EKS-MOD-00434

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MOD-00434

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	271.3	9.1E-81	76	228	153

Status

Unreviewed

Ensembl Protein

ENSMODP00000026843

UniProt Accession

F7G2Y1;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK1

Gene Synonyms/Alias

ROCK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMODG00000021484	ENSMODP00000026843	ENSMODT00000027324

Organism

Monodelphis domestica

Functional Description

Protein Length

1334

Protein Sequence
(FASTA)

MSTGDSFETR FEKIDNLLWD PKSEVNSDCL LDGLDALVYD LDFPALRKNK NIDNFLSKYK 60

DTISKIRDLR MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK VYAMKLLSKF EMIKRSDSAF 120

FWEERDIMAF ANSPWVVQLY YAFQDDRYLY MVMEYMPGGD LVNLMSNYDV PEKWARFYTA 180

EVVLALDAIH SMGFIHRDVK PDNMLLDKSG HLKLADFGTC MKMNKKITLL ENVTELTSLM 240

WTSTVLMWTV LTMLYKEFED SLVGTYSKIM SHKNSLTFPD DNDISKEAKN LICAFLTDRE 300

VRLGRNGVEE IKRHLFFKND QWAWETLRDT VAPVVPDLSS DIDTSNFDDL EEDKGDEETF 360

PVPKAFVGNQ LPFVGFTYYS NRRYLSVSSV NPNDNRTATS VDKSLQESLQ NTIYKLEEQL 420

HNEIQLKDEM EQKCRTSNIK LDKIMKELDE EGNQRKNLES TVSQIEKEKM LLQHRVNEYQ 480

RKIEQENEKR RNIENEVSTL KDQLDDLKKI SQNSQLTNEK MAQLQKQLED ANDLLRTESD 540

TAVRLRKSHT ELSKSVSQLE SLNRELQERN RILETTKSQV DQDYYQLQAA LEAERRDRSH 600

GSEMIGDLQA RITSLQEEVK YLKHNLERVE GERKEAQDML NHSEKEKNNL EIDLNYKLKS 660

LQQRLEQEVN EHKVTKARLT DKHQSIEEAK SVAMYEMEKK LKEERAAREK AENRVVHIEK 720

QCSMLDVDLK QSQQKLEHLA EHKERIEDEV KNLTLQLEQE SNKRLLIQNE LKTQAFEKDN 780

LKGLEKQMKQ EINMLLEAKR SLEFELAQLT KQYRGNEGQM RELQDQLEAE QYFSTLYKTQ 840

VKELKEDIEE KNRENLKKIQ ELQNEKDTLT AQLDLAETKA ESEQLARRLL EEQYFELTQE 900

CKKAASRNKQ EITDKDHTVG RLEEIKTTLT KDIELLRKEN EELAEKMRKE QEDYKLKKEE 960

EINNLKASFE KNINTERTLK TQAVNKLAEI MNRKDFKIDR KKANTQDLRK KEKENRKLQL 1020

ELNQEREKFN QMVVKHQKEL NEMQAQLVEE CTHRNELQMQ LASKESDIEQ LRAKLLDLSD 1080

STSVTSFPSA DETDGNLPES RIEGWLSVPN RGNIKRYGWK KQYVVVSSKK ILFYNDEQDK 1140

EQSNPSMVLD IDKLFHVRPV TQGDVYRAET EEIPKIFQIL YANEGECRKD LEMEPVQQAE 1200

KTNFQNHKGH EFIPTLYHFP ANCEACAKPL WHVFPPPALE CRRCHVKCHR DHLDKKEDLI 1260

SPCKVSYDVT SARDMLLLAC SQDEQKKWVT HLVKKIPKNP PSSFVRASPR TLSTRSSANQ 1320

SFRKVVKNTS GKTR 1334

Nucleotide Sequence
(FASTA)

