EKS-MOD-00001
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MOD-00001
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph520.46.7E-157621878258
StatusUnreviewed
Ensembl ProteinENSMODP00000026482
UniProt AccessionF6XVY7;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA4
Gene Synonyms/Alias EPHA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMODG00000021189ENSMODP00000026482ENSMODT00000026955
OrganismMonodelphis domestica
Functional Description
Protein Length986
Protein Sequence
(FASTA)
MAGILYFILF SFLFGICNGV TGSRIYPANE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM 60
DEKNTPIRTY QVCNVMESSQ NNWLRTDWIP REGAQRVYIE IKFTLRDCNS LPGVMGTCKE 120
TFNLYYYESN NDKERFIRES QFAKIDTIAA DESFTQVDIG DRIMKLNTEI RDVGPLSKKG 180
FYLAFQDVGA CIALVSVRVF YKKCPLTVRN LAQFPDTITG ADTSSLVEVR GSCVNNSEEK 240
DVPKMYCGAD GEWLVPIGNC LCNAGHEERN GECQACKIGY YKALSTDTAC AKCPPHSYSV 300
WEGSTSCTCD RGYFRAEDDA ASMPCTRPPS APLNLISNVN ETSVNLEWSS PENTGGRQDI 360
SYNVVCKKCG AGEVNRCGSC GSGVHYTPQQ NGLKSTKVSI TDLLAHTNYT FEILAVNGVS 420
KYNPSQDQSV SVTVTTNQAA PSSIALIQAK EITRYSVALA WLEPDRPNGV ILEYEVKYYE 480
KDQNERSYRI VRTASRNTDI KGLNPLTSYV FHVRARTAAG YGDFSEPFEV TTNTVPSRII 540
GDGTNSTVLL VSVSGSVVLV VILIAAFVIS RRRSKYSKAK QEADEEKHLN QGVRTYVDPF 600
TYEDPNQAVR EFAKEIDASC IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT 660
DKQRRDFLSE ASIMGQFDHP NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV 720
IQLVGMLRGI GSGMKYLSDM SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT 780
TRGGKIPIRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG 840
YRLPPPMDCP IALHQLMLDC WQKERSDRPK FGQIVNMLDK LIRNPNSLKR TGTESSRPNT 900
ALLDPSSPEF SAVVSVGDWL QAIKMDRYKD NFTAAGYTTL EAVVHMNQDD LARIGITAVT 960
HQNKILNSVQ AMRTQMQQMH GRMVPV 986
Nucleotide Sequence
(FASTA)
ATGGCTGGGA TTTTATATTT CATTCTCTTT TCGTTTCTAT TTGGGATTTG CAATGGTGTC 60
ACCGGTTCTA GGATATATCC CGCCAATGAA GTTACTTTAT TGGATTCCAG ATCGGTTCAG 120
GGAGAACTTG GGTGGATAGC CAGCCCTTTG GAAGGAGGGT GGGAAGAAGT GAGCATTATG 180
GATGAGAAAA ATACTCCAAT CCGTACCTAC CAAGTCTGCA ATGTGATGGA GTCCAGCCAA 240
AACAACTGGT TACGAACTGA TTGGATTCCT CGGGAAGGGG CTCAGAGGGT GTATATCGAG 300
ATTAAATTCA CACTGAGGGA CTGCAATAGC CTACCAGGAG TTATGGGAAC TTGCAAAGAG 360
ACTTTTAACT TGTACTACTA TGAATCCAAC AATGATAAAG AACGCTTTAT TAGAGAGAGC 420
CAGTTTGCCA AGATCGACAC CATTGCTGCT GATGAGAGCT TCACCCAAGT GGACATTGGT 480
GACAGAATCA TGAAGTTGAA CACTGAGATA CGAGATGTGG GACCATTGAG TAAGAAAGGG 540
TTCTATTTGG CTTTTCAAGA TGTTGGAGCT TGTATTGCCC TAGTATCTGT TCGGGTTTTC 600
TATAAGAAGT GCCCATTGAC AGTTCGCAAT CTGGCTCAAT TTCCAGACAC CATCACTGGG 660
GCTGATACAT CCTCCCTAGT GGAAGTTCGA GGCTCTTGTG TCAACAACTC AGAAGAGAAG 720
GATGTGCCAA AAATGTATTG TGGGGCAGAT GGTGAATGGC TGGTACCCAT TGGCAACTGT 780
CTATGCAATG CTGGGCATGA AGAGAGAAAT GGAGAATGCC AAGCCTGCAA GATTGGATAC 840
