EKS-MOD-00357

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00357

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	436.3	3.5E-131	245	494	250

Status

Unreviewed

Ensembl Protein

ENSMODP00000021795

UniProt Accession

F6Z574;

Protein Name

Protein Synonyms/Alias

Gene Name

LCK

Gene Synonyms/Alias

LCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000017464	ENSMODP00000021795	ENSMODT00000022174

Organism

Monodelphis domestica

Functional Description

Protein Length

509

Protein Sequence
(FASTA)

MGCCCSSSLD EDWMENIDVC ERCHYPIVPL DAKDMLPMRN GSEVRDPLVD YNGLDPPVSP 60

LQDNLVIALH SYKPSHDGDL GFEKGEQLKI LEQNGEWWKA QSLTTGQEGF IPFNFVAKVN 120

SLEPEPWFFK DLSRKDAERQ LLAPGNTHGS FLIRESETTA GSFSLSVRDF DQNQGEVVKH 180

YKIRNLDNGG FYISPRITFP GLHELVQHYS KVSDGLCTRL SRPCQTQKPQ KPWWEDEWEV 240

PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKAGSM SPDAFLAEAN LMKQLQHQRL 300

VRLYAVVTQE PIYIITEYME NGSLVDFLKT STGVKLTIHK LLDMAAQIAE GMAFIEERNY 360

IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 420

SDVWSFGILL TEIVTYGRIP YPGMTNPEVI QNLEQGYRMV RPDNCPEELY KLMMLCWKER 480

PEERPTFDYL RSVLEDFFTA TEGQYQPQP 509

Nucleotide Sequence
(FASTA)

ATGGGCTGCT GCTGCAGCTC CAGCCTCGAT GAGGACTGGA TGGAAAATAT CGACGTGTGC 60

GAACGATGCC ACTACCCTAT TGTTCCATTG GATGCTAAGG ACATGCTCCC AATGAGGAAT 120

GGTTCTGAAG TGCGGGATCC CTTGGTCGAC TATAATGGCT TAGACCCACC TGTGTCTCCG 180

TTACAAGATA ACCTGGTCAT CGCCCTGCAC AGTTATAAAC CCTCCCATGA TGGGGACCTG 240

GGCTTTGAGA AGGGGGAGCA GCTCAAGATC CTGGAGCAGA ATGGAGAATG GTGGAAGGCA 300

CAGTCCCTGA CCACTGGCCA GGAGGGCTTC ATTCCCTTCA ATTTTGTGGC CAAAGTTAAC 360

AGCCTGGAGC CTGAGCCTTG GTTTTTCAAG GACCTGAGTC GGAAGGATGC TGAGAGACAA 420

CTTCTGGCCC CTGGGAACAC CCATGGATCC TTCCTGATCA GAGAGAGTGA GACAACTGCA 480

GGTTCCTTCT CACTCTCTGT GCGAGACTTT GACCAGAACC AGGGGGAGGT GGTGAAACAT 540

TACAAGATCC GCAATCTGGA CAATGGTGGC TTCTACATTT CCCCCCGAAT CACCTTTCCT 600

GGTCTGCATG AGCTGGTCCA GCATTACTCC AAAGTCTCAG ATGGGCTCTG CACTCGATTG 660

AGCCGGCCCT GCCAGACCCA GAAACCACAG AAGCCCTGGT GGGAAGATGA GTGGGAGGTA 720

CCAAGAGAGA CGCTGAAGCT GGTGGAGAGG CTGGGAGCTG GCCAATTTGG GGAGGTCTGG 780

ATGGGGTACT ATAATGGACA CACCAAGGTA GCTGTGAAAA GCCTAAAAGC GGGCAGCATG 840

TCCCCTGATG CCTTCCTGGC AGAGGCCAAC CTGATGAAAC AGTTGCAGCA CCAACGGCTG 900

GTACGCCTGT ATGCAGTGGT CACGCAGGAG CCCATCTACA TCATCACTGA ATACATGGAG 960

AACGGGAGCC TCGTAGACTT CCTCAAAACC TCAACAGGGG TCAAACTAAC CATCCACAAA 1020

TTGCTGGATA TGGCTGCACA GATTGCTGAG GGCATGGCCT TCATTGAGGA GCGGAATTAC 1080

ATTCACCGAG ACCTTCGGGC AGCCAACATC CTCGTGTCAG ACACACTCAG CTGTAAGATC 1140

GCTGACTTTG GCTTGGCCCG GCTAATTGAG GACAATGAGT ACACAGCTAG GGAGGGAGCA 1200

AAATTTCCCA TCAAGTGGAC AGCTCCTGAA GCCATCAACT ACGGGACATT CACCATCAAG 1260

TCAGATGTCT GGTCTTTTGG CATCCTACTA ACAGAAATTG TCACCTATGG GAGGATTCCC 1320

TACCCAGGAA TGACCAACCC CGAGGTGATC CAGAACCTGG AGCAGGGTTA TCGGATGGTG 1380

AGGCCTGACA ACTGCCCAGA GGAGCTGTAC AAACTGATGA TGTTGTGCTG GAAGGAAAGG 1440

CCTGAGGAGC GACCTACCTT TGACTACTTG AGGAGTGTAT TAGAGGACTT CTTCACTGCC 1500

ACAGAGGGCC AGTACCAGCC CCAGCCATGA 1530

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklv++lG+GqfGevw+g+++g++kvavk+lk g++sp+afl+ea+++k+l+h++lv+ly

Q: 245   LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKAGSMSPDAFLAEANLMKQLQHQRLVRLY  304

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyi+te+m++Gsl+dflk+++g kl+++kl+d+aaq+aeGma++ee+n+ihr

Q: 305   AVVTQ-EPIYIITEYMENGSLVDFLKTSTGVKLTIHKLLDMAAQIAEGMAFIEERNYIHR  363

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+++l +k+adfGlarlied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 364   DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV  423

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillteivt+G++PypGmtn ev++++e+gyr+ rp++cpeely+l++ cwk++pee

Q: 424   WSFGILLTEIVTYGRIPYPGMTNPEVIQNLEQGYRMVRPDNCPEELYKLMMLCWKERPEE  483

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++l++vl

Q: 484   RPTFDYLRSVL  494

         *******9876

Domain Sequence
(FASTA)

LKLVERLGAG QFGEVWMGYY NGHTKVAVKS LKAGSMSPDA FLAEANLMKQ LQHQRLVRLY 60

AVVTQEPIYI ITEYMENGSL VDFLKTSTGV KLTIHKLLDM AAQIAEGMAF IEERNYIHRD 120

LRAANILVSD TLSCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFTIKSDVW 180

SFGILLTEIV TYGRIPYPGM TNPEVIQNLE QGYRMVRPDN CPEELYKLMM LCWKERPEER 240

PTFDYLRSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013