EPS-MOD-00023

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MOD-00023

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	234.6	1.7E-69	94	344	251

Status

Unreviewed

Ensembl Protein

ENSMODP00000024020

UniProt Accession

F6QTI3;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1K

Gene Synonyms/Alias

PPM1K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000019241	ENSMODP00000024020	ENSMODT00000024447

Organism

Monodelphis domestica

Functional Description

Protein Length

372

Protein Sequence
(FASTA)

MSTAALITLI RSGGFQVRRR ALLTSRLLQD DKRVTSASPS STSERRLSRF DPDGSGRPAT 60

WDTFGIWDNR IDEPILLPPS IKYGKPIPKI SLENVGCSSL IGKRKENEDR FGFAQLTDEV 120

LYFAVYDGHG GSAAADFCHT HMEKYIMDFL TKEKNLETVL TNAFLEIDKA FARQASLSAD 180

GTLLTSGTTA TVALLRDGIE LVIASVGDSR ALLCRKGKPL KLTTDHTPER KDEKERVKKC 240

GGFVAWNSLG QPHVNGRLAM TRSIGDLDLK NSGVIAEPET KRIKLQHAAD SFLVLTTDGI 300

NFMVNSQEIC DFVNQCHDPN EAAHVVTEQA IQYGTEDNST AVVIPFGAWG KYKNSEVSFS 360

FSRSFASSGR WA 372

Nucleotide Sequence
(FASTA)

ATGTCCACAG CTGCTCTAAT TACTTTAATT AGAAGCGGAG GGTTCCAGGT GAGAAGAAGA 60

GCTCTGTTAA CATCACGTCT GCTGCAGGAT GACAAGAGAG TGACCTCCGC CAGCCCCAGC 120

TCCACCTCTG AGCGAAGACT CTCTAGATTC GATCCTGACG GCAGCGGGCG ACCAGCTACA 180

TGGGACACTT TTGGGATCTG GGATAACCGC ATCGATGAGC CCATTCTTCT CCCTCCAAGC 240

ATTAAGTATG GAAAGCCAAT TCCAAAAATT AGCCTGGAAA ATGTGGGCTG CTCCTCCCTT 300

ATTGGAAAAC GGAAAGAGAA TGAGGACCGC TTTGGCTTTG CCCAGTTGAC CGATGAAGTT 360

CTGTACTTTG CAGTGTATGA TGGGCATGGT GGATCTGCAG CAGCTGACTT CTGCCACACA 420

CATATGGAAA AATATATTAT GGATTTCCTT ACTAAGGAGA AGAACTTGGA AACTGTATTG 480

ACCAATGCTT TCCTAGAAAT AGATAAAGCA TTTGCACGGC AAGCATCCTT ATCGGCTGAT 540

GGCACTTTGC TGACCTCTGG GACCACTGCA ACAGTAGCCC TGCTGCGAGA TGGTATTGAG 600

CTGGTCATAG CTAGTGTTGG AGATAGCCGT GCTCTCCTGT GTAGAAAAGG AAAGCCCTTA 660

AAACTGACCA CAGACCATAC GCCAGAGAGA AAAGATGAAA AAGAAAGGGT CAAGAAATGT 720

GGTGGCTTTG TAGCTTGGAA CAGTTTGGGG CAGCCACATG TGAACGGCAG GCTTGCAATG 780

ACAAGGAGCA TTGGAGACTT GGATCTCAAA AACAGTGGTG TGATCGCGGA ACCTGAAACA 840

AAAAGGATTA AGCTGCAGCA TGCTGCTGAT AGCTTCCTGG TCCTCACTAC GGATGGAATT 900

AACTTCATGG TGAATAGTCA AGAGATTTGT GACTTTGTCA ATCAGTGCCA TGATCCTAAT 960

GAAGCAGCCC ATGTTGTTAC TGAACAGGCA ATACAGTATG GTACTGAAGA TAATAGCACC 1020

GCAGTAGTCA TACCTTTTGG TGCCTGGGGA AAATACAAAA ACTCAGAAGT CAGCTTCTCC 1080

TTCAGCAGAA GCTTTGCCTC AAGTGGACGC TGGGCTTAA 1119

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         +vg++s+ g+r+e ed++    +f++ +++   + +f+vyDGhggs +a+fc++++++++

Q: 94    NVGCSSLIGKRKENEDRF----GFAQLTDE---VLYFAVYDGHGGSAAADFCHTHMEKYI  146

         589***************....78888766...78*************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidk....sGstavvalikds.k  116

            l     +e++++++l++aFl++d+++    ++sl+ d     sG+ta+val++d  +

Q: 147   MDFLT----KEKNLETVLTNAFLEIDKAF--ARQASLSADGtlltSGTTATVALLRDGiE  200

         ***88....9*******************..33333333334688*************9*

S: 117   lyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkd.ga.RvlGvLav  174

         l++a vGdSra+Lcr+gk+++l++dH+p+r+dE+eR+++ gg v+ ++ g+ +v+G La+

Q: 201   LVIASVGDSRALLCRKGKPLKLTTDHTPERKDEKERVKKCGGFVAWNSlGQpHVNGRLAM  260

         ********************************************98889999********

S: 175   sRalGdlylk.pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekk  232

         +R++Gdl+lk + v++ePe+  ++l++  + fl+L +DG+  +v+++e++++v+++++

Q: 261   TRSIGDLDLKnSGVIAEPETKRIKLQHAADsFLVLTTDGINFMVNSQEICDFVNQCHD--  318

         **********555************998888***************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           ++eaa+ ++++a+++g++dn +a+v+

Q: 319   --PNEAAHVVTEQAIQYGTEDNSTAVVI  344

         ..***********************997

Domain Sequence
(FASTA)

NVGCSSLIGK RKENEDRFGF AQLTDEVLYF AVYDGHGGSA AADFCHTHME KYIMDFLTKE 60

KNLETVLTNA FLEIDKAFAR QASLSADGTL LTSGTTATVA LLRDGIELVI ASVGDSRALL 120

CRKGKPLKLT TDHTPERKDE KERVKKCGGF VAWNSLGQPH VNGRLAMTRS IGDLDLKNSG 180

VIAEPETKRI KLQHAADSFL VLTTDGINFM VNSQEICDFV NQCHDPNEAA HVVTEQAIQY 240

GTEDNSTAVV I 251

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

mdo:100024867

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013