EKS-MOD-00358

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00358

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	433.3	2.9E-130	273	523	251

Status

Unreviewed

Ensembl Protein

ENSMODP00000024291

UniProt Accession

F6RBD8;

Protein Name

Protein Synonyms/Alias

Gene Name

HCK

Gene Synonyms/Alias

HCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000019471	ENSMODP00000024291	ENSMODT00000024721

Organism

Monodelphis domestica

Functional Description

Protein Length

538

Protein Sequence
(FASTA)

MPQKRRGPQK TEVGAPGAGL KPQKLGHFGR LKARMGCVKS RFNQDGRKIF KKDSPTNNQG 60

PVYVPDPTSP GKRVVNGANQ SISSDASENV DITVVALYDY EAIHNEDLSF RKGDQMAILE 120

KSGEWWRARS LATRKEGYIP SNYVAQVNSL ETEEWFFKDI SRKDAERHLL APGNVLGSFM 180

IRDSETTKGS YSLSIRDYDP QHQDAVKHYK IRTLDNGGFY ISPRSTFSTL QDLVAHYKKG 240

SDGLCQKLTV ACVVPKPQKP WEKDAWEIPR ESLKFEKKLG AGQFGEVWMA TYNKHTKVAV 300

KTMKPGSMSV EAFLAEANLM KTLQHDKLVK LHAVVTKEEP IYIITEFMAK GSLLDFLKTD 360

EGRRQPLPKL IDFSAQIAEG MAFIELRNYI HRDLRAANIL VSSALVCKIA DFGLARLIED 420

NLYNAREGAK FPIKWTAPEA INFGSFTIKS DVWSFGILLM EIVTYGRIPY PGMSNPEVIR 480

SLDHGYRMPR TENCPEELYS IMTRCWMNKP EDRPTFEYLQ SVLEDFYTAT ESQYQKQP 538

Nucleotide Sequence
(FASTA)

ATGCCCCAGA AGCGGCGGGG CCCCCAGAAG ACCGAGGTGG GGGCGCCTGG AGCAGGGCTG 60

AAGCCGCAGA AATTGGGCCA TTTTGGAAGA CTGAAAGCCA GGATGGGGTG TGTGAAGTCC 120

AGGTTTAACC AGGATGGCAG AAAGATCTTC AAAAAAGATT CTCCAACAAA CAACCAGGGC 180

CCGGTCTATG TGCCAGATCC AACATCCCCT GGAAAAAGGG TAGTCAATGG CGCCAACCAG 240

TCCATCTCCT CTGATGCCTC TGAGAATGTG GACATTACAG TTGTGGCCCT ATATGACTAT 300

GAGGCCATTC ACAATGAGGA CCTCAGCTTT CGGAAGGGTG ACCAGATGGC AATCCTAGAA 360

AAATCTGGAG AGTGGTGGAG AGCTCGCTCC CTTGCTACGA GGAAGGAGGG CTATATTCCA 420

AGTAACTATG TAGCCCAAGT CAACTCACTG GAGACAGAAG AATGGTTCTT CAAAGACATT 480

AGCCGTAAGG ATGCAGAGCG ACACCTGTTG GCACCTGGGA ATGTATTAGG CTCCTTCATG 540

ATTCGGGACA GTGAAACCAC CAAAGGCAGT TATTCTTTAT CAATACGCGA CTATGATCCC 600

CAGCACCAGG ATGCAGTGAA ACATTATAAG ATCCGGACCC TGGACAATGG TGGTTTCTAT 660

ATCTCCCCAC GGAGTACTTT CAGTACTTTG CAGGATCTGG TGGCCCACTA CAAGAAAGGA 720

AGTGATGGCT TATGCCAGAA GCTAACAGTG GCCTGTGTGG TCCCCAAGCC CCAAAAACCC 780

TGGGAGAAGG ATGCTTGGGA GATCCCAAGG GAATCTCTGA AATTTGAGAA GAAACTGGGG 840

GCTGGACAGT TTGGAGAAGT CTGGATGGCT ACCTACAACA AGCACACCAA AGTGGCTGTG 900

AAGACCATGA AGCCAGGGAG CATGTCTGTG GAAGCCTTCT TGGCCGAAGC CAACCTGATG 960

AAGACCCTGC AGCACGACAA GCTTGTGAAA CTGCATGCAG TGGTCACCAA GGAAGAACCC 1020

ATCTACATCA TCACTGAATT CATGGCAAAA GGAAGCCTGC TGGACTTTCT GAAAACTGAT 1080

GAGGGCCGAA GACAGCCTCT GCCAAAACTC ATCGATTTCT CAGCCCAGAT CGCCGAGGGA 1140

ATGGCCTTCA TTGAGCTGAG GAACTATATC CACCGAGATC TAAGAGCAGC CAACATCCTT 1200

GTCTCCTCAG CCCTGGTGTG TAAGATTGCT GATTTTGGCC TGGCACGGCT CATCGAAGAC 1260

AACCTATACA ATGCTCGAGA GGGAGCCAAG TTTCCCATCA AGTGGACAGC TCCAGAAGCC 1320

ATCAACTTTG GCTCCTTTAC CATCAAGTCA GATGTGTGGT CCTTTGGCAT CCTCCTGATG 1380

GAGATTGTCA CTTATGGCCG GATCCCCTAC CCAGGAATGT CTAACCCTGA AGTGATCCGT 1440

TCCTTGGATC ATGGATACCG GATGCCTCGA ACAGAGAACT GCCCAGAAGA ACTATACAGC 1500

ATCATGACCC GCTGCTGGAT GAATAAACCT GAGGATCGGC CTACATTTGA GTACCTCCAG 1560

AGTGTGCTAG AGGACTTTTA CACTGCCACT GAGAGCCAGT ACCAAAAACA GCCATAA 1617

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lk++kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+

Q: 273   LKFEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLH  332

         6889********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++eePiyi+te+makGslldflk++eg++++lpkl+d++aq+aeGma++e +n+ihr

Q: 333   AVVTKEEPIYIITEFMAKGSLLDFLKTDEGRRQPLPKLIDFSAQIAEGMAFIELRNYIHR  392

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+  lv+k+adfGlarlied+ y+a+egak+PikWtaPeai++g+ftiksdv

Q: 393   DLRAANILVSSALVCKIADFGLARLIEDNLYNAREGAKFPIKWTAPEAINFGSFTIKSDV  452

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+eivt+G++PypGm+n ev++++++gyr+pr+e+cpeely+++++cw ++pe+

Q: 453   WSFGILLMEIVTYGRIPYPGMSNPEVIRSLDHGYRMPRTENCPEELYSIMTRCWMNKPED  512

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq+vl

Q: 513   RPTFEYLQSVL  523

         ********986

Domain Sequence
(FASTA)

LKFEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKT LQHDKLVKLH 60

AVVTKEEPIY IITEFMAKGS LLDFLKTDEG RRQPLPKLID FSAQIAEGMA FIELRNYIHR 120

DLRAANILVS SALVCKIADF GLARLIEDNL YNAREGAKFP IKWTAPEAIN FGSFTIKSDV 180

WSFGILLMEI VTYGRIPYPG MSNPEVIRSL DHGYRMPRTE NCPEELYSIM TRCWMNKPED 240

RPTFEYLQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013