EKS-MUP-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	345.7	1.9E-103	874	1146	273

Status

Unreviewed

Ensembl Protein

ENSMPUP00000000717

UniProt Accession

G9K6H8;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

Jak1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000000719	ENSMPUP00000000717	ENSMPUT00000000730

Organism

Mustela putorius furo

Functional Description

Protein Length

1153

Protein Sequence
(FASTA)

MQYLNIKEDC NAMAFCAKMR SSKKTEVNLE APEPGVEVLF YLSDREPLRL GSGEYTAEEI 60

CIRAAQECCI SPLCHNLFAL YDENSKLWYA PNRAITVDDK TSLRLHYRMR FYFTNWHGTN 120

DNEQSVWRHS PKKQKNGYEK KKVPDATPLL DASSLEYLFA QGQYDLVKCL APIRDPKTEQ 180

DGHDIENECL GMAVLAISHY AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI 240

NNVFKDFLKE FNNKTICDSS VSTHDLKVKY LATLETLTKH YGAEIFETSM LLISSENELN 300

WFHPNDSGNV LYYEVMVTGN LGIQWRQKPN VVPVEKEKNK LKRKKLENKH KKDEEKNKIR 360

EEWNNFSYFP EITHIVIKES VVSINKQDNK KMELKLSSHE EALSFVSLID GYFRLTADAH 420

HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT 480

CFEKSEVLGG QKQFKNFQIE VQKGRYSLHG SDRSFPSLGD LMSHLKKQIL RTDNISFVLK 540

RCCQPKPREI SNLLVATKKA QEWQPVYPMS QLSFDRILKK DIVQGEHLGR GTRTHIYSGT 600

LVDYKDDEGT SEEKRIKVIL KVLDPSHRDI SLAFFEAASM MRQVSHKHIV YLYGVCVRDV 660

ENIMVEEFVE GGPLDLFMHR KSDVLTTPWK FKVAKQLASA LSYLEDKDLV HGNVCTKNLL 720

LAREGIDSEC GPFIKLSDPG IPITVLSRQE CIERIPWIAP ECVEDSKNLS VAADKWSFGT 780

TLWEICYNGE IPLKDKTLIE KERFYESRCR PVTPSCKELA DLMTRCMNYD PNQRPFFRAI 840

MRDINKLEEQ NPDIVSERKP ATEVDPTHFE KRFLKRIRDL GEGHFGKVEL CRYDPEGDNT 900

GEQVAVKSLK PESGGNHIAD LKKEIEILRN LYHENIVKYK GICTEDGGNG IKLIMEFLPS 960

GSLKEYLPKN KNKINLKQQL KYAVQICKGM DYLGSRQYVH RDLAARNVLV ESEHQVKIGD 1020

FGLTKAIETD KEYYTVKDDR DSPVFWYAPE CLIQCKFYIA SDVWSFGVTL HELLTYCDSD 1080

YSPMALFLKM IGPTHGQMTV TRLVNTLKEG KRLPCPLHCP DEVYQLMRKC WEFQPSNRTT 1140

FQNLIEGFEA LLK 1153

Nucleotide Sequence
(FASTA)

