EKS-MOD-00004
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00004
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph517.35.5E-156628884257
StatusUnreviewed
Ensembl ProteinENSMODP00000022635
UniProt AccessionF7CWR4;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA7
Gene Synonyms/Alias EPHA7;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000018150ENSMODP00000022635ENSMODT00000023033
OrganismMonodelphis domestica
Functional Description
Protein Length993
Protein Sequence
(FASTA)
MVFQTRYPSW IILCYIWLLR FAHLGEAQAA KEVLLLDSKA QQTELEWISF PPNGWEEISG 60
LDENYTPIRT YQVCQVMEPN QNNWLRTNWI AKGNAQRIFV ELKFTLRDCN SLPGVLGTCK 120
ETFNLYYYET DYNTGRNIRE NLYVKIDTIA ADESFTQGDL GERKMKLNTE VREIGPLSRK 180
GFYLAFQDVG ACIALVSVKV YYKKCWSIIE NLAIFPDTVT GSEFSSLVEV RGTCVSSAEE 240
EAENSPRMHC SAEGEWLVPI GKCICKAGYQ QKGDTCEPCG RGFYKSSSQD LQCSRCPTHS 300
FSDKEGSSRC DCEDGYYRAI SDPPYVACTR PPSAPQNLIF NINQTTVSLE WSPPADNGGR 360
NDVTYRVLCK RCSWEQGECV PCGSNIGYMP QQTGLADNYV TVMDLLAHAN YTFEVEAVNG 420
VSDLSRSQRL FAAVSITTGQ AAPSQVSGVM KERVLQRSVE LSWQEPEHPN GVITEYEIKY 480
YEKDQRERTY STVKTKSTSA SINNLKPGTV YVFQIRAFTA AGYGNYSPRL DVATLEEATA 540
TAVSSEQNPV IIIAVVAVAG TIILVFMVFG FIIGRRHCGY SKADQEGDEE LYFHFKFPGT 600
KTYIDPETYE DPNRAVHQFA KELDASCIKI ERVIGAGEFG EVCSGRLKLP GKRDVAVAIK 660
TLKVGYTEKQ RRDFLCEASI MGQFDHPNVV HLEGVVTRGK PVMIVIEYME NGALDAFLRK 720
HDGQFTVIQL VGMLRGIAAG MRYLADMGYV HRDLAARNIL VNSNLVCKVS DFGLSRVIED 780
DPEAVYTTTG GKIPVRWTAP EAIQYRKFTS ASDVWSYGIV MWEVMSYGER PYWDMSNQDV 840
IKAIEEGYRL PAPMDCPAGL HQLMLDCWQK DRAERPKFEQ IVGILDKMIR NPNSLKTPLG 900
TCSRPISPLL DQNTPDFTTF CSVGEWLQAI KMERYKDNFT AAGYNSLESV ARMTIEDVMS 960
LGITLVGHQK KIMSSIQTMR AQMLHLHGTG IQV 993
Nucleotide Sequence
(FASTA)
ATGGTTTTTC AAACTCGGTA CCCTTCCTGG ATTATTTTAT GCTACATCTG GCTGCTCCGC 60
TTTGCACACT TGGGGGAGGC ACAGGCTGCA AAAGAAGTAC TTCTTCTGGA CTCTAAAGCA 120
CAACAGACAG AGTTAGAGTG GATTTCCTTT CCTCCCAATG GGTGGGAAGA AATTAGTGGA 180
TTGGATGAAA ACTACACACC TATACGAACA TACCAGGTAT GCCAGGTCAT GGAACCTAAC 240
CAAAACAACT GGCTCCGGAC TAACTGGATT GCAAAAGGCA ATGCCCAAAG AATTTTTGTA 300
GAACTGAAAT TCACCTTGAG GGATTGTAAC AGTCTTCCTG GAGTGCTGGG AACATGCAAA 360
GAAACCTTTA ATTTGTACTA TTATGAAACA GACTACAACA CTGGCAGAAA TATAAGGGAA 420
AATCTCTATG TAAAAATAGA TACTATTGCT GCTGATGAAA GTTTTACCCA GGGTGACCTT 480
GGGGAGAGAA AAATGAAACT TAACACAGAG GTGAGAGAGA TTGGACCTTT GTCCAGAAAG 540
GGATTCTATT TGGCCTTTCA GGATGTTGGG GCTTGCATTG CTTTGGTTTC TGTCAAGGTG 600
TACTACAAGA AATGCTGGTC CATTATTGAG AACTTAGCTA TTTTTCCAGA TACAGTGACT 660
GGTTCAGAGT TTTCCTCTCT AGTGGAGGTC CGAGGGACAT GTGTCAGCAG TGCAGAAGAG 720
