EKS-MOD-00461

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00461

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	374.8	2.7E-112	142	428	287

Status

Unreviewed

Ensembl Protein

ENSMODP00000024004

UniProt Accession

F6RE45;

Protein Name

Protein Synonyms/Alias

Gene Name

NLK

Gene Synonyms/Alias

NLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000019231	ENSMODP00000024004	ENSMODT00000024431

Organism

Monodelphis domestica

Functional Description

Protein Length

528

Protein Sequence
(FASTA)

MSLCGTAANA KMMAAYNGGT SAAAAAGHHH HHHHHLPHLP PPHLHHHHHP QHHLHPGSAA 60

AVHPVQQHTS SAAAAAAAAA AAAAMLNPGQ QQPYFPSPAP GQAPGPAATA PAQVQAAAAA 120

AVKAHHHQHS HHPQQQLDIE PDRPIGYGAF GVVWSVTDPR DGKRVALKKM PNVFQNLVSC 180

KRVFRELKML CFFKHDNVLS ALDILQPPHI DYFEEIYVVT ELMQSDLHKI IVSPQPLSSD 240

HVKVFLYQIL RGLKYLHSAG ILHRDIKPGN LLVNSNCVLK ICDFGLARVE ELDESRHMTQ 300

EVVTQYYRAP EILMGSRHYS NAIDIWSVGC IFAELLGRRI LFQAQSPIQQ LDLITDLLGT 360

PSLEAMRTAC EGAKAHILRG PHKQPSLPVL YTLSSQATHE AVHLLCRMLV FDPSKRISAK 420

DALAHPYLDE GRLRYHTCMC KCCFSTSTGR VYTSDFEPIT NPKFDDTFEK NLSSVRQVKE 480

IIHQFILEQQ KGNRVPLCIN PQSAAFKSFI SSTVAQPSEM PPSPLVWE 528

Nucleotide Sequence
(FASTA)

ATGTCTCTTT GTGGCACGGC AGCCAACGCA AAAATGATGG CGGCTTATAA TGGTGGTACA 60

TCTGCAGCGG CAGCAGCAGG TCACCACCAC CACCATCACC ACCACCTTCC ACACCTTCCT 120

CCTCCACACC TTCACCACCA CCACCACCCT CAACACCATC TTCATCCCGG ATCAGCTGCT 180

GCCGTCCATC CAGTGCAGCA GCATACCTCT TCAGCGGCTG CCGCGGCTGC TGCAGCCGCG 240

GCGGCTGCTG CCATGTTAAA CCCCGGGCAA CAACAGCCAT ATTTCCCATC ACCGGCACCA 300

GGTCAGGCCC CTGGACCAGC TGCCACGGCC CCAGCTCAGG TACAGGCTGC AGCAGCCGCT 360

GCAGTTAAAG CGCACCATCA TCAGCACTCA CATCATCCAC AACAGCAACT GGATATTGAG 420

CCGGACAGAC CTATTGGATA TGGAGCCTTT GGTGTTGTCT GGTCAGTAAC AGATCCAAGA 480

GATGGAAAGA GAGTCGCTCT CAAAAAGATG CCCAACGTCT TCCAGAATCT TGTCTCTTGC 540

AAAAGGGTCT TCCGAGAACT GAAGATGTTG TGTTTTTTTA AGCATGATAA CGTACTCTCT 600

GCCCTTGACA TACTCCAGCC TCCACACATT GACTATTTTG AAGAAATCTA TGTTGTCACA 660

GAATTGATGC AGAGTGACCT ACATAAAATT ATCGTCTCTC CTCAACCACT CAGCTCAGAT 720

CATGTCAAAG TTTTTCTTTA TCAGATTTTA AGAGGTTTGA AATATCTTCA TTCAGCCGGC 780

ATTTTACATC GCGACATTAA GCCAGGGAAT CTCCTTGTGA ACAGCAACTG TGTGCTTAAG 840

ATTTGCGACT TTGGATTGGC CAGAGTGGAG GAACTGGATG AATCCCGTCA TATGACTCAG 900

GAAGTTGTCA CTCAGTATTA TCGGGCCCCC GAGATCCTGA TGGGCAGCCG TCATTACAGC 960

AATGCTATTG ACATCTGGTC TGTAGGCTGC ATCTTTGCAG AGCTGCTAGG ACGAAGAATA 1020

TTGTTTCAGG CACAGAGTCC CATTCAACAG TTGGATTTGA TCACAGATTT ACTGGGCACA 1080

CCATCACTGG AAGCAATGAG GACAGCTTGC GAAGGTGCAA AGGCACACAT ACTCAGGGGT 1140

CCTCATAAAC AGCCATCTCT TCCTGTACTC TATACACTGT CTAGCCAAGC AACACATGAA 1200

GCTGTTCATC TCCTTTGCAG GATGTTGGTC TTTGATCCAT CCAAAAGAAT ATCTGCTAAG 1260

GACGCCTTAG CCCACCCCTA CCTAGATGAA GGGCGGTTGC GATACCACAC CTGTATGTGT 1320

AAATGTTGTT TTTCCACCTC CACTGGAAGA GTTTATACCA GTGACTTTGA ACCCATCACC 1380

AATCCCAAAT TTGATGACAC TTTTGAGAAG AATCTCAGTT CTGTTCGACA GGTAAAAGAA 1440

ATTATTCATC AGTTCATTTT GGAACAGCAG AAAGGAAACC GAGTGCCTCT CTGCATCAAC 1500

CCTCAATCTG CTGCTTTTAA GAGCTTCATT AGTTCCACTG TTGCCCAGCC ATCTGAGATG 1560

CCGCCATCTC CACTGGTCTG GGAGTGA 1587

Domain Profile

S: 4     lkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiikl  63

          +p+g Ga+gvv+s++d r+++rva+kk+ ++fq+ +s+kr++RElk+l  +kh+N+++

Q: 142   DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSA  201

         689*********************************************************

S: 64    ldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylHsan  122

         ld+++p + ++ ++++Y+vtelm++dL+k+i s   ls++h+k++lyqilrglkylHsa+

Q: 202   LDILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPqPLSSDHVKVFLYQILRGLKYLHSAG  260

         *******9.**********************99879************************

S: 123   viHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeyt  182

         ++HrD+KP+Nllvn++c lki+dFGlar+++ ++++++t++v+t++YraPeil+ +++y+

Q: 261   ILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYS  320

         *********************************999************************

S: 183   kavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyiks  242

         +a+DiWsvGCI+aEll +++lf++++ i+ql++i+++lgtps e +++ ++  a+++i +

Q: 321   NAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEG-AKAHILR  379

         ************************************************9996.7777777

S: 243   lpkkkkk..dfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          p+k+     + +l ++a++ea++Ll ++Lv+dp+kRis+++aL+hpYl

Q: 380   GPHKQPSlpVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL  428

         77666644457788888*******************************7

Domain Sequence
(FASTA)

DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK RVFRELKMLC FFKHDNVLSA 60

LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH VKVFLYQILR GLKYLHSAGI 120

LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE VVTQYYRAPE ILMGSRHYSN 180

AIDIWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP SLEAMRTACE GAKAHILRGP 240

HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DPSKRISAKD ALAHPYL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004707	; F:MAP kinase activity
GO:0030178	; P:negative regulation of Wnt receptor signaling pathway
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent
GO:0033136	; P:serine phosphorylation of STAT3 protein
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

mdo:100019356

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013