EKS-MOD-00391
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00391
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR574.21.1E-172582916335
StatusUnreviewed
Ensembl ProteinENSMODP00000035939
UniProt AccessionF7A906;
Protein Name
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000020671ENSMODP00000035939ENSMODT00000037528
OrganismMonodelphis domestica
Functional Description
Protein Length967
Protein Sequence
(FASTA)
MTVARGAGDL LYLLILLSFQ TGYLQPTSSP ADSSPSIIPA VSQLIVSSGS EIKLSCFDHG 60
SVKWTFENAL QFELSRNTET WLTTSANAHD TGKYTCTNKE GLSTSIYVFV KDPQNLFLLD 120
PLLYGKEGSD AFVKCSVTDP EVSNFTLKLC NGKPLPKDLT LIPDIQKGIT IKNVKRTHNK 180
ICFQCAAYLD GQWRLSERVT LKVRPAPQSV PEVRLPKANY LLREGETFEV VCTIKDVASS 240
VQSMWIKDNN KIDTQTQSWH SGDYIYERQE VLKIKSARVN DSGIFMCFAN NTFGPANVTA 300
TLEVVEKGFI NIFPMMNTTI FINDGENIDL VVEYEAFPKP EKLEWIYMNE TVTDKWDDYT 360
KPESESNIRY ISELHLNRLK GTEGGPYIFS VSNSDVNASV TFNVYVKTKP EILTSDRLMN 420
GLLQCVAAGF PKPTIDWYFC PGTEQRCSTS VLPVDVKINS SMLSPFGKIV IESTIDSSAF 480
KNNGTVECKA SNDVGKSSAF FNFAIKEQIT PHTLFTPLLI GFVIAAGLMC IVVIILTYKY 540
FQKPMYEVQW KVVEEINGNN YVYIDPTQLP YDHKWEFPRN RLSFGKTLGA GAFGKVVEAT 600
AYGLFKSDAA MTVAVKMLKP SAHLTEREAL MSELKVLSYL GNHMNIVNLL GACTIGGPPL 660
VITKNCCHGD LLNFLRKKRD SFFCSKHEDH AETTLYKNLL QSKDSSCDGA NEYMDMKPGV 720
SYVVPTKADK RRSARIGSYI ERDVTTAIMD DDELALDIED LLSFSYQVAK GMSFLASKNC 780
IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN ARLPVKWMAP ESIFNCVYTF 840
ESDVWSYGIF LWELFSLGSS PYPGMPVDSK FYKMIKEGFR MLSPECAPPE MYDIMKSCWN 900
ADPLQRPTFK QIVQLIEQQL LDSTNHVYSN ITTSSPNQES PVDHSVRINS VGSSASSTQP 960
LLVHEDA 967
Nucleotide Sequence
(FASTA)
ATGACCGTGG CTCGTGGCGC CGGGGATCTT CTCTATCTTC TGATCCTGCT AAGCTTCCAG 60
ACAGGTTATC TTCAGCCCAC TAGTAGCCCA GCTGATTCTT CACCATCCAT CATTCCAGCC 120
GTATCACAAT TAATAGTGAG TTCTGGAAGT GAGATTAAGT TGTCATGCTT TGATCATGGC 180
TCGGTGAAGT GGACTTTTGA GAATGCTCTT CAGTTTGAAC TGAGCAGAAA TACAGAAACG 240
TGGCTCACAA CCAGTGCCAA TGCTCATGAT ACAGGCAAAT ATACGTGTAC CAACAAAGAA 300
GGCTTGAGCA CTTCCATTTA TGTCTTCGTT AAAGATCCCC AAAATCTCTT CCTTTTGGAT 360
CCTCTTCTTT ATGGGAAAGA AGGCAGTGAT GCTTTTGTGA AATGTTCTGT GACAGACCCA 420
GAAGTATCTA ATTTTACCTT GAAATTATGT AATGGAAAGC CGCTTCCCAA GGACCTGACA 480
CTTATTCCTG ACATCCAGAA AGGAATCACC ATCAAAAATG TGAAGAGAAC TCACAACAAG 540
