EKS-MOD-00396

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00396

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	359.0	2.0E-107	186	451	266

Status

Unreviewed

Ensembl Protein

ENSMODP00000023115

UniProt Accession

F7GD74;

Protein Name

Protein Synonyms/Alias

Gene Name

IRAK4

Gene Synonyms/Alias

IRAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000018536	ENSMODP00000023115	ENSMODT00000023528

Organism

Monodelphis domestica

Functional Description

Protein Length

458

Protein Sequence
(FASTA)

MNKTVTSSTY VRCLNVGLIR QLADFIDPQE GWKKLAVDIK KPSGENRYNQ FHIRRFEGLL 60

QNGKSPTSEL LFDWGTTNCT VGDLVDLLIR NDFLAPARLL LPDIIPEIVQ VLPQEKLATQ 120

KKLLPPYDKE KTHVKPVQNH EHISSSLDSS PDRKSLEVSD TRFQSFSFYE LKSVTNNFDE 180

RPMSAGGNKM GEGGFGVVYK GCINSRTVAV KKLTRMTDMC TEELKQQFDQ EIKILAKCQH 240

ENLVQLLGFS SDSNDFCLVY VYMPNGSLLD RLSCLDGTEP LSWQTRCKIA QGTANGIYYL 300

HANNHVHRDI KSANILLDED FLPKISDFGL ARTSAKFNQT VMTSRIVGTT AYMAPEALRG 360

EITPKSDIYS FGVVLLEIIT GLPAVDEQRE PQLLLDIKEE IEDEEKHIED YIDAKMNDVD 420

STSVENMYSI ATLCLHEKKN KRPDTEMVKH HLQKMTSS 458

Nucleotide Sequence
(FASTA)

ATGAACAAAA CAGTAACTTC ATCAACATAT GTGAGGTGCT TAAATGTTGG CCTGATTAGG 60

CAGCTGGCGG ATTTTATTGA TCCTCAAGAA GGATGGAAGA AGTTAGCAGT TGATATAAAA 120

AAGCCTTCTG GAGAGAATAG ATATAACCAG TTTCATATAA GGAGATTTGA AGGATTACTT 180

CAAAATGGAA AGAGTCCCAC TAGTGAATTA CTCTTTGACT GGGGAACCAC AAACTGTACA 240

GTTGGAGATC TTGTGGATCT TTTGATCAGA AATGATTTTC TAGCACCAGC ACGCCTGTTG 300

CTGCCAGATA TTATTCCAGA AATTGTCCAG GTACTTCCAC AAGAAAAATT AGCCACTCAG 360

AAGAAATTGC TGCCTCCTTA TGACAAAGAA AAGACACATG TGAAACCTGT TCAGAATCAT 420

GAGCACATCT CTTCATCTCT AGACTCAAGT CCAGACAGAA AAAGTTTAGA AGTTAGTGAT 480

ACACGTTTTC AGAGTTTTTC ATTCTATGAA TTAAAGAGTG TTACAAATAA TTTTGATGAG 540

CGCCCTATGT CGGCTGGTGG AAACAAAATG GGAGAAGGAG GCTTTGGAGT TGTCTATAAA 600

GGCTGCATCA ACAGCAGAAC GGTGGCCGTG AAGAAACTTA CAAGGATGAC TGATATGTGT 660

ACTGAAGAAC TGAAACAACA ATTTGATCAA GAAATAAAAA TACTGGCAAA GTGTCAACAT 720

GAAAACTTAG TACAACTGCT TGGTTTCTCA AGTGATAGCA ATGACTTCTG CTTGGTGTAT 780

GTCTATATGC CCAATGGTTC ATTGCTTGAC AGACTATCTT GTCTGGATGG CACTGAACCA 840

CTTTCCTGGC AGACAAGATG CAAAATTGCT CAAGGTACAG CTAATGGTAT CTACTACTTA 900

CATGCAAACA ATCATGTTCA TAGAGATATT AAAAGTGCAA ATATTTTACT TGATGAGGAC 960

TTCTTACCCA AGATTTCTGA CTTTGGACTT GCAAGAACTT CTGCAAAATT TAACCAAACA 1020

GTCATGACTA GCAGAATTGT GGGAACAACA GCCTATATGG CACCTGAAGC TTTGAGAGGA 1080

GAGATAACAC CTAAATCTGA CATTTATAGT TTTGGTGTGG TCTTGCTAGA AATAATAACC 1140

GGACTTCCAG CAGTAGATGA GCAGCGTGAA CCTCAATTAT TGCTAGATAT CAAAGAAGAA 1200

ATTGAAGATG AAGAAAAGCA TATTGAAGAC TATATTGATG CAAAAATGAA TGATGTAGAT 1260

TCCACTTCTG TTGAAAATAT GTATTCTATT GCTACTCTTT GTCTTCATGA AAAGAAAAAC 1320

AAGAGACCAG ACACTGAGAT GGTAAAACAT CACCTCCAAA AGATGACGTC TTCCTGA 1377

Domain Profile

S: 3     ednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdnile  62

          +n++geGgfg+vy+g+++  +vavkkl  ++d+ ++elkq+f++E+k+la+++H+n+++

Q: 186   GGNKMGEGGFGVVYKGCINSRTVAVKKLTRMTDMCTEELKQQFDQEIKILAKCQHENLVQ  245

         579*********************************************************

S: 63    llgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHeasp  122

         llg+s++s+++cLvY ym+nGsL drL+c +g+epLsW++R++i++Gta++i++LH +

Q: 246   LLGFSSDSNDFCLVYVYMPNGSLLDRLSCLDGTEPLSWQTRCKIAQGTANGIYYLHAN--  303

         **********************************************************..

S: 123   slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpeefir  182

         +++h+diksaNiLLDe++ pK++Dfglar   +s+k ++tv+ ts+++gt+aY+++e++r

Q: 304   NHVHRDIKSANILLDEDFLPKISDFGLAR---TSAKFNQTVM-TSRIVGTTAYMAPEALR  359

         *****************************...9999*****9.*****************

S: 183   vgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfldkka  242

          g++t k+D+ySfG+VllE++tGl+avde+r+++ L+d+ keeie+e+ + +e+++d+k+

Q: 360   -GEITPKSDIYSFGVVLLEIITGLPAVDEQREPQLLLDI-KEEIEDEE-KHIEDYIDAKM  416

         .*************************************9.********.99*********

S: 243   gkleeellealielalaclaekakkrPtmsqvlel  277

         ++++++++e ++++a+ cl+ek++krP+ + v ++

Q: 417   NDVDSTSVENMYSIATLCLHEKKNKRPDTEMVKHH  451

         ****************************9998876

Domain Sequence
(FASTA)

GGNKMGEGGF GVVYKGCINS RTVAVKKLTR MTDMCTEELK QQFDQEIKIL AKCQHENLVQ 60

LLGFSSDSND FCLVYVYMPN GSLLDRLSCL DGTEPLSWQT RCKIAQGTAN GIYYLHANNH 120

VHRDIKSANI LLDEDFLPKI SDFGLARTSA KFNQTVMTSR IVGTTAYMAP EALRGEITPK 180

SDIYSFGVVL LEIITGLPAV DEQREPQLLL DIKEEIEDEE KHIEDYIDAK MNDVDSTSVE 240

NMYSIATLCL HEKKNKRPDT EMVKHH 266

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0001816	; P:cytokine production
GO:0019221	; P:cytokine-mediated signaling pathway

KEGG

mdo:100019202

;

InterPros

IPR011029	; DEATH-like.
IPR017428	; Interleukin-1_rcpt-assoc_kin4.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013