EKS-MOD-00363

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00363

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	385.4	1.2E-115	253	502	250

Status

Unreviewed

Ensembl Protein

ENSMODP00000021076

UniProt Accession

F6XJB6;

Protein Name

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000016887	ENSMODP00000021076	ENSMODT00000021447

Organism

Monodelphis domestica

Functional Description

Protein Length

514

Protein Sequence
(FASTA)

MKQHWHPGGQ SAVSMEPFLR KHLTFLSFFW DKLWPTSVPD DCIPRYPGPD PVTMDLDPDP 60

DPEPLSPKSS SPPPTVLFMA LYDFTARCAD ELSVSRGDKL FVIKEEGDYI FARRLSGRPS 120

TGLVPINYVA KATQETFSDQ PWYFDGISRS EAQQLLLSSS NQHGAFLVRP SESSRGDYSL 180

SVRMQAKVCH YRIAKAPEGG LYIQKGQVFP SLEELLIYYK ANWKIIQTPL LQPCMQERPL 240

ERDEWERPRT EFALRRKLGE GYFGEVWEGL WLNKIPVAIK IIKSADMKLD DFTKEIQNLK 300

SLKHEKLIRL HAVCSIGEPV YIVTELMRKG NLQSFLNSPD GKALSIIHLM SIACQVAEGM 360

TYLEERHIVH RDLAARNILV GDDLTCKIAD FGLARLLKDD IYSTKSSTKI PVKWTAPEAA 420

NYRIYSQKSD VWSYGILLYE VFTYGQCPYE GMTNQETIQQ ISRGYRLPRP PTCSPEVYVL 480

MLECWKGNAE ERPAFFVLRE KLSSIYRRLH HSFT 514

Nucleotide Sequence
(FASTA)

ATGAAACAAC ATTGGCACCC TGGGGGTCAG TCAGCAGTCA GTATGGAGCC TTTTTTAAGG 60

AAACACTTGA CCTTCCTATC ATTCTTTTGG GACAAACTTT GGCCCACAAG TGTCCCTGAT 120

GACTGCATCC CCAGATATCC TGGTCCTGAT CCTGTTACAA TGGACCTAGA TCCTGATCCT 180

GACCCAGAGC CTCTTTCTCC AAAATCAAGC AGCCCTCCTC CCACCGTCCT ATTCATGGCT 240

CTGTATGACT TCACAGCCAG GTGTGCGGAT GAATTGAGTG TGAGCCGAGG AGACAAGCTT 300

TTCGTGATCA AAGAAGAGGG TGACTACATC TTTGCCAGGA GGCTCTCTGG TCGGCCAAGC 360

ACTGGGCTGG TGCCCATTAA TTATGTGGCC AAAGCCACTC AGGAGACCTT CTCTGATCAG 420

CCGTGGTATT TTGATGGAAT CAGTCGAAGC GAGGCTCAAC AGCTTCTACT CTCCTCTTCT 480

AACCAGCATG GAGCCTTTCT GGTTCGGCCC AGTGAGAGTA GTCGAGGGGA TTACTCACTA 540

TCAGTTCGAA TGCAAGCCAA GGTCTGCCAC TATCGAATTG CCAAGGCTCC AGAAGGGGGC 600

CTGTATATTC AGAAAGGCCA AGTTTTCCCC AGCCTGGAGG AACTCCTCAT CTATTACAAA 660

GCCAACTGGA AGATTATCCA GACACCCCTG CTTCAGCCCT GTATGCAAGA GCGGCCACTG 720

GAGAGGGATG AATGGGAACG GCCCCGGACT GAGTTTGCAC TTCGAAGAAA GCTGGGAGAA 780

GGCTATTTTG GAGAAGTGTG GGAAGGCTTG TGGCTGAATA AGATTCCGGT GGCCATAAAG 840

ATCATAAAGT CTGCTGACAT GAAGCTTGAT GACTTCACCA AGGAGATTCA GAACTTAAAG 900

AGTCTAAAAC ATGAGAAGCT GATCAGGTTG CATGCAGTCT GCTCCATCGG GGAGCCTGTA 960

TACATTGTGA CAGAGCTCAT GAGGAAAGGG AACCTCCAGA GCTTCCTCAA CAGTCCAGAC 1020

GGGAAGGCTC TCAGCATCAT CCACCTCATG AGCATCGCCT GCCAGGTGGC TGAGGGTATG 1080

ACATACCTGG AAGAGAGGCA CATTGTGCAC CGGGATCTAG CTGCTCGAAA CATCCTGGTG 1140

GGAGATGACC TCACCTGCAA GATCGCAGAC TTTGGCCTGG CCAGGCTGCT AAAGGACGAT 1200

ATTTATTCAA CAAAAAGCAG CACCAAAATC CCTGTAAAAT GGACAGCTCC AGAAGCAGCC 1260

AATTATAGGA TCTACTCACA GAAGTCAGAC GTTTGGTCCT ATGGGATCCT GCTTTATGAA 1320

GTCTTCACAT ATGGACAGTG TCCTTATGAA GGTATGACCA ATCAGGAGAC TATTCAGCAG 1380

ATCTCCCGAG GTTATAGACT GCCACGCCCA CCCACTTGTT CCCCTGAGGT CTATGTGCTC 1440

ATGTTGGAGT GTTGGAAGGG CAATGCTGAG GAGAGACCTG CTTTCTTTGT GCTAAGGGAG 1500

AAACTCAGCT CTATTTACAG ACGTCTCCAT CATTCCTTCA CATGA 1545

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

          l +klGeG+fGevw+g+w ++++va+k +k+++++ ++f++e+q lk+l+hekl++l+a

Q: 253   ALRRKLGEGYFGEVWEGLWLNKIPVAIKIIKSADMKLDDFTKEIQNLKSLKHEKLIRLHA  312

         688*********************************************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         v+s +eP+yivtelm+kG+l++fl++ +gk+l++ +l+ +a+qvaeGm+ylee++++hrd

Q: 313   VCSIGEPVYIVTELMRKGNLQSFLNSPDGKALSIIHLMSIACQVAEGMTYLEERHIVHRD  372

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarn+lvg++l++k+adfGlarl++dd+y++k+++k+P+kWtaPea++++ +++ksdvW

Q: 373   LAARNILVGDDLTCKIADFGLARLLKDDIYSTKSSTKIPVKWTAPEAANYRIYSQKSDVW  432

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         s+Gill+e++t+G++Py+Gmtn+e+++q++rgyrlprp +c  e+y l+lecwk ++eer

Q: 433   SYGILLYEVFTYGQCPYEGMTNQETIQQISRGYRLPRPPTCSPEVYVLMLECWKGNAEER  492

         ************************************************************

S: 242   Ptfetlqevl  251

         P+f +l+e+l

Q: 493   PAFFVLREKL  502

         ***9999875

Domain Sequence
(FASTA)

ALRRKLGEGY FGEVWEGLWL NKIPVAIKII KSADMKLDDF TKEIQNLKSL KHEKLIRLHA 60

VCSIGEPVYI VTELMRKGNL QSFLNSPDGK ALSIIHLMSI ACQVAEGMTY LEERHIVHRD 120

LAARNILVGD DLTCKIADFG LARLLKDDIY STKSSTKIPV KWTAPEAANY RIYSQKSDVW 180

SYGILLYEVF TYGQCPYEGM TNQETIQQIS RGYRLPRPPT CSPEVYVLML ECWKGNAEER 240

PAFFVLREKL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013