EKS-MOD-00381

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00381

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	323.7	1.2E-96	1222	1486	265

Status

Unreviewed

Ensembl Protein

ENSMODP00000024354

UniProt Accession

F6VCJ3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000019524	ENSMODP00000024354	ENSMODT00000024784

Organism

Monodelphis domestica

Functional Description

Protein Length

1491

Protein Sequence
(FASTA)

MAAAAGNRTS SSGLPGSAAA SPEAGGGLLR EGGGGSRERA DWRRRQLRQV RSVELEPPLF 60

PASPPPSSAS PSPEPGEPVP PVTAGGGFQP SAPSPPPPPV PLARGACQPP EPPPPPDSGA 120

SSCPAGAEPG DRRAAPSEPQ PAGAGAPASR DMENKETLKG LQKMDDRPEE RMIREKLKAT 180

CMPAWKHEWL ERRSRRGPVV VKPIPVKGDG SEISKLTPES QTEGHNNTSS PTPKGRRSPS 240

PSSSSSSNRA VKSESPGVRR KRVSPVPFQS GRITPPRRAP SPDGFSPYSP EETNRRVNKV 300

MRARLYLLQQ IGPNSFLIGG DSPDNKYRVF IGPQTCSCGR GTFCIHLLFV MLRVFQLEPS 360

DPMLWRKTLK NFEVESLFQK YHSRRSSRIK APSRSTIQKF VSRMSNSHTL SSSSTSTSSS 420

ENSMKDEEEQ MCPICLLGML DEESLTVCED GCRNKLHHHC MSIWAEECRR NREPLICPLC 480

RSKWRSHDFY SHELPSPVDS SSVLRATQQQ TVQQQSSIGS QRRNQDSNFN LTHYGVQQIP 540

PAYKDLAEPW IQVFGMELVG CLFSRNWNIR EMALRRLSHD VSGALLLANG ESTGNSGSNN 600

GNNPSAGAAS GSSQPGISGD IVVEACCSVL SMVCADPVYK VYVAALKTLR AMLVYTPCHS 660

LAERIKLQKL LRPVVETILV KCADANSRTS QLSVSTLLEL CKGQAGELAV GREILKSGSI 720

GIGGIDYVLN CILGSQMESS NWQALLGRLC LIDRMLLEFP AEFYPHIVSG EVLQADAVVD 780

RYKKLLSLLN FALQFIDNSH SMVGKLSRRV FLSAARMVAR VPHVFLKLLE MLSVTSSTHY 840

TRMRRRLMAI ADEMEIAEAI QLGLEDCLDC RQDNFLQPSA PDNTPETTEN NSPEHTVQLE 900

KTGKPLCDAK SNASPEDVSD TLADMSVGLP NSVTTEQPKP ALQTKGRPHS QCLNSSSSNH 960

SQLLFPTLPS PPSSTPSVPA GSVTDVSKHK TQGFVPCKVP TPSPQMQRKF SLQILRNCSE 1020

IKESDKLSPV FTQARPLPSS HIHRPKPSRP SPGDLNKQEV SKNSMTLDLN AISQGDGGSG 1080

GGSAVIPSEE TVFTPVDEKC RLDVNTELNS SIEDLLEAMP TSDTTVTFKS EVAVLSPERA 1140

ENDDTYKDDV NHNQKCKEKM EAEEEEALSI AMAMSASQDA LPIVPQLQVE NGEDIIIIQQ 1200

DTPETLPGHT KAKHHYREDA EWLKGQQIGL GAFSSCYQAQ DVGTGTLMAV KQVTYVRNTS 1260

SEQEEVVEAL REEIRMMSHL NHPNIIRMLG ATCEKSNYNL FIEWMAGGSV AHLLSKYGAF 1320

KESVVINYTE QLLRGLSYLH ENQIIHRDVK GANLLIDSTG QRLRIADFGA AARLASKGTG 1380

AGEFQGQLLG TIAFMAPEVL RGQQYGRSCD VWSVGCAIIE MTCAKPPWNA EKHSNHLALI 1440

FKIASATTAP SIPSHLSPGL RDVTLRCLEL QPQDRPPSRE LLKHPVFRTT W 1491

Nucleotide Sequence
(FASTA)

