EKS-MOD-00400
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00400
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Trk532.02.7E-160448717270
StatusUnreviewed
Ensembl ProteinENSMODP00000020848
UniProt AccessionF7D2D8;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameNTRK1
Gene Synonyms/Alias NTRK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000016703ENSMODP00000020848ENSMODT00000021215
OrganismMonodelphis domestica
Functional Description
Protein Length734
Protein Sequence
(FASTA)
HIENQKALKH LTLSDLSGLR ELRNLTIIHS GLRFVAPDAF RFTPRLSRLG IIKRLINQSI 60
RQVESRAWGM GRGSTEAEGG VLTGNPLNCS CALQWLQRRE EEGTAQLGFA CQSYFALMPN 120
DSCGVPLLKV EPSNITVDVG DNVTLHCQVE SQSQSWTSWN TEELSEFVTV MICKTPGKCI 180
LTLVLVRYTS SLARSLSFLY FNDVGRAQLS VQVNVSFPPK VQLHHPVSQH HWCIPFSVDG 240
QPPPTLTWRF NGFLLNETNF IFTEFLEQTA NETVRHGCLR LNQPTHVNNG NYTLEVSNSG 300
GRAIDSVMAS FMDNPFQFNP EDPIPESGEM SDHESHHLLS PCSSDPFVSH HILLYQVSVA 360
VGLAVFACLF LSVLLILLNK CGRRSKFGIN RPAALAPEEG LAMSLHFMTL GNSSLSPEGK 420
GAGLQGHIIE NPQYFSDACV HHIKRRDIVL KWELGEGAFG KVFLAECHNL LPEQDKMLVA 480
VKALKEVSES ARQDFQREAE LLTVLQHQHI VRFFGVCTEG RPLLMVFEYM KHGDLNRFLR 540
SHGPDAKILA NGVGTAPGPL GLGQLLAVAG QVAAGMVYLA SLHFVHRDLA TRNCLVGQGL 600
VVKIGDFGMS RDIYSTDYYR VGGRTMLPIR WMPPESILYR KFTTESDVWS FGVLLWEIFT 660
YGKQPWYQLS NTEAIECITQ GRELERPRAC PPEVYAIMRG CWQREPQQRH SIKDIHARLQ 720
ALIKAPPVYL DVLG 734
Nucleotide Sequence
(FASTA)
CACATTGAGA ATCAGAAGGC TCTGAAGCAC TTGACCCTGA GTGACCTGAG CGGCCTGAGA 60
GAACTGAGGA ACCTCACTAT TATACACAGT GGTCTCCGAT TTGTGGCTCC AGATGCCTTT 120
CGTTTCACCC CTCGGCTCAG CCGACTAGGC ATCATTAAGC GTCTGATTAA TCAGAGCATC 180
AGACAGGTGG AGAGCAGGGC TTGGGGGATG GGACGAGGCT CAACCGAAGC GGAGGGAGGG 240
GTTCTGACTG GAAACCCCCT GAACTGTTCC TGTGCCCTTC AATGGCTGCA GCGCCGGGAA 300
GAGGAAGGAA CGGCCCAACT GGGGTTTGCG TGCCAGAGTT ACTTTGCCCT CATGCCCAAT 360
GACAGCTGTG GAGTTCCTCT GCTGAAGGTG GAGCCATCCA ATATTACAGT GGATGTGGGT 420
GACAACGTAA CACTGCATTG CCAGGTGGAG AGCCAGAGCC AAAGTTGGAC CAGCTGGAAC 480
ACTGAAGAGC TATCAGAGTT TGTCACTGTG ATGATTTGCA AGACTCCAGG CAAATGCATT 540
CTTACATTAG TGCTTGTCAG GTATACTTCG TCCTTGGCCA GAAGCCTGTC ATTCCTGTAT 600
TTTAATGATG TGGGCCGGGC CCAGCTCTCG GTGCAGGTCA ACGTCTCCTT TCCACCCAAA 660
GTGCAGCTCC ATCACCCAGT CTCCCAGCAC CACTGGTGCA TTCCTTTTTC TGTGGATGGG 720
CAGCCACCTC CTACCCTCAC CTGGCGCTTC AATGGATTCC TGCTCAATGA AACCAACTTC 780
ATCTTCACGG AGTTCCTGGA GCAGACAGCC AATGAGACTG TGAGGCATGG ATGCCTACGA 840
