EKS-MOD-00480

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00480

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	403.8	2.5E-121	18	273	256

Status

Unreviewed

Ensembl Protein

ENSMODP00000025787

UniProt Accession

F6ZB23;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000020615	ENSMODP00000025787	ENSMODT00000026248

Organism

Monodelphis domestica

Functional Description

Protein Length

835

Protein Sequence
(FASTA)

MFPLKDAEIG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60

RGKHERLVVV AEHCERSLEE LLRERKPVSP LKVLCIAFEV LQGLQYMNQH GMVHRALSPH 120

NILLDQEEHI KLAKFGLYHM TAHGIDVDFP IGYPSYLAPE VIAQGIIKPS DHTPSEKPLP 180

SGPKSDVWSL GIILFELCMG RKLFQGLDIS ERLKFLLTLG CMDDTVTVLA EEHGCLDIIK 240

ELPENVIDLL KKCLTFHPSK RPTPNDLLQD KVFSEVSPLY TPFHKPASLF SSSLRCADLT 300

LPEDISQLCK DADSDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PICTLPNFLF 360

EDGESFGQDR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL 420

SAAVTLPLII RERDTEYQLN RIVLFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 480

GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPPKQA 720

TDTNGVRNSA PYFSIDSQDA PKTDLSRESI QLNDLKSEVS PRISAEDLID LCELTGPGHF 780

KTPTKKTKSS KPKLLVVDIR NTEEYPLILI KDLKERRADF TNVTSFLLVF MHSVH 835

Nucleotide Sequence
(FASTA)

