EKS-MUP-00162

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00162

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	615.7	8.7E-186	456	734	279

Status

Unreviewed

Ensembl Protein

ENSMPUP00000000814

UniProt Accession

G9KTH4;

Protein Name

Protein Synonyms/Alias

Tousled-like kinase 1;

Gene Name

Tlk1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000000818	ENSMPUP00000000814	ENSMPUT00000000830

Organism

Mustela putorius furo

Functional Description

Protein Length

766

Protein Sequence
(FASTA)

MSVQSSSGSL EGPPSWSQLS TSPTPGSAAA ARSLLNHTPP SGRPREGAMD ELHSLDPRRQ 60

ELLEARFTGV ASGSTGSTGS CSVGAKASTN NESSNHSFGS LGSLSDKESE TPEKKQSESS 120

RGRKRKAENQ NESSQGKSIG GRGHKISDYF EYQGGNGSSP VRGIPPAIRS PQNSHSHSTP 180

SSSVRPNSPS PTALAFGDHP VIQPKQLSFK ITQTDLTMLK LAALESNKNQ DLEKKEGRID 240

DLLRANCDLR RQIDEQQKLL EKYKERLNKC ISMSKKLLIE KSTQEKLSSR EKSMQDRLRL 300

GHFTTVRHGA SFTEQWTDGF AFQNLVKQQE WVNQQREDIE RQRKLLAKRK PPTANNSQAP 360

STNSEPKQRK NKAVNGAEND PFVRPNLPQL LTLAEYHEQE EIFKLRLGHL KKEEAEIQAE 420

LERLERVRNL HIRELKRINN EDNSQFKDHP TLNERYLLLH LLGRGGFSEV YKAFDLYEQR 480

YAAVKIHQLN KSWRDEKKEN YHKHACREYR IHKELDHPRI VKLYDYFSLD TDTFCTVLEY 540

CEGNDLDFYL KQHKLMSEKE ARSIVMQIVN ALRYLNEIKP PIIHYDLKPG NILLVDGTAC 600

GEIKITDFGL SKIMDDDSYG VDGMDLTSQG AGTYWYLPPE CFVVGKEPPK ISNKVDVWSV 660

GVIFFQCLYG RKPFGHNQSQ QDILQENTIL KATEVQFPVK PVVSSEAKAF IRRCLAYRKE 720

DRFDVHQLAN DPYLLPHMRR SNSSGNLHMA GLTASPTPPS SSIITY 766

Nucleotide Sequence
(FASTA)

