EKS-MUP-00019

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MUP-00019

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	514.6	4.7E-155	995	1262	268

Status

Unreviewed

Ensembl Protein

ENSMPUP00000003699

UniProt Accession

G9K5W5;

Protein Name

Protein Synonyms/Alias

Insulin receptor-related receptor;

Gene Name

INSRR

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMPUG00000003729	ENSMPUP00000003699	ENSMPUT00000003767

Organism

Mustela putorius furo

Functional Description

Protein Length

1358

Protein Sequence
(FASTA)

PRSRSETGKL QMGWEQGMGS ERPQRPCQRG VCPSLDIRSE VAELRRLENC SVVEGHLQIL 60

LMFTATGEDF RGLSFPRLTQ VTDYLLLFRV YGLESLRDLF PNLAVVRGAR LFLGYALVIY 120

EMPHLRDVGL PALGAVLRGA VRVEKNQELC HLSTIDWGLL QPSPGANHIV GNKLREECAD 180

VCPGVLGATG QPCARTTFGG HTDYRCWTSS HCQRVCPCPH GLACTAWGEC CHSECLGGCS 240

RPEDPRACLA CRHLYFQGAC HRACPPGTYQ HESWRCVTAE RCASLRSVPG RASTFGIHEG 300

SCLAQCPPGF TRNSSSIFCH KCEGLCPKEC KVGTKTIDSI QVAQDLAGCT HVEGSLIVNL 360

RQGYNLEPEL QQSLGLIETI TGFLKIKHSF ALVSLGFFRN LKLIRGDAMV DGNYTLYVLD 420

NQNLQQLGSW VAAGLTIPVG KIYFAFNPRL CLEHIYRLEE VTGTRGRQNK AEINPRTNGD 480

RAACETRTLR FVSNVTQADS ILLRWERYEP LEARDLLSFI VYYKESPFQN ATEHIGPDAC 540

GTQSWNLLDV ELPLSRTQEP GVTLAPLKPW TQYAVFVRAI TLTTAEDSPH QGAQSPIVYL 600

RTLPAAPTVP QDVISTSNSS SHLLVRWKPP TQRNGNITYY LVLWQRLAED GDLYLNDYCH 660

RGLRLPTSHS DPRFDREDEE PEAETEPGCC PCQHPPPGQV LPPLEAQEAS GRGLTQPSLV 720

SPDPPGRRTL TGEPGGIEGW RSRGAAAALT RALPRDSGRQ RRAAGTLRLG GNTSDFEIQE 780

DKVPRERAVL SGLRHFTEYR IDIHACNHAA HTVGCSAATF VFARTMPHRE ADGIPGKVAW 840

EAASKSSVLL RWLEPPDPNG LILKYEIKYR RLGEEATVLC VSRLRYAKFG GVQLALLPPG 900

NYSARVRATS LAGNGSWTES IAFYVPGPEE EDSGGLHVLL TVTPVGLMLL IILAALGFFY 960

GRKRSSTLYA SVNPEYFSAS EMYVPDEWEV PREQISIIRE LGQGSFGMVY EGLAQGLEAG 1020

EESTPVALKT VNELASPRER IEFLKEASVM KAFKCHHVVR LLGVVSQGQP TLVIMELMTR 1080

GDLKSHLRSL RPESENNPGL PRPALGDMIQ MAGEIADGMA YLAANKFVHR DLAARNCMVS 1140

QDFTVKIGDF GMTRDVYETD YYRKGGKGLL PVRWMAPESL KDGIFTTHSD VWSFGVVLWE 1200

IVTLAEQPYQ GLSNEQVLKF VMDGGVLEEL ESCPLQLQEL MRRCWQQSPR LRPAFTHILD 1260

SIRGELRPSF RLFSFYYSPE CRAARGALLP DVKPDSLPTP EEASSGCRRH SHPIPCRVAS 1320

PPPSSPSLKP GTPQLGVPPP SSPGTCLGAV SPLPTGPS 1358

Nucleotide Sequence
(FASTA)

