EKS-MOD-00452

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00452

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	431.4	1.5E-129	24	312	289

Status

Unreviewed

Ensembl Protein

ENSMODP00000022098

UniProt Accession

F7FHD1;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100028096

Gene Synonyms/Alias

LOC100028096;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000017722	ENSMODP00000022098	ENSMODT00000022485

Organism

Monodelphis domestica

Functional Description

Protein Length

359

Protein Sequence
(FASTA)

MAAGGGGAGP EMVRGQVFDV GPRYTNLSYI GEGAYGMVCS AYDNVNKVRV AIKKISPFEH 60

QTYCQRTLRE IKILLRFRHE NIIGINDIIR APAIEQMKDV YIVQDLMETD LYKLLKTQHL 120

SNDHICYFLY QILRGLKYIH SANVLHRDLK PSNLLLNTTC DLKICDFGLA RVADPDHDHT 180

GFLTEYVATR WYRAPEIMLN SKGYTKSIDI WSVGCILAEM LSNRPIFPGK HYLDQLNHIL 240

GILGSPSQED LNCIINLKAR NYLLSLPHKN KVPWNRLFPN ADPKALDLLD KMLTFNPHKR 300

IEVEQALAHP YLEQYYDPSD EPVAEAPFKF DMELDDLPKE KLKELIFEET ARFQPGYRS 359

Nucleotide Sequence
(FASTA)

ATGGCGGCAG GAGGCGGCGG CGCGGGTCCC GAGATGGTCC GCGGGCAGGT GTTCGACGTG 60

GGCCCACGCT ACACCAATCT CTCGTACATC GGCGAGGGAG CCTATGGCAT GGTGTGTTCT 120

GCGTATGACA ACGTCAACAA GGTCCGCGTG GCCATCAAGA AAATCAGCCC CTTTGAGCAC 180

CAGACCTACT GCCAGCGGAC CCTGCGCGAA ATCAAGATTT TGCTGCGCTT CCGCCACGAG 240

AATATCATCG GCATCAACGA TATCATTCGG GCACCAGCCA TCGAGCAGAT GAAAGATGTA 300

TATATCGTAC AGGACCTTAT GGAAACGGAC CTTTACAAGC TCTTGAAGAC GCAACACCTC 360

AGCAATGACC ACATCTGTTA TTTCCTTTAC CAGATCCTCA GAGGTTTAAA ATACATCCAT 420

TCAGCCAACG TTCTGCACCG TGACCTCAAA CCTTCTAACT TACTGCTCAA CACCACCTGC 480

GATCTCAAGA TCTGTGACTT TGGCCTGGCA CGTGTTGCAG ATCCAGACCA TGACCACACA 540

GGCTTCCTGA CAGAATATGT GGCCACACGC TGGTACCGAG CACCTGAAAT CATGCTGAAT 600

TCCAAGGGTT ACACCAAGTC CATTGACATC TGGTCTGTGG GCTGTATTCT GGCTGAGATG 660

CTCTCCAACA GGCCCATTTT CCCTGGAAAG CATTACCTTG ATCAGCTGAA CCACATTCTC 720

GGCATTCTTG GGTCTCCTTC ACAAGAAGAC TTGAATTGCA TAATAAATCT AAAAGCCAGG 780

AACTATTTAC TGTCTCTTCC TCACAAAAAC AAGGTGCCGT GGAATAGACT CTTCCCCAAT 840

GCCGACCCCA AAGCCCTGGA CTTACTGGAT AAGATGTTGA CGTTCAACCC TCACAAGAGG 900

ATCGAAGTGG AGCAGGCGCT GGCCCACCCC TACCTGGAGC AGTATTACGA CCCCAGTGAC 960

GAGCCTGTGG CCGAAGCCCC GTTCAAGTTT GACATGGAGC TGGACGACCT GCCCAAGGAG 1020

AAGCTGAAGG AGCTGATTTT TGAAGAGACT GCTAGATTCC AGCCCGGATA CCGATCTTAA 1080

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+++geGayg+v+sa+d+ ++ rvaikk+s pf+++t ++rtlRE+k+l +++heNi

Q: 24    YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENI  82

         78999***************************9.**************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i + d++++   +e++kdvY+v++lmetdL+k++k+q+ls++hi ++lyqilrglky+Hs

Q: 83    IGINDIIRAPA-IEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHS  141

         *********99.************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178

         anv+HrDlKPsNll+n++c+lki+dFGlar+ad++++++  lteyvatrwYraPei+l++

Q: 142   ANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgfLTEYVATRWYRAPEIMLNS  201

         ***********************************999999*******************

S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238

         k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il +lg+ps+e+l++i + +arn

Q: 202   KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARN  261

         ************************************************************

S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         y+ slp+k+k ++++lfp+a+++aldLl+k+L+++p+kRi+ve+aL+hpYl

Q: 262   YLLSLPHKNKVPWNRLFPNADPKALDLLDKMLTFNPHKRIEVEQALAHPYL  312

         **************************************************7

Domain Sequence
(FASTA)

YTNLSYIGEG AYGMVCSAYD NVNKVRVAIK KISPFEHQTY CQRTLREIKI LLRFRHENII 60

GINDIIRAPA IEQMKDVYIV QDLMETDLYK LLKTQHLSND HICYFLYQIL RGLKYIHSAN 120

VLHRDLKPSN LLLNTTCDLK ICDFGLARVA DPDHDHTGFL TEYVATRWYR APEIMLNSKG 180

YTKSIDIWSV GCILAEMLSN RPIFPGKHYL DQLNHILGIL GSPSQEDLNC IINLKARNYL 240

LSLPHKNKVP WNRLFPNADP KALDLLDKML TFNPHKRIEV EQALAHPYL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013