EKS-MOD-00016

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00016

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	510.2	1.1E-153	987	1254	268

Status

Unreviewed

Ensembl Protein

ENSMODP00000020864

UniProt Accession

F7CI05;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

INSRR

Gene Synonyms/Alias

INSRR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000016712	ENSMODP00000020864	ENSMODT00000021231

Organism

Monodelphis domestica

Functional Description

Protein Length

1308

Protein Sequence
(FASTA)

MTASSSWLWG ACLLMNFLPL GFGLDTPEVC PSLDIRTEVA ELRRLENCTV VEGYLQILLI 60

FTATGEDFQG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN LAVIRGNRLF FSYALVIFEM 120

PHLRDVGLPG LGAILRGAVR VEKNQELCHL STVDWGLLQP TTDANHIVGN KLGEECADVC 180

PGMLGTEEPC IRTTVNGRTD YRCWTSGHCQ RVCPCARGLA CTPRGECCHP QCLGGCSRPN 240

DPQACVACRH FHFGGTCHSA CPRGTYRYEA WRCVTADYCA SLRALPDLPG HASDFVIHQG 300

SCLAQCPPGY THNDSSIFCL KCEGLCPKEC KVGTKTIDSL QAAQELVGCT HVKGSLILNL 360

RQGYNLEAEL QQSLGLVETI TGFLKIKHSF ALISLGFFRN LKLIQGDSMV DGNYTLYVLD 420

NQNLQQLGQW AEAGLSIPVG KIYFAFNPRL CLEHIYQLEE VTGTRGRQNK AEINPRTNGD 480

RAACKTRSLR FVSNVTESDR ILLRWERYEP LEARDLLSFI VYYKESPFQN ATEHMGPDAC 540

GAPNWNLLDV ELPLSRTQEP GVTLAPLKPW TQYAVFVRAI TLSMAEDSPH QGAQSPIIYL 600

RTLPAAPTVP LDVISTSNSS SHLLVRWKPP TLRNGNLTYY LVLWQRLAED ADLYLNDYCQ 660

RGLRLPTSST DTRFDQEEGE PLAEAEPGCC PCQSPSPEQP QQPALEAHEA SFQKKFENFL 720

HNAITLPRSP WKVTSLNKSP QRDPGRYRRA SRAPGEGGNS SDFGIQDKVP RERAVLSGLR 780

HFTEYRIDIH ACNHAAHTVG CSAATFVFAR TMPHREADSI PGKVAWKPAS KSSVLLHWPE 840

PPDPNGLILK YEIKYKRLGE EATVLCVSRL RYAKFGGVHL ALLPPGNYTA RVRATSLAGN 900

GSWTDGLAFY IPGSEEEESG GLHVLLTVTP VGLLLLIVLA ALGFFYSKKR NSGGYPNGTL 960

YASVNPEYFS TSDMYVPDEW EVPREQISVI RELGQGSFGM VYEGLAQGLE AGEAPTPVAL 1020

KTVNELASLR ERIEFLKEAS VMKAFKCHHV VRLLGVVSQG QPVLVIMELM TRGDLKSYLR 1080

SLRPEAENNP GLPRPGLGDM IQMAGEIADG MAYLTANKFV HRDLAARNCM VSQDFTVKIG 1140

DFGMTRDVYE TDYYRKGGKG LLPVRWMAPE SLKDGIFSTH SDVWSFGVVL WEIVTLAEQP 1200

YQGLSNEQVL RFVMDNGILD EPEGCPPQLR ELMSRCWQQN PRQRPTFLQI LDSIKDELRP 1260

SFRLLSFYYS PESRGGRGSL APPDTDPDTH LSPEPPPDFS PPNGSLGH 1308

Nucleotide Sequence
(FASTA)

