EKS-MOD-00362

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00362

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	413.2	4.0E-124	148	400	253

Status

Unreviewed

Ensembl Protein

ENSMODP00000022256

UniProt Accession

F6Z7T8;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000017852	ENSMODP00000022256	ENSMODT00000022645

Organism

Monodelphis domestica

Functional Description

Protein Length

421

Protein Sequence
(FASTA)

MSVDGPGQQL QGYIPSNYVA EDQSIQAEPW FFGSIKRVDA EKQLLYPGNQ NGAFLIRESE 60

TQKGDFSLSV LDNKIVKHYR VRRLDEGGFF LTRRRTFDTL NAFVDYYTKT SDGLCVKLGK 120

PCLKKEVPTT FDLSYKTVDQ WEIDRNSLQL LKILGSGQFG EVWEGLWNNT TPVAVKTLKP 180

GSMDPRDFLR EAQIMKNLRH PKLIQLYAVC TLEDPIYIIT ELMRHGSLQV YLQNDGGSKI 240

HLPQQLDMAA QVASGMAYLE SQNYIHRDLA ARNVLVGEHN VYKVADFGLA RVFKVENEDI 300

YESKPEIKLP VKWTAPEAIR SHKFSIKSDV WSFGILLHEI ITYGKMPYPG MTGMQVIQKL 360

DQNYRLPQPE NCPLELYNIM LQCWNVEPKD RPTFESLHWS LEDYYYELDS SSYLDANNFI 420

R 421

Nucleotide Sequence
(FASTA)

ATGAGTGTAG ATGGCCCTGG GCAGCAACTC CAAGGTTATA TTCCTTCGAA CTACGTGGCT 60

GAAGATCAGA GCATCCAGGC TGAACCGTGG TTCTTTGGTT CAATCAAGCG AGTAGATGCA 120

GAAAAACAAC TACTGTACCC AGGAAACCAG AACGGTGCCT TTCTAATTAG AGAAAGTGAA 180

ACCCAGAAAG GAGACTTCTC CCTTTCAGTT TTAGATAACA AAATTGTGAA GCACTACCGA 240

GTGAGAAGAC TTGATGAGGG AGGCTTTTTC CTTACCCGCA GAAGAACTTT TGATACCTTG 300

AATGCTTTTG TGGACTACTA CACCAAGACG AGTGATGGCC TCTGTGTCAA ACTTGGAAAA 360

CCATGCCTGA AGAAAGAAGT CCCAACTACT TTTGATTTGT CATATAAGAC TGTGGACCAG 420

TGGGAAATAG ATCGAAACTC TCTGCAACTT CTGAAAATAT TAGGATCTGG CCAGTTTGGT 480

GAGGTGTGGG AAGGCTTATG GAATAATACT ACTCCAGTGG CAGTCAAAAC ATTAAAACCA 540

GGTTCAATGG ATCCAAGGGA CTTCCTGAGG GAGGCACAGA TAATGAAGAA CCTGAGACAT 600

CCCAAGCTTA TCCAGCTTTA TGCTGTTTGC ACTTTAGAGG ATCCAATTTA TATTATAACA 660

GAACTGATGA GACATGGAAG TCTGCAAGTC TATCTCCAAA ATGATGGTGG GTCCAAAATC 720

CATCTGCCTC AACAGCTGGA CATGGCAGCT CAAGTTGCTT CAGGAATGGC TTACCTAGAA 780

TCCCAGAACT ATATCCACAG AGATTTAGCT GCCAGAAATG TCCTCGTTGG TGAACACAAT 840

GTTTACAAAG TGGCAGACTT TGGACTTGCA AGAGTTTTTA AGGTAGAAAA TGAAGATATC 900

TATGAATCTA AACCAGAAAT CAAACTACCA GTGAAATGGA CGGCACCTGA AGCCATTCGT 960

TCTCATAAAT TCAGCATTAA GTCTGATGTG TGGTCATTTG GGATACTTCT TCATGAAATC 1020

ATTACTTATG GAAAGATGCC TTATCCAGGC ATGACAGGTA TGCAGGTAAT CCAGAAATTG 1080

GATCAAAACT ATAGACTTCC TCAACCAGAG AATTGTCCAT TGGAACTCTA CAACATCATG 1140

TTGCAATGTT GGAATGTAGA ACCCAAAGAT CGACCAACAT TTGAATCATT GCACTGGAGT 1200

CTTGAAGACT ATTATTATGA ATTGGATTCT TCTTCTTATT TAGATGCAAA TAATTTCATT 1260

AGATAA 1266

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+k lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 148   LQLLKILGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPRDFLREAQIMKNLRHPKLIQLY  207

         689999******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+ +l+++ g+k++lp+++d+aaqva+Gmayle++n+ihr

Q: 208   AVCTLEDPIYIITELMRHGSLQVYLQNDGGSKIHLPQQLDMAAQVASGMAYLESQNYIHR  267

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++v+kvadfGlar+++   +d+y++k + klP+kWtaPeai+ +kf+ik

Q: 268   DLAARNVLVGEHNVYKVADFGLARVFKvenEDIYESKPEIKLPVKWTAPEAIRSHKFSIK  327

         ************************99887899****************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+Gk+PypGmt  +v+++++++yrlp+pe+cp ely+++l+cw+ +

Q: 328   SDVWSFGILLHEIITYGKMPYPGMTGMQVIQKLDQNYRLPQPENCPLELYNIMLQCWNVE  387

         ************************************************************

S: 238   peerPtfetlqev  250

         p++rPtfe l++

Q: 388   PKDRPTFESLHWS  400

         **********986

Domain Sequence
(FASTA)

LQLLKILGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPRD FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LQVYLQNDGG SKIHLPQQLD MAAQVASGMA YLESQNYIHR 120

DLAARNVLVG EHNVYKVADF GLARVFKVEN EDIYESKPEI KLPVKWTAPE AIRSHKFSIK 180

SDVWSFGILL HEIITYGKMP YPGMTGMQVI QKLDQNYRLP QPENCPLELY NIMLQCWNVE 240

PKDRPTFESL HWS 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

mdo:100022866

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013