ATGAGTGTCC AAAGTAGCAG TGGAAGTTTG GAGGGGCCGC CATCTTGGTC CCAGCTCTCC 60

ACGTCTCCAA CCCCGGGCTC GGCGGCGGCG GCCAGGTCCC TGCTGAATCA CACGCCGCCA 120

TCCGGGAGGC CCAGGGAAGG TGCAATGGAT GAGCTTCATA GTCTGGATCC AAGAAGGCAA 180

GAATTACTGG AAGCTAGATT TACAGGAGTT GCAAGTGGGA GCACAGGCAG CACTGGCAGT 240

TGCAGTGTTG GAGCAAAAGC CTCAACAAAT AATGAAAGTT CTAATCACAG TTTTGGAAGC 300

TTGGGATCTT TAAGTGACAA AGAATCTGAG ACACCAGAGA AGAAACAATC AGAGTCATCC 360

AGAGGAAGAA AGAGAAAAGC AGAAAACCAG AATGAAAGTA GTCAGGGAAA AAGTATTGGG 420

GGACGTGGCC ACAAAATTAG TGACTATTTT GAATACCAAG GTGGGAATGG CTCAAGTCCA 480

GTAAGAGGCA TACCTCCTGC GATCCGTTCT CCTCAGAATT CACATTCACA TTCCACTCCT 540

TCTTCATCTG TTCGACCGAA TAGCCCTTCT CCTACTGCAT TAGCTTTTGG GGACCACCCT 600

GTTATACAAC CAAAGCAGTT ATCCTTTAAA ATTACTCAGA CTGATCTCAC AATGCTGAAA 660

TTAGCAGCAT TAGAAAGTAA TAAAAACCAG GACCTGGAAA AGAAGGAAGG TCGTATAGAT 720

GACTTGCTCA GGGCTAACTG TGATCTCAGA CGGCAGATAG ATGAACAACA AAAATTACTT 780

GAAAAATACA AAGAACGATT AAATAAGTGT ATATCAATGA GCAAGAAGCT GCTTATTGAA 840

AAGAGTACAC AAGAAAAATT GTCAAGCAGA GAAAAGAGTA TGCAAGACCG ATTACGCCTT 900

GGGCACTTCA CAACAGTTAG ACATGGTGCT TCATTTACTG AACAATGGAC AGATGGTTTT 960

GCATTTCAGA ATCTTGTGAA GCAACAAGAA TGGGTGAATC AGCAAAGGGA AGATATTGAA 1020

AGGCAAAGGA AACTTCTAGC CAAACGCAAA CCTCCCACGG CTAATAATTC TCAGGCACCC 1080

TCTACCAATT CTGAACCAAA ACAAAGGAAA AACAAAGCAG TTAATGGAGC AGAGAATGAT 1140

CCCTTTGTTA GACCAAATTT ACCACAACTG TTGACTTTGG CAGAATATCA TGAACAGGAA 1200

GAAATTTTCA AACTTAGACT AGGACATCTC AAAAAGGAAG AGGCAGAAAT CCAGGCAGAA 1260

CTTGAACGTT TGGAAAGAGT CAGAAATCTT CATATTCGAG AGCTGAAAAG AATAAATAAT 1320

GAAGATAATT CGCAGTTCAA AGATCACCCA ACGTTAAATG AAAGATATTT GTTACTTCAT 1380

CTGCTTGGTA GAGGTGGCTT TAGTGAAGTG TATAAGGCTT TTGACCTTTA TGAACAAAGA 1440

TATGCTGCTG TGAAGATCCA CCAGCTTAAT AAAAGCTGGA GGGATGAGAA GAAGGAAAAC 1500

TACCACAAAC ACGCCTGCAG AGAATATAGA ATACACAAAG AACTGGATCA CCCTAGGATA 1560

GTTAAACTCT ATGATTATTT CTCCTTGGAT ACAGATACGT TTTGTACAGT GTTGGAATAC 1620

TGTGAAGGCA ATGACTTGGA TTTCTATCTG AAGCAACATA AGTTAATGTC AGAGAAGGAA 1680

GCTAGGTCTA TTGTAATGCA GATTGTAAAT GCACTAAGAT ATCTCAATGA AATCAAACCC 1740

CCTATTATAC ATTATGATCT TAAGCCAGGA AACATCCTTC TGGTAGATGG CACAGCATGT 1800

GGAGAAATCA AAATCACTGA TTTTGGTCTG TCCAAGATCA TGGATGATGA TAGCTATGGT 1860

GTAGATGGAA TGGATCTAAC TTCTCAAGGG GCAGGCACTT ACTGGTATTT ACCTCCCGAG 1920

TGTTTTGTAG TTGGAAAAGA ACCACCAAAG ATTTCCAACA AGGTCGATGT GTGGTCAGTT 1980

GGTGTTATTT TCTTTCAGTG TCTTTATGGT AGAAAGCCAT TTGGTCACAA TCAATCACAA 2040

CAAGACATTC TTCAAGAAAA TACAATATTG AAAGCCACAG AAGTCCAGTT CCCTGTAAAA 2100

CCAGTTGTAA GCAGTGAAGC AAAGGCCTTC ATAAGACGCT GTCTGGCCTA CCGAAAAGAA 2160

GATCGGTTTG ATGTGCACCA ACTGGCAAAT GACCCATACC TTCTCCCACA TATGAGAAGA 2220

TCGAATTCTT CAGGAAACTT ACACATGGCT GGGCTTACAG CATCCCCCAC ACCCCCTTCC 2280

TCAAGCATCA TCACTTACTG A 2301

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqry+avkihqlnk+w+dekkeny+kha+reyrihkel

Q: 456   YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL  515

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctvley+egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 516   DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  575

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy++d g++ltsqgagty

Q: 576   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVD-GMDLTSQGAGTY  634

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkate

Q: 635   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE  694

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvvsseakafirrclayrkedr+dv+qla+d+yl

Q: 695   VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL  734

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LYEQRYAAVK IHQLNKSWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVLEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATEV 240

QFPVKPVVSS EAKAFIRRCL AYRKEDRFDV HQLANDPYL 279

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006886	; P:intracellular protein transport
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013