ATGACAGCAT CCAGCTCTTG GCTCTGGGGA GCTTGCCTGC TGATGAACTT CCTCCCTTTG 60

GGATTTGGCC TGGACACTCC AGAAGTCTGC CCCAGCCTAG ATATCCGCAC AGAGGTGGCA 120

GAGCTCCGTC GTCTGGAAAA CTGCACTGTG GTGGAAGGCT ACCTACAGAT CCTGCTTATA 180

TTCACAGCAA CTGGAGAAGA TTTCCAGGGT CTCAGTTTCC CCCGCCTCAC CCAGGTCACC 240

GACTATCTGC TCCTCTTCCG TGTCTATGGG CTGGAGAGTC TTCGAGACCT CTTTCCCAAC 300

CTTGCTGTCA TTCGAGGCAA CCGCCTCTTC TTCAGTTATG CCCTGGTCAT CTTTGAGATG 360

CCCCACTTAA GGGATGTGGG GCTTCCAGGC TTGGGTGCCA TCCTTCGAGG GGCCGTGCGT 420

GTGGAGAAGA ACCAGGAGTT GTGCCATCTG TCCACTGTTG ACTGGGGCCT GCTGCAGCCA 480

ACAACTGATG CCAACCACAT TGTGGGCAAC AAACTGGGAG AGGAATGTGC TGATGTGTGC 540

CCTGGAATGC TGGGCACTGA GGAACCCTGC ATCAGAACCA CTGTCAATGG ACGCACAGAC 600

TATCGCTGCT GGACCTCTGG GCACTGCCAG AGAGTGTGCC CATGTGCCCG GGGCCTGGCT 660

TGCACCCCGA GGGGTGAGTG CTGCCACCCC CAGTGTCTGG GAGGATGCAG CCGGCCCAAT 720

GACCCCCAGG CGTGTGTGGC CTGTCGCCAC TTCCATTTTG GAGGCACGTG CCATTCAGCC 780

TGTCCTAGAG GCACCTACCG CTACGAGGCC TGGCGCTGTG TCACCGCGGA TTACTGCGCG 840

AGCCTGCGGG CGCTGCCCGA CCTGCCCGGC CACGCCTCTG ACTTCGTCAT CCACCAGGGC 900

AGCTGCTTGG CCCAGTGCCC TCCAGGCTAC ACCCACAATG ACAGCAGCAT CTTCTGCCTT 960

AAGTGTGAGG GCCTGTGCCC CAAAGAGTGC AAGGTTGGCA CCAAGACCAT CGACTCCCTG 1020

CAGGCAGCCC AGGAGCTCGT GGGCTGTACC CACGTGAAGG GCAGCCTGAT CCTCAACCTG 1080

CGTCAAGGCT ATAACTTGGA AGCAGAATTA CAGCAAAGTC TGGGCCTGGT GGAAACCATC 1140

ACCGGCTTCC TCAAAATCAA GCACTCCTTT GCCCTCATCT CCCTGGGATT CTTCAGGAAC 1200

CTCAAACTCA TCCAAGGAGA CTCCATGGTG GACGGGAACT ATACCCTCTA TGTGCTGGAC 1260

AATCAGAACC TGCAGCAGCT GGGGCAGTGG GCAGAGGCTG GGCTGTCCAT CCCGGTGGGG 1320

AAGATATATT TTGCCTTCAA TCCACGCCTC TGCCTGGAAC ACATCTACCA GCTCGAGGAG 1380

GTGACTGGAA CGAGGGGCCG GCAGAACAAG GCTGAGATCA ATCCCCGAAC CAATGGAGAC 1440

CGAGCAGCCT GCAAGACCCG ATCTCTCCGG TTTGTCTCCA ACGTGACAGA ATCAGACCGA 1500

ATCCTGCTTC GTTGGGAGCG CTATGAACCA TTAGAAGCTC GAGACCTGCT CAGTTTCATC 1560

GTTTACTACA AGGAATCACC ATTCCAGAAT GCCACGGAGC ACATGGGGCC AGATGCTTGC 1620

GGTGCCCCCA ACTGGAACCT GCTGGATGTC GAACTGCCCC TGAGCAGAAC CCAGGAACCA 1680

GGAGTGACCC TTGCCCCACT CAAGCCCTGG ACCCAGTATG CGGTCTTCGT GCGGGCTATC 1740