TATAAGGCCC TTTCCACTGA TACTGCCTGT GCCAAGTGCC CACCCCACAG CTACTCCGTC 900
TGGGAGGGAT CCACCTCCTG CACCTGTGAC CGAGGCTATT TTCGAGCAGA GGATGATGCG 960
GCTTCCATGC CCTGCACTCG CCCACCATCT GCTCCCCTCA ACTTGATTTC GAATGTCAAT 1020
GAAACATCAG TGAACTTGGA GTGGAGCAGT CCTGAGAACA CTGGGGGCCG TCAAGACATT 1080
TCCTACAACG TAGTGTGCAA GAAGTGTGGT GCTGGAGAGG TCAACCGATG TGGATCCTGC 1140
GGCAGTGGAG TCCACTATAC ACCCCAGCAG AATGGCCTCA AGAGCACCAA AGTCTCCATC 1200
ACCGACCTCC TGGCACATAC TAACTATACT TTTGAAATCT TGGCTGTGAA TGGAGTGTCC 1260
AAGTACAATC CGAGTCAGGA CCAATCAGTT TCAGTTACTG TGACGACAAA CCAAGCAGCT 1320
CCGTCTTCCA TCGCTTTGAT CCAGGCTAAA GAAATAACGA GATACAGTGT TGCATTGGCT 1380
TGGCTGGAAC CTGATCGGCC AAATGGAGTC ATCTTAGAGT ATGAAGTCAA ATATTATGAG 1440
AAGGATCAGA ATGAACGCAG CTATAGGATT GTTCGAACAG CCTCCAGGAA CACTGACATC 1500
AAAGGCTTGA ATCCCTTGAC TTCCTATGTA TTCCATGTGA GAGCCCGAAC AGCAGCTGGC 1560
TATGGAGACT TCAGTGAACC CTTTGAGGTC ACAACTAACA CAGTGCCTTC TCGAATCATT 1620
GGAGATGGAA CCAACTCCAC AGTCCTTCTG GTGTCCGTTT CGGGCAGCGT GGTTCTGGTG 1680
GTCATCCTCA TTGCAGCCTT CGTCATCAGC CGGAGACGGA GTAAATACAG TAAGGCAAAG 1740
CAGGAAGCAG ATGAAGAGAA ACATTTGAAT CAAGGTGTGA GAACCTATGT TGACCCTTTT 1800
ACATATGAAG ATCCCAACCA AGCTGTTCGA GAGTTTGCCA AAGAAATTGA TGCCTCCTGC 1860
ATTAAGATAG AAAAAGTTAT AGGAGTGGGT GAATTTGGTG AAGTGTGCAG TGGGCGACTC 1920
AAAGTACCTG GGAAGAGAGA GATCTGTGTG GCTATTAAGA CTCTTAAAGC TGGGTATACA 1980
GACAAACAGA GGAGGGATTT CCTAAGTGAA GCCAGCATCA TGGGACAGTT TGACCACCCA 2040
AATATCATCC ACTTAGAAGG CGTAGTTACC AAATGTAAAC CTGTAATGAT CATAACCGAG 2100
TACATGGAGA ATGGCTCCTT GGATGCATTC CTGAGGAAGA ATGATGGAAG ATTTACAGTG 2160
ATTCAGTTGG TTGGGATGCT TCGTGGCATT GGTTCTGGGA TGAAATACCT CTCTGATATG 2220
AGCTATGTGC ATAGAGATCT AGCTGCCCGG AACATCTTGG TCAATAGCAA CTTGGTCTGC 2280
AAAGTATCTG ACTTTGGCAT GTCTCGTGTT CTTGAAGATG ATCCTGAAGC AGCTTACACA 2340
ACCAGGGGTG GCAAGATTCC CATCCGGTGG ACTGCACCAG AAGCGATTGC TTATCGTAAA 2400
TTCACATCCG CGAGTGATGT ATGGAGCTAT GGAATTGTGA TGTGGGAAGT GATGTCGTAT 2460
GGAGAGCGGC CTTACTGGGA TATGTCCAAC CAGGATGTTA TAAAAGCCAT TGAAGAAGGC 2520
TACCGGCTAC CTCCACCAAT GGACTGCCCC ATCGCTCTCC ACCAGCTGAT GCTAGACTGC 2580
TGGCAGAAGG AAAGAAGTGA CAGACCTAAA TTTGGACAGA TTGTCAACAT GTTGGACAAA 2640
CTCATTCGCA ACCCCAACAG CTTGAAGAGG ACGGGTACTG AGAGCTCCAG GCCCAATACT 2700
GCTCTGTTGG ATCCTAGCTC TCCCGAGTTC TCTGCTGTGG TATCTGTAGG TGATTGGCTT 2760
CAGGCCATTA AAATGGACCG GTATAAGGAC AACTTCACAG CTGCCGGTTA CACCACCCTC 2820
GAGGCTGTGG TGCACATGAA CCAGGACGAC CTGGCGAGAA TCGGTATCAC GGCCGTCACG 2880
CACCAGAATA AGATCTTGAA CAGCGTCCAG GCAATGCGGA CCCAAATGCA ACAGATGCAT 2940
GGCAGGATGG TTCCTGTCTG A 2961
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kiekviG GefGevcsGrlk+pgkrei+vaiktlkag+t+kqrrdflseasi+Gqfdhp
Q: 621   IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP  680
