EKS-MOD-00280
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00280
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR383.75.9E-115203502300
StatusUnreviewed
Ensembl ProteinENSMODP00000020362
UniProt AccessionF7AU53;
Protein Name
Protein Synonyms/Alias
Gene NameBMPR2
Gene Synonyms/Alias BMPR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000016287ENSMODP00000020362ENSMODT00000020719
OrganismMonodelphis domestica
Functional Description
Protein Length1035
Protein Sequence
(FASTA)
MTASLQSLGP MLLLSWTVLL ISTAAASQNQ ERLCAFKDPY QQDPGIGESR ISHENGTVLC 60
SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PEECHSEECV VTTTPPSIQN GTYRFCCCRT 120
DLCNVNFTEN FPPPDTTPLS PPHSFHRDET IVIVLASVSV LAVLIAALFF GYRMLAGDRK 180
QGLHSMNMME AAASEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF 240
INERNIYRIP LMDHDNIARF IVGDERFTAD ARMEYLLVME YYPNGSLCKY LSLHTSDWVS 300
SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS DFGLSMRLTG 360
NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEIFMRC 420
TDLFPAGESV PEYQMAFQTE VGNRPTFEDM QVLVSREKQR PRFPEAWKEN SLAVRSLKET 480
IEDCWDQDAE ARLTAQCAEE RMAELMMIWE RNKSVSPTVN PMSTAMQNER NLSHNRRVPK 540
IGPYPDYSSS SYIEDSIHHP DSIVKNISLE HSVSSSTPLT VGEKNRNSIN YERQQAQARI 600
PSPETSVTSL STNTTTTNTT GLTPSTGMTT ISEMPYSDET SVHASGGTQP VGPTPVCLQL 660
TEEDLETNKL DPKEVDKNLK ESSDENLMEH SLKQFSGPDP LSSTSSSLLY PLIKLAVEGS 720
GPQDFPPAAN GQACLLAGVP PAQIYPLPKQ QNLPKRPTSL PLNTKNSTKE PRLKFGSKHK 780
SNLKQVETGV AKMNTINAAE PHVVTVTMNG VAGRSHGVSA HVAAAPYANG ALPSGQPPGA 840
AAHRAQDMLH NQFSGEDSRL TINSSPDEHE PLLRREQQAG HDEGVLDRLV DRRERPLEGG 900
RTNSNNNNSN PGQDVLRAGP GADPGQPKPR RAQRPNSLDL SATNALDGGA LQLGESSQDG 960
KPGSGEKIKK RVKTPYSLKR WRPSTWVIST EPLDCEVNNN GGDRAAHSKS STAVYLAEGG 1020
TATTRVSQDT GMNCL 1035
Nucleotide Sequence
(FASTA)
ATGACTGCCT CGCTGCAAAG CCTCGGGCCG ATGCTGCTGC TCTCCTGGAC CGTATTGCTG 60
ATCAGCACTG CGGCTGCTTC CCAGAATCAA GAACGGTTAT GTGCATTTAA AGATCCATAT 120
CAGCAAGATC CAGGAATTGG TGAGAGTCGT ATATCCCATG AAAATGGCAC TGTTTTATGT 180
TCAAAGGGCA GCACTTGCTA TGGACTTTGG GAAAAATCCA AAGGGGACAT AAATCTCGTG 240
AAACAAGGAT GTTGGTCTCA CATTGGAGAT CCTGAAGAAT GTCATTCTGA AGAATGTGTT 300
GTAACAACTA CCCCTCCCTC AATTCAGAAT GGAACGTACC GTTTCTGTTG TTGCAGAACA 360
GACTTATGTA ATGTCAACTT CACTGAGAAC TTTCCACCTC CAGATACCAC ACCTTTGAGT 420
CCTCCTCATT CATTTCACCG AGATGAAACA ATAGTAATTG TCTTGGCATC AGTCTCTGTA 480
TTAGCTGTTT TGATAGCTGC CCTATTCTTT GGCTATAGGA TGCTGGCAGG GGATCGTAAG 540
CAAGGTCTTC ACAGTATGAA TATGATGGAA GCAGCAGCCT CTGAGCCTTC TCTGGACCTA 600
GATAATCTCA AACTTCTGGA GCTGATTGGT CGGGGACGAT ATGGAGCAGT ATATAAAGGT 660
TCTTTGGATG AGCGTCCAGT AGCTGTAAAA GTTTTTTCTT TTGCCAATCG TCAAAACTTT 720
ATCAATGAGA GGAACATTTA TCGAATTCCT CTTATGGACC ATGACAACAT TGCTCGCTTC 780
ATTGTTGGAG ATGAAAGATT CACTGCTGAT GCACGAATGG AATATTTGTT GGTTATGGAG 840
TATTACCCCA ATGGTTCTTT GTGCAAGTAT TTGAGTCTTC ATACCAGTGA TTGGGTAAGC 900
TCTTGTCGTT TGGCACATTC TGTGACCAGA GGCCTGGCAT ACCTTCATAC AGAATTACCA 960
AGAGGAGATC ATTATAAACC TGCAATTTCC CATCGAGACT TAAACAGCCG AAATGTTCTT 1020
GTAAAGAATG ATGGAACCTG TGTCATTAGC GATTTTGGAT TATCTATGAG ACTAACAGGA 1080
AATAGGCTTG TCCGTCCTGG GGAAGAGGAC AATGCAGCAA TAAGTGAGGT TGGTACAATC 1140