ATGTCGACTG GGGACAGTTT TGAGACTCGG TTTGAGAAAA TCGACAACCT GCTGTGGGAC 60

CCGAAGTCGG AAGTGAATTC GGATTGTTTG CTGGATGGAT TGGATGCTTT GGTATATGAT 120

CTGGATTTTC CTGCACTAAG AAAAAACAAA AATATTGACA ACTTTTTAAG CAAATATAAA 180

GATACAATAA GTAAAATTAG AGATTTGCGC ATGAAAGCTG AAGATTATGA AGTAGTGAAA 240

GTGATTGGTA GAGGAGCATT TGGAGAAGTG CAATTGGTAA GACATAAATC CACCAGGAAG 300

GTGTATGCTA TGAAGCTGTT GAGTAAATTT GAGATGATTA AGAGATCAGA TTCTGCTTTC 360

TTCTGGGAAG AACGAGACAT TATGGCTTTT GCTAACAGCC CCTGGGTGGT TCAGTTATAT 420

TATGCATTCC AAGATGATCG GTATCTCTAC ATGGTAATGG AATATATGCC TGGTGGAGAT 480

CTTGTTAATT TAATGAGCAA CTATGATGTG CCTGAAAAAT GGGCCCGCTT CTATACTGCA 540

GAAGTAGTTC TTGCTTTGGA TGCAATCCAT TCTATGGGCT TTATTCATAG AGATGTGAAG 600

CCTGACAACA TGCTGCTGGA TAAATCTGGT CACTTGAAGC TAGCTGATTT TGGTACTTGT 660

ATGAAGATGA ATAAGAAAAT TACATTGTTA GAAAATGTTA CAGAATTAAC TAGCCTTATG 720

TGGACTTCTA CGGTATTGAT GTGGACTGTC TTAACGATGC TGTATAAAGA ATTTGAAGAT 780

TCACTGGTCG GGACATATAG CAAGATTATG AGCCATAAGA ATTCGCTTAC CTTCCCTGAT 840

GATAATGATA TATCAAAGGA AGCAAAAAAT CTTATTTGTG CCTTCCTTAC TGACAGGGAA 900

GTGAGATTAG GACGAAATGG TGTGGAAGAA ATCAAACGAC ATCTCTTCTT CAAAAATGAT 960

CAGTGGGCTT GGGAAACTCT TCGAGATACT GTTGCACCTG TTGTACCTGA TCTCAGTAGT 1020

GACATCGATA CTAGTAATTT TGATGACTTA GAAGAGGACA AGGGAGATGA AGAAACATTC 1080

CCTGTTCCAA AAGCTTTTGT TGGTAATCAA CTACCTTTTG TAGGATTTAC ATATTATAGC 1140

AATCGTAGAT ATTTATCTGT ATCTTCAGTA AATCCTAACG ATAATAGAAC TGCCACCAGT 1200

GTGGATAAAA GCTTGCAGGA AAGTTTGCAA AACACAATCT ATAAGCTGGA AGAACAACTG 1260

CATAATGAAA TACAGTTAAA AGATGAAATG GAACAAAAAT GCAGAACTTC AAACATAAAG 1320

CTAGACAAGA TAATGAAAGA ACTGGATGAA GAGGGAAATC AAAGAAAAAA TTTAGAATCC 1380

ACGGTGTCTC AAATTGAGAA GGAGAAAATG TTGCTTCAGC ACAGAGTTAA TGAGTACCAA 1440

AGAAAAATAG AACAGGAGAA TGAGAAGAGA AGAAATATTG AAAATGAGGT TTCTACATTA 1500

AAAGATCAAT TGGATGACTT GAAGAAAATT AGTCAGAATT CTCAGCTTAC AAATGAGAAA 1560

ATGGCACAGT TACAGAAGCA ACTAGAAGAC GCCAATGACT TACTGAGGAC GGAATCAGAC 1620

ACAGCAGTAA GATTAAGGAA GAGCCACACA GAATTGAGTA AATCAGTAAG TCAGTTAGAG 1680

TCCCTGAACA GAGAATTGCA GGAGCGAAAC AGAATTTTAG AAACAACCAA ATCACAAGTG 1740

GACCAGGATT ATTACCAGCT ACAGGCTGCA TTAGAAGCTG AACGAAGAGA CCGAAGTCAT 1800

GGATCTGAGA TGATTGGAGA TCTCCAAGCT CGAATTACAT CTTTGCAGGA AGAAGTGAAA 1860

TACCTCAAAC ATAACCTTGA AAGAGTGGAG GGGGAAAGAA AAGAGGCTCA GGACATGCTT 1920

AATCATTCAG AAAAGGAAAA GAATAATTTG GAAATAGATT TAAACTATAA GCTAAAATCA 1980

TTACAACAAA GGTTAGAACA AGAAGTAAAT GAGCATAAGG TAACTAAAGC CCGTTTAACA 2040

GATAAGCATC AGTCTATTGA AGAGGCAAAA TCAGTTGCAA TGTATGAAAT GGAAAAGAAA 2100

CTGAAGGAAG AGAGAGCAGC ACGAGAGAAA GCTGAAAATA GAGTTGTTCA CATTGAAAAG 2160

CAATGTTCCA TGCTAGATGT CGACTTGAAA CAGTCACAGC AGAAACTGGA GCATTTGGCT 2220

GAACACAAAG AAAGGATAGA GGATGAAGTT AAGAATTTAA CACTGCAGCT GGAGCAAGAA 2280

TCAAATAAGC GGTTACTGAT ACAGAATGAA TTAAAAACTC AGGCTTTTGA GAAGGACAAT 2340

CTGAAAGGAT TAGAAAAGCA AATGAAACAA GAGATCAACA TGTTGTTGGA AGCAAAGAGA 2400

TCATTGGAAT TTGAACTAGC TCAACTCACA AAACAATATC GTGGAAACGA AGGACAGATG 2460

CGGGAACTAC AGGATCAACT TGAAGCTGAA CAATACTTTT CAACACTTTA TAAAACTCAG 2520

GTAAAGGAAC TTAAAGAAGA CATTGAAGAA AAAAATCGAG AAAATCTAAA GAAAATACAG 2580

