EPS-MOD-00024

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MOD-00024

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	228.8	1.0E-67	93	349	257

Status

Unreviewed

Ensembl Protein

ENSMODP00000020371

UniProt Accession

F7ATH3;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1L

Gene Synonyms/Alias

PPM1L;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000016297	ENSMODP00000020371	ENSMODT00000020729

Organism

Monodelphis domestica

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MIEDTMTLLS LLGRIMRYFL LRPETLFLLC ISLALWSYFF HTDEVKTIVK SSRDAVKMVK 60

GKVAEIMQND RLGGLDVLEA EFSKTWEFKS HNVAVYSIQG RRDHMEDRFE VLTDLVNKTH 120

PSIFGIFDGH GGESAAEYVK SRLPEALKQH LQDYEKDKEN SVLSYQAILE QQILSIDREM 180

LEKLTVSYDE AGTTCLIALL SDKDLTVANV GDSRGVLCDK DGNAIPLSHD HKPYQLKERK 240

RIKRAGGFIS FNGSWRVQGI LAMSRSLGDY PLKNLNVVIP DPDILTFDLD KLQPEFMILA 300

SDGLWDAFSN EEAVRFIKER LDEPHFGAKS IVLQSFYRGC PDNITVMVVK FRSSSKADEQ 360

Nucleotide Sequence
(FASTA)

ATGATAGAGG ATACAATGAC TTTGCTGTCT CTGCTGGGTC GCATCATGCG TTACTTCTTG 60

CTGAGACCGG AGACTCTCTT CCTGCTCTGC ATCAGCCTGG CCCTGTGGAG TTACTTCTTC 120

CACACGGACG AGGTGAAAAC CATCGTCAAG TCGAGCCGGG ACGCCGTGAA GATGGTCAAG 180

GGCAAGGTGG CCGAGATCAT GCAGAACGAC CGGCTCGGGG GGCTCGACGT GCTCGAGGCC 240

GAGTTCTCCA AGACCTGGGA GTTCAAGAGC CACAACGTGG CCGTCTACTC CATCCAGGGC 300

CGGAGGGACC ACATGGAGGA CCGCTTCGAA GTGCTCACCG ACCTGGTCAA CAAGACCCAC 360

CCGTCCATCT TCGGCATCTT CGACGGGCAC GGCGGCGAGT CAGCCGCCGA ATATGTGAAA 420

TCCCGCCTGC CCGAGGCCTT GAAGCAGCAT CTCCAGGACT ATGAAAAAGA CAAGGAGAAC 480

AGCGTGCTCT CCTACCAGGC CATCCTGGAG CAGCAGATCC TGTCCATTGA CCGAGAGATG 540

CTGGAGAAGC TGACCGTCTC CTATGACGAA GCAGGGACCA CGTGTCTGAT CGCGCTCCTG 600

TCGGACAAGG ACCTCACCGT GGCCAATGTG GGCGACTCGA GGGGCGTCCT CTGCGACAAG 660

GACGGCAATG CCATCCCTCT GTCCCACGAC CACAAGCCCT ACCAGCTCAA GGAGAGGAAG 720

AGGATCAAGA GAGCCGGTGG CTTCATCAGC TTCAACGGGT CGTGGCGGGT GCAGGGCATC 780

CTGGCCATGT CGCGCTCGCT GGGCGACTAC CCCCTGAAGA ACCTGAACGT GGTCATCCCG 840

GACCCGGACA TCCTGACCTT CGACCTGGAC AAGCTGCAGC CCGAGTTCAT GATCCTGGCG 900

TCGGACGGCC TGTGGGACGC CTTCAGCAAC GAGGAGGCCG TCCGCTTCAT CAAGGAGCGC 960

CTGGACGAGC CGCACTTCGG GGCCAAGAGC ATCGTGCTGC AGTCCTTCTA CCGCGGCTGC 1020

CCCGACAACA TCACCGTCAT GGTGGTCAAG TTCAGAAGCA GCAGCAAAGC GGACGAGCAG 1080

TGA 1083

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         v v+s++grr++med++++ +++++++      ++fg++DGhgg+++a++++++l e+l+

Q: 93    VAVYSIQGRRDHMEDRFEVLTDLVNKTHP----SIFGIFDGHGGESAAEYVKSRLPEALK  148

         6789***************9999998775....69*************************

S: 63    eele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskly  118

         + l+    ++e++    +++l++  ls+d+e+  le+ + + d+ G+t+++al++d++l+

Q: 149   QHLQdyekDKENSVLSYQAILEQQILSIDREM--LEKLTVSYDEAGTTCLIALLSDKDLT  206

         ****6543333333344599************..999999********************

S: 119   vanvGdSravLcr.ngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsR  176

         vanvGdSr vLc+ +g+a++ls dHkp + +E++Ri++agg +  + g  Rv+G La+sR

Q: 207   VANVGDSRGVLCDkDGNAIPLSHDHKPYQLKERKRIKRAGGFISFN-GSwRVQGILAMSR  265

         *************566************************999977.667**********

S: 177   alGdlylk..pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekke  233

         +lGd+ lk   +v+p+P++  ++l++ +  f+iLasDGlwd +sneeav++++++l+

Q: 266   SLGDYPLKnlNVVIPDPDILTFDLDKLQPeFMILASDGLWDAFSNEEAVRFIKERLD---  322

         ********8889************765544***************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

         ++   ak++v ++  rg+ dn++++vv

Q: 323   EPHFGAKSIVLQSFYRGCPDNITVMVV  349

         999********************9997

Domain Sequence
(FASTA)

VAVYSIQGRR DHMEDRFEVL TDLVNKTHPS IFGIFDGHGG ESAAEYVKSR LPEALKQHLQ 60

DYEKDKENSV LSYQAILEQQ ILSIDREMLE KLTVSYDEAG TTCLIALLSD KDLTVANVGD 120

SRGVLCDKDG NAIPLSHDHK PYQLKERKRI KRAGGFISFN GSWRVQGILA MSRSLGDYPL 180

KNLNVVIPDP DILTFDLDKL QPEFMILASD GLWDAFSNEE AVRFIKERLD EPHFGAKSIV 240

LQSFYRGCPD NITVMVV 257

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000165	; P:MAPK cascade
GO:0006470	; P:protein dephosphorylation
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

mdo:100011268

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013