ATCTGCTTCC AGTGTGCTGC CTACCTCGAT GGACAGTGGA GGCTGTCTGA AAGGGTGACC 600
CTGAAAGTGA GGCCAGCTCC CCAAAGTGTA CCTGAAGTCA GATTGCCCAA AGCGAACTAC 660
CTTCTCCGGG AGGGGGAGAC CTTTGAGGTC GTGTGCACGA TTAAAGATGT GGCTAGTTCA 720
GTGCAGTCCA TGTGGATAAA GGACAATAAT AAGATTGACA CCCAAACTCA AAGCTGGCAT 780
TCTGGTGATT ATATTTATGA ACGCCAAGAA GTATTGAAAA TCAAGTCGGC GAGAGTGAAT 840
GATTCCGGAA TCTTCATGTG TTTTGCCAAT AATACTTTTG GACCAGCAAA CGTCACAGCC 900
ACCTTAGAAG TAGTAGAAAA AGGATTCATA AACATTTTTC CCATGATGAA TACGACGATA 960
TTTATAAATG ATGGTGAAAA CATAGACTTA GTGGTCGAAT ATGAAGCATT TCCTAAACCT 1020
GAGAAGCTTG AGTGGATATA TATGAATGAA ACAGTAACTG ACAAGTGGGA TGATTATACC 1080
AAACCTGAAA GTGAGAGCAA TATCAGGTAT ATAAGTGAAC TTCACCTTAA CAGATTAAAG 1140
GGAACCGAAG GAGGCCCTTA TATCTTTTCA GTGTCTAATT CGGACGTCAA TGCCTCTGTA 1200
ACATTTAATG TTTATGTAAA AACAAAGCCA GAGATTCTTA CTTCTGACAG ACTCATGAAT 1260
GGTCTGCTCC AGTGTGTGGC AGCAGGATTT CCCAAACCTA CAATAGATTG GTATTTTTGT 1320
CCAGGAACTG AGCAGAGGTG TTCAACATCT GTTCTGCCAG TGGATGTGAA GATAAATTCA 1380
TCTATGCTAT CACCCTTTGG AAAAATAGTG ATTGAAAGCA CCATTGATTC CAGTGCCTTT 1440
AAAAACAATG GCACTGTTGA GTGTAAGGCT TCCAATGATG TTGGCAAGAG TTCAGCCTTT 1500
TTTAACTTTG CTATTAAAGA ACAAATCACC CCGCACACAC TATTCACACC TTTACTGATT 1560
GGCTTTGTGA TAGCAGCGGG ACTGATGTGC ATCGTCGTAA TAATTCTAAC CTACAAGTAT 1620
TTTCAGAAAC CCATGTACGA AGTTCAGTGG AAAGTCGTGG AAGAGATAAA TGGAAACAAC 1680
TATGTTTACA TAGACCCAAC ACAACTTCCT TATGATCATA AATGGGAGTT TCCCAGAAAC 1740
AGGCTGAGTT TTGGCAAAAC ACTTGGTGCA GGAGCTTTTG GGAAAGTGGT TGAGGCTACT 1800
GCCTATGGCT TGTTTAAATC GGATGCTGCA ATGACTGTCG CTGTGAAGAT GTTGAAACCA 1860
AGTGCCCATT TAACGGAACG AGAAGCTCTA ATGTCTGAAC TAAAGGTCCT GAGTTACCTC 1920
GGTAACCACA TGAATATAGT GAATCTTCTT GGAGCATGCA CTATTGGAGG ACCCCCATTG 1980
GTCATTACAA AAAATTGTTG CCATGGGGAT CTTTTGAATT TTTTGAGAAA AAAACGGGAT 2040
TCCTTTTTTT GCTCCAAGCA TGAAGATCAT GCAGAAACAA CGCTTTATAA GAACCTTCTG 2100
CAATCAAAGG ACTCTTCATG TGATGGTGCT AATGAATATA TGGACATGAA ACCAGGTGTT 2160
TCTTATGTTG TCCCAACCAA AGCTGACAAG AGGAGATCTG CAAGAATAGG GTCATACATA 2220
GAGAGAGATG TGACAACTGC CATCATGGAT GATGATGAAC TGGCTTTGGA CATCGAAGAC 2280
CTATTGAGCT TTTCTTACCA GGTTGCAAAG GGCATGAGTT TCCTTGCTTC TAAGAATTGT 2340
ATTCATAGAG ACTTGGCAGC CAGAAATATT CTACTTACTC ATGGTCGAAT AACAAAAATC 2400
TGTGATTTTG GCCTGGCCAG AGACATCAAG AATGACTCTA ATTATGTGGT CAAAGGAAAT 2460
