EPS-MOD-00074

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MOD-00074

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2A	418.5	3.7E-126	51	243	193

Status

Unreviewed

Ensembl Protein

ENSMODP00000023713

UniProt Accession

F7CP86;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP2CB

Gene Synonyms/Alias

PPP2CB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000019001	ENSMODP00000023713	ENSMODT00000024136

Organism

Monodelphis domestica

Functional Description

Protein Length

309

Protein Sequence
(FASTA)

MEDKIFTKEL DQWVEQLNEC KQLNENQVRT LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60

QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VSLKVRYPER ITILRGNHES 120

RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 180

RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 240

HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 300

TRRTPDYFL 309

Nucleotide Sequence
(FASTA)

ATGGAGGACA AGATATTCAC GAAGGAGCTG GACCAGTGGG TGGAGCAGCT GAACGAATGC 60

AAGCAGCTGA ACGAGAACCA AGTGCGCACG CTCTGCGAGA AGGCTAAGGA AATCCTCACA 120

AAAGAATCCA ATGTACAAGA AGTTCGTTGT CCTGTCACTG TCTGCGGTGA TGTCCACGGC 180

CAATTCCACG ATCTGATGGA ACTCTTTAGA ATTGGGGGAA AGTCGCCAGA CACAAACTAT 240

CTCTTTATGG GTGACTATGT AGACAGAGGT TATTACTCAG TGGAGACTGT GACTCTTCTT 300

GTATCATTAA AGGTACGCTA TCCAGAGCGG ATCACAATCT TAAGAGGAAA CCACGAGAGC 360

CGACAAATTA CCCAGGTGTA TGGCTTTTAC GATGAGTGTC TGAGGAAGTA TGGCAATGCC 420

AACGTGTGGA AATACTTCAC TGATCTGTTT GATTATCTCC CACTCACAGC TTTAGTAGAT 480

GGACAGATAT TTTGCCTCCA TGGTGGCCTT TCTCCATCCA TTGATACACT GGATCATATT 540

AGAGCCCTGG ATCGTCTGCA AGAAGTTCCA CATGAGGGTC CAATGTGTGA CCTGTTATGG 600

TCAGATCCCG ATGATCGTGG TGGATGGGGC ATTTCTCCAC GAGGTGCTGG TTACACATTT 660

GGACAGGACA TTTCTGAAAC ATTTAACCAT GCCAATGGCC TCACACTGGT TTCCCGTGCT 720

CACCAACTTG TGATGGAGGG TTACAACTGG TGTCATGATC GGAACGTGGT TACCATTTTC 780

AGTGCCCCCA ATTACTGCTA CCGTTGTGGG AACCAGGCTG CTATCATGGA ACTCGATGAC 840

ACTTTAAAAT ATTCCTTCCT GCAATTTGAC CCTGCACCCC GTCGTGGAGA GCCCCATGTA 900

ACTCGGCGCA CCCCAGACTA CTTCCTATAA 930

Domain Profile

S: 1     pvtvcgdvhgqfhdllelfriggkspdtnylflgdyvdrgyysvetvtllvalkvryrer  60

         pvtvcgdvhgqfhdl+elfriggkspdtnylf+gdyvdrgyysvetvtllv+lkvry+er

Q: 51    PVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVSLKVRYPER  110

         9***********************************************************

S: 61    itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgkifclhggl  120

         itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdg+ifclhggl

Q: 111   ITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGL  170

         ************************************************************

S: 121   spsidtldeiraldrlqevphegplcdllwsdpddregwgisprgagytfgqdiseqfnh  180

         spsidtld+iraldrlqevphegp+cdllwsdpddr+gwgisprgagytfgqdise+fnh

Q: 171   SPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNH  230

         ************************************************************

S: 181   angleliarahql  193

         angl+l++rahql

Q: 231   ANGLTLVSRAHQL  243

         ************8

Domain Sequence
(FASTA)

PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VSLKVRYPER 60

ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL 120

SPSIDTLDHI RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH 180

ANGLTLVSRA HQL 193

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0000159	; C:protein phosphatase type 2A complex
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0043066	; P:negative regulation of apoptotic process
GO:0043161	; P:proteasomal ubiquitin-dependent protein catabolic process
GO:0010468	; P:regulation of gene expression
GO:0046677	; P:response to antibiotic
GO:0042542	; P:response to hydrogen peroxide

KEGG

mdo:100012652

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013