GAGGCAGAAA ACTCTCCTAG GATGCACTGC AGTGCAGAAG GAGAATGGTT AGTGCCTATT 780
GGAAAGTGTA TCTGCAAAGC CGGTTACCAG CAAAAAGGGG ATACTTGTGA ACCTTGTGGT 840
CGTGGGTTCT ACAAGTCTTC TTCCCAAGAT CTTCAATGTT CTCGCTGCCC AACACACAGT 900
TTTTCTGACA AAGAAGGCTC TTCGCGATGT GACTGTGAAG ATGGGTATTA CAGAGCTATT 960
TCTGATCCAC CATATGTTGC TTGCACAAGA CCTCCATCTG CACCACAGAA CCTCATTTTC 1020
AACATCAACC AAACCACAGT GAGCTTGGAG TGGAGTCCTC CTGCTGACAA CGGAGGAAGA 1080
AACGATGTCA CCTACCGAGT TTTGTGTAAA CGGTGCAGTT GGGAACAAGG TGAATGTGTA 1140
CCCTGTGGTA GTAACATTGG GTACATGCCC CAGCAAACTG GATTAGCTGA TAACTATGTT 1200
ACTGTCATGG ACTTGTTAGC TCATGCCAAT TACACCTTTG AAGTTGAAGC TGTCAATGGA 1260
GTTTCAGACC TAAGCCGTTC CCAGAGGCTT TTTGCTGCTG TCAGTATCAC CACTGGTCAA 1320
GCAGCTCCCT CGCAAGTTAG TGGAGTAATG AAGGAGAGAG TGCTGCAGCG AAGCGTCGAG 1380
CTTTCCTGGC AGGAGCCAGA ACATCCCAAT GGAGTCATCA CTGAATATGA AATCAAGTAT 1440
TACGAGAAAG ATCAAAGAGA GAGGACCTAC TCGACAGTAA AAACCAAGTC CACTTCAGCC 1500
TCCATTAATA ACCTGAAACC AGGAACAGTA TATGTTTTCC AGATTCGTGC TTTCACTGCT 1560
GCTGGTTATG GAAATTATAG TCCCAGGCTT GATGTTGCTA CACTAGAGGA AGCTACAGCC 1620
ACAGCCGTCT CCAGTGAACA GAATCCTGTA ATTATCATAG CTGTGGTTGC TGTGGCAGGA 1680
ACTATCATTC TGGTTTTCAT GGTATTTGGC TTCATCATTG GAAGAAGGCA CTGTGGCTAT 1740
AGCAAAGCTG ACCAAGAAGG AGATGAAGAA CTTTACTTTC ATTTTAAATT TCCAGGCACC 1800
AAAACCTACA TTGACCCTGA AACCTATGAG GACCCAAATA GAGCTGTCCA TCAATTCGCC 1860
AAGGAGCTAG ATGCCTCTTG TATTAAAATT GAGCGTGTGA TTGGCGCAGG AGAGTTTGGA 1920
GAAGTCTGCA GCGGCCGCTT GAAACTCCCA GGGAAGAGAG ATGTTGCAGT AGCCATAAAG 1980
ACCTTGAAAG TTGGTTATAC AGAAAAACAA AGACGAGATT TTTTATGTGA GGCAAGCATC 2040
ATGGGGCAGT TTGACCACCC TAATGTTGTT CATTTAGAAG GGGTTGTCAC AAGGGGGAAA 2100
CCAGTCATGA TTGTAATAGA ATACATGGAA AATGGAGCCC TCGATGCATT TCTTAGGAAA 2160
CATGATGGGC AATTTACAGT CATTCAGCTT GTAGGAATGC TGAGAGGGAT TGCCGCTGGA 2220
ATGAGATATT TGGCTGATAT GGGATATGTT CATCGGGACC TTGCAGCCCG AAATATTCTT 2280
GTCAACAGTA ATCTTGTTTG CAAAGTGTCA GACTTTGGCC TGTCCCGAGT TATAGAAGAT 2340
GATCCGGAAG CTGTCTACAC AACTACTGGT GGAAAAATTC CAGTACGGTG GACAGCCCCA 2400
GAAGCCATCC AGTACCGGAA ATTTACATCT GCCAGTGATG TGTGGAGCTA TGGAATTGTT 2460
ATGTGGGAAG TAATGTCTTA TGGAGAGCGG CCCTATTGGG ACATGTCAAA TCAAGATGTT 2520
ATAAAAGCAA TTGAAGAAGG TTATCGTTTG CCAGCACCCA TGGACTGCCC AGCTGGTCTT 2580
CATCAGCTGA TGCTGGATTG TTGGCAGAAG GATCGTGCTG AAAGGCCAAA GTTTGAACAA 2640
ATAGTTGGAA TTCTGGACAA AATGATCAGG AACCCAAATA GCCTGAAAAC CCCTCTGGGA 2700
ACCTGTAGCA GGCCAATTAG CCCCCTTCTG GATCAAAATA CTCCTGATTT CACTACCTTC 2760
TGTTCTGTGG GAGAATGGCT TCAAGCTATC AAGATGGAAA GGTATAAAGA TAACTTCACA 2820
