EKS-MOD-00078
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00078
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/GSK449.84.0E-13556340285
StatusUnreviewed
Ensembl ProteinENSMODP00000022711
UniProt AccessionF6PGQ1;
Protein Name
Protein Synonyms/Alias
Gene NameGSK3B
Gene Synonyms/Alias GSK3B;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000018216ENSMODP00000022711ENSMODT00000023110
OrganismMonodelphis domestica
Functional Description
Protein Length420
Protein Sequence
(FASTA)
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 60
VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 120
EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPLIYVKL YMYQLFRSLA YIHSFGICHR 180
DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 240
WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300
WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF 360
NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NAGDRGQTNN AASASASNST 420
Nucleotide Sequence
(FASTA)
ATGTCAGGGC GGCCCAGAAC CACCTCCTTT GCGGAGAGCT GCAAACCAGT GCAGCAGCCT 60
TCAGCTTTTG GCAGCATGAA AGTTAGCAGA GATAAGGATG GCAGCAAGGT GACAACAGTG 120
GTGGCAACTC CTGGACAAGG TCCAGACAGG CCACAGGAAG TCAGTTATAC AGACACTAAG 180
GTGATTGGGA ATGGGTCGTT TGGTGTTGTC TATCAAGCCA AACTTTGTGA TTCAGGAGAA 240
CTAGTTGCCA TCAAAAAAGT ACTACAAGAC AAAAGATTTA AGAACAGAGA GCTCCAGATC 300
ATGAGAAAGC TAGATCACTG TAACATAGTC CGATTGCGTT ATTTCTTCTA CTCCAGTGGA 360
GAGAAGAAAG ATGAAGTATA TCTTAATCTG GTGCTGGACT ACGTTCCTGA AACAGTATAC 420
AGAGTTGCCA GACATTATAG TCGGGCCAAA CAGACGCTCC CTTTGATCTA TGTTAAGTTG 480
TACATGTATC AACTGTTTCG AAGTTTAGCC TATATCCATT CCTTTGGAAT CTGTCATCGG 540
GATATTAAAC CACAGAACCT CTTGCTTGAT CCTGATACGG CTGTCCTAAA ACTTTGTGAC 600
TTTGGAAGTG CAAAGCAGCT GGTTCGAGGA GAGCCCAATG TTTCCTATAT CTGCTCTCGC 660
TACTATAGAG CACCAGAGTT GATCTTTGGA GCAACTGATT ACACCTCTAG CATAGATGTA 720
TGGTCTGCAG GATGTGTATT GGCTGAGCTG TTGCTAGGAC AACCAATCTT TCCAGGAGAC 780
AGTGGTGTGG ATCAGTTGGT GGAAATAATC AAGGTCCTGG GAACGCCAAC ACGAGAGCAA 840
ATTCGAGAAA TGAATCCAAA CTACACTGAA TTCAAATTTC CTCAGATTAA GGCACATCCT 900
TGGACTAAGG TCTTCCGACC CCGAACTCCA CCTGAGGCAA TTGCATTATG TAGCCGTCTG 960
CTGGAATATA CCCCGACTGC CCGATTGACA CCCTTGGAAG CTTGTGCACA TTCTTTTTTT 1020
GATGAATTAC GGGACCCAAA TGTCAAATTA CCAAATGGGC GAGATACACC TGCACTCTTC 1080
AATTTCACCA CTCAAGAACT GTCAAGTAAT CCACCTCTGG CTACAATCCT TATCCCTCCC 1140
CATGCTCGGA TTCAAGCAGC TGCTTCAACC CCTACAAATG CTACAGCAGC TTCAGATGCT 1200
AATGCAGGAG ACCGAGGACA GACCAATAAT GCAGCGTCAG CTTCAGCCTC CAACTCCACC 1260
TGA 1263
Domain Profile
S: 1     leelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLly  60
         ++++k+ig+GsFg+Vyqa+l+++ e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+y
Q: 56    YTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY  114
         5789**********************.*********************************
S: 61    ffsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhs  120
         ff++s ekkd+vylnlvl+y+Pet+++v+r+++++k++l++++vkly+yQlfr+lay+hs
Q: 115   FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPLIYVKLYMYQLFRSLAYIHS  174
         ************************************************************
S: 121   leivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakey  180
         ++i+HrDiKPqNll+d++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++y
Q: 175   FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY  234
         ************************************************************
S: 181   ttkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfk  240