ACCCTGAGCA TGGCAGAGGA CAGCCCCCAT CAGGGCGCCC AGAGCCCCAT CATCTACCTC 1800

CGAACCCTGC CCGCAGCCCC GACGGTGCCC CTGGACGTCA TTTCTACGTC CAACTCTTCT 1860

TCCCACCTGC TGGTGCGCTG GAAGCCGCCC ACGCTGCGTA ACGGCAATCT CACCTACTAC 1920

CTGGTGTTGT GGCAGCGGCT GGCGGAGGAC GCGGATCTGT ACCTCAATGA TTACTGCCAG 1980

CGTGGCCTGC GACTGCCCAC CAGCAGCACA GACACACGCT TCGACCAGGA GGAAGGGGAG 2040

CCCCTTGCGG AGGCTGAGCC GGGCTGCTGC CCCTGCCAGA GCCCATCCCC GGAGCAGCCC 2100

CAGCAGCCGG CCCTGGAGGC TCACGAGGCT TCCTTCCAGA AGAAGTTTGA GAACTTCCTG 2160

CACAATGCTA TCACCCTGCC CAGATCCCCC TGGAAGGTAA CTTCTCTCAA CAAGAGCCCC 2220

CAGAGGGACC CAGGGCGCTA CCGTCGGGCT TCGAGGGCCC CTGGGGAAGG GGGAAATAGC 2280

TCAGACTTTG GGATCCAGGA CAAGGTGCCT CGAGAGCGGG CAGTGCTAAG TGGTCTTCGC 2340

CATTTCACTG AGTACCGAAT CGACATCCAT GCCTGCAACC ATGCAGCTCA CACAGTGGGC 2400

TGCAGTGCTG CCACCTTCGT CTTTGCCCGA ACTATGCCCC ATCGTGAGGC AGACAGCATC 2460

CCTGGGAAGG TGGCTTGGAA GCCAGCCAGT AAAAGCAGTG TCCTCTTGCA CTGGCCTGAG 2520

CCCCCAGACC CTAATGGGCT CATTCTCAAG TATGAGATCA AGTACAAGCG CCTAGGTGAG 2580

GAGGCCACAG TGCTGTGTGT GTCCCGCCTC CGTTATGCCA AGTTTGGGGG AGTCCACCTG 2640

GCCTTGCTTC CCCCAGGCAA CTACACAGCC CGAGTTCGAG CCACTTCACT AGCTGGAAAT 2700

GGCTCCTGGA CCGATGGCCT GGCATTCTAC ATCCCTGGCT CTGAGGAAGA GGAGTCAGGA 2760

GGACTACATG TTCTCCTCAC CGTCACCCCT GTGGGGCTCC TGTTGCTCAT TGTTCTTGCT 2820

GCCCTCGGCT TCTTCTACAG CAAGAAGAGG AACAGTGGTG GTTACCCCAA TGGGACCCTC 2880

TATGCTTCTG TCAACCCTGA ATACTTCAGC ACTTCAGACA TGTATGTTCC AGATGAATGG 2940

GAAGTACCTC GAGAACAGAT TTCAGTCATC CGGGAGCTGG GTCAGGGCTC CTTCGGGATG 3000

GTGTACGAAG GGCTGGCACA GGGGCTTGAG GCCGGGGAAG CCCCCACGCC AGTGGCCCTA 3060

AAGACCGTGA ATGAGCTGGC CAGTCTTCGG GAGCGCATCG AATTCCTCAA GGAGGCCTCT 3120

GTCATGAAAG CCTTCAAATG TCACCATGTG GTGCGGCTTC TGGGTGTTGT ATCACAAGGT 3180

CAGCCAGTCC TAGTCATCAT GGAACTCATG ACTCGAGGGG ACCTCAAAAG CTATCTCCGA 3240

TCCCTGAGGC CTGAAGCAGA GAACAACCCA GGTCTCCCTA GACCAGGGCT GGGTGACATG 3300

ATCCAGATGG CAGGCGAGAT CGCCGATGGC ATGGCCTACC TTACTGCCAA CAAGTTTGTG 3360

CACCGAGACC TGGCTGCTCG AAACTGCATG GTGTCTCAAG ACTTCACAGT CAAGATTGGA 3420