CTTAACCAGC CCACCCATGT CAACAATGGC AACTATACTC TGGAGGTCTC CAACTCTGGG 900
GGACGAGCCA TTGACTCTGT GATGGCCTCC TTCATGGACA ATCCTTTCCA GTTCAACCCT 960
GAGGATCCCA TCCCTGAGTC TGGAGAAATG AGTGATCATG AGAGCCACCA TCTCCTTTCT 1020
CCTTGTAGCT CTGACCCATT TGTGTCCCAC CATATCCTCC TCTACCAGGT CTCAGTGGCA 1080
GTGGGTCTAG CTGTTTTTGC CTGCCTCTTT CTCTCTGTCC TACTCATTCT TCTCAACAAA 1140
TGTGGCCGGA GAAGCAAGTT CGGGATCAAC CGTCCTGCAG CACTGGCCCC CGAGGAAGGT 1200
CTGGCCATGT CCTTACACTT CATGACTCTG GGAAACAGCT CCCTGTCTCC TGAGGGAAAG 1260
GGAGCTGGGC TACAGGGACA CATCATTGAG AATCCACAAT ACTTCAGTGA TGCTTGTGTC 1320
CATCACATTA AACGCAGGGA CATCGTGCTC AAATGGGAGC TGGGAGAAGG GGCCTTTGGC 1380
AAGGTCTTCC TGGCAGAGTG CCACAACTTG CTTCCAGAGC AGGACAAGAT GCTTGTGGCT 1440
GTCAAGGCCC TGAAGGAGGT GTCAGAGAGT GCCCGGCAAG ACTTCCAGCG AGAGGCAGAG 1500
CTGCTGACGG TCCTGCAGCA CCAGCATATC GTCCGCTTTT TTGGGGTCTG CACGGAGGGC 1560
CGCCCGCTGC TCATGGTCTT TGAATACATG AAGCATGGAG ACCTGAACCG CTTTCTCAGA 1620
TCTCATGGAC CAGATGCCAA GATACTGGCC AATGGAGTGG GCACAGCTCC AGGGCCCCTA 1680
GGCCTGGGGC AGCTGCTGGC AGTGGCTGGC CAGGTGGCTG CTGGTATGGT CTACCTGGCT 1740
AGCCTGCACT TTGTGCATCG AGATCTAGCC ACCCGAAACT GCCTGGTGGG CCAGGGACTT 1800
GTGGTAAAGA TTGGAGACTT TGGCATGAGC CGAGACATCT ACAGCACTGA CTACTACCGA 1860
GTGGGGGGCC GCACGATGCT GCCTATCCGA TGGATGCCAC CGGAGAGCAT CCTCTATCGG 1920
AAGTTTACCA CGGAAAGTGA CGTCTGGAGC TTCGGTGTCT TGCTCTGGGA GATCTTCACC 1980
TATGGCAAAC AGCCCTGGTA CCAGCTCTCC AACACTGAGG CAATCGAGTG TATCACTCAG 2040
GGCAGGGAAC TGGAGAGGCC TCGGGCCTGT CCCCCCGAGG TGTATGCCAT CATGAGGGGC 2100
TGTTGGCAGC GGGAGCCCCA GCAACGCCAC AGCATCAAAG ACATCCACGC TCGGCTCCAG 2160
GCCCTCATCA AGGCACCTCC TGTCTACCTG GATGTCCTGG GCTAG 2205
Domain Profile
S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60
         ivlk+elgegafgkvflaec+nllpe+dk+lvavkalk+ se+ar+df+reaellt lqh
Q: 448   IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEVSESARQDFQREAELLTVLQH  507
         89**********************************************************
S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegep..kgelglsqlla  118
         +hiv+++Gvcteg+pll+vfeymkhGdln+flr+hgpdak+l++g    +g+lgl+qlla
Q: 508   QHIVRFFGVCTEGRPLLMVFEYMKHGDLNRFLRSHGPDAKILANGVGtaPGPLGLGQLLA  567
         *******************************************9876669**********
S: 119   iakqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtml  178
         +a q+aaG+vylas+hfvhrdlatrnclvg++l+vkigdfgmsrd+ystdyyrvggrtml
Q: 568   VAGQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML  627