GCAGCTGGCT ACAACTCTCT TGAATCAGTG GCCAGAATGA CTATAGAGGA TGTGATGAGT 2880
TTAGGGATCA CATTGGTTGG CCATCAAAAG AAAATAATGA GCAGCATTCA GACTATGAGA 2940
GCACAAATGC TACATTTACA CGGCACTGGC ATCCAAGTGT GA 2982
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kie+viGaGefGevcsGrlklpgkr++avaiktlk g+tekqrrdfl+easi+Gqfdhp
Q: 628   IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHP  687
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         n+++leGvvt++kpvmiv+eymengald+flrk+dgqftviqlvgmlrGia+gm+yl+dm
Q: 688   NVVHLEGVVTRGKPVMIVIEYMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADM  747
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnilvnsnlvckvsdfGlsrv+edd+ea+ytt+ggkip+rwtapeai+yrk
Q: 748   GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK  807
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlp+pmdcpa+l+qlmldc
Q: 808   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDC  867
         ************************************************************
S: 241   wqkdraerpkfeqivsi  257
         wqkdraerpkfeqiv i
Q: 868   WQKDRAERPKFEQIVGI  884
         **************987
Domain Sequence
(FASTA)
IKIERVIGAG EFGEVCSGRL KLPGKRDVAV AIKTLKVGYT EKQRRDFLCE ASIMGQFDHP 60
NVVHLEGVVT RGKPVMIVIE YMENGALDAF LRKHDGQFTV IQLVGMLRGI AAGMRYLADM 120
GYVHRDLAAR NILVNSNLVC KVSDFGLSRV IEDDPEAVYT TTGGKIPVRW TAPEAIQYRK 180
FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPAPMDCP AGLHQLMLDC 240
WQKDRAERPK FEQIVGI 257
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00003
EKS-BOT-00010
EKS-CAJ-00004
EKS-CAF-00004
EKS-CAP-00003
EKS-CII-00002
EKS-DAR-00005
EKS-EQC-00004
EKS-FEC-00002
EKS-GAG-00004
EKS-GOG-00003
EKS-HOS-00004
EKS-LAC-00004
EKS-LOA-00004
EKS-MAM-00004
EKS-MEG-00003
EKS-MUM-00004
EKS-MUP-00003
EKS-MYL-00004
EKS-NOL-00014
EKS-ORN-00005
EKS-ORA-00004
EKS-ORC-00003
EKS-ORL-00002
EKS-OTG-00002
EKS-PAT-00003
EKS-POA-00008
EKS-RAN-00004
EKS-SOA-00002
EKS-SUS-00003
EKS-TAG-00003
EKS-TEN-00018
EKS-TUT-00003
EKS-VIP-00001
EKS-XET-00004
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0045499; F:chemorepellent activity
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0007420; P:brain development
GO:0048755; P:branching morphogenesis of a nerve
GO:0043525; P:positive regulation of neuron apoptotic process
GO:0022407; P:regulation of cell-cell adhesion
GO:0043281; P:regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0031952; P:regulation of protein autophosphorylation
GO:0031290; P:retinal ganglion cell axon guidance
KEGG
mdo:100020059;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013