EKS-MUP-00322

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00322

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	319.8	1.3E-95	26	277	252

Status

Unreviewed

Ensembl Protein

ENSMPUP00000002840

UniProt Accession

G9KSD9;

Protein Name

Protein Synonyms/Alias

TAO kinase 3;

Gene Name

TAOK3

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000002869	ENSMPUP00000002840	ENSMPUT00000002899

Organism

Mustela putorius furo

Functional Description

Protein Length

914

Protein Sequence
(FASTA)

MRKGVPKDSE IADLFYKDDP EELFIDLHEI GHGSFGAVYF ATNAHTNEVV AIKKMSYSGK 60

QTQEKWQDIL KEVKFLRQLK HPNTIEYKGC YLKEHTAWLV MEYCLGSASD LLEVHKKPLQ 120

EVEIAAITHG ALQGLAYLHS HAMIHRDIKA GNILLTEPGQ VKLADFGSAS MASPANSFVG 180

TPYWMAPEVI LAMDEGQYDG KVDIWSLGIT CIELAERKPP LFNMNAMSAL YHIAQNDSPT 240

LQSNEWTDSF RRFVDYCLQK IPQERPTSAE LLRHDFVRRD RPLRVLIDLI QRTKDAVREL 300

DNLQYRKMKK ILFQETRNGP LNESQEDEED SEHGTSLIRE MDSLGSNHSI PSMSVSTGSQ 360

SSSVNSMPEV MDENSSEPVM MHDDESTVNS SSSVVPKKDH VFIRDEAGHG DPRPEPRPTQ 420

SVQSQALHYR NRERFATIKS ASLVTRQIHE HEQENELREQ MSGYKRMRRQ HQKQLIALEN 480

KLKAEMDEHR LKLQKEVETH ANNSSIELEK LAKKQVAIIE KEAKVAAADE KKFQQQILAQ 540

QKKDLTTFLE SQKKQYKICK EKIKEEMNED HSTPKKEKQE RISKHKENLQ HTQAEEEAHL 600

LTQQRLYYDK NCRFFKRKIM IKRHEVEQQN IREELNKKRT QKEMEHAMLI RHDESTRELE 660

YRQLHTLQKL RMDLIRLQHQ TELENQLEYN KRRERELHRK HVMELRQQPK NLKAMEMQIK 720

KQFQDTCKVQ TKQYKALKNH QLEVTPKNEH KTILKTLKDE QTRKLAILAE QYEQSINEMM 780

ASQALRLDEA QEAECQALRL QLQQEMELLN AYQSKIKMQT EAQHERELQK LEQRVSLRRA 840

HLEQKIEEEL AALQKERSER IKYLLESIWS STLSLDQIIL IFFFIPLPLP ESHILVINIA 900

LFTLSNCVFS YNKK 914

Nucleotide Sequence
(FASTA)