GCCCGACTAC CTGTGAAATG GATGGCACCT GAAAGTATTT TCAACTGTGT TTACACTTTT 2520
GAAAGTGACG TCTGGTCCTA TGGCATCTTT CTGTGGGAGC TCTTCTCTTT AGGAAGTAGT 2580
CCATACCCTG GAATGCCTGT TGATTCCAAG TTCTACAAGA TGATTAAAGA AGGCTTCCGA 2640
ATGCTCAGTC CGGAATGCGC ACCTCCTGAA ATGTATGACA TCATGAAGAG CTGCTGGAAC 2700
GCGGATCCTT TGCAGAGACC CACCTTCAAG CAAATTGTAC AACTCATTGA GCAGCAGCTC 2760
TTGGATAGTA CTAACCATGT TTACTCCAAT ATTACAACCA GCAGCCCCAA CCAAGAGAGT 2820
CCTGTTGACC ATTCTGTGAG GATCAATTCC GTAGGCAGCA GCGCATCATC CACTCAACCT 2880
CTGCTTGTAC ATGAAGATGC CTGA 2904
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 582   LSFGKTLGAGAFGKVVEATAYGLFKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  641
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact gGp +vit+ cc+Gdlln+lr+kr+sf+   ++k+++++e + +k+
Q: 642   NHMNIVNLLGACTIGGPPLVITKNCCHGDLLNFLRKKRDSFF---CSKHEDHAETTLYKN  698
         *****************************************9...999999********9
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l+sk s++ ++ +ey+d+k++vs+v ++kadk++s+++ s++er+v++a++++d
Q: 699   L-----LQSKDSSC-DGANEYMDMKPGVSYVVPTKADKRRSARIGSYIERDVTTAIMDDD  752
         9.....77777666.9********************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l++edllsfsyqvakGm flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 753   ELALDIEDLLSFSYQVAKGMSFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND  812
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdskfy
Q: 813   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY  872
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeG+rm +p+ a+ e+y+im++cw+a+p +rp+fkq+v+l+
Q: 873   KMIKEGFRMLSPECAPPEMYDIMKSCWNADPLQRPTFKQIVQLI  916
         *****************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLFKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHMNIVNLLG ACTIGGPPLV ITKNCCHGDL LNFLRKKRDS FFCSKHEDHA ETTLYKNLLQ 120
SKDSSCDGAN EYMDMKPGVS YVVPTKADKR RSARIGSYIE RDVTTAIMDD DELALDIEDL 180
LSFSYQVAKG MSFLASKNCI HRDLAARNIL LTHGRITKIC DFGLARDIKN DSNYVVKGNA 240
RLPVKWMAPE SIFNCVYTFE SDVWSYGIFL WELFSLGSSP YPGMPVDSKF YKMIKEGFRM 300
LSPECAPPEM YDIMKSCWNA DPLQRPTFKQ IVQLI 335
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-PEM-00219
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013