EKS-MOD-00309

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00309

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	348.6	2.4E-104	249	500	252

Status

Unreviewed

Ensembl Protein

ENSMODP00000023014

UniProt Accession

F7CU42;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK2

Gene Synonyms/Alias

PAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000018459	ENSMODP00000023014	ENSMODT00000023424

Organism

Monodelphis domestica

Functional Description

Protein Length

524

Protein Sequence
(FASTA)

MSDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEERKPR HKIISIFSGT 60

EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSN ITKLEQKKNP 120

QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF PSGTPALNAK GSETSAAVTE EDDDEEETAP 180

PVIAPRPDHT KSIYTRSVID PIPAPAGDSN VDSAAKSSDK QKKKTKMTDE EIMEKLRTIV 240

SIGDPKKKYT RYEKIGQGAS GTVFTATDVA LGQEVAIKQI NLQKQPKKEL IINEILVMKE 300

LKNPNIVNFL DSYLVGDELF VVMEYLAGGS LTDVVTETCM DEAQIAAVCR ECLQALEFLH 360

ANQVIHRDIK SDNVLLGMEG SVKLTDFGFC AQITPEQSKR STMVGTPYWM APEVVTRKAY 420

GPKVDIWSLG IMAIEMVEGE PPYLNENPLR ALYLIATNGT PELQNPEKLS PIFRDFLNRC 480

LEMDVEKRGS AKELLQHPFL KLAKPLSSLT PLIMAAKEAM KSNR 524

Nucleotide Sequence
(FASTA)

ATGTCTGATA ACGGAGAACT GGAAGACAAG CCACCAGCGC CTCCTGTTCG AATGAGCAGT 60

ACCATTTTTA GCACTGGAGG CAAAGACCCT TTGTCTGCCA ACCATAGTTT GAAACCTTTG 120

CCATCTGTTC CAGAGGAAAG AAAGCCTAGG CATAAAATCA TCTCCATATT TTCAGGCACT 180

GAGAAAGGAA GTAAGAAAAA AGAAAAGGAA CGGCCAGAAA TTTCTCCTCC TTCTGATTTT 240

GAACACACCA TCCATGTTGG CTTTGATGCA GTTACTGGAG AATTCACTGG AATGCCAGAA 300

CAGTGGGCTC GATTGCTACA GACCTCTAAT ATCACCAAGC TAGAACAGAA GAAGAACCCC 360

CAGGCTGTGC TTGATGTTCT GAAGTTCTAT GACTCCAATA CAGTGAAACA GAAATATTTG 420

AGCTTTACCC CTCCTGAGAA AGATGGCTTC CCCTCAGGAA CACCAGCACT GAATGCAAAA 480

GGCTCAGAAA CTTCAGCAGC AGTAACAGAA GAAGATGATG ATGAAGAGGA GACTGCGCCA 540

CCTGTCATTG CTCCTAGACC GGATCATACA AAATCAATTT ACACACGGTC TGTAATTGAC 600

CCTATTCCTG CACCAGCTGG TGATTCTAAC GTTGATAGTG CTGCCAAATC TTCAGACAAA 660

CAGAAAAAGA AGACTAAGAT GACAGATGAG GAAATTATGG AGAAACTAAG AACTATAGTC 720

AGCATAGGTG ATCCGAAGAA AAAATATACC AGATATGAAA AAATTGGGCA GGGAGCTTCC 780

GGTACAGTAT TCACTGCTAC AGATGTGGCA CTGGGACAGG AGGTTGCCAT CAAACAGATA 840

AATTTGCAGA AACAGCCTAA GAAGGAATTA ATCATTAATG AAATTCTTGT AATGAAAGAA 900

TTAAAGAACC CCAACATAGT TAATTTCTTA GATAGTTATC TTGTAGGGGA TGAATTATTT 960

GTGGTTATGG AGTACCTTGC TGGAGGGTCT CTTACTGATG TTGTAACAGA AACCTGCATG 1020

GATGAAGCAC AGATTGCTGC TGTGTGTAGA GAGTGTTTAC AAGCTCTGGA ATTTCTACAT 1080

GCCAATCAGG TGATTCACAG AGACATCAAA AGTGACAATG TGCTTTTGGG AATGGAAGGA 1140

TCAGTGAAAC TCACCGACTT TGGTTTCTGT GCTCAGATCA CACCAGAGCA GAGCAAAAGG 1200

AGTACCATGG TTGGGACCCC TTACTGGATG GCACCAGAAG TGGTCACACG TAAAGCTTAT 1260

GGGCCTAAAG TGGACATTTG GTCTCTGGGA ATTATGGCAA TTGAGATGGT AGAAGGAGAA 1320

CCCCCATACC TTAATGAGAA TCCTCTGAGG GCCTTGTATC TAATAGCAAC AAATGGAACT 1380

CCTGAACTAC AGAATCCAGA GAAACTCTCC CCCATATTTC GAGATTTTTT AAATCGGTGT 1440

TTGGAGATGG ATGTAGAAAA AAGGGGTTCA GCTAAAGAAT TGTTACAGCA TCCTTTCCTG 1500

AAACTGGCTA AACCTTTGTC TAGTTTGACA CCGCTGATCA TGGCAGCTAA AGAAGCAATG 1560

AAGAGTAACC GTTAA 1575

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+v++a+++  g+ vaik+inl+kq+k+e++++ei v+k+lk+pniv+

Q: 249   YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVN  308

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l+s+l+ +el++vmeylagGsl+d+v+   ++ ++E qia+++re+l+aLe+lH+++vi

Q: 309   FLDSYLVGDELFVVMEYLAGGSLTDVVT---ETCMDEAQIAAVCRECLQALEFLHANQVI  365

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++n+Ll +eg+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 366   HRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  423

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++k+s+ f++f+++cl+

Q: 424   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEM  483

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++ekR sa+ell+h+Fl

Q: 484   DVEKRGSAKELLQHPFL  500

         ****************7

Domain Sequence
(FASTA)

YTRYEKIGQG ASGTVFTATD VALGQEVAIK QINLQKQPKK ELIINEILVM KELKNPNIVN 60

FLDSYLVGDE LFVVMEYLAG GSLTDVVTET CMDEAQIAAV CRECLQALEF LHANQVIHRD 120

IKSDNVLLGM EGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPEK LSPIFRDFLN RCLEMDVEKR 240

GSAKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030296	; F:protein tyrosine kinase activator activity
GO:0043066	; P:negative regulation of apoptotic process
GO:2001271	; P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0018105	; P:peptidyl-serine phosphorylation
GO:2001238	; P:positive regulation of extrinsic apoptotic signaling pathway
GO:0046777	; P:protein autophosphorylation

KEGG

mdo:100015796

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013