EKS-MOD-00187
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00187
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CASK542.12.2E-16312276265
StatusUnreviewed
Ensembl ProteinENSMODP00000026374
UniProt AccessionF6UIF1;
Protein Name
Protein Synonyms/Alias
Gene NameCASK
Gene Synonyms/Alias CASK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000021095ENSMODP00000026374ENSMODT00000026843
OrganismMonodelphis domestica
Functional Description
Protein Length897
Protein Sequence
(FASTA)
MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS SPGLSTEDLK 60
REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC FEIVKRADAG FVYSEAVASH 120
YMRQILEALR YCHDNNIIHR DVKPHCVLLA SKENSAPVKL GGFGVAIQLG ESGLVAGGRV 180
GTPHFMAPEV VKREPYGKPV DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR 240
QWSHISESAK DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA 300
RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGA VSQVLDSLEE IHALTDCSEK 360
DLDFLHSVFQ DQHLHTLLDL YDKINTKSSP HIRNPPSDAV QRAKEVLEEI SCYPENSDAK 420
ELKRILTQPH FMALLQTHDV VAHEVYSDEA LRVTPPPTSP YLNGDSPESA NGDMDMENVT 480
RVRLVQFQKN TDEPMGITLK MNELNHCIVA RIMHGGMIHR QGTLHVGDEI REINGISVAN 540
QTVEQLQKML REMRGSITFK IVPSYRTQSS SCEDLPSTTQ PKGRQVYVRA QFEYDPAKDD 600
LIPCKEAGIR FRVGDIIQII SKDDHNWWQG KLENSKNGTA GLIPSPELQE WRVACIAMEK 660
TKQEQQASCT WFGKKKKQYK DKYLAKHNAV FDQLDLVTYE EVVKLPAFKR KTLVLLGAHG 720
VGRRHIKNTL ITKHPDRFAY PIPHTTRPPK KDEENGKNYY FVSHDQMMQD ISNNEYLEYG 780
SHEDAMYGTK LETIRKIHEQ GLIAILDVEP QALKVLRTAE FAPFVVFIAA PTITPGINED 840
ESLQRLQKES DILQRTYAHY FDLTIINNEI DETIRHLEEA IELVCTAPQW VPVSWVY 897
Nucleotide Sequence
(FASTA)
ATGGCCGACG ACGACGTGCT GTTTGAAGAT GTGTATGAGC TGTGCGAGGT GATCGGCAAG 60
GGCCCCTTCA GTGTTGTGCG GCGATGTATC AACAGAGAAA CTGGGCAACA ATTTGCAGTA 120
AAAATTGTTG ATGTAGCCAA GTTCACATCA AGTCCAGGGC TAAGTACAGA AGATCTGAAA 180
CGGGAAGCCA GTATCTGTCA TATGCTGAAG CATCCACATA TTGTGGAACT GTTGGAGACA 240
TATAGCTCAG ATGGAATGCT TTATATGGTT TTTGAATTTA TGGATGGAGC TGATCTGTGT 300
TTTGAAATTG TAAAACGAGC AGATGCTGGT TTTGTATACA GTGAAGCTGT AGCCAGTCAT 360
TACATGAGAC AGATACTGGA AGCACTACGC TACTGTCATG ATAATAACAT AATTCACAGG 420
GATGTGAAGC CCCATTGTGT CCTCCTTGCC TCAAAAGAAA ATTCAGCACC TGTTAAACTT 480
GGGGGCTTTG GAGTAGCTAT TCAGTTAGGG GAGTCTGGAC TTGTTGCTGG AGGACGTGTA 540
GGAACACCTC ATTTTATGGC CCCAGAGGTG GTAAAAAGAG AGCCCTATGG GAAACCTGTA 600
GATGTCTGGG GTTGTGGAGT GATCCTTTTT ATTCTGCTGA GTGGTTGTTT GCCTTTTTAC 660
GGAACCAAGG AAAGATTGTT TGAAGGCATT ATTAAAGGAA AATATAAGAT GAATCCCAGA 720
CAGTGGAGCC ATATCTCTGA AAGTGCCAAA GACCTTGTCC GCCGAATGTT GATGCTGGAT 780
CCAGCTGAAA GGATAACAGT TTACGAGGCA CTTAATCATC CTTGGCTTAA GGAAAGGGAT 840
CGCTATGCAT ACAAGATTCA TCTTCCTGAA ACAGTAGAGC AACTACGGAA ATTTAACGCA 900
AGGAGGAAAC TAAAGGGTGC AGTACTAGCA GCTGTATCAA GCCACAAATT CAACTCGTTC 960
TATGGGGATC CCCCTGAAGA GTTGCCAGAT TTCTCTGAAG ATCCTACCTC CTCAGGAGCA 1020
