EKS-MOD-00338

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00338

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	449.9	2.7E-135	158	416	259

Status

Unreviewed

Ensembl Protein

ENSMODP00000022973

UniProt Accession

F6XU33;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK2

Gene Synonyms/Alias

TNK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000018423	ENSMODP00000022973	ENSMODT00000023381

Organism

Monodelphis domestica

Functional Description

Protein Length

1094

Protein Sequence
(FASTA)

MQHFTPLILP LSTERSMFRL FWRSKRLEGS SMQAEEGTGW LLELLAEVQL QQYFLRLRDD 60

LNITRLSHFE YVKNEDLEKI GMGRPGQRRL WEAVKRRKAM CKRKSWMSKV FSGKRLDAEF 120

STPQSQNTFR KTSPIPGISV GEGSLQSLTC LIGEKDLNLF EKLGDGSFGV VRRGEWDAPS 180

GKKVSVAVKC LKPDVLSQPE AMDDFIREVN AMHSLDHRNL IRLYGVVLTP PMKMVTELAP 240

LGSLLDRLRK HQGHFLLGTL SRYAVQVAEG MGYLESKRFI HRDLAARNLL LATRDLVKIG 300

DFGLMRALPQ NDDHYVMQEH RKVPFAWCAP ESLKTRTFSH ASDTWMFGVT LWEMFTYGQE 360

PWIGLNGSQI LHKIDKEGER LPRPEDCPRD IYNVMVQCWA HKPEDRPTFV ALRDFLLEAQ 420

PTDMRALQDF EEPDKLHIQM NDVITVIEGR AENYWWRGQN TRTLCVGPFP RNAVTSVAGL 480

SAHDISQPLQ NSFIHTGHGD SDPRHCWGFP DKIDELYLGN PMDPPDLLAV ELSTSRPTQL 540

LGRVKREPPP RPPQPAIFAQ KSTYDPVSDE QDPLATDLKR LCLRKPGLPR GLWLVKPSAR 600

VPGTKTGRAG AEVSLIDFGD ELAAPYPKPS APSLAQLAMD ACSLLDKTPP QSPTRALPRP 660

LHPTPVVDWD TRPLPPPPAY DDVAQDEDDF EVCSINSTLV GARTPEGPPH GETNYAFVPE 720

AGRPPPPLED NLFLPPQGGT KPPNSLQTAE IFQALQQECM RQLQVPSSSL ASSPSPGVAG 780

EDKPQVPPRV PIPPRPTRQR SELGCRSGEL SPASGGEEEP GRWRGAAPPP QIPPREPFSP 840

QGSRTPSPLA LSGGSPLPPR LSSSPGKAMP TTQSFGSDPK YATPQVIQAP GPRTGPCILP 900

IVRDGKKISN THYYLLPERP PYLERYQRFL QEAQSPEEEP PSIPVPLLLP PPSTPAPAAP 960

TATVRPMPQA TLDPKANFSA NNSNAGARAP SLRASARLVK GCPGDGLEAG RPTDKIQMVQ 1020

AMVHGVTTEE CQAALQNHNW SIPRAVQYLK VEQLFGLGLR PRQECHKVLE MFDWNLEQAG 1080

CHLLDSCGPA HQKR 1094

Nucleotide Sequence
(FASTA)