ATGCGTAAAG GGGTGCCGAA GGACTCAGAG ATTGCTGATC TCTTCTACAA AGATGATCCT 60

GAAGAACTTT TTATTGATTT GCACGAAATT GGACATGGAA GTTTTGGAGC AGTTTATTTT 120

GCCACAAATG CTCACACCAA TGAGGTGGTG GCAATTAAGA AAATGTCCTA CAGTGGGAAA 180

CAGACACAAG AGAAATGGCA AGATATTCTC AAGGAAGTCA AATTTTTAAG ACAATTGAAG 240

CATCCTAACA CCATTGAGTA TAAAGGTTGT TACTTGAAAG AGCACACTGC TTGGTTGGTG 300

ATGGAATATT GCTTAGGCTC AGCCTCTGAT TTGTTAGAAG TTCACAAAAA ACCACTTCAG 360

GAAGTGGAAA TTGCTGCCAT TACTCACGGT GCCTTGCAGG GGCTGGCCTA CCTGCATTCT 420

CATGCAATGA TTCATAGGGA TATTAAAGCA GGAAATATTC TTCTAACAGA GCCAGGTCAG 480

GTGAAACTAG CTGATTTTGG ATCTGCCTCG ATGGCTTCTC CTGCCAACTC CTTTGTGGGC 540

ACTCCTTACT GGATGGCTCC AGAGGTGATC TTGGCTATGG ATGAAGGACA GTATGATGGG 600

AAAGTTGATA TTTGGTCACT TGGAATCACC TGTATTGAAT TGGCGGAACG GAAGCCCCCC 660

CTTTTCAACA TGAATGCAAT GAGTGCCTTA TACCACATTG CCCAGAACGA CTCCCCAACG 720

CTACAGTCTA ATGAATGGAC AGACTCCTTT CGGAGATTTG TTGATTACTG CTTGCAGAAA 780

ATACCTCAGG AAAGGCCAAC GTCAGCGGAG CTATTAAGGC ATGATTTTGT TCGACGAGAC 840

CGGCCACTCC GTGTCCTAAT TGACCTCATA CAGAGGACAA AAGATGCTGT CCGTGAATTA 900

GATAACCTAC AGTACCGAAA AATGAAAAAA ATCCTTTTCC AAGAGACACG AAATGGACCC 960

TTGAATGAGT CACAGGAGGA TGAAGAGGAC AGCGAACATG GAACCAGCCT GATCAGGGAA 1020

ATGGACAGCC TGGGCAGCAA CCATTCCATC CCAAGCATGT CTGTGAGCAC AGGCAGCCAG 1080

AGCAGCAGTG TGAACAGCAT GCCAGAGGTC ATGGATGAGA ACAGCTCTGA ACCTGTTATG 1140

ATGCACGATG ACGAAAGCAC CGTAAATTCC AGTTCCTCTG TTGTGCCCAA GAAGGATCAT 1200

GTATTCATAA GGGATGAGGC GGGCCACGGC GATCCCAGGC CTGAGCCGCG GCCTACCCAG 1260

TCAGTTCAGA GCCAGGCCCT CCACTACCGG AACAGAGAGC GCTTTGCCAC GATCAAATCA 1320

GCATCTTTGG TTACACGACA GATCCATGAG CATGAGCAGG AGAACGAGTT GCGGGAACAG 1380

ATGTCAGGTT ATAAGCGGAT GCGGCGCCAG CACCAGAAGC AGCTGATCGC CCTGGAGAAC 1440

AAGCTGAAGG CTGAGATGGA CGAGCACCGC CTCAAGCTAC AGAAGGAGGT GGAGACGCAT 1500

GCCAACAACT CGTCCATCGA GCTGGAGAAG CTGGCCAAGA AGCAAGTGGC TATCATAGAG 1560

AAGGAGGCAA AGGTAGCTGC AGCAGATGAG AAGAAGTTCC AGCAACAGAT CTTGGCCCAG 1620

CAGAAGAAAG ATTTGACAAC TTTCTTAGAA AGTCAGAAGA AACAGTATAA GATTTGTAAG 1680

GAAAAAATAA AAGAGGAGAT GAACGAGGAC CATAGCACAC CCAAGAAAGA AAAGCAAGAG 1740

CGGATATCCA AGCATAAAGA GAACTTGCAG CACACACAGG CTGAAGAGGA AGCCCACCTT 1800

CTCACCCAGC AGAGACTGTA CTACGACAAA AACTGTCGTT TCTTCAAGCG GAAAATAATG 1860

ATCAAGCGGC ATGAGGTGGA GCAGCAGAAC ATCCGGGAGG AACTAAATAA AAAGAGGACC 1920

CAGAAGGAGA TGGAGCACGC CATGCTGATC CGACACGACG AGTCCACCCG AGAGCTCGAG 1980

TACAGGCAGC TGCACACGTT ACAGAAGCTG CGCATGGACC TGATCCGTCT ACAGCACCAG 2040

ACCGAACTGG AAAACCAGCT GGAGTACAAT AAGAGGCGGG AAAGGGAACT GCACAGGAAG 2100

CATGTCATGG AACTTCGGCA ACAGCCAAAA AACTTAAAGG CCATGGAAAT GCAAATTAAA 2160