CCCAGGAGCA GGTCGGAGAC AGGAAAGCTG CAAATGGGTT GGGAGCAGGG GATGGGGTCA 60

GAGAGGCCGC AGAGGCCTTG CCAGCGAGGA GTGTGTCCCA GCCTGGACAT CCGCTCGGAG 120

GTGGCCGAGC TGCGCCGTCT GGAGAACTGC AGCGTGGTGG AGGGCCATCT GCAGATCCTG 180

CTCATGTTCA CGGCCACCGG TGAGGACTTC CGCGGCCTCA GCTTCCCGCG CCTCACTCAG 240

GTCACGGACT ACCTGCTCCT CTTCCGCGTC TATGGCCTGG AGAGCCTGCG GGACCTCTTC 300

CCCAACCTGG CAGTGGTGCG CGGCGCCCGC CTCTTCCTGG GCTACGCACT GGTCATCTAC 360

GAGATGCCGC ACCTGCGGGA CGTGGGGCTG CCGGCGCTGG GGGCCGTGCT GCGCGGGGCC 420

GTGCGGGTGG AGAAGAACCA GGAGCTGTGC CACCTCTCCA CCATCGACTG GGGCCTACTG 480

CAGCCCTCAC CTGGCGCCAA CCACATCGTG GGCAACAAGC TGCGTGAGGA GTGTGCGGAC 540

GTGTGCCCCG GCGTGCTGGG TGCCACCGGC CAGCCCTGCG CCAGGACCAC CTTCGGCGGG 600

CACACTGACT ACAGGTGCTG GACCTCCAGC CACTGCCAGA GAGTGTGTCC CTGTCCCCAT 660

GGGCTGGCCT GCACAGCTTG GGGGGAGTGC TGCCACTCCG AATGCCTGGG GGGCTGCAGC 720

CGACCAGAGG ACCCCCGGGC CTGCCTGGCC TGTCGTCACC TCTACTTCCA GGGTGCCTGT 780

CACCGGGCCT GCCCTCCAGG CACCTACCAG CATGAGTCCT GGCGCTGTGT CACGGCAGAG 840

CGCTGTGCCA GCCTGCGCTC TGTGCCCGGC CGCGCCTCCA CCTTCGGCAT CCACGAGGGC 900

AGCTGCCTGG CCCAGTGCCC CCCGGGCTTC ACCCGCAACA GCAGCAGCAT ATTCTGCCAC 960

AAGTGTGAGG GGCTGTGCCC CAAAGAGTGC AAGGTGGGCA CCAAGACCAT CGACTCCATC 1020

CAGGTGGCAC AGGACCTGGC GGGCTGCACC CATGTGGAGG GGAGCCTCAT CGTCAACCTT 1080

CGCCAAGGCT ATAACCTAGA GCCGGAGCTA CAGCAAAGCC TGGGGCTCAT CGAGACCATC 1140

ACTGGCTTCC TCAAAATCAA GCACTCCTTT GCCCTCGTGT CCCTGGGCTT TTTCAGGAAC 1200

CTCAAACTAA TCCGAGGGGA CGCCATGGTG GATGGGAACT ACACTCTGTA CGTGCTGGAC 1260

AACCAGAACC TACAACAGCT GGGGTCCTGG GTGGCTGCGG GGCTCACCAT TCCCGTGGGC 1320

AAGATCTACT TCGCCTTCAA CCCTCGCCTC TGCTTGGAGC ACATCTACCG CCTGGAGGAG 1380

GTGACCGGCA CTCGGGGACG GCAAAACAAG GCCGAGATCA ACCCCCGCAC CAATGGAGAC 1440

CGCGCCGCCT GTGAGACTCG CACCCTGCGC TTCGTGTCCA ACGTGACGCA GGCCGACAGC 1500

ATCTTGCTGC GCTGGGAGCG CTACGAGCCG CTGGAGGCTC GCGACCTGCT CAGCTTCATC 1560

GTGTACTACA AGGAGTCCCC ATTCCAGAAC GCCACAGAGC ACATAGGTCC AGACGCCTGC 1620

GGGACCCAGA GCTGGAACCT GCTGGATGTG GAGCTGCCCT TAAGCCGCAC CCAGGAACCC 1680

GGGGTGACTC TTGCACCCCT CAAGCCTTGG ACACAATATG CAGTGTTTGT AAGGGCCATC 1740

ACACTGACCA CCGCTGAGGA CAGCCCCCAC CAAGGAGCCC AGAGCCCCAT CGTCTACCTC 1800

