqftviqlvgmlrGia+gmkyl+dm
Q: 671   NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM  730
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt++ ggkipirwtapeai+y
Q: 731   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTsDPTYTSAlGGKIPIRWTAPEAIQY  790
         **********************************99*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+syGerpywdm+nqdvi+aie++yrlpppmdcp+al+qlml
Q: 791   RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPNALHQLML  850
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rpkf qiv++l
Q: 851   DCWQKDRNHRPKFGQIVNTL  870
         *****************975
Domain Sequence
(FASTA)
VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT EKQRRDFLSE ASIMGQFDHP 60
NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLADM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY TSALGGKIPI RWTAPEAIQY 180
RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE QDYRLPPPMD CPNALHQLML 240
DCWQKDRNHR PKFGQIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00006
EKS-CAJ-00005
EKS-CAF-00005
EKS-CAP-00004
EKS-CIS-00001
EKS-DAR-00002
EKS-DIO-00001
EKS-DRM-00001
EKS-EQC-00005
EKS-GAG-00005
EKS-GAA-00006
EKS-GOG-00004
EKS-HOS-00006
EKS-ICT-00004
EKS-LAC-00005
EKS-LOA-00005
EKS-MEG-00004
EKS-MUM-00005
EKS-MUP-00004
EKS-MYL-00005
EKS-NOL-00004
EKS-ORN-00004
EKS-ORA-00005
EKS-ORC-00004
EKS-ORL-00005
EKS-OTG-00003
EKS-PAT-00005
EKS-PES-00010
EKS-PEM-00001
EKS-POA-00013
EKS-PTV-00003
EKS-RAN-00005
EKS-SAH-00004
EKS-SUS-00004
EKS-TAG-00009
EKS-TAR-00006
EKS-TEN-00005
EKS-TUT-00002
EKS-XIM-00002
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0043025; C:neuronal cell body
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005003; F:ephrin receptor activity
GO:0048593; P:camera-type eye morphogenesis
GO:0021952; P:central nervous system projection neuron axonogenesis
GO:0007612; P:learning
GO:0050771; P:negative regulation of axonogenesis
GO:0021631; P:optic nerve morphogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity
GO:0031290; P:retinal ganglion cell axon guidance
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013