CGATATATGG CACCAGAAGT GCTAGAAGGA GCCGTGAACC TGAGGGACTG TGAATCAGCT 1200
CTAAAACAAG TGGACATGTA TGCACTTGGC CTAATCTACT GGGAAATATT TATGAGATGT 1260
ACTGACCTCT TCCCAGCAGG TGAGTCTGTG CCAGAGTACC AGATGGCCTT CCAGACAGAA 1320
GTAGGGAACC GTCCCACTTT TGAAGACATG CAAGTCCTGG TATCTAGGGA AAAGCAGCGG 1380
CCCAGATTCC CAGAAGCCTG GAAGGAAAAC AGCTTGGCTG TAAGATCACT AAAGGAGACA 1440
ATCGAAGACT GTTGGGACCA GGACGCAGAG GCTCGGCTTA CTGCTCAGTG TGCTGAGGAG 1500
AGGATGGCTG AACTCATGAT GATTTGGGAA AGGAACAAAT CAGTCAGTCC AACAGTCAAT 1560
CCAATGTCTA CTGCTATGCA GAATGAACGC AACCTGTCCC ATAACAGGCG TGTGCCAAAG 1620
ATTGGCCCTT ATCCAGATTA TTCTTCTTCC TCATACATAG AAGACTCCAT CCACCACCCT 1680
GACAGCATCG TCAAGAACAT TTCCTTAGAA CATTCAGTGT CTAGTAGCAC ACCTTTAACC 1740
GTAGGCGAAA AGAACCGAAA TTCAATTAAC TATGAACGAC AGCAAGCCCA GGCTCGCATT 1800
CCCAGTCCTG AAACGAGCGT CACCAGCTTG TCCACGAACA CCACCACCAC GAACACCACC 1860
GGCCTTACTC CCAGCACCGG CATGACCACC ATCTCGGAGA TGCCCTACTC CGACGAGACC 1920
AGCGTCCACG CCAGCGGCGG GACTCAGCCG GTGGGGCCGA CCCCCGTGTG CCTGCAGCTC 1980
ACCGAGGAAG ACCTGGAGAC CAACAAGCTG GACCCCAAGG AGGTGGACAA GAACCTGAAG 2040
GAGAGCTCCG ACGAGAACCT CATGGAGCAC TCGCTGAAGC AGTTCAGCGG CCCGGACCCC 2100
CTGAGCAGCA CCAGCTCCAG CCTGCTCTAC CCCCTCATCA AGCTCGCCGT GGAGGGATCC 2160
GGGCCGCAGG ACTTCCCGCC GGCCGCCAAC GGCCAGGCGT GTCTCCTCGC CGGCGTCCCG 2220
CCGGCCCAGA TCTACCCTCT TCCCAAGCAG CAGAACCTTC CCAAGAGACC GACGAGCCTC 2280
CCCCTCAACA CCAAAAACTC CACCAAAGAG CCCCGGCTCA AGTTCGGCAG CAAGCACAAG 2340
TCCAACCTGA AGCAGGTGGA AACCGGAGTC GCCAAGATGA ACACCATCAA TGCCGCGGAG 2400
CCGCACGTGG TGACGGTCAC CATGAACGGC GTGGCGGGCC GAAGCCACGG CGTGAGCGCG 2460
CACGTCGCCG CGGCCCCCTA CGCCAACGGC GCGCTGCCCT CGGGCCAGCC CCCCGGCGCC 2520
GCCGCGCACC GAGCCCAGGA CATGCTGCAC AACCAGTTCA GCGGGGAGGA CAGCCGGCTC 2580
ACCATCAACT CCAGCCCCGA CGAGCACGAG CCCCTGCTGA GGCGGGAGCA GCAGGCCGGC 2640
CACGACGAAG GCGTCCTGGA CCGCCTGGTG GACAGGAGGG AGCGGCCCCT GGAAGGCGGG 2700
CGGACAAACT CCAATAACAA CAACAGCAAC CCGGGCCAAG ATGTGCTCCG CGCGGGCCCC 2760
GGCGCCGATC CCGGGCAGCC CAAGCCCAGA AGAGCCCAGA GGCCCAACTC CTTGGACCTC 2820
TCGGCCACCA ACGCACTGGA CGGCGGCGCT CTGCAGCTAG GTGAGTCATC ACAAGATGGC 2880
AAGCCAGGAT CAGGTGAAAA GATCAAGAAA CGTGTGAAAA CCCCCTATTC CCTTAAGCGG 2940
TGGCGCCCTT CTACCTGGGT CATCTCCACG GAACCACTGG ACTGTGAGGT CAACAACAAT 3000
GGCGGTGACA GGGCCGCTCA TTCCAAATCC AGCACTGCTG TTTACCTTGC AGAGGGGGGC 3060
ACTGCCACAA CCAGGGTGTC TCAAGATACA GGAATGAACT GTCTGTGA 3108
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +E++iy+ +l+ h+ni +fi+
Q: 203   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINERNIYRIPLMDHDNIARFIV  262
         6899********************************************************
S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119
          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++  
Q: 263   GDErFTADARMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  322
         **9899**************************************************9766
S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175
          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R
Q: 323   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  381
