EKS-MUP-00042

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00042

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/VRK	434.1	1.6E-130	37	303	267

Status

Unreviewed

Ensembl Protein

ENSMPUP00000003018

UniProt Accession

G9KXG9;

Protein Name

Protein Synonyms/Alias

Vaccinia related kinase 1;

Gene Name

Vrk1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000003048	ENSMPUP00000003018	ENSMPUT00000003079

Organism

Mustela putorius furo

Functional Description

Protein Length

395

Protein Sequence
(FASTA)

MPRVKAAQAG RQGPGKRRLA ENFAPGEVIT DMAKKEWKLG APVGQGGFGC IYLADMNSSK 60

SVGSDAPCVV KVEPSDNGPL FTELKFYQRA AKPEQIQKWI RTHKLKYLGV PKYWGSGLHD 120

KNGKSYRFMI MDRFGSDLQK IYEANARRFS RKTVLQLSLR ILDILEYIHE HEYVHGDIKA 180

SNLLLSYKNP DQVYLVDYGL AYRYCPEGIH KEYKEDPKRC HDGTIEFTSI DAHKGVAPSR 240

RGDLEILGYC MIQWLSGHLP WEDNLKDPNY VRDSKIRYRE NIADLMDRCF PERNKPDEIA 300

KYMETVKLLD YAEKPLYQNL RDILLQGLRA IGSKDDGKLD LSLVENGGLR TKSITKRKKG 360

IEESTKSSVE DMDCSSTQTE EATKTRSKAR KRVQK 395

Nucleotide Sequence
(FASTA)

ATGCCTCGTG TAAAAGCCGC TCAAGCTGGA AGACAGGGCC CTGGAAAGAG ACGACTTGCG 60

GAAAACTTTG CCCCTGGGGA GGTGATCACT GACATGGCGA AGAAGGAGTG GAAGCTGGGC 120

GCTCCCGTTG GCCAGGGTGG CTTTGGTTGT ATATATCTCG CTGATATGAA TTCTTCAAAA 180

TCGGTGGGCA GCGATGCACC TTGTGTTGTA AAAGTGGAGC CCAGTGACAA CGGACCTCTC 240

TTTACTGAAC TGAAGTTCTA CCAGCGAGCT GCCAAACCAG AGCAAATTCA GAAGTGGATT 300

CGTACCCATA AACTGAAGTA CCTGGGTGTT CCTAAGTATT GGGGGTCTGG CCTACATGAT 360

AAAAACGGAA AGAGTTACAG GTTTATGATA ATGGATCGCT TTGGGAGTGA CCTTCAGAAA 420

ATATATGAAG CAAATGCCAG AAGGTTTTCT CGGAAAACTG TCTTGCAGCT AAGCTTGAGA 480

ATTCTGGATA TTCTGGAATA TATTCATGAG CATGAGTATG TACATGGAGA TATCAAGGCC 540

TCAAATCTTC TTTTGAGCTA CAAGAATCCT GACCAGGTGT ACTTGGTAGA TTACGGCCTT 600

GCTTACCGGT ATTGCCCAGA AGGAATCCAT AAAGAATACA AAGAAGACCC CAAAAGATGT 660

CACGATGGCA CTATTGAATT CACCAGCATC GACGCACACA AGGGTGTCGC CCCGTCAAGA 720

CGTGGTGATT TGGAAATCCT TGGTTATTGC ATGATCCAGT GGCTTAGTGG CCATCTTCCT 780

TGGGAGGATA ATTTGAAAGA TCCTAACTAT GTTAGAGATT CCAAAATTAG ATACAGAGAA 840

AATATTGCAG ATTTGATGGA CAGATGTTTT CCCGAGAGAA ACAAGCCAGA TGAGATTGCT 900

AAATACATGG AAACAGTGAA ATTACTGGAC TATGCCGAGA AACCTCTTTA TCAGAACTTG 960

CGAGACATTC TTCTGCAAGG ACTGAGAGCT ATAGGAAGCA AAGATGATGG CAAGCTGGAC 1020

CTCAGCCTCG TGGAGAATGG AGGCTTGAGA ACAAAGTCAA TAACGAAGCG CAAGAAAGGA 1080

ATTGAGGAGA GCACCAAATC CAGTGTCGAA GATATGGACT GCTCCAGTAC ACAGACAGAA 1140

GAGGCCACAA AAACCCGTTC AAAAGCCAGA AAGAGAGTCC AGAAGTAA 1188

Domain Profile

S: 1     wklgkkigkggfGeiyla..ltckkeekdaklvvkvepkenGpLfvelkfyqraakkeqi  58

         wklg ++g+ggfG+iyla  +++k++++da +vvkvep++nGpLf+elkfyqraak+eqi

Q: 37    WKLGAPVGQGGFGCIYLAdmNSSKSVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI  96

         9*****************9999**************************************

S: 59    kkwkkkkklkllgiPtliasGlhefegekyRflvlprlgrdLqklleqngkrlsektvlq  118

         +kw++++klk+lg+P++++sGlh+++g++yRf++++r+g+dLqk++e+n++r+s+ktvlq

Q: 97    QKWIRTHKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANARRFSRKTVLQ  156

         ************************************************************

S: 119   lavrlldvleylHeneYvHgdikAanllleeeeasqvyLvdyGlayrycpegkhkeyked  178

         l++r+ld+ley+He+eYvHgdikA+nlll++++++qvyLvdyGlayrycpeg hkeyked

Q: 157   LSLRILDILEYIHEHEYVHGDIKASNLLLSYKNPDQVYLVDYGLAYRYCPEGIHKEYKED  216

         ************************************************************

S: 179   krraHdGtleftslDaHkGvapsrRsDleiLgYcllkWltgkLPWeallkdpekvqkake  238

         ++r+HdGt+efts+DaHkGvapsrR+DleiLgYc+++Wl+g+LPWe++lkdp++v+++k

Q: 217   PKRCHDGTIEFTSIDAHKGVAPSRRGDLEILGYCMIQWLSGHLPWEDNLKDPNYVRDSKI  276

         ************************************************************

S: 239   kfldelpellkkllkkkssseelakyl  265

         ++ +++++l+++++++++++ e+aky+

Q: 277   RYRENIADLMDRCFPERNKPDEIAKYM  303

         **************************8

Domain Sequence
(FASTA)

WKLGAPVGQG GFGCIYLADM NSSKSVGSDA PCVVKVEPSD NGPLFTELKF YQRAAKPEQI 60

QKWIRTHKLK YLGVPKYWGS GLHDKNGKSY RFMIMDRFGS DLQKIYEANA RRFSRKTVLQ 120

LSLRILDILE YIHEHEYVHG DIKASNLLLS YKNPDQVYLV DYGLAYRYCP EGIHKEYKED 180

PKRCHDGTIE FTSIDAHKGV APSRRGDLEI LGYCMIQWLS GHLPWEDNLK DPNYVRDSKI 240

RYRENIADLM DRCFPERNKP DEIAKYM 267

Keyword

ATP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005795	; C:Golgi stack
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0090166	; P:Golgi disassembly
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013