EKS-MOD-00274

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00274

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	449.8	4.1E-135	236	523	288

Status

Unreviewed

Ensembl Protein

ENSMODP00000024044

UniProt Accession

F6Q8L1;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000019262	ENSMODP00000024044	ENSMODT00000024471

Organism

Monodelphis domestica

Functional Description

Protein Length

534

Protein Sequence
(FASTA)

MGWLEDPNWQ LHVHFSLLVL LSMHTRANFL DNMLLRSSGK LNVDNKKEDG VITAPTPRPK 60

VLQCKCHHHC PEDSVNNICS TDGYCFTMIE EDDSGMPVVT SGCLGLEGSD FQCRDTPISH 120

QRRSIECCTE RNECNKDLHP TLPPLKNREF VDGPIHHKAL LISVTVCSFL LVLIILFCYF 180

RYKRQEARPR YSIGLEQDET YIPPGESLKD LIEQSQSSGS GSGLPLLVQR TIAKQIQMVK 240

QIGKGRYGEV WMGKWRGEKV AVKVFFTTEE ASWFRETEIY QTVLMRHENI LGFIAADIKG 300

TGSWTQLYLI TDYHENGSLY DYLKSTTLDT NAMLKLAYSS VSGLCHLHTE IFSTQGKPAI 360

AHRDLKSKNI LVKKNGACCI ADLGLAVKFI SDTNEVDIPP NTRVGTKRYM PPEVLDESLN 420

RNHFQSYIMA DMYSFGLILW EIARRCVSSG IVEEYQLPYH DLVPSDPSYE DMREIVCIKK 480

LRPSFPNRWS SDECLRQMGK LMTECWAHNP ASRLTALRVK KTLAKMSESQ DIKL 534

Nucleotide Sequence
(FASTA)

ATGGGGTGGC TGGAAGACCC AAACTGGCAG CTTCACGTTC ACTTTTCTTT GCTCGTTCTG 60

CTGTCCATGC ACACAAGGGC TAATTTCCTT GACAATATGC TTTTGAGAAG TTCGGGAAAA 120

TTGAATGTGG ACAACAAGAA GGAAGATGGT GTGATCACAG CCCCCACCCC TCGGCCAAAG 180

GTTTTGCAAT GCAAGTGCCA CCATCACTGT CCTGAAGACT CTGTCAACAA TATTTGCAGC 240

ACAGATGGCT ACTGTTTCAC TATGATAGAA GAAGATGATT CTGGTATGCC TGTGGTCACT 300

TCTGGATGTC TAGGACTAGA GGGCTCAGAC TTTCAGTGCC GGGACACTCC CATCTCTCAC 360

CAAAGGAGGT CAATTGAATG TTGCACAGAA CGGAATGAAT GCAATAAAGA CCTTCACCCT 420

ACACTGCCTC CATTGAAAAA TCGAGAATTT GTTGATGGAC CCATACATCA TAAGGCCTTA 480

CTGATATCGG TGACAGTCTG TAGCTTCCTT CTGGTCCTTA TAATTTTATT CTGTTATTTC 540

AGGTATAAAA GACAAGAAGC CAGACCTCGT TACAGCATTG GATTGGAACA GGATGAGACC 600

TACATCCCCC CGGGGGAATC TCTGAAAGAT TTAATAGAAC AATCTCAGAG TTCGGGGAGT 660

GGATCCGGAC TCCCTCTGCT GGTCCAAAGG ACTATAGCTA AGCAGATTCA GATGGTGAAA 720

CAGATTGGAA AAGGTCGCTA TGGGGAAGTT TGGATGGGAA AGTGGCGTGG TGAAAAGGTA 780

GCTGTGAAAG TGTTCTTTAC CACTGAGGAA GCCAGCTGGT TCAGAGAGAC AGAAATATAT 840

CAGACGGTCT TGATGAGGCA TGAAAATATT TTGGGATTTA TTGCTGCAGA TATCAAAGGC 900

ACAGGGTCTT GGACCCAACT ATATCTAATC ACAGACTACC ATGAGAATGG CTCCTTGTAT 960

GATTATCTGA AGTCCACTAC TCTAGATACC AACGCAATGC TAAAGCTTGC CTATTCTTCA 1020

GTAAGTGGCC TGTGCCACTT ACATACGGAG ATCTTTAGCA CTCAAGGAAA ACCAGCAATT 1080

GCACATCGCG ATCTGAAAAG TAAGAACATC CTGGTGAAGA AAAATGGAGC ATGCTGTATA 1140

GCTGATCTGG GATTGGCGGT TAAATTTATT AGTGACACCA ATGAAGTAGA CATCCCACCC 1200

AACACTCGGG TTGGCACCAA ACGGTACATG CCACCAGAAG TTCTGGATGA GAGTTTGAAT 1260

CGGAACCACT TCCAGTCCTA CATCATGGCA GATATGTACA GTTTTGGTCT TATTCTGTGG 1320

GAAATCGCCC GGAGATGTGT ATCCAGCGGA ATAGTAGAAG AATACCAGCT TCCCTATCAT 1380

GACCTGGTAC CCAGTGACCC CTCCTATGAA GACATGAGGG AAATTGTGTG CATCAAGAAA 1440

CTCCGTCCAT CCTTTCCCAA CAGATGGAGT AGTGATGAGT GTCTACGGCA AATGGGGAAA 1500

CTCATGACAG AATGCTGGGC TCACAATCCT GCCTCTCGTC TCACAGCACT TCGAGTTAAG 1560

AAAACACTTG CCAAAATGTC AGAGTCACAG GACATTAAAC TTTGA 1605

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 236   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  295

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++ +l+la+s +sGl+hLH+ei+ t+

Q: 296   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTNAMLKLAYSSVSGLCHLHTEIFSTQ  355

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk+++cciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 356   G--KPAIAHRDLKSKNILVKKNGACCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  413

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWE+a+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 414   VLDESLNRNHFQSYIMADMYSFGLILWEIARRCVS-SGIVEEYQLPYHDLVPSDPSYEDM  472

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 473   REIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  523

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTNAMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GACCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEIARR CVSSGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKKLRPSF PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0030509	; P:BMP signaling pathway
GO:0001502	; P:cartilage condensation
GO:0009953	; P:dorsal/ventral pattern formation
GO:0006954	; P:inflammatory response
GO:0035108	; P:limb morphogenesis
GO:0001550	; P:ovarian cumulus expansion
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0060041	; P:retina development in camera-type eye
GO:0031290	; P:retinal ganglion cell axon guidance
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013