AAACAGTTTC AGGACACTTG CAAAGTACAG ACCAAACAGT ATAAAGCACT CAAGAATCAC 2220

CAGTTGGAAG TTACTCCAAA GAATGAGCAC AAAACAATCT TAAAGACACT GAAAGATGAG 2280

CAGACAAGAA AACTTGCCAT TTTGGCAGAG CAGTATGAAC AGAGTATAAA TGAAATGATG 2340

GCCTCTCAAG CGTTACGGCT AGATGAGGCT CAAGAAGCAG AATGCCAGGC CTTGAGGCTA 2400

CAGCTCCAGC AGGAAATGGA GCTGCTCAAT GCCTACCAGA GCAAAATCAA GATGCAAACA 2460

GAGGCACAGC ATGAACGTGA GCTCCAGAAG CTAGAGCAGA GGGTGTCTCT ACGTAGAGCA 2520

CATCTTGAGC AGAAGATTGA AGAAGAGCTG GCTGCCCTTC AGAAGGAACG CAGCGAGAGA 2580

ATAAAGTACC TATTGGAAAG TATTTGGAGT TCGACACTGT CTCTCGATCA GATCATCTTG 2640

ATCTTTTTCT TTATTCCCCT TCCCCTCCCT GAGTCCCATA TCTTGGTCAT AAATATTGCA 2700

TTATTCACAC TTTCAAACTG TGTATTTTCT TACAATAAAA AATGA 2745

Domain Profile

S: 3     lleeigkGalgkvylarekktgelvaikkinlekq...ekleelqkeisvlkklkhpniv  59

          l+eig+G++g+vy a++ +t+e+vaikk++++ +   ek++++ ke+++l++lkhpn +

Q: 26    DLHEIGHGSFGAVYFATNAHTNEVVAIKKMSYSGKqtqEKWQDILKEVKFLRQLKHPNTI  85

         5789****************************9887889*********************

S: 60    eylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkv  119

         ey +++lke++ wlvmey+  Gs+sdl++ ++k++l+E +ia+i++++l++L+ylHs+ +

Q: 86    EYKGCYLKEHTAWLVMEYCL-GSASDLLE-VHKKPLQEVEIAAITHGALQGLAYLHSHAM  143

         *******************7.********.******************************

S: 120   iHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYd  178

         iHrdika+niLlte g+VkL+dfg+a+  +      +++vgtpywmAPEvi ++ e +Yd

Q: 144   IHRDIKAGNILLTEPGQVKLADFGSASMASP----ANSFVGTPYWMAPEVILAMdEGQYD  199

         ************************9998888....69**************9887999**

S: 179   ekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekcl  238

          k+DiwslGIt+ielae++pP++++++++al++i++n++p+l+s+ +++++f++fv+ cl

Q: 200   GKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSN-EWTDSFRRFVDYCL  258

         ******************************************888.**************

S: 239   qknpekRpsasellkhkFl  257

         qk p++Rp+++ell+h F+

Q: 259   QKIPQERPTSAELLRHDFV  277

         *****************97

Domain Sequence
(FASTA)

DLHEIGHGSF GAVYFATNAH TNEVVAIKKM SYSGKQTQEK WQDILKEVKF LRQLKHPNTI 60

EYKGCYLKEH TAWLVMEYCL GSASDLLEVH KKPLQEVEIA AITHGALQGL AYLHSHAMIH 120

RDIKAGNILL TEPGQVKLAD FGSASMASPA NSFVGTPYWM APEVILAMDE GQYDGKVDIW 180

SLGITCIELA ERKPPLFNMN AMSALYHIAQ NDSPTLQSNE WTDSFRRFVD YCLQKIPQER 240

PTSAELLRHD FV 252

Keyword

Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0000165	; P:MAPK cascade
GO:0046329	; P:negative regulation of JNK cascade
GO:0046330	; P:positive regulation of JNK cascade
GO:0043507	; P:positive regulation of JUN kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013