ATGCAACATT TCACCCCACT AATACTCCCT CTCTCTACTG AAAGAAGTAT GTTTCGTCTC 60

TTCTGGAGAT CAAAGAGGCT GGAAGGAAGC AGTATGCAGG CAGAAGAGGG CACTGGTTGG 120

TTGCTTGAGC TACTGGCCGA GGTTCAGTTG CAGCAGTATT TCCTTCGTCT TCGAGATGAC 180

CTCAACATCA CCCGCCTGTC CCACTTCGAG TATGTCAAGA ATGAAGACCT GGAGAAGATT 240

GGCATGGGCC GACCTGGCCA GCGGCGGCTG TGGGAGGCCG TGAAACGAAG AAAAGCCATG 300

TGTAAGCGAA AGTCCTGGAT GAGCAAGGTT TTCAGTGGCA AGCGCTTAGA TGCAGAATTC 360

TCCACTCCTC AGTCACAGAA TACCTTCAGA AAGACGTCAC CCATTCCAGG GATCTCAGTC 420

GGGGAGGGGT CTCTGCAGAG CCTTACTTGT CTCATCGGGG AGAAAGACCT GAATTTATTT 480

GAGAAGCTAG GAGATGGCTC CTTTGGAGTT GTTCGCAGAG GGGAGTGGGA TGCTCCCTCA 540

GGAAAGAAGG TGAGTGTGGC TGTCAAATGC CTGAAGCCGG ATGTCCTGAG TCAGCCTGAG 600

GCCATGGACG ACTTCATCCG GGAGGTCAAT GCGATGCATT CCTTGGACCA TCGAAATCTA 660

ATCCGTCTCT ATGGGGTAGT CCTCACTCCC CCCATGAAAA TGGTTACAGA GCTAGCTCCT 720

CTGGGATCTC TGCTGGACCG TCTGCGCAAA CACCAGGGCC ATTTCCTCCT GGGGACGTTG 780

AGCCGCTATG CCGTGCAGGT GGCAGAGGGA ATGGGCTATT TAGAGTCCAA GCGCTTCATT 840

CACCGAGACC TGGCTGCCCG GAACCTGCTA CTGGCCACCC GAGACCTGGT CAAGATTGGG 900

GACTTCGGAC TGATGAGGGC CCTGCCCCAG AATGATGATC ATTATGTCAT GCAAGAGCAC 960

CGGAAGGTTC CCTTTGCCTG GTGTGCCCCA GAGAGCCTCA AGACCCGGAC TTTCTCCCAT 1020

GCCAGTGACA CCTGGATGTT TGGCGTGACC CTATGGGAGA TGTTTACTTA TGGCCAAGAG 1080

CCCTGGATTG GTCTCAATGG AAGCCAGATC TTACACAAGA TTGACAAAGA GGGAGAGAGG 1140

CTGCCTCGAC CCGAAGACTG TCCCCGAGAT ATTTACAACG TCATGGTCCA GTGCTGGGCC 1200

CACAAACCCG AGGACAGGCC TACCTTTGTA GCCTTACGAG ACTTCTTGTT GGAGGCTCAG 1260

CCCACAGACA TGCGGGCCCT TCAAGACTTT GAGGAGCCTG ACAAGTTGCA TATTCAGATG 1320

AATGATGTCA TCACTGTCAT TGAGGGAAGG GCGGAGAATT ACTGGTGGCG TGGGCAGAAT 1380

ACGAGGACGC TGTGTGTGGG GCCCTTCCCG AGAAACGCAG TGACCTCGGT GGCAGGGCTG 1440

TCAGCCCATG ACATCAGCCA GCCCCTCCAG AACAGCTTCA TCCATACCGG CCATGGCGAC 1500

AGTGACCCCC GACACTGCTG GGGATTCCCA GACAAGATCG ATGAATTGTA TCTGGGAAAC 1560

CCGATGGATC CTCCCGACCT GCTAGCGGTG GAGCTGAGCA CCTCCCGCCC CACGCAGCTC 1620

CTAGGAAGGG TCAAAAGGGA GCCTCCGCCT CGCCCGCCTC AGCCTGCCAT CTTCGCTCAG 1680

AAGTCTACCT ACGACCCCGT CAGCGACGAG CAGGACCCGC TGGCCACCGA CCTCAAGCGT 1740

CTCTGTCTTC GGAAGCCGGG CCTCCCCAGG GGCCTGTGGC TGGTCAAGCC CTCCGCCCGA 1800

GTGCCGGGCA CCAAGACGGG CCGGGCCGGG GCTGAAGTGT CCCTCATTGA CTTTGGTGAC 1860

GAGCTCGCGG CGCCGTACCC CAAGCCCAGC GCCCCCTCCC TCGCCCAGCT GGCCATGGAC 1920

GCCTGCTCGC TGCTGGACAA AACGCCCCCG CAGAGCCCCA CGCGGGCGCT TCCTCGGCCC 1980

CTGCACCCCA CGCCTGTGGT CGACTGGGAT ACCCGCCCGC TGCCCCCGCC GCCAGCCTAC 2040

GATGACGTGG CCCAGGATGA AGATGACTTC GAGGTGTGCT CCATCAACAG CACCCTGGTT 2100

GGGGCCAGAA CCCCCGAGGG GCCTCCCCAC GGAGAGACCA ACTACGCCTT CGTGCCTGAG 2160

GCTGGGCGGC CCCCTCCACC CCTGGAAGAC AATTTGTTCC TCCCGCCCCA AGGAGGGACC 2220

AAACCCCCTA ACTCCCTGCA GACTGCGGAA ATCTTCCAGG CTCTCCAGCA GGAGTGCATG 2280

CGCCAGCTGC AGGTGCCATC CTCGTCTCTG GCCTCCTCTC CGAGCCCCGG CGTAGCTGGA 2340

GAAGACAAGC CCCAGGTTCC CCCCCGAGTG CCAATCCCAC CTCGGCCCAC ACGGCAGCGA 2400

AGCGAGTTGG GCTGCCGCTC GGGGGAACTG TCTCCAGCTT CGGGGGGTGA AGAGGAGCCC 2460

GGACGGTGGA GGGGGGCGGC CCCACCCCCT CAGATCCCCC CGAGGGAGCC CTTCTCTCCC 2520

