EKS-MUP-00044

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00044

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/VRK	360.8	3.6E-108	148	413	266

Status

Unreviewed

Ensembl Protein

ENSMPUP00000002265

UniProt Accession

G9KXH1;

Protein Name

Protein Synonyms/Alias

Vaccinia related kinase 3;

Gene Name

VRK3

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000002289	ENSMPUP00000002265	ENSMPUT00000002311

Organism

Mustela putorius furo

Functional Description

Protein Length

455

Protein Sequence
(FASTA)

MFTFCPDCGK SIEASFKFCP YCGKPLSLAE HEGSQTFVRP RTSSFRGSRK QSNSSPEIPC 60

KKVKWSSSVT SPSSSLCLDG DSSGSEDTVR SKGSWSRPPT PKSSPQATKR SPQAMKRSPQ 120

TLKRSRVTTS LEALPTGVVV TDKSGRHWKL GPLQTRDDQG ILYEAEALST LACKSSQKQT 180

FSLKLDAKDG RLFNEQNFFQ RAAKPLQVNK WKKLNSTPLL AIPTCVGFGI HQDRYRFLVF 240

PMLGRSLQSV LDDNPKHVLS MKSVFQMACR LLDVLEFLHE NEYVHGNVTA KNIFVNPEDL 300

SQVTLAGYGF TFRYAPGGKH VAYVEGSRSP HEGDLEFMSL DLHKGCGPSR RSDLQTLGYC 360

LLKWLYGILP WTDCLPNIED IMKLKQKFLD NPETLVGQCS HWICPSETLQ EYMKVVMTLE 420

YDEKPPYNML RSSLEDLLRD LRSSAYDPVD LQMVP 455

Nucleotide Sequence
(FASTA)

