EKS-MUP-00225

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00225

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	386.3	7.0E-116	69	361	293

Status

Unreviewed

Ensembl Protein

ENSMPUP00000000360

UniProt Accession

G9K9F7;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase 1;

Gene Name

Map2k1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000000363	ENSMPUP00000000360	ENSMPUT00000000367

Organism

Mustela putorius furo

Functional Description

Protein Length

393

Protein Sequence
(FASTA)

MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV 60

GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE 120

CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL 180

REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY 240

SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELVFGCPVE GDAAETPPRP RTPGRPLSSY 300

GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF 360

IKRSDGEEVD FAGWLCSTIG LNQPSTPTHA AGV 393

Nucleotide Sequence
(FASTA)

ATGCCCAAGA AGAAGCCGAC GCCCATCCAG CTGAACCCGG CCCCCGACGG CTCCGCGGTT 60

AACGGGACCA GCTCGGCGGA GACCAACCTG GAGGCCTTAC AGAAGAAGCT TGAGGAGCTG 120

GAGCTTGATG AGCAGCAGCG GAAGCGCCTT GAGGCCTTTC TCACCCAGAA GCAGAAGGTC 180

GGGGAATTGA AGGATGATGA CTTTGAGAAG ATCAGTGAGC TTGGCGCAGG CAACGGTGGT 240

GTGGTGTTCA AGGTCTCCCA CAAGCCATCA GGCCTGGTCA TGGCCAGAAA GCTCATTCAC 300

CTGGAGATCA AACCTGCAAT CCGGAACCAG ATCATAAGGG AGCTTCAGGT CCTACACGAG 360

TGCAACTCCC CCTACATCGT GGGCTTCTAC GGTGCATTCT ACAGCGATGG CGAGATCAGC 420

ATCTGCATGG AGCACATGGA TGGGGGTTCC TTGGATCAAG TCCTGAAGAA AGCTGGAAGA 480

ATTCCTGAGC AAATTTTAGG AAAAGTTAGC ATTGCTGTAA TAAAAGGTCT GACATACCTG 540

AGGGAGAAGC ACAAGATTAT GCACAGAGAT GTCAAGCCTT CCAACATCCT CGTGAACTCC 600

CGTGGGGAGA TCAAGCTCTG TGACTTTGGG GTCAGTGGGC AACTCATCGA CTCCATGGCC 660

AACTCCTTTG TGGGCACAAG GTCCTACATG TCGCCGGAAA GACTCCAGGG GACCCACTAC 720

TCAGTGCAGT CGGACATCTG GAGCATGGGG CTGTCTCTGG TTGAGATGGC GGTGGGGAGG 780

TATCCCATCC CTCCCCCAGA CGCCAAGGAG CTGGAGCTGG TGTTTGGGTG CCCAGTGGAG 840

GGAGATGCGG CGGAGACACC ACCCAGACCC AGGACTCCTG GAAGGCCCCT CAGCTCTTAT 900

GGAATGGACA GCCGACCTCC CATGGCAATT TTTGAGCTGC TGGATTACAT AGTCAATGAG 960

CCTCCTCCAA AACTGCCCAG TGGAGTGTTC AGTCTGGAAT TTCAAGATTT TGTGAATAAA 1020

TGCTTAATAA AAAACCCAGC AGAGAGAGCA GATCTGAAGC AACTCATGGT TCATGCCTTT 1080

ATCAAGAGAT CTGATGGGGA GGAAGTGGAT TTTGCAGGTT GGCTCTGCTC CACCATTGGC 1140

CTTAACCAGC CCAGCACACC GACCCACGCA GCTGGCGTTT AA 1182

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         ek++elGaGnggvV kv+hk+sg ++a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 69    EKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  127

         799**************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlkk    ++ripe++lgk+++av+k+l+yl+ek

Q: 128   GFYGAFYSDGEISICMEHMDGGSLDQVLKK----AGRIPEQILGKVSIAVIKGLTYLREK  183

         *****************************9....8*************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         +ki+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 184   HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  242

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lve+a+gryp++++++

Q: 243   QSDIWSMGLSLVEMAVGRYPIPPPDAkelelvfgcpvegdaaetpprprtpgrplssygm  302

         ************************999*********************************

S: 208   .......ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhafi  259

                i+ell++ivne+ppklp+  fs efq+fv+kCl+k+++eR++lk+l+ hafi

Q: 303   dsrppmaIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI  361

         *********************************************************97

Domain Sequence
(FASTA)

EKISELGAGN GGVVFKVSHK PSGLVMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKKA GRIPEQILGK VSIAVIKGLT YLREKHKIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180

MGLSLVEMAV GRYPIPPPDA KELELVFGCP VEGDAAETPP RPRTPGRPLS SYGMDSRPPM 240

AIFELLDYIV NEPPPKLPSG VFSLEFQDFV NKCLIKNPAE RADLKQLMVH AFI 293

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004708	; F:MAP kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004728	; F:receptor signaling protein tyrosine phosphatase activity
GO:0007050	; P:cell cycle arrest
GO:0048870	; P:cell motility
GO:0090398	; P:cellular senescence
GO:0030216	; P:keratinocyte differentiation
GO:0060711	; P:labyrinthine layer development
GO:0008285	; P:negative regulation of cell proliferation
GO:0030182	; P:neuron differentiation
GO:0060674	; P:placenta blood vessel development
GO:0045597	; P:positive regulation of cell differentiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013