CAGGGCTCCC GGACCCCCAG CCCCTTGGCA CTGTCTGGCG GATCTCCCTT GCCCCCTCGG 2580

CTTTCCAGCT CCCCGGGGAA GGCCATGCCC ACCACGCAGA GCTTTGGCTC TGACCCCAAG 2640

TATGCCACAC CCCAAGTGAT CCAGGCCCCC GGCCCTCGGA CGGGGCCCTG CATCCTGCCG 2700

ATCGTCCGAG ATGGCAAGAA GATCAGCAAC ACGCATTATT ACCTGCTTCC GGAGCGGCCC 2760

CCCTACCTGG AGAGATACCA GCGGTTCTTG CAGGAGGCGC AGAGCCCCGA GGAAGAGCCT 2820

CCCTCCATCC CCGTCCCTCT GCTGCTGCCG CCCCCCAGCA CGCCGGCCCC CGCGGCCCCC 2880

ACTGCTACCG TGAGGCCCAT GCCCCAGGCC ACCCTTGACC CTAAGGCCAA CTTCTCAGCC 2940

AACAATAGCA ACGCAGGGGC CCGCGCCCCA TCCTTGAGGG CCTCCGCCCG TCTGGTGAAG 3000

GGCTGCCCAG GGGACGGGCT GGAGGCTGGG CGGCCCACAG ACAAGATACA GATGGTCCAG 3060

GCCATGGTGC ATGGGGTGAC CACAGAGGAG TGCCAGGCGG CCTTGCAGAA CCACAACTGG 3120

AGCATTCCGA GGGCTGTGCA GTATCTGAAG GTGGAGCAAC TCTTTGGCCT GGGTCTGCGG 3180

CCAAGGCAGG AGTGCCATAA GGTGCTGGAG ATGTTTGATT GGAACCTGGA GCAGGCTGGC 3240

TGCCACCTGC TAGATTCCTG TGGTCCCGCC CACCAGAAGC GCTGA 3285

Domain Profile

S: 2     klleklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllkleh  60

         +l eklG+Gsfgvv+rgeW+apsgk+v+vavk+lk+d+l+++e+ ddf+rev+++++l+h

Q: 158   NLFEKLGDGSFGVVRRGEWDAPSGKKVSVAVKCLKPDVLSQPEAmDDFIREVNAMHSLDH  217

         6789***************************************99***************

S: 61    enlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayle  120

         +nl+rlyGvvlt p+k+vtela+lgslldrlrk++   ++l+ +l++yavq+aeg+ yle

Q: 218   RNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG--HFLLGTLSRYAVQVAEGMGYLE  275

         ***********************************9..9*********************

S: 121   skrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrt  180

         skr++hrdlaarnllla+++lvki+dfGl+ral++++d+yv++e++kvPfaWcaPesl+t

Q: 276   SKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKT  335

         ************************************************************

S: 181   rkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediysll  240

         r+fs+asd+W+fGvtlWemf+yG+ePW+gl+g+qil+kidke+erl++Pe+cp+diy+++

Q: 336   RTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPRDIYNVM  395

         ************************************************************

S: 241   lkcWakkpadrpkfsalkekl  261

         ++cWa+kp+drp+f+al+++l

Q: 396   VQCWAHKPEDRPTFVALRDFL  416

         ******************986

Domain Sequence
(FASTA)

NLFEKLGDGS FGVVRRGEWD APSGKKVSVA VKCLKPDVLS QPEAMDDFIR EVNAMHSLDH 60

RNLIRLYGVV LTPPMKMVTE LAPLGSLLDR LRKHQGHFLL GTLSRYAVQV AEGMGYLESK 120

RFIHRDLAAR NLLLATRDLV KIGDFGLMRA LPQNDDHYVM QEHRKVPFAW CAPESLKTRT 180

FSHASDTWMF GVTLWEMFTY GQEPWIGLNG SQILHKIDKE GERLPRPEDC PRDIYNVMVQ 240

CWAHKPEDRP TFVALRDFL 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR015116	; GTPase_binding.
IPR021619	; Inhibitor_Mig-6.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR000449	; UBA/transl_elong_EF1B_N.

Pfam

PF09027	; GTPase_binding; 1.
PF11555	; Inhibitor_Mig-6; 1.
PF07714	; Pkinase_Tyr; 1.
PF00627	; UBA; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50002	; SH3; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013