EKS-MOD-00417

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00417

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	541.2	4.8E-163	98	355	258

Status

Unreviewed

Ensembl Protein

ENSMODP00000021847

UniProt Accession

F7F0V9;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK1

Gene Synonyms/Alias

SGK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000017509	ENSMODP00000021847	ENSMODT00000022227

Organism

Monodelphis domestica

Functional Description

Protein Length

431

Protein Sequence
(FASTA)

MTVKTEASGA TLTYSKMRGM VAILIAFMKQ RRMGLNDFIQ KIASNSYACK HPEVQSILKI 60

SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF LKVIGKGSFG KVLLARHKAE 120

EQFYAVKVLQ KKAILKKKEE KHIMSERNVL LKNVKHPFLV GLHFSFQTAD KLYFVLDYIN 180

GGELFYHLQR ERCFLEPRAR FYAAEIASAL GYLHSLNIVY RDLKPENILL DSQGHIVLTD 240

FGLCKENIEH NGTTSTFCGT PEYLAPEVLH KQPYDRTVDW WCLGAVLYEM LYGLPPFYSR 300

NTAEMYDNIL NKPLQLKPNI TNSARHLLEG LLQKDRTKRL GAKDDFMEIK NHIFFSLINW 360

DDLINKKITP PFNPNVSGPN DLRHFDPEFT EEPVPNSIGK SPDSILITAS VKEAAEAFLG 420

FSYAPPMDSF L 431

Nucleotide Sequence
(FASTA)

ATGACGGTGA AAACCGAGGC TTCTGGAGCT ACGCTCACTT ACTCAAAAAT GAGGGGCATG 60

GTAGCAATCC TTATTGCTTT CATGAAACAG AGGAGGATGG GGCTGAATGA TTTTATTCAG 120

AAGATTGCCA GCAACTCATA TGCCTGCAAA CACCCTGAAG TTCAATCTAT TTTGAAAATT 180

TCTCAACCTC AAGAACCTGA GCTTATGAAT GCCAATCCTT CTCCTCCACC CAGTCCATCT 240

CAGCAGATCA ACCTTGGCCC ATCATCCAAC CCCCATGCAA AACCATCGGA TTTTCATTTC 300

TTGAAAGTAA TTGGAAAAGG CAGTTTTGGA AAGGTTCTTC TTGCAAGACA CAAGGCAGAG 360

GAGCAATTCT ATGCTGTCAA GGTTCTTCAG AAAAAAGCAA TCCTGAAAAA GAAGGAGGAA 420

AAACACATCA TGTCAGAGCG GAATGTACTT CTGAAGAATG TCAAACACCC TTTCCTGGTT 480

GGGCTGCATT TTTCCTTCCA GACTGCAGAC AAGCTCTACT TTGTCCTAGA CTACATCAAT 540

GGTGGAGAGT TGTTTTACCA TCTCCAGAGA GAGCGATGCT TCCTGGAACC CCGGGCTCGA 600

TTTTATGCTG CTGAAATCGC CAGTGCCCTG GGTTACCTAC ACTCTCTGAA TATTGTTTAT 660

AGAGACTTGA AGCCAGAGAA TATTTTGCTG GATTCACAAG GGCATATAGT CCTGACAGAC 720

TTTGGACTCT GTAAAGAAAA CATTGAGCAC AATGGTACAA CGTCCACCTT CTGCGGCACC 780

CCTGAGTATC TTGCTCCTGA AGTGCTTCAC AAGCAGCCTT ATGACCGAAC AGTTGACTGG 840

TGGTGCCTAG GAGCTGTCTT ATATGAAATG CTCTATGGTC TGCCTCCTTT TTATAGTCGA 900

AACACAGCTG AGATGTATGA CAACATTCTG AACAAGCCAC TCCAATTGAA GCCAAATATT 960

ACAAATTCTG CCAGACACCT TCTTGAGGGC CTCCTGCAAA AAGATAGGAC AAAAAGGCTT 1020

GGTGCCAAGG ATGATTTTAT GGAGATTAAG AATCATATCT TCTTCTCCCT TATTAACTGG 1080

GATGATCTCA TTAATAAGAA GATTACTCCT CCTTTTAACC CAAATGTGAG TGGACCCAAT 1140

GATCTTCGAC ATTTCGATCC TGAATTTACC GAAGAACCTG TTCCAAACTC CATTGGCAAG 1200

TCCCCAGATA GCATCCTGAT CACTGCCAGT GTCAAGGAAG CAGCAGAAGC TTTCCTGGGT 1260

TTCTCCTATG CACCTCCTAT GGATTCTTTC CTGTGA 1296

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         f+flkvigkgsfgkvlla++ka+e+fyavkvlqkkailkkkeekhim+ernvllknvkhp

Q: 98    FHFLKVIGKGSFGKVLLARHKAEEQFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP  157

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglh+sfqta+klyfvldy+nggelf+hlqrer+fleprarfyaaeiasalgylhsln

Q: 158   FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN  217

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds+gh+vltdfglcke+ie++ ttstfcgtpeylapevl+k+pydrt

Q: 218   IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRT  277

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfysr++aemydnilnkplqlkp+i+++a++lle+ll+kdr+

Q: 278   VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRT  337

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         krlgak+df+eiknh+ff

Q: 338   KRLGAKDDFMEIKNHIFF  355

         *****************9

Domain Sequence
(FASTA)

FHFLKVIGKG SFGKVLLARH KAEEQFYAVK VLQKKAILKK KEEKHIMSER NVLLKNVKHP 60

FLVGLHFSFQ TADKLYFVLD YINGGELFYH LQRERCFLEP RARFYAAEIA SALGYLHSLN 120

IVYRDLKPEN ILLDSQGHIV LTDFGLCKEN IEHNGTTSTF CGTPEYLAPE VLHKQPYDRT 180

VDWWCLGAVL YEMLYGLPPF YSRNTAEMYD NILNKPLQLK PNITNSARHL LEGLLQKDRT 240

KRLGAKDDFM EIKNHIFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006974	; P:response to DNA damage stimulus

KEGG

mdo:100025435

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013