GAACTGCAAA ATGAAAAAGA TACACTTACT GCACAGTTAG ACCTTGCAGA AACAAAAGCT 2640

GAATCAGAGC AGTTGGCTCG ACGCCTTCTG GAAGAACAAT ATTTTGAATT GACACAAGAG 2700

TGTAAGAAAG CAGCTTCACG AAATAAACAA GAAATTACAG ATAAAGATCA TACTGTTGGT 2760

CGGCTAGAAG AAATTAAAAC CACATTAACC AAAGATATTG AGTTACTAAG AAAAGAAAAT 2820

GAAGAGTTGG CTGAAAAAAT GAGGAAGGAA CAAGAAGATT ATAAATTGAA GAAAGAAGAG 2880

GAGATCAATA ATCTAAAAGC TTCTTTTGAA AAGAATATTA ATACTGAAAG AACCCTAAAA 2940

ACACAGGCCG TTAACAAGTT GGCAGAAATA ATGAATCGCA AAGATTTTAA AATCGATAGA 3000

AAGAAGGCTA ATACCCAAGA TTTAAGAAAG AAGGAAAAGG AAAACAGAAA GCTACAACTA 3060

GAACTCAACC AAGAAAGAGA GAAATTTAAC CAAATGGTAG TGAAACACCA GAAGGAACTC 3120

AATGAAATGC AAGCGCAATT GGTTGAAGAA TGCACACACA GGAATGAACT TCAGATGCAG 3180

CTGGCTAGCA AAGAGAGTGA CATAGAGCAG TTGCGTGCAA AACTTTTGGA CCTTTCAGAT 3240

TCTACCAGTG TTACTAGTTT TCCTAGTGCT GATGAAACTG ATGGAAACCT TCCAGAATCA 3300

AGAATTGAAG GTTGGCTATC AGTCCCAAAC AGAGGAAATA TAAAACGATA TGGCTGGAAG 3360

AAACAGTATG TTGTTGTGAG CAGCAAAAAA ATTTTGTTCT ATAATGATGA ACAGGATAAG 3420

GAACAGTCAA ATCCATCTAT GGTACTGGAC ATAGACAAAC TATTCCATGT CCGACCTGTA 3480

ACCCAAGGTG ATGTGTATAG AGCAGAAACT GAAGAAATCC CTAAGATATT CCAGATCCTA 3540

TATGCAAATG AAGGTGAATG TAGAAAAGAT TTGGAGATGG AACCAGTACA ACAAGCTGAG 3600

AAGACTAATT TTCAGAATCA CAAAGGCCAT GAGTTTATTC CTACACTCTA TCACTTTCCA 3660

GCCAACTGTG AGGCTTGTGC CAAACCTCTC TGGCATGTTT TTCCACCCCC TGCCCTTGAA 3720

TGTCGAAGAT GCCATGTCAA GTGCCACAGA GATCACTTAG ACAAGAAAGA AGACTTAATT 3780

TCTCCATGCA AAGTGAGTTA TGATGTAACA TCCGCAAGAG ATATGCTGCT GTTAGCTTGT 3840

TCTCAGGATG AACAGAAGAA GTGGGTAACC CATTTAGTAA AGAAGATCCC TAAGAATCCA 3900

CCATCCAGTT TTGTTCGTGC ATCCCCTAGA ACACTTTCTA CCAGATCTAG TGCAAATCAG 3960

TCTTTCCGAA AAGTTGTCAA AAATACATCT GGAAAAACTA GGTAA 4005

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         +e++kviGrGafgev++vr+k+t+kvyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 76    YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql+yafqd++yly+vmey++GGdl++l+s+y+  +pe++arfy+ae+vlald++h++g

Q: 136   VVQLYYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMG  193

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgt  155

         ++hrd+kpdn+lldksGh+kladfG+c+k+n++ t

Q: 194   FIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKKIT  228

         *******************************9865

Domain Sequence
(FASTA)

YEVVKVIGRG AFGEVQLVRH KSTRKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60

VVQLYYAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA RFYTAEVVLA LDAIHSMGFI 120

HRDVKPDNML LDKSGHLKLA DFGTCMKMNK KIT 153

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030036	; P:actin cytoskeleton organization
GO:0003383	; P:apical constriction
GO:0032060	; P:bleb assembly
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction
GO:0050901	; P:leukocyte tethering or rolling
GO:0022614	; P:membrane to membrane docking
GO:0016525	; P:negative regulation of angiogenesis
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:0032970	; P:regulation of actin filament-based process
GO:0045616	; P:regulation of keratinocyte differentiation

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013