CGAACCCTGC CGGCGGCGCC CACGGTGCCC CAGGACGTCA TCTCCACGTC CAACTCCTCC 1860

TCCCACCTGC TGGTGCGCTG GAAGCCGCCG ACTCAGCGCA ACGGGAACAT CACCTACTAC 1920

CTGGTGCTGT GGCAGCGTCT GGCGGAGGAC GGCGACCTCT ACCTCAACGA CTACTGCCAC 1980

CGCGGCTTGC GCCTGCCCAC CAGCCACAGC GACCCCCGCT TCGACCGCGA AGACGAGGAG 2040

CCGGAAGCCG AGACGGAGCC CGGCTGCTGC CCCTGCCAGC ACCCCCCTCC CGGGCAGGTC 2100

CTGCCGCCGC TGGAGGCGCA GGAGGCCTCC GGGCGGGGCC TGACGCAGCC CTCCCTGGTC 2160

TCCCCAGATC CCCCTGGAAG AAGAACCCTC ACAGGTGAGC CGGGCGGGAT TGAGGGGTGG 2220

CGGTCCCGGG GCGCGGCCGC GGCTCTGACT CGCGCCCTCC CCAGGGACTC GGGGAGGCAG 2280

CGCCGGGCCG CCGGGACCCT CCGGCTTGGG GGAAACACCT CGGATTTCGA GATCCAGGAG 2340

GACAAAGTGC CCCGGGAGCG CGCAGTGTTG AGTGGCCTGC GTCACTTCAC GGAATATCGC 2400

ATCGACATCC ACGCCTGCAA CCACGCGGCG CACACCGTGG GCTGCAGCGC CGCCACCTTC 2460

GTCTTCGCGC GCACCATGCC CCACAGAGAA GCCGATGGCA TCCCAGGGAA GGTGGCCTGG 2520

GAGGCGGCCA GCAAAAGCAG TGTCCTCCTG CGCTGGCTGG AGCCACCGGA CCCCAACGGA 2580

CTCATCCTCA AATACGAAAT CAAGTACCGC CGCTTGGGAG AGGAGGCCAC CGTGCTGTGT 2640

GTGTCCCGAC TGCGGTACGC CAAGTTTGGG GGCGTCCAGC TGGCCCTGCT ACCCCCTGGA 2700

AACTACTCTG CCAGAGTCCG GGCCACCTCG CTGGCAGGCA ATGGCTCCTG GACAGAAAGC 2760

ATCGCTTTCT ATGTCCCCGG CCCAGAGGAG GAAGACTCCG GGGGGCTGCA CGTCCTTCTC 2820

ACTGTCACCC CCGTGGGGCT CATGCTGCTC ATCATTCTTG CTGCCCTTGG TTTCTTCTAC 2880

GGCAGGAAGA GAAGCAGCAC CCTGTATGCC TCTGTGAATC CGGAGTACTT CAGCGCCTCT 2940

GAGATGTACG TCCCTGATGA GTGGGAGGTG CCTCGGGAGC AGATCTCCAT AATCCGGGAA 3000

CTGGGTCAGG GCTCCTTTGG GATGGTATAC GAGGGGCTGG CACAAGGGCT GGAGGCCGGA 3060

GAGGAGTCCA CACCGGTGGC CCTGAAGACC GTCAATGAGC TGGCCAGTCC ACGAGAACGC 3120

ATCGAGTTCC TCAAGGAAGC CTCTGTCATG AAGGCATTCA AGTGTCACCA TGTGGTACGT 3180

CTCCTGGGCG TGGTGTCCCA GGGCCAGCCA ACTCTGGTCA TCATGGAGTT AATGACCCGG 3240

GGGGACCTCA AGAGCCATCT TCGATCTCTG CGGCCCGAGT CAGAGAACAA CCCGGGGCTC 3300

CCACGGCCAG CGCTGGGAGA TATGATCCAG ATGGCTGGTG AGATTGCAGA TGGCATGGCC 3360

TACCTTGCTG CCAACAAGTT TGTGCACCGA GATCTGGCGG CCCGGAACTG CATGGTGTCC 3420

CAGGACTTCA CTGTCAAGAT TGGGGACTTT GGGATGACTC GAGACGTGTA CGAAACTGAC 3480

TATTACCGCA AGGGTGGGAA GGGGCTGCTG CCCGTGCGCT GGATGGCCCC CGAGTCCCTC 3540