ATGGCGGCGG CGGCGGGGAA TCGCACCTCG TCGTCAGGAT TACCGGGCTC CGCGGCGGCC 60

AGCCCTGAAG CCGGCGGCGG GCTCCTGCGG GAGGGGGGCG GCGGGAGCCG CGAGCGGGCA 120

GACTGGCGGC GGAGGCAGCT GCGCCAAGTG CGGAGCGTGG AGCTGGAGCC GCCGCTCTTC 180

CCCGCCTCCC CGCCACCCTC CTCGGCGTCC CCCTCCCCGG AGCCCGGAGA GCCTGTGCCG 240

CCGGTCACCG CGGGGGGCGG CTTCCAGCCC TCAGCTCCCT CGCCCCCGCC GCCCCCCGTT 300

CCCCTGGCCC GCGGTGCCTG CCAGCCTCCG GAGCCGCCGC CACCGCCGGA CAGCGGCGCC 360

TCTAGCTGCC CGGCGGGAGC CGAGCCCGGA GACCGGAGGG CGGCCCCGAG CGAGCCGCAG 420

CCTGCAGGCG CCGGTGCCCC TGCGAGTCGA GATATGGAGA ATAAAGAAAC TCTCAAAGGA 480

TTGCAGAAAA TGGATGACCG CCCAGAAGAA CGAATGATCA GGGAGAAGCT CAAGGCAACA 540

TGTATGCCAG CCTGGAAACA TGAATGGCTA GAGAGGAGAA GCAGGAGAGG CCCTGTGGTG 600

GTTAAACCAA TTCCTGTCAA AGGAGATGGA TCTGAAATCA GCAAATTAAC ACCAGAATCT 660

CAAACTGAAG GACATAACAA TACTTCTTCC CCTACTCCAA AAGGAAGACG AAGTCCTTCT 720

CCTAGTAGCT CTTCATCTTC AAATCGTGCT GTTAAATCAG AATCTCCTGG AGTAAGAAGA 780

AAAAGAGTGT CTCCAGTGCC TTTTCAGAGT GGGAGAATCA CACCACCCCG AAGAGCTCCA 840

TCCCCTGATG GCTTCTCCCC GTATAGCCCT GAGGAAACAA ATCGCCGCGT CAACAAAGTC 900

ATGCGAGCCA GGTTATACTT ACTACAGCAG ATAGGACCGA ACTCTTTCCT AATTGGAGGA 960

GACAGCCCAG ACAATAAATA CAGGGTGTTT ATTGGACCTC AGACCTGCAG CTGTGGCCGT 1020

GGAACATTTT GTATCCATCT GTTATTTGTT ATGCTCCGAG TATTTCAACT AGAACCCTCA 1080

GATCCAATGT TATGGAGGAA AACTTTGAAA AATTTTGAGG TTGAGAGTTT GTTCCAGAAA 1140

TATCACAGTA GGCGTAGCTC AAGGATCAAA GCTCCATCTC GTAGCACCAT CCAGAAGTTT 1200

GTATCACGCA TGTCAAATTC TCATACATTG TCATCATCTA GTACTTCTAC ATCTAGTTCA 1260

GAAAACAGTA TGAAGGATGA AGAGGAGCAG ATGTGCCCCA TTTGTTTGTT AGGAATGCTT 1320

GATGAAGAGA GTCTTACAGT ATGTGAAGAT GGCTGTAGGA ACAAGTTGCA CCACCACTGC 1380

ATGTCAATTT GGGCAGAAGA ATGTAGAAGA AACAGAGAGC CTCTGATATG CCCTCTTTGT 1440

AGATCTAAGT GGAGATCCCA TGATTTTTAC AGCCACGAAT TGCCAAGTCC CGTGGATTCC 1500

TCTTCTGTGC TCCGAGCTAC ACAGCAGCAA ACTGTACAGC AGCAGTCTTC TATTGGATCA 1560

CAAAGAAGAA ATCAGGATAG TAATTTTAAC CTGACTCATT ATGGAGTTCA GCAGATCCCT 1620

CCTGCCTATA AAGACTTAGC TGAGCCATGG ATTCAGGTAT TTGGAATGGA GCTGGTGGGC 1680

TGCTTATTTT CTCGAAACTG GAATATAAGA GAGATGGCCC TCAGGCGTCT TTCCCATGAT 1740

