EKS-MOD-00205

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00205

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	501.5	5.4E-151	4	287	284

Status

Unreviewed

Ensembl Protein

ENSMODP00000023973

UniProt Accession

F6ZIW9;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL2

Gene Synonyms/Alias

CDKL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000019201	ENSMODP00000023973	ENSMODT00000024397

Organism

Monodelphis domestica

Functional Description

Protein Length

614

Protein Sequence
(FASTA)

MEKYERLGLV GEGSYGAVMK CRNKANGRIV AVKKFLESED DKTIKKIATR EIKLLKQLRH 60

ENLVNLLEVC KKKKRWYLVF EFVDHTMLDD LDLFPQGLEY QRVQKYLYQI IKGIEFCHNH 120

NIIHRDIKPE NILISRSGVV KLCDFGFARM LGAPGEVYTD YVATRWYRAP ELLVGDIKYG 180

KAVDIWAIGC LLIEMFMGQP LFPGDSDIDQ LYHIVKCLGN LIPRHQELFY QNPLFASVKL 240

PEVEEQESLE SHCPKLSAVV IDMAKKCLQI DPDKRPFCDE LLNHDFFNQD GFVERFSKEL 300

KLNIQKDARK FSSSKISKNR KKGKDNSSGE ERKTLVIQDV NTDPKARDSK VIKAKAPKTD 360

SEKIKKPSRA SNPGCLPNSG MSQVRMIPPA TFGVPGNSSV DCTKRPGTGI PPIVHNISGT 420

ASSISSGVGT IPGGHTYRVD DKAKKNHVPF VRLGKHDPAT SLNANLTTLV SNEKNILQEN 480

KKRWEVSKTE VHLPELNSNY FPEVRGIESP GIRMLPARLS RSQLPSSRVL KLKNIEDLCH 540

DYTPKSRMTN SRNQTGDILR GERHGLEFIP LKCIIFPGSN AMEMKGKQKG NGFPAYLRQI 600

QHFPTITANP SPPW 614

Nucleotide Sequence
(FASTA)