ATGTTCACCT TCTGTCCAGA CTGTGGCAAA AGTATTGAAG CCTCATTCAA GTTCTGCCCC 60

TACTGTGGAA AACCTTTGTC CTTAGCAGAG CATGAAGGGT CCCAGACCTT TGTCAGACCG 120

CGTACGTCAT CCTTCCGAGG CTCAAGGAAA CAAAGCAACT CCAGTCCTGA GATCCCTTGT 180

AAGAAAGTGA AATGGTCCAG CTCTGTCACC TCCCCCTCCT CATCCCTCTG CTTAGATGGT 240

GACAGTTCTG GGTCTGAAGA TACTGTGAGA TCCAAAGGGT CCTGGAGCAG ACCCCCAACC 300

CCCAAAAGCA GCCCACAGGC AACCAAGCGA AGCCCGCAGG CGATGAAGAG AAGCCCACAG 360

ACACTGAAGC GGAGCCGGGT GACAACCTCA CTTGAGGCTC TGCCCACAGG GGTGGTGGTG 420

ACAGACAAGA GTGGGCGGCA CTGGAAGCTG GGACCCCTCC AGACCAGGGA TGACCAGGGC 480

ATTCTCTATG AAGCTGAGGC TCTCTCCACC CTCGCCTGCA AGTCAAGTCA GAAGCAGACG 540

TTCTCGCTTA AACTTGATGC CAAGGATGGG CGCTTGTTCA ACGAGCAGAA CTTCTTCCAG 600

CGGGCCGCCA AGCCTCTGCA AGTGAACAAG TGGAAGAAGC TGAACTCGAC CCCCCTCCTG 660

GCCATCCCCA CCTGCGTTGG TTTTGGGATT CACCAGGACA GGTACAGGTT CCTGGTGTTT 720

CCCATGCTGG GGAGGAGCCT TCAGTCGGTC CTGGATGACA ACCCGAAGCA CGTCTTGTCG 780

ATGAAGTCTG TGTTCCAGAT GGCCTGCCGG CTGCTGGATG TCCTGGAGTT TCTCCATGAG 840

AATGAGTACG TCCATGGAAA TGTGACAGCT AAGAACATCT TTGTGAATCC AGAGGACCTG 900

AGCCAGGTGA CACTGGCAGG CTACGGCTTC ACCTTCCGCT ATGCCCCCGG TGGCAAACAC 960

GTGGCCTACG TGGAAGGCAG CAGGAGCCCA CATGAGGGGG ATCTTGAGTT CATGAGCCTT 1020

GACCTGCACA AGGGATGCGG GCCATCCCGC CGCAGTGACC TCCAGACCCT GGGCTACTGT 1080

TTGCTGAAAT GGCTCTACGG GATACTGCCA TGGACAGACT GCCTTCCCAA CATCGAGGAT 1140

ATCATGAAAC TGAAACAGAA GTTTCTTGAC AACCCAGAGA CCCTCGTGGG ACAGTGCAGT 1200

CACTGGATCT GTCCCTCAGA GACCCTGCAG GAGTACATGA AGGTGGTGAT GACCCTCGAG 1260

TACGATGAGA AGCCGCCCTA CAACATGCTG AGGAGCAGTC TAGAAGACCT GCTACGGGAT 1320

CTGCGGTCGT CAGCCTATGA CCCAGTGGAC CTCCAGATGG TTCCATAG 1368

Domain Profile

S: 1     wklgkkigkggfGeiyla....ltckkeekdaklvvkvepkenGpLfvelkfyqraakke  56

         wklg  ++++++G++y+a    + + k+++++++++k+++k+ G+Lf+e++f+qraak+

Q: 148   WKLGPLQTRDDQGILYEAealsTLACKSSQKQTFSLKLDAKD-GRLFNEQNFFQRAAKPL  206

         9*****************998844556778899********9.*****************

S: 57    qikkwkkkkklkllgiPtliasGlhefegekyRflvlprlgrdLqklleqngkr.lsekt  115

         q++kwkk ++++ll+iPt++++G+h+   ++yRflv+p lgr+Lq++l++n+k+ ls+k+

Q: 207   QVNKWKKLNSTPLLAIPTCVGFGIHQ---DRYRFLVFPMLGRSLQSVLDDNPKHvLSMKS  263

         **************************...*************************99****

S: 116   vlqlavrlldvleylHeneYvHgdikAanllleeeeasqvyLvdyGlayrycpegkhkey  175

         v+q+a+rlldvle+lHeneYvHg+++A+n+++++e+ sqv+L++yG+++ry+p+gkh++y

Q: 264   VFQMACRLLDVLEFLHENEYVHGNVTAKNIFVNPEDLSQVTLAGYGFTFRYAPGGKHVAY  323

         ************************************************************

S: 176   kedkrraHdGtleftslDaHkGvapsrRsDleiLgYcllkWltgkLPWeallkdpekvqk  235

         +e++r++H+G+lef+slD+HkG++psrRsDl++LgYcllkWl+g LPW+++l++ e+++k

Q: 324   VEGSRSPHEGDLEFMSLDLHKGCGPSRRSDLQTLGYCLLKWLYGILPWTDCLPNIEDIMK  383

         ************************************************************

S: 236   akekfldelpellkkllkkkssseelakyl  265

          k+kfld++++l+ ++ ++  +se+l++y+

Q: 384   LKQKFLDNPETLVGQCSHWICPSETLQEYM  413

         *****************************7

Domain Sequence
(FASTA)

WKLGPLQTRD DQGILYEAEA LSTLACKSSQ KQTFSLKLDA KDGRLFNEQN FFQRAAKPLQ 60

VNKWKKLNST PLLAIPTCVG FGIHQDRYRF LVFPMLGRSL QSVLDDNPKH VLSMKSVFQM 120

ACRLLDVLEF LHENEYVHGN VTAKNIFVNP EDLSQVTLAG YGFTFRYAPG GKHVAYVEGS 180

RSPHEGDLEF MSLDLHKGCG PSRRSDLQTL GYCLLKWLYG ILPWTDCLPN IEDIMKLKQK 240

FLDNPETLVG QCSHWICPSE TLQEYM 266

Keyword

Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0070373	; P:negative regulation of ERK1 and ERK2 cascade
GO:0032516	; P:positive regulation of phosphoprotein phosphatase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013