GTTAGTGGTG CTCTGCTGTT GGCTAATGGG GAAAGCACTG GAAATTCTGG GAGCAACAAT 1800

GGAAACAACC CAAGCGCTGG AGCAGCTAGT GGGTCATCTC AGCCTGGTAT CTCAGGAGAC 1860

ATTGTTGTTG AAGCTTGCTG CAGCGTTCTG TCAATGGTTT GTGCTGACCC TGTCTACAAA 1920

GTCTATGTTG CTGCTTTAAA AACATTAAGA GCCATGTTGG TGTATACTCC TTGCCATAGT 1980

TTGGCCGAAA GAATAAAACT GCAAAAACTT CTGAGGCCAG TAGTAGAAAC TATATTAGTC 2040

AAATGTGCAG ATGCCAATAG CCGTACAAGT CAGCTTTCAG TTTCAACACT TTTAGAATTG 2100

TGCAAGGGCC AAGCAGGAGA ACTGGCAGTT GGCAGAGAAA TACTTAAATC TGGATCTATT 2160

GGTATTGGTG GTATTGATTA TGTTTTAAAT TGCATTCTTG GAAGCCAAAT GGAATCAAGT 2220

AACTGGCAGG CTCTGTTGGG GCGCCTTTGT CTTATTGACA GAATGTTGTT GGAATTTCCT 2280

GCAGAATTTT ATCCCCATAT TGTCAGTGGA GAAGTTTTGC AAGCTGATGC TGTAGTAGAC 2340

AGGTATAAGA AGCTGCTGTC CCTCTTGAAC TTTGCTTTGC AATTCATTGA TAATTCCCAC 2400

TCAATGGTTG GTAAATTGTC CCGAAGGGTG TTTTTGAGTG CTGCAAGAAT GGTTGCCAGA 2460

GTACCCCATG TGTTTTTGAA ACTTTTGGAA ATGTTGAGTG TTACAAGCTC CACTCATTAT 2520

ACAAGGATGC GTCGTCGTTT GATGGCTATT GCCGATGAAA TGGAAATTGC CGAAGCCATC 2580

CAGCTGGGCC TAGAAGACTG TTTGGATTGC AGACAGGATA ACTTTTTGCA GCCATCTGCC 2640

CCAGATAACA CCCCAGAAAC AACTGAAAAT AATTCTCCTG AACACACAGT CCAGTTAGAG 2700

AAAACTGGAA AGCCTTTATG TGATGCAAAA TCAAATGCCA GTCCAGAAGA TGTTTCTGAT 2760

ACGTTGGCTG ACATGTCTGT AGGACTTCCT AATTCAGTAA CAACAGAGCA ACCAAAGCCA 2820

GCCCTGCAGA CAAAAGGCAG ACCCCATAGT CAGTGTTTGA ACTCTTCTTC ATCCAATCAT 2880

TCCCAGTTAT TGTTCCCAAC TTTGCCCTCT CCTCCCTCTT CTACCCCATC TGTGCCAGCT 2940

GGCTCTGTAA CAGATGTCTC TAAACACAAA ACTCAGGGTT TTGTTCCCTG CAAAGTACCC 3000

ACACCTTCTC CACAAATGCA ACGGAAATTT TCTCTACAGA TACTTAGAAA CTGTTCTGAA 3060

ATCAAAGAAT CCGATAAACT TTCCCCAGTT TTTACACAGG CAAGGCCTCT GCCTTCCAGT 3120

CACATACACA GGCCAAAGCC ATCTCGACCC AGTCCAGGAG ATTTGAACAA GCAAGAAGTC 3180

TCAAAAAATA GTATGACGCT CGATCTGAAT GCCATCTCAC AGGGTGATGG CGGCAGTGGC 3240

GGCGGCAGCG CTGTCATCCC AAGTGAAGAG ACGGTCTTCA CACCAGTAGA TGAGAAATGC 3300

CGATTAGATG TCAATACCGA ACTCAACTCC AGCATCGAGG ACTTGCTTGA GGCTATGCCG 3360

ACTAGTGACA CGACGGTAAC TTTTAAGTCC GAAGTTGCAG TCCTTTCTCC TGAAAGGGCT 3420

