EPS-MUP-00019

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUP-00019

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	236.5	4.0E-70	94	344	251

Status

Unreviewed

Ensembl Protein

ENSMPUP00000002170

UniProt Accession

G9KI37;

Protein Name

Protein Synonyms/Alias

Protein phosphatase 1K;

Gene Name

PPM1K

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000002192	ENSMPUP00000002170	ENSMPUT00000002214

Organism

Mustela putorius furo

Functional Description

Protein Length

372

Protein Sequence
(FASTA)

MSTAALITLV RSGGSHVRRR VLLSSRLLQD DKRLTPTCHS STSEPRCSRF DPDGSGRPAT 60

WDNFGIWDNR IDEPILLPPS IKYGKPIPKI SLENVGCASH IGKRKENEDR FDSAQLTDEV 120

LYFAVYDGHG GPAAADFCHT HMEKCIMDLL PKEKNLETVL TLAFLEIDKA FSRHAHLSAD 180

ATLLTSGTTA TIALVRDGIE LVVASVGDSR AILCRKGKPM KLTIDHTPER KDEKERIKKC 240

GGFVAWNSLG QPHVNGRLAM TRSLGDLDLK TSGVIAEPET KRIKLQHADD SFLVLTTDGI 300

NFMVNSQEIC DFVNQCHDPN EAAHAVIEQA IQYGSEDNST VVVVPFGAWG KYKNSEINFS 360

FSRSFASSGR WA 372

Nucleotide Sequence
(FASTA)

ATGTCCACAG CTGCCCTAAT TACTTTGGTG AGAAGCGGTG GGAGCCACGT GAGAAGGAGA 60

GTGCTGCTAA GCTCCCGCCT ACTGCAGGAC GACAAGCGGC TGACACCCAC CTGCCACAGC 120

TCCACTTCGG AGCCCAGGTG TTCTCGGTTT GATCCGGATG GTAGTGGGCG TCCGGCCACC 180

TGGGATAATT TTGGGATCTG GGATAACCGC ATCGATGAGC CCATTCTGCT GCCGCCCAGC 240

ATTAAGTATG GCAAGCCAAT TCCCAAAATC AGCCTGGAGA ACGTGGGCTG CGCCTCGCAT 300

ATTGGGAAAC GGAAAGAGAA TGAAGACCGG TTTGACAGCG CTCAGCTGAC AGATGAGGTC 360

CTGTACTTCG CGGTGTATGA CGGCCACGGC GGACCTGCAG CCGCGGATTT CTGTCACACC 420

CACATGGAGA AATGCATCAT GGACTTGCTT CCTAAGGAGA AGAACTTGGA AACTGTGTTG 480

ACCTTGGCTT TTCTAGAAAT AGATAAAGCG TTTTCAAGGC ACGCCCACCT GTCTGCGGAT 540

GCAACCCTTC TGACCTCTGG GACTACTGCA ACGATAGCCC TGGTGAGAGA TGGTATTGAA 600

CTGGTTGTAG CCAGTGTTGG GGATAGCCGG GCTATTTTGT GTAGAAAAGG AAAACCTATG 660

AAGCTGACCA TTGACCATAC TCCAGAAAGA AAAGATGAAA AAGAAAGGAT CAAGAAATGT 720

GGTGGTTTTG TGGCTTGGAA TAGTTTGGGA CAGCCTCACG TGAATGGCAG ACTTGCAATG 780

ACAAGGAGTC TTGGAGACTT GGATCTTAAA ACCAGTGGTG TGATAGCAGA ACCAGAAACA 840

AAGAGGATTA AGCTACAGCA TGCTGATGAC AGCTTCCTGG TCCTCACAAC AGATGGAATT 900

AATTTCATGG TGAATAGTCA AGAGATCTGT GACTTTGTCA ACCAGTGCCA TGATCCCAAC 960

GAAGCAGCCC ATGCAGTGAT TGAACAGGCA ATACAATATG GTAGTGAAGA TAATAGTACT 1020

GTGGTCGTAG TGCCTTTTGG TGCGTGGGGA AAGTACAAGA ACTCTGAAAT CAACTTTTCA 1080

TTCAGCAGAA GCTTTGCCTC CAGCGGACGA TGGGCCTGA 1119

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         +vg++s  g+r+e ed+++s    +   + +d++ +f+vyDGhgg  +a+fc++++++++

Q: 94    NVGCASHIGKRKENEDRFDS----A---QLTDEVLYFAVYDGHGGPAAADFCHTHMEKCI  146

         57999999*******99975....3...3445589*************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidk....sGstavvalikds.k  116

            l     +e++++++l+ aFl++d+++    +++l+ d+    sG+ta++al++d  +

Q: 147   MDLLP----KEKNLETVLTLAFLEIDKAF--SRHAHLSADAtlltSGTTATIALVRDGiE  200

         ***87....********************..44444444445789*************9*

S: 117   lyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkd.ga.RvlGvLav  174

         l+va vGdSra+Lcr+gk+++l+ dH+p+r+dE+eRi++ gg v+ ++ g+ +v+G La+

Q: 201   LVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSlGQpHVNGRLAM  260

         ********************************************98889999********

S: 175   sRalGdlylk.pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekk  232

         +R+lGdl+lk + v++ePe+  ++l++ d+ fl+L +DG+  +v+++e++++v+++++

Q: 261   TRSLGDLDLKtSGVIAEPETKRIKLQHADDsFLVLTTDGINFMVNSQEICDFVNQCHD--  318

         **********566**************9999***************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           ++eaa+ ++++a+++gs+dn +++vv

Q: 319   --PNEAAHAVIEQAIQYGSEDNSTVVVV  344

         ..*********************99987

Domain Sequence
(FASTA)

NVGCASHIGK RKENEDRFDS AQLTDEVLYF AVYDGHGGPA AADFCHTHME KCIMDLLPKE 60

KNLETVLTLA FLEIDKAFSR HAHLSADATL LTSGTTATIA LVRDGIELVV ASVGDSRAIL 120

CRKGKPMKLT IDHTPERKDE KERIKKCGGF VAWNSLGQPH VNGRLAMTRS LGDLDLKTSG 180

VIAEPETKRI KLQHADDSFL VLTTDGINFM VNSQEICDFV NQCHDPNEAA HAVIEQAIQY 240

GSEDNSTVVV V 251

Keyword

Hydrolase; Magnesium; Metal-binding; Protein phosphatase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013