EKS-MOD-00165

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00165

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	491.1	6.6E-148	450	708	259

Status

Unreviewed

Ensembl Protein

ENSMODP00000025995

UniProt Accession

F6YKH9;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000020783	ENSMODP00000025995	ENSMODT00000026460

Organism

Monodelphis domestica

Functional Description

Protein Length

759

Protein Sequence
(FASTA)

MGNGSVKPKQ SKIPDGHAGK LSGTIDALRS KVTELERELK KKDDELQQRE YHLRELQEKL 60

SKQTIALAEI TEELQNKCIQ LNKLQDVVNI QGGNSLLFSP YKVPLQVNRR TSGLVSLHSR 120

RGAKEGVSAE PTTRTFAEFS FEKARVRKDS SDKKLITDAL NKNQFLKRLD PQQIKDMVEC 180

MYGRNYPQGS YIIKQGEPGN HIFVLAEGRL EVFQGNKLLS SIPMWTTFGE LAILYNCTRT 240

ASVKAISNVK TWALDREVFQ NIMRRTAQAR DEQYRQFLRS VCLLKNLPED KLTKIIDCLE 300

VEYYDKGDYI IREGEEGSTF FILAKGVVKV TQSTEGYDQP QLIKTLKKGD YFGEKALISD 360

DVRSANIIAE ENDVACLVID RETFSQTVGT FEELQKYLEG YVANLNRDDE KRHAKRSMSG 420

WRQTKALSLE MIQLKEKVAK FSSSSPFQNL EIVTTLGVGG FGRVELVKVK NENVAFAMKC 480

IRKKHIVDTK QQEHIYSEKK ILEEMCSPFI VKFYRTFKDR KYVYMLLEAC LGGELWSILR 540

DRGSFDEPTS KFCVACVTEA FDYLHRLGII YRDLKPENLI LDAEGYLKLV DFGFAKKIGS 600

GQKTWTFCGT PEYVAPEVIL NKGHDFSVDF WSLGILVYEL LTGNPPFSGI DQMMTYNLIL 660

KGIEKIDFPK KITRRPEDLI RRLCRQNPTE RLGNLKNGIN DIKRHRWLNG FNWEGLKARS 720

LPSPLKRELS GPIDHSYFDN YPPEKGIPPD ELSGWDKDF 759

Nucleotide Sequence
(FASTA)