GTCTCACAGG TGCTAGACAG CCTGGAGGAA ATTCATGCAC TTACAGACTG CAGTGAAAAG 1080
GACTTAGATT TTCTACACAG TGTTTTCCAG GATCAACATC TCCACACACT CCTAGATCTA 1140
TATGACAAAA TTAATACAAA GTCTTCACCA CATATCAGGA ATCCTCCGAG TGATGCTGTA 1200
CAGAGAGCCA AAGAGGTATT GGAAGAAATT TCATGTTACC CTGAAAACAG TGATGCAAAG 1260
GAGCTAAAGC GTATTTTAAC ACAGCCTCAT TTCATGGCCT TACTTCAGAC TCATGATGTA 1320
GTGGCACATG AAGTTTACAG TGATGAGGCA TTAAGGGTTA CACCTCCTCC CACCTCTCCA 1380
TATTTAAACG GAGATTCTCC AGAAAGTGCC AATGGTGACA TGGATATGGA GAATGTTACT 1440
CGAGTACGGC TGGTACAATT CCAGAAGAAC ACAGATGAGC CAATGGGTAT CACTTTGAAA 1500
ATGAATGAGC TAAACCATTG CATTGTAGCA AGAATTATGC ATGGGGGAAT GATTCACAGA 1560
CAAGGTACAC TTCACGTAGG TGATGAAATC CGAGAAATAA ACGGTATCAG TGTAGCAAAC 1620
CAAACCGTGG AGCAGCTGCA AAAAATGCTT AGGGAAATGC GGGGGAGCAT CACCTTCAAG 1680
ATTGTGCCGA GCTACCGCAC TCAATCTTCA TCCTGTGAGG ACTTGCCATC AACTACCCAA 1740
CCAAAAGGAC GACAGGTCTA TGTAAGAGCA CAATTTGAAT ACGACCCAGC AAAGGATGAC 1800
CTCATACCAT GCAAGGAAGC TGGTATCCGA TTTAGAGTCG GCGACATTAT CCAGATTATT 1860
AGTAAGGATG ACCACAATTG GTGGCAAGGT AAACTGGAGA ACTCCAAAAA TGGTACTGCA 1920
GGTCTCATTC CCTCTCCTGA ACTTCAAGAA TGGAGAGTTG CTTGTATTGC CATGGAGAAG 1980
ACCAAACAGG AGCAGCAAGC TAGCTGTACT TGGTTTGGAA AGAAGAAGAA GCAATACAAA 2040
GATAAATATT TGGCAAAGCA CAATGCAGTG TTTGATCAAT TAGATCTTGT TACATATGAA 2100
GAAGTAGTAA AACTGCCAGC ATTTAAAAGG AAAACACTAG TCTTACTAGG TGCACATGGT 2160
GTTGGAAGAA GACACATAAA AAACACACTC ATTACAAAAC ACCCAGACAG ATTTGCATAC 2220
CCTATTCCAC ACACAACTAG ACCTCCAAAG AAAGATGAAG AAAATGGCAA GAATTATTAC 2280
TTTGTATCTC ATGACCAAAT GATGCAAGAC ATATCTAACA ATGAATACTT AGAGTATGGC 2340
AGCCATGAGG ATGCCATGTA TGGGACAAAA CTGGAGACAA TACGGAAGAT CCACGAGCAG 2400
GGACTGATTG CAATACTGGA TGTAGAACCT CAGGCACTGA AGGTCCTGAG AACTGCAGAG 2460
TTTGCTCCTT TTGTAGTTTT TATTGCTGCA CCCACGATTA CTCCAGGCAT AAATGAGGAT 2520
GAATCCCTTC AGCGCCTGCA GAAGGAGTCG GATATCTTGC AGAGAACGTA CGCACACTAC 2580
TTTGATCTAA CCATCATCAA CAATGAAATC GACGAAACGA TCCGACATCT GGAGGAAGCC 2640
ATCGAGCTCG TTTGTACAGC ACCACAGTGG GTTCCGGTCT CCTGGGTCTA TTAG 2694
Domain Profile
S: 1     yelcevigkGpfsvvrriihresnqkfavkivdvakftsspGlstedlkreasichmlkh  60
         yelcevigkGpfsvvrr+i+re++q+favkivdvakftsspGlstedlkreasichmlkh
Q: 12    YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH  71
         89**********************************************************
S: 61    pyivelletyssegmlylvfefmeGadlcfeivkrasaGfvyseavashymrqilealry  120
         p+ivelletyss+gmly+vfefm+Gadlcfeivkra+aGfvyseavashymrqilealry
Q: 72    PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY  131
         ************************************************************
S: 121   chdnkivhrdvrphcvllaskdnsapvklgGfGvaiqlseisglvagGrvGvphfmapev  180
         chdn+i+hrdv+phcvllask+nsapvklgGfGvaiql+e sglvagGrvG+phfmapev
Q: 132   CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE-SGLVAGGRVGTPHFMAPEV  190
