EKS-MUP-00229

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00229

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	336.4	1.2E-100	91	342	252

Status

Unreviewed

Ensembl Protein

ENSMPUP00000000283

UniProt Accession

G9K9G1;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase 5 isoform A;

Gene Name

Map2k5

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000000285	ENSMPUP00000000283	ENSMPUT00000000287

Organism

Mustela putorius furo

Functional Description

Protein Length

371

Protein Sequence
(FASTA)

MKAMLSYYYS TVMEQQVNGQ LIEPLQIFPR ACKPPGERNI HGLKVNTRAG PSQHDSPAVS 60

DSLPSNSLKK SSAELKKILA NGQMNEQDIR YRDTLGHGNG GTVYKAYHVP SGKILAVKVI 120

LLDITLELQK QIMSELEILY KCDSSYIIGF YGAFFVENRI SICTEFMDGG SLDVYRKIPE 180

HVLGRIAIAV VKGLTYLWSL KILHRDVKPS NMLVNTRGQV KLCDFGVSTQ LVNSIAKTYV 240

GTNAYMAPER ISGEQYGIHS DVWSLGISFM ELALGRFPYP QIQKNQGSLM PLQLLQCIVD 300

EDSPVLPVGE FSEPFVHFIT QCMRKQPKER PAPEDLMGHP FIMQFNDGNA TVVSMWVCRA 360

LEERRNQQGP P 371

Nucleotide Sequence
(FASTA)

ATGAAGGCCA TGCTGTCCTA TTATTATTCC ACAGTAATGG AACAGCAAGT AAATGGACAG 60

TTAATAGAGC CTCTGCAGAT ATTTCCGAGA GCCTGCAAGC CTCCTGGGGA ACGGAACATA 120

CATGGCCTGA AGGTGAATAC CCGGGCTGGA CCCTCCCAAC ATGATAGCCC AGCAGTCTCC 180

GACTCACTCC CAAGCAATAG CTTAAAGAAA TCTTCTGCTG AACTGAAAAA AATATTAGCC 240

AATGGCCAGA TGAATGAACA AGACATACGA TATCGAGACA CTCTTGGCCA TGGCAACGGA 300

GGCACAGTCT ACAAAGCATA TCATGTCCCG AGTGGGAAAA TATTAGCTGT AAAGGTCATA 360

CTACTAGATA TTACACTGGA ACTTCAGAAG CAAATTATGT CTGAATTGGA AATTCTTTAT 420

AAGTGTGATT CATCATATAT CATAGGGTTT TATGGTGCAT TTTTCGTAGA AAACAGGATT 480

TCAATATGTA CAGAATTCAT GGATGGGGGC TCCTTGGATG TATATAGAAA AATTCCAGAG 540

CATGTCCTTG GAAGAATTGC AATAGCAGTT GTTAAAGGCC TCACCTATTT GTGGAGTTTA 600

AAGATTTTAC ATAGAGATGT AAAACCCTCC AATATGCTAG TAAACACAAG AGGACAGGTC 660

AAGCTGTGTG ATTTTGGAGT TAGCACTCAG CTGGTGAATT CTATAGCCAA GACGTATGTT 720

GGAACAAACG CTTATATGGC GCCCGAAAGA ATTTCAGGGG AGCAGTATGG AATCCATTCC 780

GATGTCTGGA GTTTAGGGAT CTCTTTTATG GAGCTTGCTC TTGGGAGGTT TCCATATCCT 840

CAGATTCAGA AAAACCAGGG ATCTTTAATG CCTCTCCAGC TTCTGCAGTG CATTGTTGAT 900

GAGGATTCGC CCGTCCTTCC GGTTGGAGAG TTCTCCGAGC CATTTGTACA TTTCATCACT 960

CAGTGCATGC GAAAACAACC CAAAGAAAGA CCAGCACCTG AGGACCTGAT GGGCCACCCG 1020

TTCATCATGC AGTTCAATGA CGGAAACGCC ACCGTGGTGT CCATGTGGGT GTGCAGGGCG 1080

CTGGAGGAGA GGCGGAACCA GCAGGGGCCC CCGTGA 1116

Domain Profile

S: 3     kleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyivk  62

           ++lG+Gngg+V+k+ h +sgkilavK i l+i+ e qkqi++ele+l k+ +s+yi++

Q: 91    YRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIG  149

         5689************************************************.*******

S: 63    fyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkekl  122

         fyGaf+ e+++sic+e+mdg+sld v++k       ipe+vlg+ia+avvk+l+yl+ +l

Q: 150   FYGAFFVENRISICTEFMDGGSLD-VYRK-------IPEHVLGRIAIAVVKGLTYLW-SL  200

         ************************.6876.......9********************.78

S: 123   kiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsvk  182

         ki+HRDvKPsN+Lvn++G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri+g ++Y ++

Q: 201   KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISG-EQYGIH  259

         *****************************************************.******

S: 183   sdvWslGltlvelatgrypyeklke......ilellkaivneeppklpeeefseefqefv  236

         sdvWslG++++ela gr+py++ ++      +l+ll++iv+e++p+lp  efse f++f+

Q: 260   SDVWSLGISFMELALGRFPYPQIQKnqgslmPLQLLQCIVDEDSPVLPVGEFSEPFVHFI  319

         ***********************9999*********************************

S: 237   skClkkdekeRpklkellkhafi  259

         ++C++k++keRp  ++l+ h+fi

Q: 320   TQCMRKQPKERPAPEDLMGHPFI  342

         **********************7

Domain Sequence
(FASTA)

YRDTLGHGNG GTVYKAYHVP SGKILAVKVI LLDITLELQK QIMSELEILY KCDSSYIIGF 60

YGAFFVENRI SICTEFMDGG SLDVYRKIPE HVLGRIAIAV VKGLTYLWSL KILHRDVKPS 120

NMLVNTRGQV KLCDFGVSTQ LVNSIAKTYV GTNAYMAPER ISGEQYGIHS DVWSLGISFM 180

ELALGRFPYP QIQKNQGSLM PLQLLQCIVD EDSPVLPVGE FSEPFVHFIT QCMRKQPKER 240

PAPEDLMGHP FI 252

Keyword

ATP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005819	; C:spindle
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007507	; P:heart development
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013