EKS-MOD-00002
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00002
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph518.32.8E-156622879258
StatusUnreviewed
Ensembl ProteinENSMODP00000021172
UniProt AccessionF6UM70;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA3
Gene Synonyms/Alias EPHA3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000016972ENSMODP00000021172ENSMODT00000021545
OrganismMonodelphis domestica
Functional Description
Protein Length984
Protein Sequence
(FASTA)
MDCHISILLF LICSARSCFG ELILQPTNEV NLLDSKAIQG ELGWISYPAH GWEEISGVDE 60
HYTPIRTYQV CNVMDHSQNN WLRTNWVPRN SAQKIYVELK FTLRDCNSIP LVLGTCKETF 120
NLYYMESDDD HGVKFREHQF TKIDTIAADE SFTQMDLGDR ILKLNTEVRE VGPVSRKGFY 180
LAFQDVGACV ALVSVRVYFK KCPFTVKNLA MFPDTVPMDS QSLVEVRGSC VNNSKEEEPP 240
RMYCSTEGEW LVPIGKCLCN AGHEERGYVC QACRPGFYKA SAGNLKCSKC PPHSSTQEDG 300
AVDCRCENNY FRADKDPPSM ACTRPPSAPR NVISNINETS VILDWSWPLD TGGRKDVTFN 360
IICKKCGGSV RQCEPCSSNV HFLPRQFGLS NTTVTVIDLL AHTNYTFEID AVNGVSDMSS 420
SPRQFAAVTI TTNQAAPSPV TIIRKDRTSR NSVSLSWQEP EHPNGIILDY EVKYYEKQEQ 480
ETSYTILRAR GTNVTISGLK PDTTYVFQIR ARTAAGYGTN SRKFEFETSP DSFSISSENS 540
QVVMIAISAA VAIILLTVVV YVLIGRFCGY NKSKHGTEEK RLHFGNGHLK LPGLRTYVDP 600
HTYEDPNQAV HEFAKELDAT SISIDKVVGA GEFGEVCSGR LKLPSKKEIS VAIKTLKVGY 660
TDKQRRDFLG EASIMGQFDH PNIIRLEGVV TKSKPVMIVT EYMENGSLDS FLRKHDAQFT 720
VIQLVGMLRG IASGMKYLSD MGYVHRDLAA RNILINSNLV CKVSDFGLSR VLEDDPEAAY 780
TTRGGKIPIR WTSPEAIAYR KFTSASDVWS YGIVLWEVMS YGERPYWEMS NQDVIKAVDE 840
GYRLPPPMDC PAALYQLMLD CWQKDRNNRP KFEQIVSILD KLIRNPSSLK IITNAAARPS 900
NLLLDQSSVD IPGFRTPGDW LNGIRTGQCK DIFTGVEYSS CDTIAKISTD DMKKVGVTVV 960
GPQKKIISSI KALETHTKNG PVPV 984
Nucleotide Sequence
(FASTA)
ATGGATTGTC ACATCTCCAT CCTCCTCTTT CTCATCTGCT CAGCTCGCAG CTGCTTCGGG 60
GAACTGATTC TGCAGCCTAC CAATGAAGTG AATCTCCTGG ATTCAAAAGC TATTCAAGGG 120
GAGCTGGGCT GGATCTCCTA CCCAGCACAT GGGTGGGAAG AGATCAGTGG GGTTGATGAG 180
CATTACACCC CTATCAGGAC CTACCAGGTG TGCAATGTTA TGGATCATAG TCAGAATAAT 240
TGGCTGAGAA CAAACTGGGT CCCAAGAAAC TCAGCTCAGA AGATCTATGT GGAACTCAAG 300
TTTACCCTCA GGGACTGCAA TAGTATCCCA TTGGTTTTGG GTACTTGCAA GGAGACTTTC 360
AACCTCTACT ACATGGAGTC AGATGATGAC CATGGGGTCA AATTCCGAGA ACATCAGTTT 420
ACCAAGATTG ACACGATCGC AGCTGATGAA AGTTTCACAC AGATGGACCT GGGCGATCGT 480
ATTCTCAAGC TCAACACTGA GGTTCGAGAA GTCGGCCCCG TGAGCAGGAA AGGCTTTTAT 540
TTGGCTTTTC AAGATGTCGG TGCCTGTGTT GCCTTAGTAT CTGTGAGGGT GTACTTTAAA 600
AAGTGCCCTT TTACAGTGAA GAACCTGGCA ATGTTTCCAG ATACAGTACC GATGGACTCC 660