GAAAATGATG ACACCTATAA AGATGACGTA AATCATAATC AGAAGTGCAA AGAAAAGATG 3480

GAAGCCGAAG AAGAGGAAGC ATTGTCCATT GCCATGGCAA TGTCTGCATC ACAGGATGCC 3540

CTGCCAATAG TTCCTCAACT ACAAGTTGAA AATGGAGAAG ACATAATCAT TATTCAGCAA 3600

GATACACCAG AGACTCTGCC AGGACATACC AAAGCAAAAC ACCATTATAG AGAAGATGCC 3660

GAGTGGCTCA AAGGTCAACA GATAGGCCTT GGGGCATTTT CTTCTTGCTA TCAAGCTCAA 3720

GATGTAGGAA CTGGAACTTT AATGGCTGTG AAACAGGTGA CTTATGTCAG AAACACATCT 3780

TCTGAGCAAG AGGAGGTAGT TGAAGCACTG AGAGAAGAGA TAAGGATGAT GAGTCACCTA 3840

AACCATCCTA ATATCATCAG AATGTTGGGT GCCACATGTG AGAAGAGCAA TTACAATCTT 3900

TTCATAGAAT GGATGGCAGG AGGGTCCGTT GCTCATTTGC TAAGTAAATA TGGAGCTTTC 3960

AAGGAATCGG TGGTAATTAA CTACACAGAG CAATTGCTTC GTGGTCTTTC TTACCTCCAT 4020

GAAAATCAGA TTATTCACAG AGATGTCAAA GGTGCCAATT TGCTAATTGA CAGCACAGGA 4080

CAGAGACTGA GAATTGCTGA CTTTGGAGCT GCTGCTAGAT TGGCATCAAA AGGAACCGGC 4140

GCTGGAGAAT TTCAAGGACA GTTGTTGGGA ACAATTGCAT TTATGGCACC AGAGGTACTA 4200

AGAGGGCAGC AGTATGGGAG GAGCTGTGAC GTGTGGAGTG TCGGCTGCGC TATCATAGAA 4260

ATGACTTGTG CCAAGCCCCC GTGGAATGCC GAGAAACACT CGAATCATCT CGCGCTGATA 4320

TTCAAGATTG CTAGTGCGAC TACTGCTCCT TCAATCCCCT CACATCTGTC TCCTGGCTTA 4380

CGAGATGTGA CTCTTCGATG TTTAGAACTT CAACCTCAGG ACAGACCTCC TTCGAGGGAG 4440

CTACTGAAGC ATCCAGTCTT CCGTACTACC TGGTAG 4476

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1222  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1281

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1282  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1341

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1342  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1401

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem ++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1402  GQ--QYGRSCDVWSVGCAIIEMTCAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1459

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1460  LRDVTLRCLELQPQDRPPSRELLKHPV  1486

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM TCAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVTLRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013