ATGGAGAAAT ATGAGCGCCT AGGACTGGTT GGTGAGGGGA GCTATGGAGC AGTGATGAAG 60

TGTAGGAATA AAGCCAACGG AAGAATTGTG GCCGTCAAGA AATTCCTGGA GAGTGAAGAT 120

GATAAAACAA TTAAAAAAAT TGCCACCCGA GAAATCAAGT TATTGAAGCA ATTGAGGCAT 180

GAGAATTTGG TGAATCTTCT GGAAGTGTGT AAGAAAAAGA AACGATGGTA CTTGGTATTT 240

GAATTTGTGG ACCACACTAT GCTTGATGAT TTAGACCTCT TTCCACAAGG CCTGGAATAC 300

CAAAGAGTTC AAAAGTATTT GTATCAGATT ATTAAAGGAA TTGAATTTTG TCACAATCAC 360

AATATTATCC ACAGAGATAT AAAGCCAGAG AACATCCTGA TCTCCCGGTC TGGAGTGGTA 420

AAGCTGTGTG ACTTTGGATT TGCTCGCATG TTGGGAGCTC CTGGGGAAGT GTATACTGAT 480

TATGTGGCTA CTCGATGGTA CAGAGCCCCA GAGCTTTTGG TTGGAGACAT AAAGTATGGC 540

AAGGCTGTTG ATATATGGGC CATTGGTTGT TTGTTGATTG AAATGTTCAT GGGGCAACCC 600

CTTTTTCCTG GGGATTCTGA TATTGATCAG CTGTATCATA TTGTGAAATG TTTGGGTAAT 660

TTAATTCCAA GACATCAGGA ACTGTTCTAT CAGAACCCAC TTTTTGCTAG TGTGAAATTG 720

CCAGAAGTTG AAGAACAGGA GTCTCTTGAA AGCCATTGTC CTAAGCTTTC TGCAGTGGTG 780

ATTGATATGG CAAAGAAATG TTTGCAGATT GATCCTGACA AGAGGCCCTT CTGTGATGAG 840

CTCCTCAACC ATGACTTCTT TAATCAGGAT GGATTTGTGG AAAGGTTTTC TAAGGAGCTA 900

AAATTAAATA TACAGAAAGA TGCCAGAAAA TTTTCTTCAT CAAAAATATC TAAAAACAGA 960

AAAAAGGGAA AAGATAATTC TTCAGGTGAA GAAAGAAAAA CACTAGTTAT ACAGGATGTC 1020

AATACTGATC CCAAAGCTAG AGATTCTAAA GTGATCAAAG CAAAGGCACC AAAAACTGAT 1080

AGTGAAAAGA TTAAAAAACC CAGCCGAGCC TCCAATCCTG GTTGTCTTCC CAACAGTGGA 1140

ATGAGTCAGG TCAGAATGAT TCCTCCAGCC ACTTTTGGAG TCCCTGGGAA CAGCAGTGTG 1200

GATTGCACAA AGAGACCTGG CACAGGGATT CCTCCAATTG TACACAATAT TTCTGGCACT 1260

GCTTCCAGTA TCAGTTCAGG AGTGGGGACT ATTCCAGGAG GTCATACTTA CAGGGTGGAT 1320

GACAAGGCTA AAAAGAACCA TGTTCCATTT GTTAGGCTGG GTAAACATGA TCCAGCCACC 1380

TCTCTTAATG CTAACCTGAC CACACTGGTC TCTAATGAAA AGAACATTCT TCAGGAAAAC 1440

AAGAAAAGAT GGGAAGTCTC CAAGACAGAG GTTCATTTGC CTGAACTAAA CTCTAATTAC 1500

TTCCCCGAAG TCAGAGGAAT TGAAAGCCCA GGTATCAGGA TGCTCCCAGC CAGACTCTCC 1560

AGAAGCCAAC TTCCCTCCAG TAGAGTACTC AAATTGAAGA ATATTGAGGA CCTGTGTCAC 1620

GATTATACTC CAAAATCCAG GATGACAAAC TCCAGGAATC AGACTGGTGA CATCCTGAGA 1680

GGAGAGCGGC ACGGGCTAGA ATTTATCCCA CTGAAATGCA TCATTTTCCC TGGGAGCAAT 1740

GCTATGGAAA TGAAAGGAAA ACAAAAGGGC AATGGTTTTC CAGCTTATCT AAGACAGATT 1800

CAGCATTTCC CCACCATCAC AGCAAACCCC TCTCCCCCTT GGTAA 1845

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lg vGeGsyG v+kcrnk  g+iva+kkfleseddk++kkia+reikllkql+henl

Q: 4     YERLGLVGEGSYGAVMKCRNKANGRIVAVKKFLESEDDKTIKKIATREIKLLKQLRHENL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllev+++kk++ylvfe+vd+t+ld+l+ +p+G+e+++v+k+lyqi+k+iefch++nii

Q: 64    VNLLEVCKKKKRWYLVFEFVDHTMLDDLDLFPQGLEYQRVQKYLYQIIKGIEFCHNHNII  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenilis+sgvvklcdfGfar+l apg+vytdyvatrwyrapellvgd+kyGk+v

Q: 124   HRDIKPENILISRSGVVKLCDFGFARMLGAPGEVYTDYVATRWYRAPELLVGDIKYGKAV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         d+waiGcll+e+++G+plfpg+sd+dqly+i+k+lG+liprhq++f++n++fa vklpev

Q: 184   DIWAIGCLLIEMFMGQPLFPGDSDIDQLYHIVKCLGNLIPRHQELFYQNPLFASVKLPEV  243

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         e++esle++ pkl+ v++d++kkcl++dp++r +c+ell+h++f

Q: 244   EEQESLESHCPKLSAVVIDMAKKCLQIDPDKRPFCDELLNHDFF  287

         ******************************************98

Domain Sequence
(FASTA)

YERLGLVGEG SYGAVMKCRN KANGRIVAVK KFLESEDDKT IKKIATREIK LLKQLRHENL 60

VNLLEVCKKK KRWYLVFEFV DHTMLDDLDL FPQGLEYQRV QKYLYQIIKG IEFCHNHNII 120

HRDIKPENIL ISRSGVVKLC DFGFARMLGA PGEVYTDYVA TRWYRAPELL VGDIKYGKAV 180

DIWAIGCLLI EMFMGQPLFP GDSDIDQLYH IVKCLGNLIP RHQELFYQNP LFASVKLPEV 240

EEQESLESHC PKLSAVVIDM AKKCLQIDPD KRPFCDELLN HDFF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mdo:100024223

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013