EKS-MOD-00390
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00390
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR607.96.9E-183591948358
StatusUnreviewed
Ensembl ProteinENSMODP00000025859
UniProt AccessionF7E5I9;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000020670ENSMODP00000025859ENSMODT00000026321
OrganismMonodelphis domestica
Functional Description
Protein Length1085
Protein Sequence
(FASTA)
MGTSPWALLV LGCLLTGPWL AFCQLPLPTV FPNEDEKVVQ LHSSFTLRCS GDSEVSWQYP 60
MQDEEDHKIE VRNEENNSGL FVTVLEVVNA SAVHTGLYTC YYNHTQTEET EIEGRDIYIY 120
VPDPDVAFVP SVMVDHLIFA EEHDSVTIPC RTTDPLAQVT LLNSDNKVVH AFYDSRQGFI 180
GNFAMGQFKC ETTIKGKTFQ TVPFNIYTIT ATPELEVEIE AEKTVYKTGE TLVVTCAVLH 240
NEVVDLQWNY PGKVKNKGIL KVDEIKVPSL KLVYTLTVPK VTVKDSGDYE CAARHATKET 300
KKIKKVTISV HEKGFIELNP NFRQSEAINL HEVRHFVVDV QAYPPPKISW LKDNMTVIEN 360
LTEIITGLDK IQEIRYQSKL KLIRAKEEDS GNYTIMAQNE DDIKNYTFQL IIQVPASILD 420
LEDDNHGSAG GQTVKCMAEG TPLPVVEWMV CKDITKCNNE TSWTHLASNT SDITEKQDSS 480
MVESQVTFNK IEDTMAVRCL ARNLLGSVTR ELKLVAPAMR SELTVAASVL VLLVIVIFSL 540
IILIVIWKQK PRYEIRWRVI ESISPDGHEY IYVDPMQLPY DSRWEFPRDG LVLGRILGSG 600
AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG PHLNIVNLLG 660
ACTKSGPIYI ITEYCFYGDL VNYLHKNRDN FLSHHPEKTK KELDIFGMNS ADESTRSYVI 720
LSFENNGDYM DMKQADTTQY VPMLERKQGS KYSDIQRSMY DRPASYKKKS VSDPEVKNLL 780
SDDSSEGLSL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV KICDFGLARD 840
IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG GTPYPGMMVD 900
STFYNKIKSG YRMAKPDHAT SEVYEIMVKC WNSEPEKRPS FYHLSEIVEN LLPGQYKKSY 960
EKIHLDFLKS DHPAVARMRV DCDNTYIGVT YKNEDQMKDW EGSYDEQRLS ADSGYIIPLP 1020
DIDPIPEDDL GKRNRHSSQT SEESAIETGS SSSTFIKRED ETIEDIDMMD DIGIDPSDLI 1080
EDSFL 1085
Nucleotide Sequence
(FASTA)
ATGGGTACCT CCCCATGGGC ATTGCTGGTC CTGGGATGTC TTCTTACAGG GCCGTGGCTC 60
GCATTTTGCC AGCTTCCATT ACCCACTGTC TTTCCGAATG AGGATGAAAA GGTTGTGCAG 120
CTGCATTCAT CTTTTACCCT AAGATGCTCT GGGGACAGTG AAGTGAGCTG GCAGTACCCC 180
ATGCAGGATG AAGAGGACCA CAAAATAGAA GTCAGAAATG AGGAGAACAA CAGTGGCCTT 240
TTTGTGACGG TCCTGGAAGT GGTCAATGCC TCAGCTGTCC ACACAGGGCT GTACACTTGT 300
TATTACAACC ATACTCAGAC AGAGGAGACG GAGATCGAAG GCAGAGATAT CTACATCTAT 360
GTGCCAGATC CAGATGTAGC GTTTGTACCT TCTGTCATGG TTGATCATTT AATTTTTGCG 420
GAGGAACATG ATTCTGTCAC TATTCCATGT CGCACAACGG ATCCTCTGGC TCAGGTGACC 480
CTTCTCAACA GTGATAACAA AGTGGTACAT GCATTCTATG ATAGCAGACA AGGCTTTATT 540
GGAAACTTTG CCATGGGACA ATTCAAGTGT GAGACAACCA TCAAGGGGAA AACATTCCAA 600
ACAGTTCCAT TCAACATTTA TACAATAACA GCTACTCCAG AGCTTGAAGT TGAGATAGAG 660
GCAGAGAAAA CTGTTTACAA AACAGGAGAA ACTCTTGTTG TAACTTGTGC TGTCTTGCAC 720
AATGAGGTGG TTGATCTTCA GTGGAATTAC CCGGGAAAAG TGAAAAACAA AGGCATTTTG 780
AAAGTTGATG AAATCAAAGT TCCATCCCTC AAGTTGGTGT ACACGCTGAC TGTCCCAAAG 840
GTGACGGTGA AAGACAGTGG TGACTATGAA TGTGCTGCCC GTCATGCTAC TAAGGAAACA 900
AAGAAGATTA AGAAAGTCAC CATTTCTGTC CATGAGAAGG GATTTATTGA GCTCAATCCC 960
