EKS-MOD-00007
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00007
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph502.32.1E-151564817254
StatusUnreviewed
Ensembl ProteinENSMODP00000023093
UniProt AccessionF7AG95;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB1
Gene Synonyms/Alias EPHB1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000018518ENSMODP00000023093ENSMODT00000023505
OrganismMonodelphis domestica
Functional Description
Protein Length922
Protein Sequence
(FASTA)
TLMDTRTATA ELGWTANPAS GWEEVSGYDE NLNTIRTYQV CNVFEPNQNN WLLTTFIHRR 60
GAHRIYTEMR FTVRDCSSLP NVPGSCKETF NLYYYETDSV IATKKSAFWT EAPYLKVDTI 120
AADESFSQVD FGGRLMKVNT EVRSFGPLTR NGFYLAFQDY GACMSLLSVR VFFKKCPSIV 180
QNFAIFPETM TGAESTSLVI ARGTCIPNAE EVDVPIKLYC NGDGEWMVPI GRCTCKAGYE 240
PENNVVCKAC PAGMFKANQE VGVCSQCPSN SRSPSEASPI CTCRTGYYRA DFDPPEVACT 300
SVPSGPRNVI SIVNETSIIL EWHPPRETGG RDDVTYNIVC KKCRADRRSC SRCDDNVEFV 360
PRQLGLTESR VFISSLWAHT PYTFDIQAIN GVSGKSPFPP QHVSVNITTN QAAPSTVPIM 420
HQVSATMRSI TLSWPQPEQP NGIILDYEIR YYEKEQNEYN SSMAKSQTNT ARIDGLRPGM 480
VYVVQVRART VAGYGKYSGK MCFQTLTDDD YKSELREQLP LIAGSAAAGV VFIVSLVAIS 540
IVCSRKRAYS KEAVYSDKLQ HYSTGRGEFG EVYKGRLKLP GKREIYVAIK TLKAGYSEKQ 600
RRDFLSEASI MGQFDHPNII RLEGVVTKSR PVMIITEFME NGALDSFLRQ NDGQFTVIQL 660
VGMLRGIAAG MKYLSEMNYV HRDLAARNIL VNSNLVCKVS DFGLSRYLQD DTSDPTYTSS 720
LGGKIPVRWT APEAIAYRKF TSASDVWSYG IVMWEVMSFG ERPYWDMSNQ DVINAIEQDY 780
RLPPPMDCPA ALHQLMLDCW QKDRNTRPRF TEIVNTLDKM IRNPASLKTV ATITAVPSQP 840
LLDRSIPDFT AFTSVDDWLN AIKMVQYRDS FLTAGFTSLQ LVTQMTSEDL LRIGVTLAGH 900
QKKILNSVHS MRVQMSQSPT SM 922
Nucleotide Sequence
(FASTA)
ACCTTAATGG ACACCCGGAC AGCTACTGCT GAGTTGGGCT GGACTGCAAA TCCTGCATCA 60
GGGTGGGAAG AGGTCAGTGG CTATGATGAA AACCTGAACA CCATCCGTAC CTACCAGGTA 120
TGCAACGTCT TTGAGCCCAA CCAGAACAAC TGGCTGCTTA CCACTTTCAT CCATCGGCGA 180
GGGGCCCACC GTATCTACAC AGAGATGCGC TTCACTGTGA GGGATTGCAG CAGTCTCCCA 240
AATGTTCCTG GTTCTTGCAA AGAGACCTTT AACCTCTACT ACTATGAGAC AGACTCAGTC 300
ATTGCCACCA AGAAGTCTGC CTTCTGGACA GAGGCTCCCT ACCTCAAAGT GGACACTATT 360
GCTGCTGACG AGAGCTTCTC CCAGGTAGAC TTTGGGGGAA GGTTGATGAA GGTTAACACA 420
GAAGTGAGAA GCTTTGGGCC CCTCACTCGG AATGGCTTTT ACCTGGCTTT TCAGGATTAT 480
GGGGCGTGCA TGTCTCTCCT CTCTGTCAGA GTCTTTTTCA AGAAGTGCCC CAGCATTGTA 540
CAGAATTTTG CAATTTTCCC AGAGACTATG ACTGGGGCTG AAAGCACATC TCTGGTGATT 600
GCTCGGGGAA CGTGCATCCC CAATGCGGAG GAGGTGGATG TCCCTATTAA ACTGTATTGC 660
AACGGGGATG GAGAGTGGAT GGTACCAATT GGGCGATGCA CCTGTAAAGC TGGCTATGAA 720
CCTGAAAACA ATGTAGTCTG CAAGGCCTGC CCAGCAGGAA TGTTCAAGGC GAATCAGGAA 780
GTGGGGGTCT GTTCTCAGTG CCCATCGAAT AGCCGTTCTC CTTCAGAGGC CTCTCCCATC 840