ATGTTTCCTT TGAAGGATGC AGAAATAGGT GCTTTTACCT TCTTTGCCTC TGCTCTGCCA 60

CATGATGTTT GTGGAAGCAA TGGACTTCCT CTGACCCCTA ATTCCATAAA AATCCTGGGA 120

CGCTTTCAAA TCCTCAAGAC CATCACCCAT CCTAGACTTT GCCAATATGT GGACATTTCA 180

AGGGGGAAAC ATGAGAGACT GGTGGTGGTA GCAGAACACT GCGAAAGGAG CCTGGAAGAA 240

TTACTTCGAG AAAGGAAACC TGTGAGCCCT CTGAAAGTGT TATGCATTGC ATTCGAGGTC 300

CTACAAGGGT TGCAGTATAT GAATCAGCAT GGCATGGTCC ACCGAGCTCT GTCTCCTCAC 360

AACATTCTCT TGGATCAAGA GGAGCATATT AAATTGGCTA AGTTTGGACT TTACCACATG 420

ACAGCTCATG GCATTGATGT TGATTTCCCA ATCGGGTACC CATCCTACCT GGCACCTGAG 480

GTCATTGCAC AAGGAATCAT CAAGCCCAGT GACCACACAC CAAGTGAAAA ACCATTGCCT 540

TCTGGCCCCA AATCTGATGT ATGGTCTCTT GGAATTATTT TATTTGAACT TTGTATGGGA 600

AGAAAGTTAT TCCAGGGCCT GGATATTTCT GAAAGGCTAA AGTTTTTGCT TACATTAGGT 660

TGCATGGATG ATACTGTAAC AGTCTTGGCT GAGGAACATG GTTGTCTGGA CATTATAAAG 720

GAGCTTCCTG AAAATGTGAT AGATCTCTTG AAGAAGTGCC TCACTTTCCA CCCTTCTAAG 780

AGGCCAACTC CAAATGATTT ACTCCAGGAT AAGGTGTTCA GTGAAGTGTC ACCTTTATAT 840

ACACCCTTCC ACAAACCTGC CAGTCTGTTC TCATCTTCTC TGAGATGTGC TGATTTAACT 900

CTGCCTGAGG ACATCAGTCA ACTGTGTAAA GATGCTGACA GTGATTACCT AGCAGAAAGA 960

TCAATTGAAG AAGTTTATTA CCTCTGGTGT TTGGCTGGAG GAGATTTGGA GAAAGAGCTT 1020

GTCAACAAGG AAATCATTCG ATCCAAACCA CCTATCTGCA CACTTCCCAA TTTTCTGTTT 1080

GAGGATGGTG AGAGCTTTGG GCAAGATCGT GATAGAAGTT CTCTTTTAGA TGACACCACT 1140

GTGACACTGT CTCTGTGCCA ATTAAGAAAT AGATTAAAAG ACGTTGGTGG AGAAGCATTT 1200

TACCCCTTAC TTGAAGATGA CCAGTCCAAT TTGCCTCATT CAAACAGTAA TAACGAGTTG 1260

TCAGCAGCTG TCACTCTTCC TTTGATCATC CGAGAGAGGG ACACAGAGTA CCAGCTCAAC 1320

AGAATTGTTC TCTTCGACAG GCTCCTGAAG GCTTACCCAT ACAAAAAAAA CCAAATCTGG 1380

AAAGAAGCCA GAGTTGACAT TCCTCCACTC ATGAGAGGTT TAACCTGGGC TGCCCTCCTG 1440

GGAGTTGAGG GTGCCATTCA TGCCAAGTAT GATGCCATTG ATAAAGATAC TCCAATTCCT 1500

ACTGATCGAC AAATTGAAGT GGATATTCCA CGCTGCCATC AGTATGATGA GTTGCTATCA 1560

TCTCCTGAAG GTCATGCAAA GTTTAGACGG GTATTAAAGG CCTGGGTGGT TTCCCATCCA 1620

GACCTTGTAT ACTGGCAAGG CCTTGATTCG CTCTGTGCTC CTTTCCTGTA TTTAAACTTC 1680

AACAACGAAG CTCTTGCTTA TGCTTGTATG TCAGCTTTTA TTCCAAAATA CCTATATAAC 1740

TTCTTTTTGA AAGACAACTC ACATGTCATA CAAGAATATC TGACAGTGTT CTCTCAGATG 1800

ATTGCATTCC ATGACCCAGA GTTGAGTAAC CATCTCAACG AGATTGGCTT TATTCCAGAT 1860

CTCTATGCCA TTCCTTGGTT CCTTACCATG TTTACACATG TATTTCCCTT ACACAAGATC 1920

TTTCATCTCT GGGATACATT ACTGCTTGGG AATTCTTCCT TTCCATTCTG TATTGGAGTG 1980

GCCATTCTCC AGCAACTACG AGACCGGCTT TTAGCGAATG GCTTCAATGA GTGCATTCTG 2040

CTCTTCTCTG ACTTACCAGA AATCGACATC GAACGTTGTG TCCGTGAATC AATCAACTTA 2100

TTTTGCTGGA CCCCTAAGAG TGCTACTTAC AGACAACACG CCCAGCCCCC CAAACAAGCC 2160

ACAGACACCA ATGGAGTGAG AAATTCAGCA CCTTATTTTT CAATTGATTC TCAGGATGCT 2220

CCCAAGACAG ACCTGTCCAG AGAATCTATC CAGCTGAATG ACCTGAAGTC AGAGGTATCG 2280

CCACGGATTT CGGCAGAGGA TCTGATTGAC CTGTGTGAAC TGACCGGCCC GGGACATTTC 2340

AAAACACCCA CCAAGAAAAC CAAATCCAGT AAACCCAAGC TGCTGGTGGT TGATATACGG 2400

AACACTGAAG AGTATCCTTT AATCTTGATC AAGGACTTAA AAGAGAGGAG AGCCGATTTC 2460

ACAAATGTGA CTTCCTTTCT GTTGGTCTTT ATGCATTCTG TTCACTGA 2508

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher++vvaeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         Le+ll+erkpvs  +vl+ia+evl+gl+y+n+h++vhral+p++illd++++ +kLak+G

Q: 78    LEELLRERKPVSPLKVLCIAFEVLQGLQYMNQHGMVHRALSPHNILLDQEEH-IKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G dvdfpigy+sylaPe+i+q+         ++k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGIDVDFPIGYPSYLAPEVIAQGiikpsdhtpSEKPLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf+ ld+serlk+ll+l++ d+t+ +laee++cldiik+l+e++++llkkCLt+

Q: 197   LCMGRKLFQGLDISERLKFLLTLGCMDDTVTVLAEEHGCLDIIKELPENVIDLLKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +pskRp+p++ll++kvf

Q: 257   HPSKRPTPNDLLQDKVF  273

         ***************98

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYV DISRGKHERL VVVAEHCERS 60

LEELLRERKP VSPLKVLCIA FEVLQGLQYM NQHGMVHRAL SPHNILLDQE EHIKLAKFGL 120

YHMTAHGIDV DFPIGYPSYL APEVIAQGII KPSDHTPSEK PLPSGPKSDV WSLGIILFEL 180

CMGRKLFQGL DISERLKFLL TLGCMDDTVT VLAEEHGCLD IIKELPENVI DLLKKCLTFH 240

PSKRPTPNDL LQDKVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

mdo:100011350

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013