EKS-MOD-00364

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00364

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	366.7	6.1E-110	194	443	250

Status

Unreviewed

Ensembl Protein

ENSMODP00000021068

UniProt Accession

F6Y152;

Protein Name

Protein Synonyms/Alias

Gene Name

PTK6

Gene Synonyms/Alias

PTK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000016881	ENSMODP00000021068	ENSMODT00000021439

Organism

Monodelphis domestica

Functional Description

Protein Length

453

Protein Sequence
(FASTA)

MDSRSLSHLG PKYLYISLWD FEARTENELS FQAGDLFHVM EKKEDWWRVT KLDATGKSLE 60

EGYVPHNYLA EQETMETEPW FFGQISRSEA LHRLLVEENG TGTFLIRISE KPGADYVLSV 120

RDNQTVKHYK IWRNAEGKYY MNQTVSFPNL AGLVQYHKTK TLSHGLRLTT PCWKHEPKPL 180

PHWDDWERPR EEFSLSRKLG SGYFGEVFEG YWKGKVKVAI KVIAKDDLMH QNTFYSEVEA 240

MKKLRHKHIL SLYAISSTGD PVYIITELMP KGNLLELLRD PKGPKLPTTE LVDIASQISE 300

GMCYLESQNY VHRDLAARNI LVGENNICKV GDFGLARLIK DNIYLSYAQN IPYKWTAPEA 360

LTYGFYSTKS DVWSFGILLY EIFSGGQIPY PGMSNHEAHM KVLDGFQMHC PTKCPPSIYD 420

LMRRCWHLTP GERPCFKTLK EKLISFTNYE NPL 453

Nucleotide Sequence
(FASTA)

ATGGATTCAA GAAGTCTTTC CCATTTAGGT CCCAAATATC TCTACATTAG TCTCTGGGAC 60

TTTGAAGCTC GTACTGAGAA TGAATTGAGC TTTCAGGCTG GGGACCTCTT TCATGTAATG 120

GAAAAGAAAG AAGATTGGTG GAGAGTCACA AAGCTTGATG CTACTGGAAA GAGCCTGGAG 180

GAAGGCTATG TCCCCCACAA TTACTTAGCA GAGCAAGAGA CAATGGAAAC TGAACCATGG 240

TTTTTTGGGC AGATCTCTCG TTCTGAAGCT TTGCATAGGC TCCTTGTAGA AGAGAATGGA 300

ACTGGCACCT TCCTCATCAG GATCAGTGAG AAGCCAGGAG CAGATTATGT TCTCTCAGTT 360

CGGGATAACC AGACTGTGAA ACACTACAAG ATCTGGAGGA ATGCTGAGGG AAAATACTAT 420

ATGAACCAGA CTGTGTCCTT CCCCAATCTT GCTGGCCTAG TGCAGTATCA CAAAACTAAG 480

ACTCTGTCTC ATGGCCTGAG GCTCACCACA CCCTGCTGGA AGCATGAGCC AAAACCATTG 540

CCCCACTGGG ATGACTGGGA AAGACCCAGG GAGGAATTTA GTCTGTCCAG GAAGCTGGGC 600

TCAGGATACT TCGGGGAAGT CTTTGAAGGA TACTGGAAAG GGAAAGTCAA AGTGGCCATT 660

AAGGTTATTG CCAAAGATGA CCTGATGCAC CAGAACACCT TCTACTCAGA GGTTGAGGCC 720

ATGAAGAAGC TACGCCACAA ACACATTCTC TCTCTGTATG CTATCTCTTC CACTGGGGAC 780

CCTGTCTACA TCATTACTGA ACTGATGCCC AAAGGAAACC TTCTAGAACT CCTTCGAGAT 840

CCTAAAGGGC CAAAATTGCC CACCACAGAG CTTGTGGACA TAGCATCTCA AATATCTGAA 900

GGCATGTGCT ACCTCGAATC ACAGAATTAT GTTCACCGAG ACCTGGCTGC CAGGAATATC 960

CTTGTGGGAG AAAATAATAT CTGCAAAGTG GGAGACTTTG GGCTGGCCCG ACTTATCAAG 1020

GATAATATTT ACCTTTCCTA TGCACAGAAC ATCCCCTACA AATGGACTGC ACCAGAAGCC 1080

CTCACCTATG GGTTTTATTC AACCAAATCT GATGTTTGGT CCTTTGGAAT TCTGCTCTAT 1140

GAAATTTTCA GTGGTGGACA GATACCTTAT CCAGGGATGT CCAATCATGA AGCTCATATG 1200

AAGGTCCTGG ATGGTTTCCA AATGCACTGC CCCACGAAAT GCCCACCCTC CATCTATGAC 1260

CTCATGCGTA GATGCTGGCA TCTGACTCCT GGAGAAAGAC CCTGCTTCAA AACCCTCAAA 1320

GAAAAACTCA TTAGTTTCAC CAATTATGAA AACCCACTTT GA 1362

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegt.lspeafleeaqilkklrheklvkly  60

          l +klG+G+fGev++g+wkg+vkva+k++ +++ +++++f +e++++kklrh+++++ly

Q: 194   SLSRKLGSGYFGEVFEGYWKGKVKVAIKVIAKDDlMHQNTFYSEVEAMKKLRHKHILSLY  253

         689***************************999879************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         a+ s+++P+yi+telm kG+ll++l++ +g kl+ ++lvd+a+q++eGm+yle++n++hr

Q: 254   AISSTGDPVYIITELMPKGNLLELLRDPKGPKLPTTELVDIASQISEGMCYLESQNYVHR  313

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dlaarn+lvge++++kv+dfGlarli+d++y +   +++P+kWtaPea+++g +++ksdv

Q: 314   DLAARNILVGENNICKVGDFGLARLIKDNIYLSYA-QNIPYKWTAPEALTYGFYSTKSDV  372

         *******************************9987.89**********************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+ei++ G++PypGm+n+e+  +v  g+++ +p++cp ++y+l+ +cw+ +p e

Q: 373   WSFGILLYEIFSGGQIPYPGMSNHEAHMKVLDGFQMHCPTKCPPSIYDLMRRCWHLTPGE  432

         ************************************************************

S: 241   rPtfetlqevl  251

         rP+f+tl+e+l

Q: 433   RPCFKTLKEKL  443

         *******9876

Domain Sequence
(FASTA)

SLSRKLGSGY FGEVFEGYWK GKVKVAIKVI AKDDLMHQNT FYSEVEAMKK LRHKHILSLY 60

AISSTGDPVY IITELMPKGN LLELLRDPKG PKLPTTELVD IASQISEGMC YLESQNYVHR 120

DLAARNILVG ENNICKVGDF GLARLIKDNI YLSYAQNIPY KWTAPEALTY GFYSTKSDVW 180

SFGILLYEIF SGGQIPYPGM SNHEAHMKVL DGFQMHCPTK CPPSIYDLMR RCWHLTPGER 240

PCFKTLKEKL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0001726	; C:ruffle
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0016477	; P:cell migration
GO:0071300	; P:cellular response to retinoic acid
GO:0060575	; P:intestinal epithelial cell differentiation
GO:0045926	; P:negative regulation of growth
GO:0061099	; P:negative regulation of protein tyrosine kinase activity
GO:0010976	; P:positive regulation of neuron projection development
GO:0046777	; P:protein autophosphorylation
GO:0042503	; P:tyrosine phosphorylation of Stat3 protein
GO:0042506	; P:tyrosine phosphorylation of Stat5 protein

KEGG

mdo:100025045

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013