TGCACCTGCC GCACAGGCTA TTATCGGGCA GACTTTGATC CACCGGAGGT GGCATGTACC 900
AGTGTTCCTT CAGGTCCCCG AAATGTCATC TCCATCGTCA ATGAGACATC CATCATTCTG 960
GAATGGCACC CACCACGAGA AACAGGAGGG CGTGATGATG TGACGTACAA TATTGTCTGT 1020
AAAAAATGCC GGGCAGATCG CCGGAGTTGT TCCCGTTGTG ATGACAATGT GGAGTTTGTG 1080
CCCAGGCAGC TGGGTCTGAC TGAGAGCCGA GTTTTCATCA GCAGCCTTTG GGCCCATACT 1140
CCCTATACCT TTGATATCCA GGCAATCAAT GGAGTATCTG GCAAGAGCCC TTTCCCCCCA 1200
CAGCATGTCT CAGTCAACAT CACAACAAAC CAAGCTGCTC CCTCCACAGT TCCCATCATG 1260
CACCAGGTAA GTGCCACCAT GAGGAGCATC ACCTTGTCAT GGCCACAGCC GGAGCAGCCC 1320
AATGGCATTA TCCTGGACTA TGAGATCCGT TATTATGAGA AGGAACAAAA TGAGTACAAC 1380
TCTTCGATGG CAAAAAGTCA GACCAACACG GCTCGGATAG ACGGACTTCG ACCTGGCATG 1440
GTTTATGTGG TTCAAGTGAG AGCTCGAACA GTGGCTGGTT ATGGCAAATA CAGTGGGAAA 1500
ATGTGCTTCC AGACACTGAC AGATGACGAT TACAAGTCAG AACTGAGGGA ACAGCTGCCA 1560
CTGATCGCTG GTTCTGCAGC CGCCGGTGTG GTGTTCATCG TATCACTGGT GGCCATTTCC 1620
ATTGTCTGTA GCAGGAAACG TGCTTACAGC AAAGAGGCCG TGTACAGTGA TAAGCTGCAG 1680
CATTACAGCA CGGGGCGAGG AGAATTTGGA GAAGTGTACA AAGGACGTCT AAAATTGCCA 1740
GGCAAGAGGG AGATCTATGT GGCCATAAAG ACATTGAAGG CAGGATACTC AGAAAAACAG 1800
CGCCGGGACT TCCTGAGTGA GGCCAGCATC ATGGGTCAGT TTGACCATCC AAATATAATC 1860
CGGCTGGAAG GAGTGGTGAC CAAGAGCCGT CCTGTCATGA TCATCACAGA ATTTATGGAA 1920
AATGGAGCTT TGGACTCCTT CCTCAGGCAA AATGATGGGC AGTTCACGGT GATCCAACTG 1980
GTGGGGATGC TCAGGGGTAT CGCTGCTGGT ATGAAGTATC TATCGGAGAT GAATTACGTA 2040
CACCGGGACC TGGCTGCCAG AAACATTCTT GTCAATAGTA ATCTAGTGTG CAAAGTATCT 2100
GACTTTGGCC TATCCCGCTA CCTACAAGAT GACACCTCGG ACCCCACCTA CACCAGCTCT 2160
TTGGGTGGAA AGATCCCAGT GAGATGGACA GCCCCGGAGG CTATTGCCTA CCGCAAGTTC 2220
ACCTCTGCCA GTGATGTCTG GAGTTATGGT ATCGTCATGT GGGAAGTCAT GTCATTTGGA 2280
GAGAGGCCCT ACTGGGATAT GTCCAACCAA GATGTCATCA ATGCCATTGA ACAGGACTAC 2340
CGACTTCCCC CACCCATGGA CTGCCCTGCT GCTCTGCACC AGCTTATGTT AGATTGTTGG 2400
CAGAAGGACC GCAATACTCG ACCACGCTTT ACAGAGATTG TCAACACTCT GGATAAAATG 2460
ATCCGGAACC CAGCAAGTCT CAAAACTGTG GCAACCATCA CCGCTGTGCC TTCTCAGCCC 2520
CTGTTAGATC GTTCCATCCC CGATTTCACT GCCTTTACCT CAGTGGATGA TTGGCTCAAT 2580
GCTATTAAAA TGGTCCAGTA CAGGGACAGT TTCCTAACTG CTGGGTTCAC CTCTCTTCAG 2640
CTGGTTACTC AGATGACATC AGAAGACCTT CTGAGAATAG GAGTGACTTT GGCAGGACAT 2700
CAGAAGAAGA TCTTGAACAG TGTTCATTCC ATGAGGGTAC AGATGAGTCA ATCTCCAACC 2760
TCAATG 2766
Domain Profile
S: 7     iGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpniirle  66
          G GefGev++Grlklpgkrei+vaiktlkag++ekqrrdflseasi+Gqfdhpniirle
Q: 564   TGRGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLE  623
         699*********************************************************