ATGCAGTATC TAAATATAAA AGAGGACTGC AATGCCATGG CTTTCTGTGC TAAAATGAGG 60

AGCTCTAAGA AGACAGAGGT GAATCTGGAG GCCCCCGAGC CAGGAGTGGA AGTGCTCTTC 120

TATCTTTCTG ATAGGGAGCC CCTCCGGCTG GGCAGCGGAG AGTACACTGC GGAGGAGATC 180

TGCATCAGGG CTGCGCAGGA ATGCTGTATC TCTCCCCTGT GTCACAACCT CTTTGCCCTG 240

TATGACGAGA ACAGCAAGCT CTGGTATGCC CCGAATCGCG CCATCACTGT TGACGACAAG 300

ACATCCCTCC GGCTCCACTA CCGGATGAGG TTCTATTTCA CCAACTGGCA TGGGACCAAT 360

GATAATGAGC AGTCTGTATG GCGACATTCT CCAAAGAAGC AGAAAAATGG CTATGAGAAA 420

AAAAAAGTCC CAGATGCAAC CCCTCTTCTT GATGCCAGTT CTTTGGAATA TCTGTTTGCT 480

CAGGGACAGT ATGATTTGGT CAAATGTCTG GCTCCTATTC GAGACCCCAA GACCGAGCAG 540

GATGGGCATG ATATCGAGAA CGAGTGTCTG GGAATGGCTG TCCTGGCCAT CTCCCACTAT 600

GCCATGATGA AGAAGATGCA GTTGCCAGAA CTGCCCAAGG ACATCAGCTA CAAGCGTTAT 660

ATTCCAGAAA CATTAAATAA GTCCATCAGA CAGAGGAACC TTCTCACCAG GATGCGGATA 720

AATAATGTTT TCAAGGATTT CCTAAAGGAA TTTAACAACA AGACTATTTG CGACAGCAGT 780

GTATCTACTC ATGACCTAAA GGTGAAGTAC CTGGCCACCT TGGAAACACT GACAAAACAT 840

TACGGCGCAG AAATATTTGA GACTTCCATG TTACTGATTT CTTCAGAAAA TGAGTTGAAT 900

TGGTTTCATC CAAACGACAG TGGAAACGTT CTCTACTATG AAGTGATGGT AACTGGAAAT 960

CTTGGAATCC AGTGGAGACA GAAACCAAAT GTTGTTCCTG TTGAAAAGGA AAAAAACAAA 1020

CTGAAACGGA AAAAACTGGA AAATAAACAC AAGAAGGATG AGGAGAAAAA CAAAATCCGG 1080

GAAGAGTGGA ACAATTTTTC TTATTTCCCT GAAATCACTC ACATTGTAAT AAAGGAGTCT 1140

GTGGTCAGCA TCAATAAGCA GGACAACAAA AAAATGGAAC TGAAGCTCTC GTCCCATGAA 1200

GAGGCCTTGT CCTTTGTGTC CCTGATAGAT GGCTACTTCC GGCTCACAGC AGATGCCCAT 1260

CATTACCTCT GCACCGATGT GGCTCCCCCA TTGATCGTCC ACAACATACA GAATGGTTGT 1320

CACGGTCCAA TTTGCACGGA ATATGCCATC AATAAGTTGC GGCAAGAAGG AAGCGAGGAG 1380

GGGATGTATG TGCTGAGGTG GAGCTGTACC GACTTTGATA ATATCCTCAT GACGGTCACC 1440

TGCTTTGAGA AATCTGAGGT GCTGGGTGGC CAGAAGCAGT TCAAGAACTT TCAGATCGAA 1500

GTGCAGAAGG GCCGCTATAG CCTGCACGGC TCGGACCGCA GCTTCCCCAG CCTGGGGGAC 1560

CTGATGAGCC ACCTCAAGAA GCAGATCCTG CGCACGGACA ACATCAGCTT CGTGCTGAAG 1620

CGCTGCTGCC AGCCCAAGCC CCGAGAGATC TCCAATCTGC TGGTGGCTAC AAAGAAAGCC 1680

CAGGAGTGGC AGCCTGTCTA CCCCATGAGC CAGCTGAGTT TTGACCGGAT CCTCAAGAAA 1740

GACATCGTGC AAGGTGAGCA TCTCGGGAGA GGCACACGGA CACACATCTA CTCCGGCACC 1800

CTGGTGGATT ACAAGGATGA CGAAGGAACT TCGGAAGAGA AGAGAATAAA AGTGATCCTC 1860

AAAGTCTTAG ACCCCAGCCA CAGGGACATT TCTCTGGCCT TCTTCGAAGC AGCCAGCATG 1920

ATGAGGCAGG TCTCCCACAA ACACATCGTG TACCTCTATG GTGTCTGTGT TCGAGATGTA 1980

GAGAATATCA TGGTGGAGGA GTTTGTGGAA GGGGGGCCCC TGGATCTCTT CATGCACCGG 2040

AAAAGCGATG TCCTCACCAC ACCATGGAAG TTCAAAGTTG CCAAACAGCT AGCCAGCGCC 2100

CTGAGTTACT TGGAGGATAA AGACCTGGTC CATGGAAACG TGTGCACGAA AAACCTTCTC 2160

CTGGCCCGTG AGGGCATTGA CAGCGAGTGT GGCCCATTCA TCAAGCTCAG TGACCCTGGC 2220

ATCCCCATCA CCGTGCTGTC CAGGCAAGAG TGCATAGAAC GAATCCCGTG GATTGCTCCT 2280

GAGTGTGTTG AAGACTCCAA GAACCTGAGT GTGGCTGCTG ACAAATGGAG CTTTGGAACC 2340

ACACTCTGGG AAATCTGCTA CAATGGCGAG ATCCCTCTGA AAGATAAGAC CCTGATTGAG 2400