CAGTCCCTGG TGGAAGTCCG AGGTTCTTGT GTTAATAATT CTAAGGAAGA GGAACCACCC 720
AGAATGTACT GCAGCACAGA AGGGGAATGG CTGGTGCCCA TTGGCAAATG TTTATGCAAT 780
GCTGGCCATG AAGAGAGGGG CTATGTTTGC CAAGCTTGTC GACCAGGGTT CTACAAGGCC 840
TCTGCTGGTA ATTTGAAGTG TTCCAAGTGT CCACCCCATA GTTCTACCCA GGAAGATGGC 900
GCCGTGGACT GCAGGTGTGA GAATAATTAC TTCAGAGCAG ACAAAGACCC TCCATCCATG 960
GCTTGTACCC GACCTCCATC TGCACCGAGA AATGTTATAT CTAATATCAA CGAGACTTCT 1020
GTTATACTGG ACTGGAGTTG GCCCCTGGAC ACAGGAGGCC GGAAGGATGT GACCTTCAAC 1080
ATCATATGTA AAAAGTGCGG GGGGAGTGTT AGACAGTGTG AGCCATGCAG CTCCAATGTT 1140
CACTTCTTGC CACGGCAATT TGGACTAAGC AACACCACGG TGACAGTGAT AGACCTTCTA 1200
GCACACACTA ACTATACATT TGAAATTGAT GCAGTTAATG GAGTATCTGA CATGAGTTCA 1260
TCTCCTCGAC AGTTTGCCGC AGTCACCATA ACAACCAATC AGGCTGCTCC ATCACCTGTC 1320
ACCATAATTA GAAAGGACCG GACATCCAGA AACAGTGTCT CGTTATCTTG GCAAGAACCC 1380
GAACATCCTA ATGGAATCAT CCTGGACTAT GAGGTCAAGT ACTATGAAAA GCAGGAGCAA 1440
GAGACAAGTT ATACTATTCT GAGGGCAAGA GGCACGAATG TTACCATCAG TGGCCTCAAA 1500
CCTGATACCA CTTACGTCTT CCAAATCCGA GCCCGGACAG CAGCTGGATA TGGGACCAAC 1560
AGCCGCAAGT TTGAGTTTGA AACTAGTCCA GATTCGTTCT CCATCTCTAG CGAGAATAGC 1620
CAGGTTGTCA TGATAGCCAT TTCAGCTGCA GTTGCAATTA TTCTTCTGAC AGTTGTGGTG 1680
TATGTCCTGA TCGGGAGATT TTGTGGCTAT AACAAATCAA AGCATGGTAC AGAGGAAAAA 1740
AGACTTCATT TTGGGAATGG ACACTTAAAG CTTCCAGGTC TCAGGACATA TGTAGACCCC 1800
CATACATATG AAGACCCTAA CCAGGCTGTC CATGAATTTG CCAAGGAGTT GGATGCTACC 1860
AGTATATCCA TTGACAAAGT TGTTGGAGCA GGTGAATTTG GAGAAGTATG TAGTGGCCGC 1920
TTGAAGCTTC CTTCCAAAAA AGAGATTTCA GTAGCCATCA AAACTCTCAA AGTAGGATAC 1980
ACTGACAAGC AGAGGAGAGA CTTCTTGGGG GAAGCCAGTA TCATGGGCCA GTTTGACCAT 2040
CCCAATATCA TTCGACTTGA AGGAGTTGTT ACCAAAAGTA AACCGGTCAT GATTGTCACA 2100
GAATACATGG AGAATGGCTC CTTGGACAGC TTCTTACGAA AACATGATGC CCAGTTTACA 2160
GTCATTCAAC TAGTAGGAAT GCTTCGAGGG ATAGCCTCTG GAATGAAATA TTTGTCAGAT 2220
ATGGGCTACG TTCATCGTGA TCTTGCTGCC CGCAATATCC TCATCAACAG CAACCTGGTG 2280
TGCAAGGTTT CTGATTTTGG CCTCTCGAGA GTTCTAGAAG ATGATCCAGA GGCTGCTTAC 2340
ACAACAAGAG GGGGAAAGAT CCCAATTCGA TGGACATCTC CAGAAGCAAT TGCATATCGC 2400
AAGTTTACGT CAGCCAGCGA CGTATGGAGC TACGGAATTG TTCTCTGGGA GGTGATGTCC 2460
TATGGAGAGA GACCATACTG GGAGATGTCC AATCAGGATG TAATTAAAGC TGTGGATGAA 2520
GGCTACCGAC TGCCACCTCC CATGGACTGC CCAGCTGCCT TATATCAGCT GATGCTGGAC 2580
TGCTGGCAGA AGGACAGAAA CAACAGACCC AAGTTTGAGC AGATTGTCAG CATTCTGGAC 2640
AAGCTTATAA GGAATCCCAG CAGTCTGAAA ATCATTACCA ATGCTGCAGC AAGGCCGTCA 2700
AACCTTCTCT TGGACCAAAG CAGCGTGGAC ATCCCCGGCT TCCGCACGCC GGGAGACTGG 2760
