EKS-MOD-00455

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00455

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	416.7	4.9E-125	73	368	296

Status

Unreviewed

Ensembl Protein

ENSMODP00000025978

UniProt Accession

F6ZA47;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000020770	ENSMODP00000025978	ENSMODT00000026443

Organism

Monodelphis domestica

Functional Description

Protein Length

441

Protein Sequence
(FASTA)

MFLTSPTVFM SRHFLSYFSE PTFDVKIAFC QGFDKQVDVS YIAKHYNMSK SKVDNQFYSV 60

EVGDSTFTVL KRYQNLKPIG SGAQGIVCAA YDAVLDRNVA IKKLSRPFQN QTHAKRAYRE 120

LVLMKCVNHK NIISLLNVFT PQKSLEEFQD VYLVMELMDA NLCQVIQMEL DHERMSYLLY 180

QMLCGIKHLH SAGIIHRDLK PSNIVVKSDC TLKILDFGLA RTAGTSFMMT PYVVTRYYRA 240

PEVILGMGYK ENVDIWSVGC IMGEMVRHKI LFPGRDYIDQ WNKVIEQLGT PCPEFMKKLQ 300

PTVRNYVENR PKYAGLTFPK LFPDSLFPAD SEHNKLKASQ ARDLLSKMLV IDPAKRISVD 360

DALQHPYINV WYDPAEVEAP PPQIYDKQLD EREHTIEEWK ELIYKEVMNS EEKTKNGVVK 420

GQPSPSALRG LGPQRGYYYL V 441

Nucleotide Sequence
(FASTA)

ATGTTCCTGA CCTCACCAAC TGTATTTATG AGCCGCCACT TCTTGTCCTA CTTCAGTGAA 60

CCTACCTTCG ATGTGAAAAT TGCCTTTTGT CAGGGATTTG ATAAACAAGT GGATGTGTCA 120

TATATTGCCA AACATTACAA CATGAGCAAA AGCAAAGTAG ACAACCAGTT CTACAGTGTA 180

GAAGTGGGAG ATTCAACGTT CACAGTTCTC AAACGCTACC AGAATCTAAA GCCTATTGGC 240

TCTGGGGCTC AGGGAATCGT TTGTGCTGCA TATGATGCTG TTCTTGACAG AAATGTGGCC 300

ATTAAGAAGC TCAGCAGACC ATTTCAGAAC CAAACACATG CCAAACGGGC TTACAGGGAG 360

CTGGTCCTCA TGAAGTGTGT GAATCATAAA AATATTATCA GTTTATTAAA TGTCTTCACA 420

CCACAGAAAT CACTAGAAGA GTTCCAAGAT GTTTACCTTG TGATGGAATT GATGGATGCA 480

AACTTGTGCC AGGTCATTCA AATGGAATTG GACCATGAGC GCATGTCTTA CCTCCTGTAC 540

CAAATGTTAT GTGGCATCAA GCACCTTCAC TCTGCTGGGA TCATCCACAG GGATTTAAAG 600

CCCAGTAACA TTGTGGTAAA ATCTGATTGC ACATTGAAAA TTCTAGACTT TGGATTGGCC 660

AGGACTGCAG GCACAAGCTT CATGATGACT CCATATGTGG TGACACGTTA TTACAGAGCC 720

CCGGAAGTCA TCCTGGGAAT GGGCTACAAA GAGAATGTGG ATATATGGTC TGTAGGATGC 780

ATTATGGGAG AAATGGTTCG CCACAAAATC CTCTTTCCAG GAAGGGATTA TATTGACCAG 840

TGGAACAAAG TAATTGAGCA ACTAGGAACA CCATGCCCAG AATTCATGAA GAAATTGCAA 900

CCTACAGTAA GAAACTATGT GGAGAATCGG CCCAAGTATG CAGGCCTTAC TTTCCCCAAG 960

CTCTTTCCGG ATTCCCTCTT CCCTGCTGAC TCTGAGCACA ATAAACTTAA AGCCAGCCAA 1020

GCCAGAGACC TTTTGTCCAA GATGCTAGTG ATTGATCCAG CCAAAAGGAT ATCAGTGGAT 1080

GATGCCTTAC AGCATCCATA CATCAATGTC TGGTATGATC CTGCAGAAGT GGAGGCGCCT 1140

CCTCCACAGA TATATGATAA ACAGCTGGAT GAAAGAGAAC ATACCATTGA AGAATGGAAA 1200

GAACTGATCT ATAAGGAAGT AATGAATTCT GAAGAAAAGA CTAAAAATGG AGTAGTAAAA 1260

GGACAACCTT CTCCTTCAGC ACTCAGAGGT TTAGGACCCC AGAGGGGATA CTACTACCTA 1320

GTTTAG 1326

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 73    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  132

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 133   ISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  191

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 192   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  248

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 249   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  307

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv++aL+hpY

Q: 308   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDDALQHPY  367

         *****************************99*****************************

S: 289   l  289

Q: 368   I  368

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KSLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDDA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013