AAAGAGAGAT TCTACGAAAG CCGGTGCCGG CCAGTGACAC CATCTTGTAA GGAGCTGGCT 2460

GACCTCATGA CACGCTGCAT GAACTATGAC CCCAACCAGA GACCCTTCTT CCGAGCCATT 2520

ATGAGAGACA TCAACAAACT AGAAGAGCAG AATCCAGACA TTGTTTCTGA AAGAAAGCCG 2580

GCAACCGAAG TAGATCCCAC ACATTTTGAA AAGCGGTTCT TGAAGAGGAT CCGTGACTTG 2640

GGAGAGGGCC ACTTTGGGAA GGTTGAGCTC TGCAGGTATG ACCCTGAGGG GGACAATACC 2700

GGGGAGCAAG TGGCGGTGAA GTCCCTGAAG CCCGAGAGTG GAGGCAACCA CATAGCTGAT 2760

CTGAAGAAGG AAATTGAAAT CCTAAGGAAC CTCTATCACG AGAACATTGT GAAGTACAAA 2820

GGCATCTGTA CAGAAGATGG AGGAAATGGT ATTAAACTCA TCATGGAATT TCTGCCTTCA 2880

GGAAGCCTTA AGGAATATCT TCCAAAGAAC AAGAACAAAA TTAACCTCAA ACAGCAATTA 2940

AAATACGCTG TTCAGATTTG TAAGGGGATG GACTATTTGG GTTCTCGGCA GTATGTTCAC 3000

CGGGACTTGG CAGCAAGAAA CGTCCTTGTT GAGAGTGAGC ACCAAGTGAA AATTGGAGAC 3060

TTTGGTTTGA CCAAAGCAAT CGAAACTGAC AAAGAGTACT ACACCGTCAA GGATGATCGG 3120

GACAGCCCTG TGTTTTGGTA TGCTCCCGAA TGTTTAATTC AGTGTAAATT TTACATCGCC 3180

TCTGATGTCT GGTCATTTGG AGTGACTCTG CATGAGTTGC TTACTTACTG TGACTCAGAT 3240

TACAGCCCCA TGGCGTTGTT CCTGAAAATG ATAGGCCCAA CTCATGGCCA GATGACAGTC 3300

ACAAGACTTG TGAATACATT AAAAGAAGGA AAACGTTTGC CTTGTCCACT TCACTGCCCA 3360

GATGAGGTTT ATCAACTTAT GAGAAAATGC TGGGAGTTCC AACCATCCAA TCGGACAACT 3420

TTTCAGAACC TTATCGAAGG ATTTGAAGCA CTTTTAAAAT AA 3462

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h

Q: 874   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYH  933

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+k+k++++l+++l++a q++k+m+YL

Q: 934   ENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYL  993

         ************************************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aarnvLve+e++      vk++d+gl+ka+++d eYy+v+++rds+++w+

Q: 994   GSRQYVHRDLAARNVLVESEHQ------VKIGDFGLTKAIETDkEYYTVKDDRDSPVFWY  1047

         **********************......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+++k +++asdvWsFgvtl+ellt c+++ sp    l++++++       r++++

Q: 1048  APECLIQCK-FYIASDVWSFGVTLHELLTyCDSDYSPmalfLKMIGPThgqmtvtRLVNT  1106

         *********.*******************************9****999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         l+e++rlp+p  cp+e+++lm++c++ +ps+r++F++++e

Q: 1107  LKEGKRLPCPLhCPDEVYQLMRKCWEFQPSNRTTFQNLIE  1146

         *************************************987

Domain Sequence
(FASTA)

LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNHIADLKK EIEILRNLYH 60

ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL KEYLPKNKNK INLKQQLKYA VQICKGMDYL 120

GSRQYVHRDL AARNVLVESE HQVKIGDFGL TKAIETDKEY YTVKDDRDSP VFWYAPECLI 180

QCKFYIASDV WSFGVTLHEL LTYCDSDYSP MALFLKMIGP THGQMTVTRL VNTLKEGKRL 240

PCPLHCPDEV YQLMRKCWEF QPSNRTTFQN LIE 273

Keyword

ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway
GO:0007167	; P:enzyme linked receptor protein signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046677	; P:response to antibiotic

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013