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leGvvtk+kpvmi+teymeng+ld+flrk+dg+ftviqlvgmlrGi+sgmkylsdm
Q: 681   NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM  740
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         +yvhrdlaarnilvnsnlvckvsdfG+srvledd+eaaytt+ggkipirwtapeaiayrk
Q: 741   SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK  800
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlpppmdcp al+qlmldc
Q: 801   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDC  860
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqk+r++rpkf qiv++l
Q: 861   WQKERSDRPKFGQIVNML  878
         ***************985
Domain Sequence
(FASTA)
IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT DKQRRDFLSE ASIMGQFDHP 60
NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV IQLVGMLRGI GSGMKYLSDM 120
SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK 180
FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPPPMDCP IALHQLMLDC 240
WQKERSDRPK FGQIVNML 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00001
EKS-ANC-00001
EKS-BOT-00001
EKS-CAF-00001
EKS-CAP-00001
EKS-CIS-00002
EKS-DAR-00001
EKS-EQC-00001
EKS-FEC-00001
EKS-GAG-00001
EKS-GAA-00001
EKS-GOG-00001
EKS-HOS-00002
EKS-ICT-00001
EKS-LAC-00002
EKS-LOA-00001
EKS-MAM-00001
EKS-MEG-00001
EKS-MUM-00001
EKS-MUP-00001
EKS-MYL-00001
EKS-NOL-00001
EKS-ORN-00001
EKS-ORA-00001
EKS-ORC-00001
EKS-ORL-00001
EKS-OTG-00005
EKS-PAT-00001
EKS-PES-00001
EKS-POA-00001
EKS-PRC-00001
EKS-PTV-00001
EKS-RAN-00001
EKS-SAH-00001
EKS-TAG-00001
EKS-TAR-00001
EKS-TAS-00001
EKS-TEN-00006
EKS-XET-00002
EKS-XIM-00001
Gene Ontology
GO:0030424; C:axon
GO:0005737; C:cytoplasm
GO:0030425; C:dendrite
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0097161; F:DH domain binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0004672; F:protein kinase activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0007628; P:adult walking behavior
GO:0021957; P:corticospinal tract morphogenesis
GO:0097156; P:fasciculation of motor neuron axon
GO:0097155; P:fasciculation of sensory neuron axon
GO:0008045; P:motor neuron axon guidance
GO:0048681; P:negative regulation of axon regeneration
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043507; P:positive regulation of JUN kinase activity
GO:2001108; P:positive regulation of Rho guanyl-nucleotide exchange factor activity
GO:0046777; P:protein autophosphorylation
GO:0048710; P:regulation of astrocyte differentiation
GO:0061001; P:regulation of dendritic spine morphogenesis
GO:0032314; P:regulation of Rac GTPase activity
GO:0032317; P:regulation of Rap GTPase activity
KEGG
mdo:100016017;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR011510; SAM_2.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013