AAAGATGGAA TCTTCACCAC GCACTCGGAT GTCTGGTCCT TCGGTGTGGT GCTCTGGGAG 3600

ATCGTGACCT TGGCCGAACA GCCCTACCAG GGCTTATCCA ACGAGCAGGT GCTCAAGTTT 3660

GTCATGGATG GTGGGGTCCT GGAGGAGCTG GAGAGCTGTC CCCTTCAGCT GCAGGAGCTG 3720

ATGCGCCGCT GTTGGCAGCA GAGCCCGCGC CTGCGACCCG CCTTCACCCA CATCCTGGAC 3780

AGCATCCGGG GCGAGCTGCG GCCCTCCTTC CGTCTCTTTT CCTTCTACTA CAGTCCAGAG 3840

TGCCGGGCGG CCCGCGGGGC GCTGCTGCCT GATGTCAAAC CTGACTCTCT GCCCACCCCA 3900

GAAGAGGCTT CCTCAGGCTG CCGCAGACAC TCACACCCCA TCCCATGCCG GGTAGCTTCC 3960

CCGCCGCCTT CCTCTCCTTC GCTGAAACCA GGAACCCCCC AGCTTGGTGT TCCTCCTCCC 4020

TCGTCCCCAG GCACATGCCT CGGTGCAGTT TCCCCCCTTC CCACAGGCCC TTCC 4074

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeG+a+++++gee+t+va+ktvne as rerieflkeasvmk+fk

Q: 995   ISIIRELGQGSFGMVYEGLAQGLEAGEESTPVALKTVNELASPRERIEFLKEASVMKAFK  1054

         6799********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlks+lrslrpe+en+++l++pal+++iqma+e

Q: 1055  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPESENNPGLPRPALGDMIQMAGE  1114

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmv++d+tvkiGdfGmtrd+yetdyyrkggkgllpvrw

Q: 1115  IADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRW  1174

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdG+ft++sdvwsfGvvlweivtlaeqpyqGlsneqvlkfv+dggvle++e+cp

Q: 1175  MAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELESCP  1234

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

          +l+elmr+cwq +p+lrp+f++i++++

Q: 1235  LQLQELMRRCWQQSPRLRPAFTHILDSI  1262

         ************************9976

Domain Sequence
(FASTA)

ISIIRELGQG SFGMVYEGLA QGLEAGEEST PVALKTVNEL ASPRERIEFL KEASVMKAFK 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SHLRSLRPES ENNPGLPRPA LGDMIQMAGE 120

IADGMAYLAA NKFVHRDLAA RNCMVSQDFT VKIGDFGMTR DVYETDYYRK GGKGLLPVRW 180

MAPESLKDGI FTTHSDVWSF GVVLWEIVTL AEQPYQGLSN EQVLKFVMDG GVLEELESCP 240

LQLQELMRRC WQQSPRLRPA FTHILDSI 268

Keyword

Receptor.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0071469	; P:cellular response to alkalinity
GO:0030238	; P:male sex determination
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013