CTCAACGGCA TCCGGACGGG GCAGTGCAAG GACATCTTTA CCGGCGTGGA GTACAGTTCT 2820
TGCGACACCA TAGCCAAGAT TTCCACGGAC GACATGAAGA AGGTCGGTGT GACCGTCGTT 2880
GGGCCACAGA AGAAGATCAT TAGCAGTATT AAAGCTCTAG AAACACATAC GAAGAACGGC 2940
CCCGTTCCTG TGTAG 2955
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++i+kv+GaGefGevcsGrlklp+k+ei+vaiktlk g+t+kqrrdfl easi+Gqfdhp
Q: 622   ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTDKQRRDFLGEASIMGQFDHP  681
         689*********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtkskpvmivteymeng+ldsflrk+d qftviqlvgmlrGiasgmkylsdm
Q: 682   NIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDM  741
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwt+peaiayrk
Q: 742   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK  801
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGivlwev+syGerpyw+msnqdvika++egyrlpppmdcpaalyqlmldc
Q: 802   FTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDC  861
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqkdr++rpkfeqivsil
Q: 862   WQKDRNNRPKFEQIVSIL  879
         ***************986
Domain Sequence
(FASTA)
ISIDKVVGAG EFGEVCSGRL KLPSKKEISV AIKTLKVGYT DKQRRDFLGE ASIMGQFDHP 60
NIIRLEGVVT KSKPVMIVTE YMENGSLDSF LRKHDAQFTV IQLVGMLRGI ASGMKYLSDM 120
GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TSPEAIAYRK 180
FTSASDVWSY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP AALYQLMLDC 240
WQKDRNNRPK FEQIVSIL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00002
EKS-ANC-00002
EKS-CAE-00001
EKS-CAJ-00002
EKS-CAF-00003
EKS-EQC-00003
EKS-FEC-00004
EKS-GAM-00003
EKS-GAG-00003
EKS-GAA-00003
EKS-GOG-00002
EKS-HOS-00003
EKS-ICT-00002
EKS-LOA-00002
EKS-MAM-00002
EKS-MEG-00002
EKS-MUM-00002
EKS-MUP-00002
EKS-MYL-00003
EKS-NOL-00002
EKS-ORN-00002
EKS-ORA-00003
EKS-ORC-00002
EKS-ORL-00003
EKS-OTG-00001
EKS-PAT-00002
EKS-PES-00003
EKS-POA-00002
EKS-PRC-00002
EKS-RAN-00003
EKS-SUS-00002
EKS-TAG-00004
EKS-TAS-00002
EKS-TEN-00001
EKS-TUT-00001
EKS-VIP-00002
EKS-XET-00001
Gene Ontology
GO:0005769; C:early endosome
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0071300; P:cellular response to retinoic acid
GO:0010976; P:positive regulation of neuron projection development
GO:0032956; P:regulation of actin cytoskeleton organization
GO:0051893; P:regulation of focal adhesion assembly
GO:0070507; P:regulation of microtubule cytoskeleton organization
GO:0032319; P:regulation of Rho GTPase activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013