AACTTCCGCC AGTCAGAAGC CATTAACTTG CACGAAGTGC GCCATTTTGT AGTGGATGTA 1020
CAGGCGTATC CACCACCAAA GATATCTTGG CTTAAGGACA ATATGACTGT GATTGAGAAT 1080
CTCACTGAGA TCATCACTGG CTTAGATAAG ATCCAGGAAA TAAGGTATCA AAGCAAGTTA 1140
AAACTGATTC GTGCTAAGGA AGAAGACAGT GGCAATTACA CTATTATGGC CCAAAATGAG 1200
GATGATATTA AGAACTATAC TTTTCAACTT ATAATTCAAG TTCCAGCTTC TATTCTGGAC 1260
CTAGAAGATG ACAACCATGG CTCTGCAGGA GGGCAGACGG TCAAATGCAT GGCAGAAGGG 1320
ACACCGCTTC CAGTTGTGGA ATGGATGGTT TGCAAGGACA TTACAAAGTG TAATAATGAA 1380
ACTTCGTGGA CACATTTGGC CAGCAATACA TCCGACATTA CAGAAAAACA AGACAGCAGT 1440
ATGGTAGAGA GCCAAGTGAC CTTCAACAAA ATTGAAGACA CTATGGCTGT ACGATGCCTA 1500
GCAAGGAACT TACTTGGGTC GGTGACTCGG GAACTGAAAC TTGTGGCTCC TGCTATGCGC 1560
TCAGAATTGA CAGTGGCTGC CTCAGTCCTA GTGCTGCTAG TGATTGTCAT CTTTTCCCTC 1620
ATTATCCTGA TCGTCATATG GAAGCAGAAA CCCAGGTATG AAATCCGGTG GAGGGTCATA 1680
GAGTCCATCA GCCCTGATGG CCATGAGTAC ATTTATGTGG ACCCAATGCA GTTGCCTTAT 1740
GATTCAAGAT GGGAGTTTCC TAGAGATGGG TTAGTCCTTG GCCGAATCCT GGGCTCAGGT 1800
GCATTTGGAA AAGTGGTGGA AGGAACTGCT TATGGATTAA GCCGTTCCCA ACCTGTGATG 1860
AAGGTGGCGG TGAAAATGCT AAAACCCACA GCTAGATCTA GTGAAAAACA GGCTCTCATG 1920
TCAGAACTGA AGATTATGAC TCATCTGGGA CCCCATTTGA ATATCGTAAA TCTTTTAGGA 1980
GCCTGTACCA AGTCAGGGCC CATTTATATC ATCACTGAAT ACTGCTTCTA TGGGGATTTA 2040
GTCAACTACC TGCATAAGAA CAGAGACAAC TTCTTGAGCC ATCATCCAGA GAAGACAAAG 2100
AAAGAGCTGG ACATCTTTGG GATGAACTCC GCTGATGAAA GCACTAGGAG CTATGTCATT 2160
TTATCCTTTG AAAACAATGG GGATTATATG GACATGAAGC AAGCGGATAC CACACAATAC 2220
GTTCCCATGC TGGAGAGAAA ACAGGGCTCT AAATATTCAG ATATCCAAAG ATCGATGTAT 2280
GATCGGCCTG CATCATACAA GAAGAAATCT GTATCAGACC CAGAAGTTAA AAACCTCCTT 2340
TCAGATGATA GTTCAGAAGG TCTCAGTCTC TTGGATCTGC TAAGCTTCAC CTATCAAGTA 2400
GCCCGAGGAA TGGAGTTTTT GGCCTCTAAA AACTGTGTGC ACCGTGATCT GGCTGCTCGT 2460
AATGTCCTTC TGGCTCAAGG AAAAATCGTG AAGATTTGTG ACTTTGGCCT GGCCAGAGAC 2520
ATCATGCATG ATTCCAACTA TGTGTCCAAG GGCAGTACTT TTCTCCCTGT GAAGTGGATG 2580
GCTCCTGAAA GTATCTTTGA CAATCTGTAT ACCACACTGA GTGACGTCTG GTCTTATGGC 2640
ATCCTGCTAT GGGAGATCTT TTCCCTTGGA GGCACACCCT ATCCTGGAAT GATGGTGGAT 2700
TCTACTTTCT ATAATAAAAT CAAAAGTGGA TACCGGATGG CCAAACCCGA CCATGCCACC 2760
AGTGAAGTAT ATGAAATCAT GGTGAAGTGC TGGAATAGTG AGCCCGAGAA GAGACCCTCC 2820
TTTTACCACC TGAGTGAGAT TGTGGAAAAT TTGCTACCTG GACAATATAA GAAGAGTTAT 2880
GAGAAAATCC ACCTGGACTT CCTGAAGAGT GACCACCCTG CCGTTGCTCG CATGAGAGTG 2940
GATTGTGATA ACACTTACAT TGGTGTCACC TACAAAAATG AAGACCAGAT GAAGGACTGG 3000
GAGGGCAGCT ATGATGAACA GAGGCTGAGT GCTGACAGTG GCTATATCAT CCCTCTGCCT 3060
GACATTGACC CTATCCCTGA AGATGACCTA GGCAAGAGAA ACAGACACAG TTCCCAGACA 3120
TCTGAGGAAA GTGCCATTGA GACAGGTTCC AGCAGCTCCA CCTTCATCAA GAGAGAGGAT 3180
GAAACCATCG AGGATATCGA CATGATGGAT GACATTGGGA TAGACCCGTC AGACCTGATT 3240
GAAGACAGCT TCCTGTAA 3258
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 591   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  650
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r++fl+++ ek   +++eld+++