         .46***********************************999877787999**********
S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee...vdeeveeyklpfeevv  231
         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++   ++e+v+ey+++f+++v
Q: 382   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfpAGESVPEYQMAFQTEV  441
         *****************99************************999**************
S: 232   gsdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkr  290
         g++P++e+m+ +v ++k+rP++peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r
Q: 442   GNRPTFEDMQVLVSREKQRPRFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEER  501
         ****************************9999*************************998
S: 291   l  291
         +
Q: 502   M  502
         7
Domain Sequence
(FASTA)
LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN ERNIYRIPLM DHDNIARFIV 60
GDERFTADAR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120
DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180
MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPAGESVPE YQMAFQTEVG 240
NRPTFEDMQV LVSREKQRPR FPEAWKENSL AVRSLKETIE DCWDQDAEAR LTAQCAEERM 300
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00267
EKS-ANC-00273
EKS-BOT-00285
EKS-CAJ-00291
EKS-CAF-00291
EKS-CAP-00320
EKS-DAR-00625
EKS-DRM-00145
EKS-EQC-00277
EKS-FEC-00271
EKS-GAG-00238
EKS-GAA-00349
EKS-GOG-00284
EKS-HOS-00291
EKS-ICT-00269
EKS-LAC-00296
EKS-LOA-00295
EKS-MAM-00287
EKS-MEG-00225
EKS-MIM-00022
EKS-MUM-00316
EKS-MUP-00281
EKS-MYL-00287
EKS-NOL-00263
EKS-ORN-00368
EKS-ORA-00247
EKS-ORC-00267
EKS-OTG-00290
EKS-PAT-00269
EKS-PES-00254
EKS-PEM-00153
EKS-POA-00276
EKS-PRC-00027
EKS-PTV-00041
EKS-RAN-00301
EKS-SAH-00267
EKS-SUS-00250
EKS-TAG-00297
EKS-TAR-00369
EKS-TAS-00021
EKS-TEN-00366
EKS-VIP-00019
EKS-XET-00358
EKS-XIM-00360
Gene Ontology
GO:0005901; C:caveola
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0009952; P:anterior/posterior pattern specification
GO:0060840; P:artery development
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0009267; P:cellular response to starvation
GO:0048286; P:lung alveolus development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0001707; P:mesoderm formation
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0003085; P:negative regulation of systemic arterial blood pressure
GO:0045906; P:negative regulation of vasoconstriction
GO:0030513; P:positive regulation of BMP signaling pathway
GO:0030501; P:positive regulation of bone mineralization
GO:0010595; P:positive regulation of endothelial cell migration
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010634; P:positive regulation of epithelial cell migration
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916; P:regulation of lung blood pressure
GO:0061298; P:retina vasculature development in camera-type eye
GO:0006366; P:transcription from RNA polymerase II promoter
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0060841; P:venous blood vessel development
KEGG
InterPros
IPR000472; Activin_rcpt.
IPR015770; BMPRII.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013