         t++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf+
Q: 235   TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP  294
         ************************************************************
S: 241   kikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286
         +ik+++++kv++ ++++ea++l++++l+y+p++Rl++le++ah+ff
Q: 295   QIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF  340
         *********************************************9
Domain Sequence
(FASTA)
YTDTKVIGNG SFGVVYQAKL CDSGELVAIK KVLQDKRFKN RELQIMRKLD HCNIVRLRYF 60
FYSSGEKKDE VYLNLVLDYV PETVYRVARH YSRAKQTLPL IYVKLYMYQL FRSLAYIHSF 120
GICHRDIKPQ NLLLDPDTAV LKLCDFGSAK QLVRGEPNVS YICSRYYRAP ELIFGATDYT 180
SSIDVWSAGC VLAELLLGQP IFPGDSGVDQ LVEIIKVLGT PTREQIREMN PNYTEFKFPQ 240
IKAHPWTKVF RPRTPPEAIA LCSRLLEYTP TARLTPLEAC AHSFF 285
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00075
EKS-ANC-00072
EKS-BOT-00080
EKS-CAE-00055
EKS-CAJ-00081
EKS-CAF-00080
EKS-CAP-00080
EKS-CII-00034
EKS-CIS-00077
EKS-DAR-00329
EKS-DRM-00034
EKS-EQC-00078
EKS-FEC-00078
EKS-GAM-00043
EKS-GAG-00064
EKS-GAA-00098
EKS-GOG-00080
EKS-HOS-00082
EKS-ICT-00073
EKS-LAC-00085
EKS-LOA-00077
EKS-MAM-00079
EKS-MAE-00033
EKS-MEG-00060
EKS-MUM-00080
EKS-MUP-00080
EKS-MYL-00089
EKS-NOL-00076
EKS-OCP-00051
EKS-ORN-00107
EKS-ORA-00064
EKS-ORC-00075
EKS-ORL-00099
EKS-OTG-00085
EKS-PAT-00073
EKS-PES-00070
EKS-POA-00075
EKS-PRC-00044
EKS-PTV-00066
EKS-RAN-00076
EKS-SAH-00076
EKS-SUS-00071
EKS-TAG-00115
EKS-TAR-00111
EKS-TEN-00105
EKS-TUT-00071
EKS-VIP-00034
EKS-XET-00075
EKS-XIM-00102
EKS-SAC-00071
EKS-SCP-00065
Gene Ontology
GO:0030877; C:beta-catenin destruction complex
GO:0005813; C:centrosome
GO:0005829; C:cytosol
GO:0043198; C:dendritic shaft
GO:0030426; C:growth cone
GO:0043025; C:neuronal cell body
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0030529; C:ribonucleoprotein complex
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0050321; F:tau-protein kinase activity
GO:0007409; P:axonogenesis
GO:0044337; P:canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process
GO:0016477; P:cell migration
GO:0001837; P:epithelial to mesenchymal transition
GO:0006983; P:ER overload response
GO:0045444; P:fat cell differentiation
GO:0005977; P:glycogen metabolic process
GO:0021766; P:hippocampus development
GO:0044027; P:hypermethylation of CpG island
GO:0035556; P:intracellular signal transduction
GO:0007520; P:myoblast fusion
GO:0043066; P:negative regulation of apoptotic process
GO:0051534; P:negative regulation of NFAT protein import into nucleus
GO:0032091; P:negative regulation of protein binding
GO:0031333; P:negative regulation of protein complex assembly
GO:0009887; P:organ morphogenesis
GO:0018105; P:peptidyl-serine phosphorylation
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation
GO:0032092; P:positive regulation of protein binding
GO:0031334; P:positive regulation of protein complex assembly
GO:0046827; P:positive regulation of protein export from nucleus
GO:0032855; P:positive regulation of Rac GTPase activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006611; P:protein export from nucleus
GO:0035372; P:protein localization to microtubule
GO:0000320; P:re-entry into mitotic cell cycle
GO:0006349; P:regulation of gene expression by genetic imprinting
GO:0032886; P:regulation of microtubule-based process
GO:0071109; P:superior temporal gyrus development
KEGG
mdo:100012447;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013