Q: 651   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDNFLSHHPEK---TKKELDIFG  707
         **********************************************99...567777888
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         +  ad+s+rs+++ls+e++++y+d+k++                +sd+++s +d++as+k
Q: 708   MnSADESTRSYVILSFENNGDYMDMKQAdttqyvpmlerkqgskYSDIQRSMYDRPASYK  767
         7789***********************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+ + evk+ l+++ se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 768   KKSVSDPEVKNLLSDDSSEGLSLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  827
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 828   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  887
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim+kcw++epekrpsf++l+e+
Q: 888   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEI  947
         *********************************************************998
S: 344   l  344
         +
Q: 948   V  948
         6
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDN FLSHHPEKTK KELDIFGMNS 120
ADESTRSYVI LSFENNGDYM DMKQADTTQY VPMLERKQGS KYSDIQRSMY DRPASYKKKS 180
VSDPEVKNLL SDDSSEGLSL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYEIMVKC WNSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-DAR-00792
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0030325; P:adrenal gland development
GO:0055003; P:cardiac myofibril assembly
GO:0060326; P:cell chemotaxis
GO:0071230; P:cellular response to amino acid stimulus
GO:0007204; P:elevation of cytosolic calcium ion concentration
GO:0048701; P:embryonic cranial skeleton morphogenesis
GO:0048557; P:embryonic digestive tract morphogenesis
GO:0008210; P:estrogen metabolic process
GO:0030198; P:extracellular matrix organization
GO:0060325; P:face morphogenesis
GO:0001701; P:in utero embryonic development
GO:0033327; P:Leydig cell differentiation
GO:0030324; P:lung development
GO:0001553; P:luteinization
GO:0030539; P:male genitalia development
GO:0072277; P:metanephric glomerular capillary formation
GO:0010544; P:negative regulation of platelet activation
GO:0042475; P:odontogenesis of dentin-containing tooth
GO:0060021; P:palate development
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0070527; P:platelet aggregation
GO:0035790; P:platelet-derived growth factor receptor-alpha signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0045740; P:positive regulation of DNA replication
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0050920; P:regulation of chemotaxis
GO:2000739; P:regulation of mesenchymal stem cell differentiation
GO:0061298; P:retina vasculature development in camera-type eye
GO:0023019; P:signal transduction involved in regulation of gene expression
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
mdo:100013088;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013