         ****************************************.*******************
S: 181   vkrerygksvdvwgaGvvlfillsGrlpflGskerlfesiikgklkldarewssisesak  240
         vkre+ygk+vdvwg+Gv+lfillsG+lpf+G+kerlfe+iikgk+k+++r+ws+isesak
Q: 191   VKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAK  250
         ************************************************************
S: 241   dlvrrmlaadpakrisvkealnhewl  266
         dlvrrml++dpa+ri+v+ealnh+wl
Q: 251   DLVRRMLMLDPAERITVYEALNHPWL  276
         *************************7
Domain Sequence
(FASTA)
YELCEVIGKG PFSVVRRCIN RETGQQFAVK IVDVAKFTSS PGLSTEDLKR EASICHMLKH 60
PHIVELLETY SSDGMLYMVF EFMDGADLCF EIVKRADAGF VYSEAVASHY MRQILEALRY 120
CHDNNIIHRD VKPHCVLLAS KENSAPVKLG GFGVAIQLGE SGLVAGGRVG TPHFMAPEVV 180
KREPYGKPVD VWGCGVILFI LLSGCLPFYG TKERLFEGII KGKYKMNPRQ WSHISESAKD 240
LVRRMLMLDP AERITVYEAL NHPWL 265
KeywordComplete proteome; Reference proteome; SH3 domain.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00177
EKS-ANC-00182
EKS-BOT-00189
EKS-CAE-00177
EKS-CAJ-00196
EKS-CAF-00195
EKS-CAP-00214
EKS-CII-00122
EKS-CIS-00227
EKS-DAR-00489
EKS-DRM-00100
EKS-EQC-00184
EKS-FEC-00177
EKS-GAM-00106
EKS-GAG-00161
EKS-GAA-00233
EKS-GOG-00185
EKS-HOS-00194
EKS-LAC-00199
EKS-LOA-00185
EKS-MAM-00189
EKS-MEG-00146
EKS-MUM-00191
EKS-MUP-00191
EKS-MYL-00194
EKS-NOL-00178
EKS-ORN-00240
EKS-ORA-00167
EKS-ORC-00172
EKS-ORL-00225
EKS-OTG-00195
EKS-PAT-00179
EKS-PES-00164
EKS-POA-00183
EKS-SAH-00181
EKS-SUS-00162
EKS-TAG-00214
EKS-TAR-00246
EKS-TEN-00240
EKS-XET-00219
EKS-XIM-00236
Gene Ontology
GO:0005604; C:basement membrane
GO:0016323; C:basolateral plasma membrane
GO:0005911; C:cell-cell junction
GO:0005829; C:cytosol
GO:0005652; C:nuclear lamina
GO:0016363; C:nuclear matrix
GO:0005730; C:nucleolus
GO:0045202; C:synapse
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0070509; P:calcium ion import
GO:0001953; P:negative regulation of cell-matrix adhesion
GO:0090288; P:negative regulation of cellular response to growth factor stimulus
GO:0010839; P:negative regulation of keratinocyte proliferation
GO:0061045; P:negative regulation of wound healing
GO:0090280; P:positive regulation of calcium ion import
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR008144; Guanylate_kin.
IPR008145; Guanylate_kin/L-typ_Ca_channel.
IPR020590; Guanylate_kinase_CS.
IPR011009; Kinase-like_dom.
IPR004172; L27.
IPR014775; L27_C.
IPR001478; PDZ.
IPR000719; Prot_kinase_cat_dom.
IPR011511; SH3_2.
IPR001452; SH3_domain.
Pfam
PF00625; Guanylate_kin; 1.
PF02828; L27; 2.
PF00595; PDZ; 1.
PF00069; Pkinase; 1.
PF07653; SH3_2; 1.
SMARTs
SM00072; GuKc; 1.
SM00569; L27; 2.
SM00228; PDZ; 1.
SM00326; SH3; 1.
Prosites
PS00856; GUANYLATE_KINASE_1; 1.
PS50052; GUANYLATE_KINASE_2; 1.
PS51022; L27; 2.
PS50106; PDZ; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50002; SH3; 1.
Prints
Created Date20-Feb-2013