ATGGGAAATG GCTCTGTGAA ACCCAAACAG TCCAAGATTC CAGATGGCCA TGCTGGGAAA 60

TTGTCAGGCA CAATTGATGC TCTTCGGAGC AAAGTGACAG AATTGGAAAG GGAGCTAAAG 120

AAGAAGGATG ATGAGCTACA GCAGAGGGAG TACCATCTGA GGGAGCTGCA GGAAAAGCTC 180

TCCAAGCAGA CAATCGCTCT TGCGGAGATC ACTGAGGAAC TCCAAAACAA GTGTATCCAG 240

CTAAACAAGC TTCAAGATGT AGTTAACATT CAGGGAGGAA ACTCACTTCT ATTTTCTCCA 300

TACAAAGTGC CTCTTCAGGT CAACCGAAGG ACCTCAGGCT TAGTCTCTCT CCACAGCAGG 360

AGAGGTGCCA AGGAAGGAGT ATCTGCTGAA CCAACTACCA GGACCTTTGC AGAATTTTCA 420

TTTGAGAAAG CAAGAGTCAG GAAGGACTCA AGTGATAAGA AGCTCATCAC AGATGCCCTG 480

AATAAAAATC AGTTTTTGAA GAGACTGGAC CCTCAGCAGA TCAAAGACAT GGTGGAATGT 540

ATGTATGGAA GAAACTACCC ACAAGGCAGT TATATCATTA AACAAGGAGA ACCAGGAAAT 600

CATATTTTTG TATTGGCAGA GGGAAGACTA GAAGTATTCC AAGGGAACAA GCTTCTGTCA 660

TCAATTCCTA TGTGGACAAC ATTTGGAGAA CTAGCCATAT TATACAACTG TACAAGGACG 720

GCTTCAGTAA AAGCTATCTC CAATGTGAAA ACGTGGGCAC TAGATAGAGA AGTATTCCAG 780

AATATTATGA GAAGAACAGC TCAAGCTCGG GATGAACAGT ACAGACAGTT CCTTAGGAGC 840

GTATGTTTGC TGAAGAACTT ACCTGAAGAC AAACTAACCA AAATCATTGA CTGCTTGGAA 900

GTGGAATACT ATGACAAAGG AGATTATATC ATCAGAGAAG GGGAGGAAGG AAGCACCTTT 960

TTCATTTTAG CAAAAGGAGT GGTAAAAGTT ACTCAGAGTA CAGAAGGGTA TGATCAACCT 1020

CAGTTGATTA AAACACTGAA AAAAGGTGAT TACTTTGGAG AAAAGGCTCT CATCAGTGAT 1080

GATGTCAGGT CAGCTAATAT CATTGCAGAA GAAAATGATG TGGCATGCCT GGTTATTGAT 1140

CGCGAAACAT TCAGTCAAAC AGTTGGAACC TTTGAGGAGC TCCAAAAGTA TCTTGAGGGA 1200

TATGTGGCGA ACTTGAACCG TGATGATGAA AAAAGGCATG CCAAGAGATC TATGTCTGGC 1260

TGGAGGCAAA CCAAAGCCCT GTCTCTGGAG ATGATTCAAC TAAAGGAGAA AGTGGCCAAA 1320

TTTTCTTCTT CGTCCCCATT CCAGAACCTT GAGATTGTCA CCACACTGGG TGTCGGTGGG 1380

TTCGGAAGAG TTGAACTTGT AAAAGTAAAA AATGAGAATG TGGCATTTGC TATGAAGTGT 1440

ATAAGGAAGA AGCACATTGT TGATACTAAG CAACAGGAAC ATATCTATTC AGAAAAGAAG 1500

ATTCTGGAAG AGATGTGCTC TCCATTTATT GTTAAGTTTT ATCGTACTTT CAAGGACAGA 1560

AAATATGTGT ATATGCTCTT GGAGGCCTGC TTAGGTGGAG AATTGTGGAG TATCCTAAGG 1620

GACAGGGGCA GCTTTGATGA GCCCACTTCT AAGTTCTGTG TTGCCTGTGT GACAGAAGCA 1680

TTTGATTATT TGCATCGCCT GGGTATTATC TACAGGGATT TAAAGCCAGA GAATTTAATT 1740

CTAGATGCGG AGGGATACCT TAAGCTGGTT GATTTTGGAT TTGCTAAGAA GATCGGATCT 1800

GGACAGAAAA CTTGGACATT CTGCGGGACC CCCGAGTATG TAGCTCCCGA AGTCATTCTC 1860

AACAAAGGGC ATGACTTCAG TGTGGACTTT TGGTCACTAG GAATTCTAGT CTATGAGCTG 1920

CTGACTGGCA ATCCTCCATT TTCTGGGATT GACCAAATGA TGACTTATAA TTTAATTCTC 1980

AAAGGAATTG AGAAAATCGA TTTTCCTAAG AAGATAACAA GACGCCCTGA AGATTTGATT 2040

CGGCGACTTT GCAGGCAAAA TCCTACAGAA AGGCTGGGAA ACCTGAAAAA TGGAATCAAT 2100

GACATTAAGA GGCACAGGTG GCTGAATGGC TTTAACTGGG AGGGGCTGAA GGCAAGGAGC 2160

CTGCCATCAC CCTTAAAAAG GGAGCTCAGC GGACCCATAG ATCACAGCTA CTTTGACAAC 2220

TACCCACCTG AGAAAGGGAT ACCACCCGAC GAGCTGTCCG GCTGGGATAA AGACTTCTGA 2280

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l++++tlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqeh++sek+ilee++s+

Q: 450   LEIVTTLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHIYSEKKILEEMCSP  508

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivk+yrtfkd kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +

Q: 509   FIVKFYRTFKDRKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLG  568

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld+egylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv

Q: 569   IIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  628

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++p+kit+++edli++lcr+np

Q: 629   DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKIDFPKKITRRPEDLIRRLCRQNP  688

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dik+h+w+

Q: 689   TERLGNLKNGINDIKRHRWL  708

         *******************7

Domain Sequence
(FASTA)

LEIVTTLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHIYSEK KILEEMCSPF 60

IVKFYRTFKD RKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120

IYRDLKPENL ILDAEGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNPPFSG IDQMMTYNLI LKGIEKIDFP KKITRRPEDL IRRLCRQNPT 240

ERLGNLKNGI NDIKRHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

mdo:100014568

;

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013