         ************************************************************
S: 179   pirwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvlerp  238
         pirw+ppesilyrkfttesdvws+Gv+lwei+tyGkqp+yqlsnte+iecitqGr+lerp
Q: 628   PIRWMPPESILYRKFTTESDVWSFGVLLWEIFTYGKQPWYQLSNTEAIECITQGRELERP  687
         ************************************************************
S: 239   racpkevydlmlgcwqrepqkrlnikeiya  268
         racp+evy++m+gcwqrepq+r++ik+i+a
Q: 688   RACPPEVYAIMRGCWQREPQQRHSIKDIHA  717
         ****************************97
Domain Sequence
(FASTA)
IVLKWELGEG AFGKVFLAEC HNLLPEQDKM LVAVKALKEV SESARQDFQR EAELLTVLQH 60
QHIVRFFGVC TEGRPLLMVF EYMKHGDLNR FLRSHGPDAK ILANGVGTAP GPLGLGQLLA 120
VAGQVAAGMV YLASLHFVHR DLATRNCLVG QGLVVKIGDF GMSRDIYSTD YYRVGGRTML 180
PIRWMPPESI LYRKFTTESD VWSFGVLLWE IFTYGKQPWY QLSNTEAIEC ITQGRELERP 240
RACPPEVYAI MRGCWQREPQ QRHSIKDIHA 270
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00382
EKS-ANC-00399
EKS-BOT-00411
EKS-CAJ-00416
EKS-CAF-00411
EKS-CAP-00439
EKS-DAR-00800
EKS-DIO-00067
EKS-EQC-00404
EKS-FEC-00394
EKS-GAG-00348
EKS-GOG-00403
EKS-HOS-00418
EKS-ICT-00391
EKS-LOA-00421
EKS-MAM-00410
EKS-MEG-00341
EKS-MUM-00444
EKS-MUP-00404
EKS-NOL-00373
EKS-OCP-00087
EKS-ORC-00386
EKS-OTG-00414
EKS-PAT-00389
EKS-PES-00364
EKS-POA-00402
EKS-RAN-00426
EKS-SAH-00381
EKS-SUS-00364
EKS-TAR-00518
EKS-TEN-00519
EKS-TUT-00123
EKS-XET-00523
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0010465; F:nerve growth factor receptor activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0060385; P:axonogenesis involved in innervation
GO:0030183; P:B cell differentiation
GO:0042490; P:mechanoreceptor differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0045766; P:positive regulation of angiogenesis
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0010976; P:positive regulation of neuron projection development
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0032320; P:positive regulation of Ras GTPase activity
GO:0046579; P:positive regulation of Ras protein signal transduction
GO:0046777; P:protein autophosphorylation
GO:0048485; P:sympathetic nervous system development
KEGG
InterPros
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR020461; Tyr_kinase_neurotrophic_rcpt_1.
IPR020777; Tyr_kinase_NGF_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR01939; NTKRECEPTOR.
PR01940; NTKRECEPTOR1.
PR00109; TYRKINASE.
Created Date20-Feb-2013