S: 67    GvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmgyvhrd  126
         Gvvtks+pvmi+te+mengaldsflr++dgqftviqlvgmlrGia+gmkyls+m+yvhrd
Q: 624   GVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRD  683
         ************************************************************
S: 127   laarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiayrkftsa  184
         laarnilvnsnlvckvsdfGlsr l+dd+ +++yt+s ggkip+rwtapeaiayrkftsa
Q: 684   LAARNILVNSNLVCKVSDFGLSRYLQDDTsDPTYTSSlGGKIPVRWTAPEAIAYRKFTSA  743
         *************************99999*****999**********************
S: 185   sdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcwqkd  244
         sdvwsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlpppmdcpaal+qlmldcwqkd
Q: 744   SDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKD  803
         ************************************************************
S: 245   raerpkfeqivsil  258
         r++rp+f++iv++l
Q: 804   RNTRPRFTEIVNTL  817
         ***********975
Domain Sequence
(FASTA)
TGRGEFGEVY KGRLKLPGKR EIYVAIKTLK AGYSEKQRRD FLSEASIMGQ FDHPNIIRLE 60
GVVTKSRPVM IITEFMENGA LDSFLRQNDG QFTVIQLVGM LRGIAAGMKY LSEMNYVHRD 120
LAARNILVNS NLVCKVSDFG LSRYLQDDTS DPTYTSSLGG KIPVRWTAPE AIAYRKFTSA 180
SDVWSYGIVM WEVMSFGERP YWDMSNQDVI NAIEQDYRLP PPMDCPAALH QLMLDCWQKD 240
RNTRPRFTEI VNTL 254
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00006
EKS-BOT-00012
EKS-CAF-00006
EKS-CAP-00013
EKS-EQC-00006
EKS-FEC-00003
EKS-GAM-00002
EKS-GAG-00006
EKS-GAA-00007
EKS-GOG-00005
EKS-ICT-00005
EKS-MAM-00005
EKS-MEG-00005
EKS-MIM-00001
EKS-MUM-00006
EKS-MUP-00006
EKS-MYL-00006
EKS-NOL-00005
EKS-ORC-00006
EKS-ORL-00006
EKS-OTG-00004
EKS-PAT-00006
EKS-PES-00006
EKS-POA-00004
EKS-RAN-00006
EKS-TAG-00013
EKS-TAR-00007
EKS-XET-00003
Gene Ontology
GO:0030424; C:axon
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0045121; C:membrane raft
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0001525; P:angiogenesis
GO:0048593; P:camera-type eye morphogenesis
GO:0031589; P:cell-substrate adhesion
GO:0021952; P:central nervous system projection neuron axonogenesis
GO:0060997; P:dendritic spine morphogenesis
GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain
GO:0030010; P:establishment of cell polarity
GO:0061351; P:neural precursor cell proliferation
GO:0021631; P:optic nerve morphogenesis
GO:0051965; P:positive regulation of synapse assembly
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0046328; P:regulation of JNK cascade
GO:0031290; P:retinal ganglion cell axon guidance
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013