GACTTTGGCA TGACGCGGGA TGTATACGAG ACAGATTATT ACCGAAAGGG AGGAAAGGGG 3480

CTGCTACCTG TTCGTTGGAT GGCTCCTGAA TCCTTAAAGG ATGGGATCTT CAGCACTCAC 3540

TCTGATGTCT GGTCATTTGG TGTAGTGTTA TGGGAGATTG TAACACTGGC AGAACAGCCT 3600

TACCAAGGCC TATCCAATGA GCAGGTGCTC AGGTTTGTCA TGGACAACGG CATCCTGGAT 3660

GAGCCCGAGG GCTGCCCTCC CCAGCTACGG GAGCTGATGA GTCGCTGCTG GCAACAGAAC 3720

CCTCGCCAGC GCCCGACCTT CCTCCAGATC CTGGACAGCA TCAAGGATGA GCTGCGCCCA 3780

TCCTTCCGTC TCCTCTCTTT CTACTATAGC CCTGAAAGCC GAGGGGGCCG GGGCTCCTTG 3840

GCACCCCCTG ATACAGATCC TGACACCCAC CTATCCCCTG AGCCCCCTCC AGACTTCAGC 3900

CCTCCTAATG GAAGCCTAGG ACACTGA 3927

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeG+a+++++ge+ t+va+ktvne as rerieflkeasvmk+fk

Q: 987   ISVIRELGQGSFGMVYEGLAQGLEAGEAPTPVALKTVNELASLRERIEFLKEASVMKAFK  1046

         6789********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslrpe+en+++l++p l+++iqma+e

Q: 1047  CHHVVRLLGVVSQGQPVLVIMELMTRGDLKSYLRSLRPEAENNPGLPRPGLGDMIQMAGE  1106

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl a+kfvhrdlaarncmv++d+tvkiGdfGmtrd+yetdyyrkggkgllpvrw

Q: 1107  IADGMAYLTANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRW  1166

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdG+f+++sdvwsfGvvlweivtlaeqpyqGlsneqvl+fv+d+g+l++pe cp

Q: 1167  MAPESLKDGIFSTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLRFVMDNGILDEPEGCP  1226

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

          +l elm++cwq np++rp+fl+i++++

Q: 1227  PQLRELMSRCWQQNPRQRPTFLQILDSI  1254

         ************************9976

Domain Sequence
(FASTA)

ISVIRELGQG SFGMVYEGLA QGLEAGEAPT PVALKTVNEL ASLRERIEFL KEASVMKAFK 60

CHHVVRLLGV VSQGQPVLVI MELMTRGDLK SYLRSLRPEA ENNPGLPRPG LGDMIQMAGE 120

IADGMAYLTA NKFVHRDLAA RNCMVSQDFT VKIGDFGMTR DVYETDYYRK GGKGLLPVRW 180

MAPESLKDGI FSTHSDVWSF GVVLWEIVTL AEQPYQGLSN EQVLRFVMDN GILDEPEGCP 240

PQLRELMSRC WQQNPRQRPT FLQILDSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0071469	; P:cellular response to alkalinity
GO:0030238	; P:male sex determination
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013